Hydrogel Formation of Enzymatically Solubilized Corn Bran Feruloylated Arabinoxylan by Laccase-Catalyzed Cross-Linking.

In order to upgrade the potential of cereal bran arabinoxylan for advanced hydrogel applications, a deep understanding of its gelation process is required. This work provides a comprehensive and systematic analysis of the laccase-catalyzed cross-linking of feruloylated arabinoxylan (FAX) to establish a clear link between processing conditions and final hydrogel properties. Endo-1,4-xylanase was used to obtain corn bran FAX rich in ferulic acid moieties, and then we demonstrated that gel formation is driven by the oxidative coupling of these feruloyl monomers into diferulic acid bridges, e.

Portable handheld ultrasound for VExUS assessment in critical care: Reliability and time efficiency in resident-led examinations.

Objectives: Pathologic venous congestion significantly impacts outcomes yet remains underrecognized, necessitating practical bedside assessment. We evaluated the reliability and reproducibility of the venous excess ultrasound (VExUS) score using handheld ultrasound among resident trainees managing critically ill patients.

Method: Two blinded residents, trained in a short VExUS course, independently performed sequential VExUS scans on 80 critically ill patients using both handheld ultrasound and conventional ultrasound.

FSP1 and CoQ10 have the potential to serve as biomarkers for severe preeclampsia.

Background: Severe preeclampsia is a condition that poses a threat to pregnant women and fetuses, which requires prompt treatment and intervention. The ferroapoptosis suppressor protein 1(FSP1)-ubiquinone10 (CoQ10)-nicotinamide adenine dinucleotide phosphate(NADPH) pathway, a recently identified pathway that inhibits ferroptosis, is parallel to the cystine/glutathione (GSH) /GPX4 pathway. However, its expression in pregnant women with severe preeclampsia has not yet been investigated.

Comparative analysis of pectic polysaccharides isolated from various thinned young red-fleshed kiwifruits: Structural properties and biological functions.

To utilize thinned young kiwifruit for potential industrial applications, this study compared structural properties and bioactivities of pectic polysaccharides isolated from three thinned young red-fleshed kiwifruit cultivars, including cv. 'Donghong', 'Hongshi', and 'Hongyang'. The results demonstrated that these young kiwifruit byproducts were rich in pectic polysaccharides, with extraction yields of 90.

Genetic analysis of three patients from two unrelated Chinese families with autosomal recessive spastic ataxia of Charlevoix-Saguenay.

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early-onset neurodegenerative disorder characterized by progressive cerebellar ataxia, spasticity, and sensorimotor peripheral neuropathy. This disorder is caused by homozygous or compound heterozygous variants in the sacsin (SACS) gene on chromosome 13q12.12.

Structural Characteristics, Gelling Properties, Antioxidant Activity and Immunomodulatory Effects of Rhamnogalacturonan-I Rich Pectic Polysaccharides Alkaline-Extracted from Wax Apple ().

To upgrade the utilization of in food industries, the key biological component, i.e., polysaccharide, was extracted from the fruit by alkaline treatment, and its structural characteristics, physicochemical properties, gelling properties and biological activities were investigated.

Case report: a case of R0 resection in a patient with PD-L1-negative, microsatellite-stabilized advanced pancreatic cancer after down-stage treatment with a PD-1 inhibitor in combination with chemotherapy.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal tumor with high morbidity and mortality. Despite advances in diagnostic and therapeutic modalities, the outcome and prognosis of PDAC remain poor. Most patients have locally advanced disease (30%-35%) or distant metastases (50%-55%) at the time of diagnosis.

Extraction, characterization, and biological activity in vitro of polysaccharides from discarded young fig fruits based on various extraction methods.

Discarded young fig fruits (DYFFs) are rich in polyphenols, polysaccharides, and other active substances, and fig polysaccharides (FPs) extracted from DYFFs using different methods vary in structure, processing characteristics, and biological activities, which are of great research value. The polysaccharides extracted from DYFFs using different extraction methods were used to compare the structures, processing characteristics, and biological activities of FPs, and to research the conformational relationships. The yield of MDP (6.

An in vitro model demonstrating homeostatic interactions between reconstructed human gingiva and a saliva-derived multispecies biofilm.

Background: In the oral cavity, host-microbe interactions (HMI) continuously occur and greatly impact oral health. In contrast to the well-studied disease-associated HMI during, for example, periodontitis, HMI that are essential in maintaining oral health have been rarely investigated, especially in a human-relevant context. The aim of this study was to extensively characterize homeostatic HMI between saliva-derived biofilms and a reconstructed human gingiva (RHG).

Exploring influencing factors and facilitating strategies for self-directed learning from the perspective of medical trainees: a multicentre qualitative study in China.

Objectives: Exploration of influencing factors and promotion strategies for self-directed learning (SDL) is a current research hotspot. However, there is a dearth of relevant research among medical trainees. The objective of the present study was to explore the perceptions of SDL among medical trainees, while also identifying the multidimensional factors associated with SDL and potential facilitating strategies from the perspective of medical trainees.

Metabolomics and LC-MS/MS analysis revealed the inhibitory effect of carboxymethyl chitosan on lignification of postharvest okra during cold storage.

Lignification is one of the key factors restricting the postharvest storage quality of fruit and vegetable. In this study, the potential effects of carboxymethyl chitosan (CMCS) on the phenolic compounds, metabolomic, lignin metabolites and related gene expression of okra during postharvest storage were explored. The results showed that CMCS could alleviate the accumulation of HO and O of postharvest okra, maintain the content of phenolic compounds and balance the antioxidant level.

Global burden of colorectal cancer attributable to metabolic risks from 1990 to 2021, with predictions to 2046.

Background: Metabolic risks are significant factors associated with colorectal cancer. This study aimed to assess global, regional and national burden for CRC attributable to metabolic risks from 1990 to 2021 and to predict mortality by 2046.

Methods: Data from the Global Burden of Disease Study 2021 were used to quantify deaths, disability-adjusted life years (DALYs), and age-standardized rates of CRC due to metabolic risk factors, disaggregated by sex, age, region, country/territory, and sociodemographic index (SDI).

Decreased RSPO3 and β-Catenin in Preeclampsia: Correlation with Blood Pressure and Pregnancy Outcomes.

BACKGROUND This study aimed to investigate the expression of RSPO3 and ß-catenin in preeclampsia and the relationship between RSPO3 and b-catenin levels and maternal-fetal outcomes. MATERIAL AND METHODS We enrolled 60 pregnant women with preeclampsia and 60 pregnant women without preeclampsia. We collected peripheral blood from the patients upon admission; placenta and cord blood were collected after delivery.

Extraction, Characterization, and In Vitro Biological Activity of Polyphenols from Discarded Young Fig Fruits Based on Deep Eutectic Solvents.

(1) Background: Discarded young fig fruits (DYFFs) result in a waste of resources, such as sparse fruits and residual fruits, and there has been no research on the relationship between phenolic compounds and biological activity in DYFFs (2) Methods: Different deep eutectic solvents (DESs) and 80% ethanol were used to prepare DYFF extracts, and polyphenol extraction efficiency and bioactivities in the DYFFs extracts were compared. (3) Results: More than 1700 phytochemicals were identified in DYFFs, and thirteen of these typical phenolic compounds were analyzed quantitatively; chlorogenic acid, rutin, luteolin 8-C-glucoside, and epicatechin are the main polyphenols in DYFFs, especially chlorogenic acid with 2720-7980 mg/kg. Ferulic acid, caffeic acid, epicatechin, (+)-catechin, luteolin 8-C-glucoside, rutin, hesperetin, and chlorogenic acid showed different degrees of correlation with in vitro antioxidant activity.

Konjac glucomannan/microcapsule of thymol edible coating reduces okra pericarp browning by regulating antioxidant activity and ROS synthesis.

Okra is susceptible to browning during storage. The effects of konjac glucomannan/microcapsule of thymol edible coating (TKL) on antioxidant activity and reactive oxygen (ROS) synthesis of okra during low-temperature storage were investigated. Thymol edible coating of thymol concentration 40 mg/mL (TKL40) had a regulatory effect on okra browning.

Research hotspots and trends in biological agents for psoriasis: Visualization and bibliometric analysis.

Psoriasis is a global health concern, and biological therapies have proven to be highly effective in treating psoriatic patients in many countries. We performed a bibliometric analysis of current research on biological agents for the treatments of psoriasis, investigating research patterns and public interest in this area. We conducted a thorough review of articles on biological agents for psoriasis in the Web of Science Core Collection spanning from 2000 to 2022.

Discovery of novel polyheterocyclic neuraminidase inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone.

Inspired by our earlier findings regarding neuraminidase (NA) inhibitors interacting with 150-cavity or 430-cavity of NA, sixteen novel polyheterocyclic NA inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone were designed and synthesized based on the lead compound ZINC13401480. Of the synthesized compounds, compound N5 targeting 150-cavity exerts the best inhibitory activity against the wild-type H5N1 NA, with IC value of 0.14 μM, which is superior to oseltamivir carboxylate (OSC) (IC = 0.

Simple bone cysts of the proximal humerus presented with limb length discrepancy: A case report.

Background: Simple bone cysts (SBC) are benign tumor-like bone lesions typically identified in children. While SBC may lead to growth disturbances or growth arrest, such cases are uncommon. The mechanisms behind these observations remain unclear.

A Polysaccharide from L. Exerts Immunomodulatory Activity in Both In Vitro and In Vivo Experimental Models.

Polysaccharides from L. (FCP) exert multiple biological activities. As a biological macromolecule, the available knowledge about the specific structures and mechanisms of the biological activity of purified 'Brunswick' fig polysaccharides is currently limited.

Median arcuate ligament syndrome complicated with gallbladder stones: A case report.

Background: Median arcuate ligament syndrome (MALS) is a rare disease caused by compression of the celiac trunk artery by the median arcuate ligament (MAL). It can cause symptoms of postprandial abdominal pain, weight loss, and nausea and vomiting.

Case Summary: A 55-year-old woman was admitted due to abdominal pain, nausea and vomiting.

The Future Landscape of Endothelial Cells Research in Psoriasis: Bibliometric Analysis and Literature Review.

Background: Psoriasis is a global health concern as a chronic inflammatory skin disease. Endothelial dysfunction has been implicated in psoriasis pathogenesis.

Objective: This study aims to explore the scientific literature on the relationship between psoriasis and endothelial cells using bibliometric analysis, identifying research trends and public interest in this topic.

The COVID-19 shock and the ownership of store Chain：Evidence from China's express delivery industry.

Utilizing stock market data of express delivery companies that have been listed on the stock market of China, this paper intends to examine the two alternative store chain ownership, namely corporate-owned versus franchised, which is more resilient to external shocks. Based on the price data of 1034 trading days from December 2, 2019, to September 30, 2022, the Quandt-Andrews method is used to compare the companies of corporate-owned store chain with those of franchised store chain. The results reveal that the stock market performance of the express delivery industry underwent a huge structural change during the COVID-19 epidemic.