GATA6 inhibits the periodontitis progression through regulating the Notch signaling pathway.

Periodontitis is a prevalent chronic infectious condition affecting the oral cavity. This research was conducted to analyze the role of GATA6 in LPS-stimulated human periodontal ligament cells (hPDLCs). Dysregulated genes associated with periodontitis were acquired from the GEO database (GSE23586).

Exosomes secreted from M2-polarized macrophages inhibit osteoclast differentiation via CYLD.

Objective: Bone resorption mediated by osteoclast differentiation induces the occurrence of bone-related diseases. Macrophages, an origin of osteoclasts, whose M2 type can reduce inflammation-induced bone damage. We aimed to investigate the effect of M2 macrophage-derived exosomes on osteoclast formation and elucidate its underlying mechanism.

Herbicidal Sorbicillinoid Analogs Cause Lignin Accumulation in TE-65L.

Five new sorbicillinoid derivatives, including (±)-aspersorbicillin A [(±)-], a pair of enantiomers at C-9, and aspersorbicillins B-D (-), together with two known analogs ( and ) were isolated from the endophytic fungus TE-65L. Their structures including absolute configurations were determined by detailed spectroscopic analyses and electronic circular dichroism calculations. The herbicidal activity of sorbicillinoids on the germ and radicle elongation of various weed types was reported for the first time.