Jingfang granule extends lifespan and healthspan in Caenorhabditis elegans: insights from RNA-seq analysis of genetic mechanisms.

Traditional Chinese Medicine (TCM), as a globally recognized phytomedicinal approach, has made significant contributions to healthcare and anti-aging research worldwide. Jingfang Granule (JFG), an established TCM preparation in China, was demonstrated to exert effects on prolonging lifespan and healthspan via the Caenorhabditis elegans model in this study. We employed RNA-seq analysis to investigate the complex genetic interactions through which JFG extends the lifespan of C.

Elucidating the anti-aging bioactive compounds and mechanisms of Jingfang Granules formula based on network pharmacology and Caenorhabditis elegans.

Jingfang Granule (JFG), a traditional Chinese medicine preparation, is widely used in clinical practice. It has been shown to extend both lifespan and healthspan in the Caenorhabditis elegans model. However, the molecular mechanisms of its main constituents and their targets remain unclear.