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Postoperative fatigue (POF) and perioperatively acquired muscle weakness (POAW) are significant yet often under-recognised interlinked postoperative complications that can significantly hinder postoperative recovery and diminish overall quality of life after surgery. Despite advancements in surgical and anaesthetic techniques and the widespread implementation of Enhanced Recovery After Surgery (ERAS) protocols, these conditions remain prevalent. In the weeks following surgery, reported incidences of fatigue of any severity range from 10% to as high as 90%, depending on the patient population.
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Introduction Patients have identified knee stiffness as a factor contributing to postoperative dissatisfaction after total knee arthroplasty (TKA). Losartan is an angiotensin receptor blocker (ARB) that has demonstrated antifibrotic effects; however, the impact of perioperative losartan on arthrofibrosis after TKA is not well understood. Therefore, the purpose of this study was to determine if losartan exhibits antifibrotic benefits in patients who undergo TKA by decreasing the rates of manipulation under anesthesia (MUA), when compared to patients who are not taking losartan.
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