A scalable zinc-based coordination network for energy-efficient NF/CF separation with unprecedented selectivity.

Nitrogen trifluoride (NF) and carbon tetrafluoride (CF) are critical gases in the semiconductor industry. However, their current lack of effective recycling and separation results in significant waste emissions, which are not only costly but also pose significant environmental challenges. Their separation remains a critical challenge due to their nearly identical physicochemical properties (Δbp <1 °C, similar polarizability).

[Clinical prediction model for patients with early-onset prostate cancer without surgical treatment: Based on the SEER Database].

Objective: The aim of this study is to investigate the risk factors of prognosis in patients with early-onset prostate cancer treated without surgery. A nomogram will be constructed and validated to predict overall survival (OS) of patients with early-onset prostate cancer treated without surgery.

Methods: The clinical data was obtained from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database on prostate cancer patients aged 18－55 years who were treated without surgery between 2010 and 2015.

Characterization, Genomic Analysis and Application of Five Lytic Phages Against Carbapenem-Resistant .

The high pathogenicity rate of carbapenem-resistant (CRPA) has resulted in substantial economic losses for humans and the breeding industry. Consequently, there is an urgent need to develop new alternatives to mitigate antibiotic use. Phage therapy has demonstrated promising results in numerous studies.

Pan-cancer analysis of UDP-glucose 6-dehydrogenase in human tumors and its function in hepatocellular carcinoma.

Background: UDP-glucose 6-dehydrogenase (UGDH) is a key enzyme in glucuronic acid metabolism and acts as a key mediator in several cancer developmental signaling pathways.

Aim: To offer a more systematic and comprehensive elucidation of the involvement of UGDH in the onset and progression of various malignancies.

Methods: The role of UGDH in cancer was investigated public databases.

Thrombospondin 2 drives liver metastasis in skin cutaneous melanoma via regulation of angiogenesis and extracellular matrix remodeling.

To explore the functional role of thrombospondin 2 (THBS2) in the metastasis of skin cutaneous melanoma (SKCM), with a focus on its regulation of angiogenesis and extracellular matrix (ECM) remodeling. THBS2 expression was assessed in normal melanocytes and SKCM cell lines with varying metastatic potential. Functional analyses were conducted after THBS2 knockdown in A375 cells and overexpression in G-361 cells.

Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair.

Spinal cord injury (SCI) is a devastating condition with limited self-repair capacity, resulting in long-term disabilities. Endogenous neural stem cells (eNSCs), which are present in the adult central nervous system (CNS), hold significant potential for repairing neural damage following SCI. These cells can proliferate, migrate to the injury site, and differentiate into various neural cell types, including neurons and glial cells.

A new mechanism of high-altitude adaptation reducing myocardium infarction: inhibiting inflammation-induced ubiquitin degradation of BK to enhance coronary vasodilation.

Our prior research demonstrated that chronic intermittent hypobaric hypoxia (CIHH) pretreatment confers cardioprotection against ischemia/reperfusion (I/R) injury in rats. However, the precise mechanisms underlying CIHH's cardioprotective effects remain insufficiently understood. This study aims to elucidate the upstream signaling pathways and dynamic regulation of BK channels in mediating CIHH-induced cardioprotection through coronary artery vasodilation in rats.

Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins.

BH3 mimetic drugs that selectively target the pro-survival BCL2 proteins are highly promising for cancer treatment, most notably for treating blood cancers. Venetoclax, which inhibits BCL2, is now approved for treating chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). Preferably, robust and validated assays would identify patients most likely to benefit from therapy with venetoclax itself or with inhibitors of other pro-survival proteins.

GNLY+CD8+ T cells bridge premature aging and persistent inflammation in people living with HIV.

People living with HIV (PLWH) exhibit accelerated aging, characterized by systemic inflammation, termed "inflammaging." While T-cell expansion is prevalent in PLWH, its connection to inflammaging remains unclear. In this study, we analyzed the TCRβ repertoire of 257 healthy controls (HC) and 228 PLWH, revealing pronounced T cell clonal expansion in PLWH.

Knockout mutation to enhance sophorolipid production in Starmerella bombicola based on computational structural analysis of fatty acid oxidation enzymes.

Sophorolipids (SLs), produced by Starmerella bombicola, consist of a hydrophilic sophorose linked to a hydrophobic ω/ω-1 hydroxyl fatty acid. Fatty acid oxidation competes with the synthesis of SL, particularly under conditions of low content of glucose or high accumulation of fatty acid. While many studies have focused on modifying key enzyme genes within the synthesis pathway of SL, research to identify key genes outside of this pathway, such as those involved in the β- and ω-oxidation of fatty acids, remains limited.

Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer.

Despite the progress of treatment in gastric cancer (GC), the overall outcomes remain poor in patients with advanced diseases, underscoring the urgency to develop more effective treatment strategies. BH3-mimetic drugs, which inhibit the pro-survival BCL2 family proteins, have demonstrated great therapeutic potential in cancer therapy. Although previous studies have implicated a role of targeting the cell survival pathway in GC, the contribution of different pro-survival BCL2 family proteins in promoting survival and mediating resistance to current standard therapies in GC remains unclear.

Engineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3.

Introduction: Endometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective diagnostic and therapeutic strategies. This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.

[Aquatic Community Structure and Biological Assessment of Water Quality in Urban Lakes of the Yangtze River Downstream： A Case Study of Three Lakes in Wuhu City].

The Yangtze River constitutes a crucial aquatic system in China, and lakes downstream play a significant role in the stability of ecosystem functions. However, human activities have caused the lakes to suffer from eutrophication. Moreover, it is important to investigate the aquatic ecosystems of Qingting Lake, Fengming Lake, and Yin Lake in Wuhu City, Anhui Province, China, for tracing and controlling eutrophication.

Chronic intermittent hypobaric hypoxia prevents pulmonary arterial hypertension through maintaining eNOS homeostasis.

Aims: Pulmonary arterial hypertension (PAH) is a pathological condition in which pulmonary artery pressure is elevated which causes patients to die of right heart failure. Chronic intermittent hypobaric hypoxia (CIHH) represents a novel method of intermittently exposing subjects to a simulated plateau hypobaric hypoxia environment. This study investigates the potential preventive and protective effects of CIHH on PAH.

Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1.

Background: Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with HIV-1 (PLWH) fail to achieve an optimal recovery of CD4 T cells, and precise metabolic regulation underlying immune recovery remained poorly understood.

Methods: In this cross-sectional study, mass spectrometry was used for quantitative analysis of plasma metabolome and lipidome in 24 treatment-naïve PLWH (TNs), 33 immunological responders (IRs), 35 immunological non-responders (INRs), and 16 healthy controls (HCs). The data were analyzed using the Mann-Whitney U-test, Kruskal-Wallis test, Spearman correlation, and LASSO regression analysis.

Regulating Charge Distribution in Porphyrin-Based Polymer for Achieving Photocatalytic CO Conversion to CH or CH.

The photocatalytic conversion of CO into products such as CH and CH poses a significant challenge due to the lengthy reaction steps and the high energy barrier involved. In this study, both benzothiadiazole (BTD) and hydroxyl groups (-OH) are introduced into cobalt-based polymerized porphyrinic network (PPN) through a C-C coupling reaction. This modification of orbital energy levels that strengthens the ability of gain electrons and facilitates the charge transfer in PPN.

Efficient Photocatalytic Propane Direct Dehydrogenation to Propylene Over PtO Clusters.

The direct dehydrogenation of alkanes to olefins under mild conditions is challenging due to the inert nature of alkyl C─H bonds. Herein, an efficient photocatalytic system is developed for propane direct dehydrogenation (PDH) to propylene, consisting of ≈1.30 nm sized PtO clusters immobilized on a layered double hydroxide -derived ZnO/AlO support (LD-Pt).

Pore Chemical Modification of Bimetallic Coordination Networks for Coal-Bed Methane Purification under Humid Conditions.

The recycling of low-concentration coal-bed methane (CBM) is environmentally beneficial and plays a crucial role in optimizing the energy mix. In this work, we present a strategy involving pore chemical modification to synthesize a series of bimetallic diamond coordination networks, namely CuIn(ina), CuIn(3-ain), and CuIn(3-Fina) (where ina = isonicotinic acid, 3-ain = 3-amino-isonicotinic acid, and 3-Fina = 3-fluoroisonicotinic acid). Among these, the amino-functionalized CuIn(3-ain) exhibits excellent CH adsorption capacity (1.

The ability of virtual noncontrast images to remove intrinsic and external iodine from the thyroid via dual-layer spectral detector computed tomography.

Background: Virtual noncontrast (VNC) images generated by dual-layer spectral computed tomography (DLCT) remove iodine influence from enhanced images to simulate true noncontrast (TNC) images. Previous research has demonstrated the high comparability of abdominal VNC images with TNC images, suggesting their potential as substitutes. Given the thyroid's significant iodine content, this study evaluated the efficacy of VNC images for removing both intrinsic and extrinsic iodine through an analysis of computed tomography (CT) attenuation and iodine density in TNC and enhanced VNC thyroid images.

An Analysis of the Efficacy of the Health Butler Application and Intelligent Accompaniment Systems in Smart Outpatient Services Based on Patient Feedback.

Objective: This study aims to explore the efficacy of a smart outpatient service system incorporating the Health Butler application and Intelligent Accompaniment based on patients' feedback.

Methods: A total of 1000 outpatients from Shenzhen Third People's Hospital were randomly selected in May 2023 and November 2023 to provide feedback before and after implementing the smart outpatient service system consisting of the Health Butler app and Intelligent Accompaniment. The changes in the patient's awareness of the medical treatment process, average waiting time, satisfaction with the experience of seeking medical treatment, and trust in medical services offered based on patient feedback were compared pre- and post-implementation.

Synthesis, structure and biological activity of silver(I) complexes containing triphenylphosphine and non-steroidal anti-inflammatory drug ligands.

Two Ag(I) complexes containing triphenylphosphine and non-steroidal anti-inflammatory drug ligands were synthesized and investigated using various spectroscopic studies and single crystal X-ray crystallography. The binding properties of tolfenamic acid, ibuprofen and the two complexes with DNA and BSA were investigated using UV or fluorescence spectroscopy. The results showed that two Ag(I) complexes bound to DNA by the intercalation mode and interacted with BSA using a static quenching procedure.

Uncovering seed vigor responsive miRNA in hybrid wheat and its parents by deep sequencing.

Background: Two-line hybrid wheat technology system is one way to harness wheat heterosis both domestically and internationally. Seed vigor is a crucial parameter for assessing seed quality, as enhanced seed vigor can lead to yield increments of over 20% to a certain extent. MicroRNAs (miRNAs) were known to participate in the development and vigor of seed in plants, but its impact on seed vigor in two-line hybrid wheat remains poorly elucidated.

Cotinine exposure enhances the association of blood manganese and non-alcoholic fatty liver disease in American children: a cross-sectional study.

This cross-sectional survey aims to determine whether cotinine exposure would enhance the relationship between blood manganese (Mn) and non-alcoholic fatty liver disease (NAFLD) in children using the NHANES database. Restricted cubic spline (RCS) and logistic regression analyses were adopted to determine the potential relationship. Besides, we tested the robustness of the results by performing trend tests and subgroup analyses.