In-Built Compatible Electrode-Electrolyte Interphases for Quasi-Solid-State Li-SPAN Batteries.

Lithium-sulfur batteries have been regarded as a promising candidate for next-generation energy storage systems owing to their high energy density and low cost. Sulfurized polyacrylonitrile (SPAN) as a cathode material has received wide interest due to the solid-solid conversion mechanism, while the Li-SPAN cell performance has been limited by the notorious issue of lithium metal anode. Developing solid-state electrolytes for lithium-sulfur batteries with favorable electrode-electrolyte compatibility is urgently desired.

Electrophysiological activity predicts children's reading ability through orthographic awareness: Evidence from a cross-sectional and longitudinal study.

The relationship between brain activity and reading acquisition has been a research focus in recent years. In the current cross-sectional and longitudinal study, we aimed to investigate whether and how resting-state (rs) and task-state brain electrophysiological activity would predict children's reading ability. Here, we tracked 73 primary school children' orthographic awareness, reading ability, and EEG signals during both rest and completed a Chinese character recognition task over two consecutive years.

Urinary exosomal RAB11A serves as a novel non-invasive biomarker for diagnosis, treatment response monitoring, and prognosis in small cell lung cancer.

Background: Small cell lung cancer (SCLC) is an aggressive malignancy with a poor prognosis. This study aimed to analyze the urinary exosomal proteome of SCLC patients to identify and validate potential non-invasive biomarkers for improving diagnosis, treatment response monitoring, and prognosis prediction.

Methods: We analyzed 90 urine samples from SCLC patients, divided into training (n = 38) and validation (n = 52) sets, including untreated, partial/complete remission, and relapsed groups.

Strontium-Loaded Chitosan/Wood Hydrogel with Anisotropic Cellular Architecture for Enhanced Critical Bone Regeneration.

The reconstruction of critical-sized bone defects remains a significant clinical challenge. Natural polymers used for bone defects exhibit excellent biocompatibility and degradability; however, their inadequate mechanical properties, absence of biomimetic topological structures, and limited osteogenic potential hinder their suitability for clinical applications. In this study, we developed an all-natural wood hydrogel by integrating natural lignocellulosic nanofibers into chitosan hydrogels through delignification and vacuum impregnation.

Characterization of the complete mitochondrial genome of A. Rich. (Poaceae).

The complete mitochondrial genome of , an African species, was sequenced and characterized for the first time. The genome is 491,311 bp long and contains 53 unique genes. Phylogenetic analysis based on these genes using maximum likelihood revealed that is most closely related to Saccharum officinarum and most distantly related to .

Prediction of high-performing spleen-targeted lipid nanoparticles using a deep learning model for robust anticancer immunotherapy.

Messenger RNA (mRNA) therapeutics hold significant potential across a wide range of medical applications. LNPs are the most clinically advanced mRNA delivery vehicles, but challenges such as off-target effects and liver accumulation limit their broader clinical use. While high-throughput screening is effective for identifying more efficient and selective ionizable lipids, the substantial experimental validation required limits its practical application.

Polymer-engineered delivery systems for Schisandra lignans: A review of advances in hepatic-targeted therapy.

The Schisandra plant (Magnoliaceae) is an important tonic herb in traditional Chinese medicine and has a long history of medicinal use in China, Japan, Korea, and other countries. In recent years, with the increasing global burden of liver diseases, the potential of Schisandra and its main bioactive component, lignans, in the prevention and treatment of liver diseases has attracted much attention. This review systematically summarizes the sources, classification, and extraction and purification methods of Schisandra lignans.

Charge-Rearrangement Averaged Dye Design for Precise, Real-Time, and Portable Monitoring of Complex Solvent Environments.

Although solvatochromic materials provide visual function to differentiate solvents, they fail to precisely monitor complex solvent environments where solvent composition varies dynamically, because of an insensitive absorptional shift in these environments. Relatively, their fluorescence signal change, which should be more sensitive, has always been inefficient, resulting from inherent challenges in excited-state dynamics. Here, we present a charge-rearrangement averaged dye design, instead of traditional donor-acceptor structures, to enable a high locally excited or twisted intramolecular charge transfer emission efficiency.

Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer's disease, with hypertensive dependency.

Background: Neuroinflammation and hypertension are involved in Alzheimer's disease (AD). However, their independent and additive impacts on astrocytes and AD-related pathologies have not been fully explored. Hence, this study investigated whether the associations between astrocyte reactivity, measured by cerebrospinal fluid (CSF), Chitinase 3-like protein 1 (CHI3L1/YKL-40), and AD-related pathologies were mediated by neuroinflammation and whether these associations were modified by hypertension.

Quercetin inhibits the cAMP/PKA/CREB/glycolysis axis to exert anti-acute lymphoblastic leukemia effects.

Acute lymphoblastic leukemia (ALL), an aggressive hematologic malignancy with high incidence and treatment resistance, demands novel therapeutic approaches. Enhanced glycolysis is a hallmark of metabolic reprogramming in ALL. Quercetin (Que) demonstrates broad antitumor effects by inhibiting glycolysis and cell proliferation.

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction.

Loss of pluripotency is an essential step in post-implantation development that facilitates the emergence of somatic cell identities essential for gastrulation. Before implantation, pluripotent cell identity is governed by a gene regulatory network that includes the key transcription factors SOX2 and NANOG. However, it is unclear how the pluripotency gene regulatory network is dissolved to enable lineage restriction.

A pan-genotypic indirect competitive ELISA for serological detection of pigeon circovirus antibodies.

Pigeon circovirus (PiCV) infection, which causes young pigeon disease syndrome (YPDS) and immunosuppression, significantly impacts both the meat and racing pigeon industries. Currently, no inactivated vaccine exists for PiCV prevention, primarily due to the challenges associated with isolating the PiCV virion, except for some gene subunit vaccines express the Cap protein of PiCV. The development of detection techniques is crucial for the diagnosis of PiCV.

Effects of low temperature on intestinal microbiota composition of silver pomfret (Pampus argenteus).

Fish are poikilothermic organisms with species-specific optimal temperature ranges for survival. As an economically important marine fish in China, silver pomfret (Pampus argenteus) has overcome artificial breeding bottlenecks. To meet aquaculture requirements in northern regions, we simulated gradual winter cooling from 18 °C to 6 °C using recirculating aquaculture systems with precision temperature control.

Sortilin-1, Targeted by miR-146a, Regulates the Behavior of Non-Small Cell Lung Cancer.

Background: Sortilin-1 (SORT1) has been implicated in the pathogenesis of various malignancies, but its role in non-small cell lung cancer (NSCLC) remains to be elucidated.

Methods: Immunohistochemistry was employed to assess the expression of SORT1 in cancerous tissues compared to adjacent non-cancerous tissues. NSCLC cell lines, including A549, H1299, and PC-9, underwent treatment with miR-146a mimics or SORT1 small interfering RNA (siRNA), followed by evaluations of cell viability, migration, invasion, and apoptosis using cell counting kit-8, transwell assays, and scratch wound assays.

A unique approach for investigating skin lesions and their relationship with TCM syndrome differentiation in alopecia areata.

Background: Alopecia areata is also known as 'oil wind' in Chinese medicine. Alopecia areata is a debilitating autoimmune skin disease characterized by patches of non-scarring hair loss and inflammation that damages the scalp and body hair in a variable, often relapsing or permanent fashion. It is not quite obvious how the various Traditional Chinese Medicine (TCM) syndromes differentiate between the skin lesions under dermatoscopy caused by alopecia areata.

Projected future changes in extreme climate indices affecting rice production in China using a multi-model ensemble of CMIP6 projections.

Assessing and predicting the spatial-temporal characteristics of extreme climate events can effectively identify the impacts of climate change on crop production and propose targeted measures. This study systematically evaluates the intensity and spatiotemporal evolution of extreme climate events during critical phenological stages in China's major rice-growing regions based on 11 extreme climate indices (ECIs). The future climate data were obtained from 18 Global Climate Models (GCMs) integrated in the Coupled Model Intercomparison Project phase 6 (CMIP6) with four shared socio-economic pathways (SSPs) to project the future changes of ECIs related rice production.

Advancing deep learning for expressive music composition and performance modeling.

The pursuit of expressive and human-like music generation remains a significant challenge in the field of artificial intelligence (AI). While deep learning has advanced AI music composition and transcription, current models often struggle with long-term structural coherence and emotional nuance. This study presents a comparative analysis of three leading deep learning architectures: Long Short-Term Memory (LSTM) networks, Transformer models, and Generative Adversarial Networks (GANs), for AI-generated music composition and transcription using the MAESTRO dataset.

Structural characterization and biological functions of echinoderm polysaccharides: A review.

Echinoderm polysaccharides are integral to the biology of these organisms and have significant implications for ecological interactions and potential applications in science and medicine. Understanding their structure and function can provide insights into marine biology and contribute to the development of new biomaterials and therapeutic agents. Various echinoderm polysaccharides have been discovered, but the structure and functional rules of echinoderm polysaccharides have not been elucidated.

Disorders of glucose metabolism and impaired energy metabolism in pfkma and pfkmb knockout zebrafish.

Background: In our previous study, Phosphofructokinase, muscle (PFKM), a key enzyme in glucose metabolism, was found to be decreased in the urinary exosomes of diabetic patients. The role of PFKM in glucose and energy metabolism is not fully understood. The study explores PFKM's implications in these metabolic pathways through the lens of a zebrafish model.

Development of Histotripsy as a Local-Regional Liver Cancer Therapy: Preclinical to Clinical Translation.

Histotripsy is the first noninvasive, nonthermal, and nonionizing focused ultrasound ablative therapy that effectively destroys targeted tissue. Histotripsy research began as an early preclinical prototype that eventually underwent small- and large-animal preclinical testing to ensure safe clinical translation to human use. Small-animal studies demonstrated the efficacy of histotripsy in destroying liver tumors and generating immune responses, while large-animal studies in human-sized livers further refined the technology for clinical translation.

Circulating Level of Oxidized Low-Density Lipoprotein Correlates with Cerebral Blood Flow in Patients with White Matter Hyperintensities.

Background: Oxidized low-density lipoprotein (ox-LDL) has been shown to promote atherosclerosis, but data have been limited on its association with white matter hyperintensities (WMH).

Objective: To assess the relationship of ox-LDL levels with WMH.

Methods And Material: This study included 45 patients with WMH, matched for age, sex, and education with 45 healthy controls (HC).

Contrast-enhanced ultrasound findings of ovarian Sertoli-Leydig cell tumor: a case report with ultrasonographic-pathological insights.

Background: Ovarian Sertoli-Leydig Cell Tumors (SLCTs) are exceedingly rare sex cord-stromal tumors with non-specific clinical features and limited diagnostic imaging. We evaluated the ultrasonographic-pathological correlation of ovarian SLCT and explored the clinical value of contrast-enhanced ultrasound (CEUS) through a case analysis of a 62-year-old woman with a SLCT.

Case Presentation: A 62-year-old postmenopausal woman presented with abdominal distension.

[Response of Land Use Change to Ecological Environment Effect in Anhui Province Under Urban Expansion].

The dynamic alterations in land utilization patterns within swiftly urbanizing regions significantly influence the ecological environmental quality. Investigating these land use transformations and their implications for ecological integrity can furnish essential theoretical underpinnings and a foundation for decision-making aimed at fostering sustainable and high-quality growth in rapidly urbanizing areas. Anhui Province was chosen as the research locale， with CLCD data （1990-2020） employed to delineate land use modifications.

Prognostic and tumor microenvironmental features of gastric cancer revealed by macrophage polarization and protein lactylation-related genes.

Background: The progression of gastric cancer (GC) is closely linked to macrophage polarization and protein lactylation; however, its underlying mechanisms remain poorly understood. This study aimed to elucidate the molecular mechanisms of GC using transcriptomic analysis.

Methods: Candidate genes were identified by intersecting differentially expressed genes with key module genes associated with protein lactylation and macrophage polarization.