Marine organism-inspired tough and adhesive patch based on thermosensitive quaternized chitin for tissue sealing/repair and hemostasis.

Tissue adhesives have emerged as a promising alternative to conventional sutures and staplers in the management of hemostasis, tissue defect sealing, and wound repair. However, the efficacy of current bio-adhesives in clinical practice is compromised by the limitations, including poor wet adhesion, inadequate mechanical strength, vulnerability to gastrointestinal fluids, and insufficient hemostatic performance. Herein, a marine organism-inspired tough and adhesive patch (MOTAP) was developed to address these challenges.

Acute left heart failure is the initial manifestation of Takayasu arteritis: a case report.

Background: Takayasu arteritis, a chronic inflammatory disease predominantly affecting the aorta and major arterial branches, can lead to serious complications such as myocardial infarction and heart failure.

Case Presentation: This case report details a rare initial presentation of a 24-year-old female with acute left heart failure, leading to a diagnosis of Takayasu arteritis. Initial misdiagnosis as viral myocarditis was reconsidered after comprehensive examinations, including echocardiography, vascular ultrasound, and imaging studies, which revealed the disease’s characteristic vascular involvement.

Construction of a core collection and SNP fingerprinting database for Chinese chive () through Hyper-seq based population genetic analysis.

Chinese chive ( Rottler ex Sprengel), an autotetraploid vegetable cultivated in Asia for over 3,000 years, possesses apomictic characteristics. However, issues like intricate genetic admixture and unclear phylogenetic relationships pose challenges for effective germplasm preservation and breeding advancements. In this research, we systematically assessed population structure, constructed a core collection, and developed a DNA fingerprinting system utilizing Hyper-seq sequencing data.

Pharmacological evaluation and formulation design of lavender volatile oil cream for the treatment of chronic prostatitis: Mechanistic insights into therapeutic efficacy.

This study optimized the formulation of lavender volatile oil cream (LVOC) through single factor experiments and response surface methodology, and investigated the effects of emulsifiers, oil phase components, and moisturizers on the physical properties of the cream. The optimized formula contains 2.00 % lavender volatile oil, 6.

Homoepitaxial growth of large-area rhombohedral-stacked MoS.

Interlayer stacking is an important degree of freedom to tune the properties of two-dimensional materials and offers enormous opportunities for designing functional devices. As a classic example, rhombohedral-stacked (3R) two-dimensional materials exhibit ferroelectricity and optical nonlinearity that are non-existent in naturally abundant hexagonal-stacked (2H) counterparts. However, the ability to grow stacking-controlled large-area films remains challenging due to the thermodynamic competition of different polytypes.

The role of granulocyte colony-stimulating factor in Takayasu arteritis.

Background: Previous studies have suggested that granulocyte colony-stimulating factor (G-CSF) treatment may trigger large vessel vasculitis (LVV). However, the role of G-CSF in Takayasu arteritis (TAK), a form of LVV, remains unclear. This study aims to investigate the potential role of G-CSF in TAK.

A novel, covalent broad-spectrum inhibitor targeting human coronavirus M.

Human coronaviruses (CoV) cause respiratory infections that range from mild to severe. CoVs are a large family of viruses with considerable genetic heterogeneity and a multitude of viral types, making preventing and treating these viruses difficult. Comprehensive treatments that inhibit CoV infections fulfill a pressing medical need and may be immensely valuable in managing emerging and endemic CoV infections.

Single-cell transcriptome analysis profiles cellular and molecular alterations in aortic tissue from patients with Behçet's syndrome.

Objectives: This study aims to analyse the expression profiles, phenotypes, functions and cell-cell communication of various cell subpopulations in the affected aortic tissues of patients with Behçet's syndrome (BS) at the transcriptomic level.

Methods: This study recruited six participants (three with BS and three with atherosclerosis) from Beijing Anzhen Hospital between January 2023 and June 2024, collected their clinical information, and performed single-cell RNA sequencing on aortic tissue specimens using the SeekOne® MM High Flux Single Cell Transcriptome Kit V4.1.

Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis.

Introduction: Since their domestication, domestic sheep (Ovis aries) have been culturally and economically significant farming animals worldwide. Fat-tailed sheep serve as a unique genetic resource for understanding adipogenesis and adaptive evolution in livestock.

Objectives: Several genomic analyses have been conducted on various sheep breeds to elucidate the genome and regulation mechanism of the fat tail trait, prior genomic studies have failed to reconcile conflicting evidence about the genetic basis of tail morphology, particularly regarding the roles of PDGFD and BMP2.

Direct orientational epitaxy of wafer-scale 2D van der Waals heterostructures of metal dichalcogenides.

Two-dimensional (2D) van der Waals (vdW) heterostructures have emerged as a groundbreaking candidate for future integrated circuits due to their tunable band structures, atomically sharp interfaces and seamless compatibility with complementary metal-oxide-semiconductor technologies. Despite their promise, existing synthesis methods, such as mechanical transfer and vapor-phase conversion, struggle to achieve the high-quality, scalable production for practical applications. In response to these longstanding challenges, our study unveils for the first time the direct epitaxial growth of wafer-scale 2D vdW heterostructures (MoS[Formula: see text]/SnS[Formula: see text]) with exceptional quality and uniformity.

Transcriptomic Analysis of Fruit Under Manganese Stress and Mining of Flavonoid Synthesis Genes.

is a deciduous tree with significant economic and medicinal value. It demonstrates notable physiological adaptability to mining areas with severe manganese contamination and is a pioneering species in the field of ecological restoration. Flavonoids are vital secondary metabolites that improve plant resilience to environmental stresses.

Designable excitonic effects in van der Waals artificial crystals with exponentially growing thickness.

When disassembled into monolayers from their bulk crystals, two-dimensional (2D) transition metal dichalcogenides (TMDCs) exhibit exotic optical properties dominated by strong excitonic effects. Reassembling 2D TMDC layers to build bulk excitonic crystals can significantly boost their optical performance and introduce emerging functionalities toward optoelectronic and valleytronic applications. However, maintaining or manipulating 2D excitonic properties in bulk structures or superlattices is challenging.

Thermodynamics and kinetics in van der Waals epitaxial growth of Te.

Chemical vapour deposition (CVD) in a tube furnace and molecular beam epitaxy (MBE) in a vacuum chamber represent the most effective methods for the production of low-dimensional nanomaterials. However, the as-synthesized products always exhibit diverse morphologies and phases due to the varying thermodynamic and kinetic factors. A comprehensive investigation into these factors is thus imperative.

Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis.

Objectives: Takayasu arteritis (TAK) is an inflammatory vasculitis that affects the aorta and its primary branches. The pathogenesis of TAK remains elusive, yet identifying key cell types in the aorta of TAK patients is crucial for uncovering cellular heterogeneity and discovering potential therapeutic targets.

Methods: This study utilized single-cell transcriptome analysis on aortic specimens from three TAK patients, with control data sourced from a publicly available database (GSE155468).

Transcriptome-wide N-methyladenosinem modifications analysis of growth and fumonisins production in Fusarium proliferatum causing banana crown rot.

Crown rot caused by Fusarium proliferatum is a severe postharvest disease of banana fruit. The N-methyladenosine (mA) modification is the most common type of RNA modification and regulates gene expression in eukaryotes. Here, we analyzed transcriptome-wide changes in mA methylation to investigate post-transcriptional regulation mechanisms of growth and fumonisin biosynthesis of F.

-like Transposon Elements Inserted in Cause Male Sterility in Maize.

Using male sterile (MS) lines instead of normal inbred maternal lines in hybrid seed production can increase the yield and quality with lower production costs. Therefore, developing a new MS germplasm is essential for maize hybrid seed production in the future. Here, we reported a male sterility gene , cloned from a newly found MS mutant .

Microstructure and Hardness of Nickel-Based Coatings Prepared by Laser Additive Manufacturing on Water-Cooled Substrate: An Experimental and Numerical Study.

The excess heat generated during the laser additive manufacturing process is prone to cause coating defects; a water-cooled substrate can effectively remove the excess heat and improve the hardness of the coating. In this study, the effects of water-cooled substrate on the microstructure and hardness of laser additive manufactured nickel-based coatings were investigated by experimental and numerical simulations. The results showed that the water-cooled substrate decreased the size of columnar crystals and increased the number as well as the length of secondary dendrite crystals at the bottom of the nickel-based coatings.

Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor.

Hypoxia-inducible factor prolyl hydroxylase (PHD) inhibitors have been approved for treating renal anemia yet have failed clinical testing for inflammatory bowel disease because of a lack of efficacy. Here we used a multimodel multimodal generative artificial intelligence platform to design an orally gut-restricted selective PHD1 and PHD2 inhibitor that exhibits favorable safety and pharmacokinetic profiles in preclinical studies. ISM012-042 restores intestinal barrier function and alleviates gut inflammation in multiple experimental colitis models.

Supplementation with Chinese herbal preparations protect the gut-liver axis of Hu sheep, promotes gut-liver circulation, regulates intestinal flora and immunity.

The gut-liver axis in ruminants can explain nutrient regulation, the gut-liver cycle, and immune function in ruminant biology through the gut microbe-gut metabolite-liver metabolite relationship. to investigate the effects of herbal feed additives on the gut-liver axis of Hu sheep. In this study, a broadly targeted UPLC-MS/MS metabolomics approach and 16s sequencing of gut microorganisms were used to detect, identify and quantify changes in ileal microorganisms, liver metabolites and ileal metabolites following the addition of Chinese herbal preparations.

Risk factors and prognosis of depression in Takayasu arteritis patients.

Background: Takayasu arteritis (TA) is associated with an increased risk of developing complicated comorbidities, which can bring both psychological and physical burdens to the patients.

Objective: TA is found to carry a high risk of developing depression. This research aimed to investigate the risk factors and prognosis of depression in TA patients.

Gemcitabine plus cisplatin versus docetaxel plus cisplatin and fluorouracil induction chemotherapy combined with locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: A single center prospective phase II clinical trial.

Purpose: This prospective clinical trial aims to compare the efficacy and safety of gemcitabine plus cisplatin (GP) versus docetaxel plus cisplatin and fluorouracil (TPF) as induction chemotherapy combined with locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma (dmNPC).

Methods: 146 dmNPC patients were randomly assigned in a 1:1 ratio to receive 4-6 cycles of GP (GP group) or TPF induction chemotherapy (TPF group) followed by locoregional radiotherapy (LRRT). The primary endpoint was overall survival (OS).

Ultralow-pressure-driven polarization switching in ferroelectric membranes.

Van der Waals integration of freestanding perovskite-oxide membranes with two-dimensional semiconductors has emerged as a promising strategy for developing high-performance electronics, such as field-effect transistors. In these innovative field-effect transistors, the oxide membranes have primarily functioned as dielectric layers, yet their great potential for structural tunability remains largely untapped. Free of epitaxial constraints by the substrate, these freestanding membranes exhibit remarkable structural tunability, providing a unique material system to achieve huge strain gradients and pronounced flexoelectric effects.