Prenatal Ultrasound Diagnosis and Prognosis Analysis of Fetal Congenital Cataract.

Purpose: To explore the prenatal ultrasound signs of fetal congenital cataract, study the potential etiologies, and evaluate the perinatal outcomes and the prognosis.

Patients And Methods: The study included 29 cases of fetal congenital cataract identified using prenatal ultrasound screening from January 2018 to September 2023 in our hospital. Ultrasound signs, the potential etiologies, the perinatal outcomes, and prognosis were analyzed.

Mitochondrial dysfunction reveals HS-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects.

Clinical studies have identified multiple mitochondrial disturbances in the peripheral tissues of patients with autism. However, how neuronal metabolism contributes to the autism-associated phenotype remains unclear. In this study, we focused on the anterior cingulate cortex (ACC) and reported hydrogen sulfide (HS) elevation as a common outcome to mitochondrial dysfunction in Shank3b and Fmr1 neurons.

Integrative Genomics and Phenotypic Profiling Reveal Lacticplantibacillus plantarum BGI-N6 as a Multifunctional Candidate for Dermatological Probiotic Development.

Probiotics and postbiotics are recognized for their potential to benefit skin health, and complete genome analysis serves as a pivotal tool to accelerate the exploration of probiotic functionalities. To investigate this relationship, this study aimed to elucidate the skin-promoting potential of Lactiplantibacillus plantarum BGI-N6 (BGI-N6) through integrated genomic analysis and phenotypic analysis. Results indicated that the high-precision complete genome of BGI-N6 comprises 3 257 641 bases with a 45% GC content and 3030 CDSs, involving multiple genes related to carbon source fermentation, gastrointestinal tolerance, and environmental adaptability.

NDUFS1 upregulates ENaCα by NAD+ to promote alveolar fluid clearance in acute lung injury.

Alveolar edema and following respiratory distress results in the aggravation of epithelial damage and the progression of acute lung injury (ALI), however, with unclear molecular mechanism remained to be elucidated. Through proteomic screening and scRNA-seq mining analysis, we detected the decline expression of NDUFS1 in epithelial cells in lungs from paraquat/LPS-induced ALI models. NDUFS1 deficiency in alveolar epithelial cells reduced ENaCα expression, which impaired alveolar fluid clearance (AFC) and led to alveolar edema.

Jingfang granule extends lifespan and healthspan in Caenorhabditis elegans: insights from RNA-seq analysis of genetic mechanisms.

Traditional Chinese Medicine (TCM), as a globally recognized phytomedicinal approach, has made significant contributions to healthcare and anti-aging research worldwide. Jingfang Granule (JFG), an established TCM preparation in China, was demonstrated to exert effects on prolonging lifespan and healthspan via the Caenorhabditis elegans model in this study. We employed RNA-seq analysis to investigate the complex genetic interactions through which JFG extends the lifespan of C.

Aloe-emodin provides dual protection against largemouth bass virus via antiviral activity and host immune enhancement.

Largemouth bass virus (LMBV) is a common pathogen in aquaculture, and with no approved therapies to curb its transmission or mortality, it has caused substantial economic losses to the largemouth bass farming industry. Here, we demonstrate that aloe-emodin (AE), a natural anthraquinone, exhibits potent antiviral activity against LMBV in vitro and in vivo. In vitro, AE (10 mg/L) suppressed viral replication by 91.

A highly sensitive ECL biosensor for NF-κB p50 detection based on entropy-driven amplification and CRISPR/Cas12a signal enhancement.

Transcription factors, particularly NF-κB p50, play crucial roles in regulating gene expression and are involved in several diseases such as cancer, autoimmune disorders, and chronic inflammation. The sensitive detection of NF-κB p50 is essential for clinical diagnostics and therapeutic monitoring. In this study, we present an electrochemiluminescence (ECL) biosensor designed for the highly sensitive and specific detection of NF-κB p50.

Ameliorating Effect of Bifidobacterium breve CM02-09T on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.

Evidences have demonstrated that the regulation of gut microbiota by probiotics can be utilized to prevent nonalcoholic fatty liver disease (NAFLD); Bifidobacterium was widely used as a potential therapeutic alternative for metabolic diseases. In this study, the probiotic functions of Bifidobacterium breve CM02-09T and its effects on NAFLD were investigated through genome annotation and high-fat diet (HFD)-induced mouse model. The genome of B.

Impacts of virtual reality-aided physical training on the balance ability and energy expenditure of children with moderate intellectual disability.

Aim/objective: To investigate the impact of Virtual Reality (VR)-aided training on balance ability, energy expenditure, and tennis learning outcomes in children with moderate intellectual disabilities.

Materials And Methods: Participants were assigned to either a VR-aided training group (experimental) or a traditional training group (control). Balance ability and energy expenditure were assessed using intelligent algorithms, while a custom questionnaire measured tennis learning interest, performance, and motivation.

Efficacy and safety of biosimilar trastuzumab (HLX02) in patients with HER2-positive advanced breast cancer: a retrospective real-world analysis.

Background: HLX02 is the first China-manufactured trastuzumab biosimilar. Few data are currently available about HLX02 in clinical practice. This study was designed to evaluate the real-world safety and efficacy of HLX02 in patients with HER2-positive metastatic breast cancer (MBC), as well as assessed the effectiveness of switching from trastuzumab originator (Herceptin) to HLX02 during treatment.

Nickel-Functionalized Nanoporous Heterostructure Microparticles for Immunoglobulin G Adsorption and Separation with High Efficiency.

Developing advanced affinity adsorbents for immunoglobulin G (IgG) selective separation and purification is vital for clinical diagnosis and therapy. However, high-cost and low-specificity methods hinder high-purity IgG production. This work has fabricated nanoporous heterostructure microparticles by emulsion polymerization of styrene, divinylbenzene, and acrylic acid on the surface of sulfonated polystyrene particles.

sIL-6R impact on aortic aneurysm: Genetic evidence from FinnGen and GWAS.

Background: The causal relationship between soluble interleukin-6 receptor (sIL-6R) and the risk of aortic aneurysm (AA) is unclear. This study used a two-sample Mendelian randomization (MR) approach, utilizing FinnGen and GWAS data, to investigate the potential causal link between sIL-6R and AA risk.

Methods: A two-phase study was conducted to comprehensively assess potential causal relationships.

Asparagine endopeptidase (AEP) inhibitor formulation via zein-based nanoparticle improves the therapeutic efficacy toward Alzheimer's disease.

Asparagine endopeptidase (AEP) plays a critical role in Alzheimer's disease (AD) by cleaving amyloid precursor protein (APP) at N585 and tau protein at N368. Genetic deletion or pharmacological inhibition of AEP using compound 11a ameliorates AD pathology in murine models. To improve the therapeutic potential of 11a, we synthesized structural analogs and developed a zein-based nanoparticle delivery system to enhance pharmacokinetics.

Social jetlag and obstructive sleep apnea severity: A retrospective study based on polysomnography.

Background: Social jetlag, representing the misalignment between endogenous circadian rhythms and socially imposed sleep schedules, has been associated with various adverse health outcomes. However, its potential relationship with obstructive sleep apnea (OSA) severity, as quantified by the apnea-hypopnea index (AHI), remains unclear.

Methods: This retrospective study analyzed data from participants with OSA (AHI ≥5 events/hour) who completed sleep questionnaires and underwent polysomnography at our sleep center.

Comprehensive Review-Chemistry and Bioactivities of Secondary Metabolites From Chaetomium globosum.

Chaetomium sp. is a widely distributed fungal genus that has been identified as a source of chemically diverse and biologically active natural products. This review aimed to comprehensively survey secondary metabolites derived from Chaetomium globosum, including chemical diversity, biological activities, and related pathways of biosynthesis and chemosynthesis.

Nonlinear Optics in Low-Dimensional Nanomaterials.

Nonlinear optics describes the study of optical phenomena related to the interaction between intense light fields and matter [...

GATA6 inhibits the periodontitis progression through regulating the Notch signaling pathway.

Periodontitis is a prevalent chronic infectious condition affecting the oral cavity. This research was conducted to analyze the role of GATA6 in LPS-stimulated human periodontal ligament cells (hPDLCs). Dysregulated genes associated with periodontitis were acquired from the GEO database (GSE23586).

Genome-wide identification and expression pattern analysis of auxin response factor (ARF) genes in Chionanthus retusus and functional characterization of CrARF37 in terms of its effect on flower shape.

Background: The Auxin Response Factor (ARF) gene family is ubiquitous in the plant kingdom, serving as a pivotal gene in the auxin signaling pathway. Members of this gene family encode transcription factors that regulate diverse aspects of plant growth and development. Notably, the Class IIa and Class IIb subfamilies within the ARF gene family play a vital role in plant flower development and morphogenesis.

Efficiency of remote monitoring and guidance in blood pressure management: a randomized controlled trial : The role of remote monitoring in improving hypertension management.

Background: Regular monitoring of blood pressure (BP) is essential for managing hypertension. The long-term effectiveness of remote monitoring in BP control requires further validation. Although self-monitoring has some benefits, its overall effectiveness remains inconclusive.

Association of Plasma Septin9 Methylation Status With Therapeutic Response to Antitumor Agents in Colorectal Cancer Patients.

Purpose: Although the diagnostic potential of septin 9 methylation (mSEPT9) in colorectal cancer (CRC) has been well documented in numerous studies, its predictive role in determining therapeutic response to antitumor agents among patients with advanced CRC remains unexplored.

Methods: This real-world, large-scale retrospective study analyzed 1098 CRC cases selected from a comprehensive database of 1490 patients who underwent mSEPT9 testing. We first investigated the association between mSEPT9 status and clinicopathological characteristics in the overall CRC cohort.

Acidic pH as the deterministic factor shaping microbial community dynamics and interactions in molasses-fed sulfate-reducing bioreactors.

Sulfate-reducing bacteria (SRB) are widely used in treating high-sulfate wastewater, but their performance is inhibited by low pH conditions. This study investigated prokaryotic community responses to pH decrements from 5.5 to 2.

Candidate gene identification and marker development for seed coat peeling rate in peanut (Arachis Hypogaea L.).

Background: Cultivated peanut (Arachis hypogaea L.) is an important economic and oilseed crop in China. The seed coat plays a crucial role in resisting pests and diseases, and seed coat peeling rate (SCPR) is a key factor influencing the efficiency and quality of mechanical shelling.

Aptamer-Conjugated Magnetic Nanoparticles Integrated with SERS for Multiplex Salmonella Detection.

is a rapidly spreading and widespread zoonotic infectious disease that poses a serious threat to the safety of both poultry and human lives. Therefore, the timely detection of in foods and animals has become an urgent need for food safety. This work describes the construction of an aptamer-based sensor for detection, using FeO magnetic beads and Ag@Au core-shell nanoparticles-embedded 4-mercaptobenzoic acid (4MBA).

Pharmacological evaluation and formulation design of lavender volatile oil cream for the treatment of chronic prostatitis: Mechanistic insights into therapeutic efficacy.

This study optimized the formulation of lavender volatile oil cream (LVOC) through single factor experiments and response surface methodology, and investigated the effects of emulsifiers, oil phase components, and moisturizers on the physical properties of the cream. The optimized formula contains 2.00 % lavender volatile oil, 6.