Predictors for Achieving Textbook Outcomes After Endoscopic Resection of Giant Submucosal Tumors in the Esophagus and Cardia.

Background And Aims: Endoscopic resection for submucosal tumors (SMTs) in the esophagus and cardia is challenging with hazards of adverse events and the exploration of its achieving textbook outcome (TO) was unknown. We aim to investigate the predictors of TO for giant SMTs with a long diameter ≥ 7 cm or a transverse diameter ≥ 3.5 cm.

Designing a mesoporous cascade reactor for enhanced enzymatic performance.

Designing biomimetic catalytic systems with enhanced activity, stability, and reusability remains a grand challenge in the field of biocatalysis. Here, we report a hierarchical and modular strategy for constructing robust biocatalytic cascade reactors by spatially organizing dual enzymes, -amino acid oxidase (DAAO) and cytochrome c (Cyt c), within defect-engineered covalent organic frameworks (COFs), followed by surface encapsulation with a polydopamine (PDA) shell to mimic cellular compartmentalization. The defective COFs provide highly tunable pore architectures and versatile surface functionalities, enabling site-specific enzyme immobilization via both physical infiltration and covalent conjugation.

Polymer-engineered delivery systems for Schisandra lignans: A review of advances in hepatic-targeted therapy.

The Schisandra plant (Magnoliaceae) is an important tonic herb in traditional Chinese medicine and has a long history of medicinal use in China, Japan, Korea, and other countries. In recent years, with the increasing global burden of liver diseases, the potential of Schisandra and its main bioactive component, lignans, in the prevention and treatment of liver diseases has attracted much attention. This review systematically summarizes the sources, classification, and extraction and purification methods of Schisandra lignans.

Decoding natural visual scenes via learnable representations of neural spiking sequences.

Visual input underpins cognitive function by providing the brain with essential environmental information. Neural decoding of visual scenes seeks to reconstruct pixel-level images from neural activity, a vital capability for vision restoration via brain-computer interfaces. However, extracting visual content from time-resolved spiking activity remains a significant challenge.

Protein levels alter yak rumen microbiota profiles, meat properties, and longissimus dorsi metabolites.

Objective: The study investigated how varying protein levels in low-energy diets affected the microbiota, meat quality, and metabolomics of the imus dorsi muscle in yaks. The aim was to determine the optimal yak diet for growth and meat quality under low-energy conditions.

Methods: Twenty-four adult male yaks were divided into two groups of 12: the Low-energy, Medium-protein (LM) group and the Low-energy, High-protein (LH) group.

Performance of conventional MRI and endoscopy in assessing complete tumor response following immunotherapy-based neoadjuvant therapy for rectal cancer.

Purpose: Endoscopy and MRI are essential tools for assessing treatment response in locally advanced rectal cancer (LARC). However, their accuracy in identifying pathological complete response (pCR; ie, ypT0N0) following immunotherapy-based neoadjuvant chemoradiotherapy (iNCRT) remains uncertain. This study evaluates the performance of endoscopy and MRI in reflecting ypT0 status and assesses MRI efficacy for lymph node metastasis in LARC following iNCRT.

Microlensing events indicate that super-Earth exoplanets are common in Jupiter-like orbits.

Exoplanets classified as super-Earths are commonly observed on short-period orbits, close to their host stars, but their abundance on wider orbits is poorly constrained. Gravitational microlensing is sensitive to exoplanets on wide orbits. We observed the microlensing event OGLE-2016-BLG-0007, which indicates an exoplanet with a planet-to-star mass ratio roughly double the Earth-Sun mass ratio, on an orbit longer than Saturn's.

Global, regional, and national burden of self-harm among adolescents aged 10-24 years from 1990 to 2021, temporal trends, health inequities and projection to 2041.

Background: Self-harm ranks as the third leading cause of disability-adjusted life years (DALYs) among adolescents globally, imposing substantial disease and economic burdens. Comprehensive analyses of global temporal trends, health inequities, and future projections are crucial for developing effective public health policies and interventions.

Methods: This study analyzed the global, regional, and national age-standardized incidence, mortality, and DALYs for self-harm among adolescents using data from the Global Burden of Disease (GBD) 2021 database.

Assisting Training of Deep Spiking Neural Networks With Parameter Initialization.

Spiking neural networks (SNNs) exhibit significant advantages in terms of information encoding, computational capabilities, and power usage. We regard initializing weight distribution as a key problem for effective SNN training. When backpropagation (BP) through time is used in the initial training phase, it has a significant impact on gradient generation.

Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study.

Objective: This study aimed to identify the potential inflammatory molecular biomarkers that could be utilized for the early prediction of different subtypes of tuberculosis (TB) in adults.

Methods: Plasma samples were obtained from a cohort of adults diagnosed with 48 cases of active TB, including drug-susceptible TB (S-TB, n = 28), multidrug-resistant TB (R-TB, n = 20), latent TB infection (LTBI, n = 20), as well as a control group of healthy individuals without any infection (HC, n = 20). The expression level of 92 inflammatory-related proteins was detected by using the high-throughput Olink proteomics platform.

GNLY+CD8+ T cells bridge premature aging and persistent inflammation in people living with HIV.

People living with HIV (PLWH) exhibit accelerated aging, characterized by systemic inflammation, termed "inflammaging." While T-cell expansion is prevalent in PLWH, its connection to inflammaging remains unclear. In this study, we analyzed the TCRβ repertoire of 257 healthy controls (HC) and 228 PLWH, revealing pronounced T cell clonal expansion in PLWH.

Evaluation of Growth, Physiological, and Biochemical Responses of Different L. Varieties Under Drought Stress.

Alfalfa (), an important leguminous forage crop, is valued for its high nutritional content, substantial yield, palatability, and broad adaptability. Drought is among the most significant environmental constraints on alfalfa growth, particularly in the karst regions of southwestern China. In this study, we conducted pot experiments to investigate the growth and physiological responses of seven alfalfa varieties introduced into the karst region of Guizhou under drought conditions.

Multi-feature fusion RFE random forest for schizophrenia classification and treatment response prediction.

Schizophrenia(SZ) classification and treatment response prediction hold substantial clinical application value. However, only a limited number of researchers have exploited the multi-feature information derived from resting-state functional magnetic resonance imaging (rs-fMRI) to achieve short-term drug-treatment SZ classification and treatment response prediction. We developed a multi-feature fusion recursive feature elimination random forest (RFE-RF) approach for SZ classification and treatment response prediction.

Effects of exogenous calcium on seed germination and physiological traits of alfalfa (Medicago sativa) seedlings.

To enhance the cultivation and utility of alfalfa (Medicago sativa) in calcium-rich environments, we assessed the germination, growth, and physiological responses of seven alfalfa varieties-Crown, Dieter, PANGO, Gladiator, Victoria, WL525, and Magnum 801-under varying calcium chloride (CaCl) concentrations (0, 5, 25, and 50 mmol·L). Germination indices, root and shoot growth, enzyme activities, and osmotic regulation parameters were analyzed to evaluate adaptive responses to calcium stress. Our results showed that alfalfa adapts to calcium stress by increasing root length, enhancing enzyme activities, regulating osmotic substance content, and reducing malondialdehyde levels, thereby striving to maintain stable dry matter content.

Self-supporting poly(3,4-ethylenedioxythiophene) and FeC Co-decorated electrospun carbon nanofibers as LiS supporters for lithium-sulfur batteries.

Lithium-sulfur (Li-S) batteries have attracted significant attention in recent years owing to their high theoretical energy density (2600 W h kg) and specific capacity (1675 mA h g), abundant reserves and environmental friendliness. However, the well-known poor electrical conductivity of sulfur/LiS, shuttle effect of lithium polysulfides (LiPSs) and formation of lithium dendrites during the cycling process extremely hinder the large-scale application of Li-S batteries. In this work, we designed and prepared poly(3,4-ethylenedioxythiophene) (PEDOT) and FeC nanoparticle co-decorated carbon nanofiber (CNF) membranes as self-supporting LiS hosts to improve the electrochemical performance of Li-S batteries.

Multi-feature fusion method combining brain functional connectivity and graph theory for schizophrenia classification and neuroimaging markers screening.

Background: The abnormalities in brain functional connectivity (FC) and graph topology (GT) in patients with schizophrenia (SZ) are unclear. Researchers proposed machine learning algorithms by combining FC or GT to identify SZ from healthy controls. The schizophrenia classification and neuroimaging markers screening using FC and GT feature fusion are blank.

Spatiotemporal pattern evolution analysis of ecological networks based on morphological spatial pattern analysis: a case study of Ningbo City, China.

The exponential expansion of urban areas has precipitated a concomitant deterioration in the natural environment. Constructing ecological networks is vital in improving landscape connectivity, protecting biodiversity, and maintaining regional sustainable development. Ningbo, China, was set as the research area.

EVALUATION OF PROGNOSTIC RISK MODELS BASED ON AGE AND COMORBIDITY IN SEPTIC PATIENTS: INSIGHTS FROM MACHINE LEARNING AND TRADITIONAL METHODS IN A LARGE-SCALE, MULTICENTER, RETROSPECTIVE STUDY.

Background: Age and comorbidity significantly impact the prognosis of septic patients and inform treatment decisions. To provide clinicians with effective tools for identifying high-risk patients, this study assesses the predictive value of the age-adjusted Charlson Comorbidity Index (ACCI) and its simplified version, the quick ACCI (qACCI), for mortality in septic patients. Methods: This retrospective study included septic patients from four Chinese medical centers.

Free-Hand Endoscopic Full-Thickness Resection for Duodenal Subepithelial Lesions.

Background And Aim: This work aims to evaluate the efficacy and safety of free-hand endoscopic full-thickness resection (EFTR) for duodenal subepithelial lesions (SELs).

Methods: We performed a retrospective review of 105 patients with duodenal SELs who underwent free-hand EFTR. Free-hand EFTR means no other devices (over-the-scope clip or full-thickness resection device) are required.

A new way to combine carboxymethyl cellulose with Fe: Application and mechanism analysis.

A new, effective powdered adsorbent (CMCFe) for removing oxytetracycline (OTC) was synthesized successfully in an acidic environment using a thermal fusion technique. CMC-Fe underwent comprehensive SEM, EDS, FT-IR, XRD, XPS, TGA, and BET analyses before and after adsorbing OTC. These studies systematically examined preparation variables such as CMC and FeCl ratios, acetic acid quantity, reaction duration, and temperature.

Diagnostic Value of RDW-Albumin Ratio for the Prediction of Mortality in Sepsis Associated Nonthyroidal Illness Syndrome Patients: A Retrospective Cohort Study.

Background: The correlation between RAR is linked to negative outcomes in sepsis, but it remains uncertain if RAR is connected to prognosis in patients with sepsis-related NTIS. So we investigated it in this study.

Methods: Patients with sepsis-associated NTIS admitted to Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, between March 2013 and April 2017 were included in the study.

Adhesive, Biocompatible, Antibacterial, and Degradable Collagen-Based Conductive Hydrogel as Strain Sensor for Human Motion Monitoring.

The conductive hydrogels (CHs) are promising for developing flexible energy storage devices, flexible sensors, and electronic skin due to the unique features of excellent flexibility and high conductivity. However, poor biocompatibility and antibacterial properties seriously limit their application in the biomedical field. Collagen, one of the main components of the extracellular Matrix (ECM), is the ideal matrix for constructing hydrogels due to good biocompatibility with human tissue.

Association of Stress Hyperglycemia Ratio and in-Hospital Mortality in Patients with Sepsis: A Two Center Retrospective Cohort Study.

Introduction: In critically ill patients, the stress hyperglycemia ratio (SHR) was significantly associated with mortality. However, the relationship between SHR and mortality in septic patients is still unclear.In this study, patients with sepsis from two Chinese academic centers were identified and divided into quartiles based on SHR levels.