Efficacy and safety of SHR-1701 combined with chemoradiotherapy as neoadjuvant treatment for locally advanced rectal cancer.

Locally advanced rectal cancer (LARC) remains challenging to treat due to high recurrence rates and limited therapeutic options, particularly for patients with high-risk features. This prospective, multicenter, single-arm, open-label phase 2 trial (ClinicalTrials.gov identifier: NCT05300269) evaluated the efficacy and safety of SHR-1701, a novel bifunctional fusion protein targeting both PD-L1 and TGF-β, in combination with neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) for high-risk LARC.

Spatial Control of Chiral Self-Assembly and Lithographic Applications in Liquid Crystal Polymer Network.

Precise spatial organization of enantiomeric domains within self-assembled materials remains a challenge despite advances in controlling supramolecular chirality. Here, it is presented a facile strategy for directing supramolecular chirality through spontaneous twist self-assembly in liquid crystal (LC) materials, generating periodic zigzag line defects that define alternating enantiomeric domains. An LC polymer network stabilizes zigzag line defects, preserving their spatial organization and mechanical integrity.

Performance of conventional MRI and endoscopy in assessing complete tumor response following immunotherapy-based neoadjuvant therapy for rectal cancer.

Purpose: Endoscopy and MRI are essential tools for assessing treatment response in locally advanced rectal cancer (LARC). However, their accuracy in identifying pathological complete response (pCR; ie, ypT0N0) following immunotherapy-based neoadjuvant chemoradiotherapy (iNCRT) remains uncertain. This study evaluates the performance of endoscopy and MRI in reflecting ypT0 status and assesses MRI efficacy for lymph node metastasis in LARC following iNCRT.

Exploration of the optimal retention method in vivo for stem cell therapy: Low-intensity ultrasound preconditioning.

Bone marrow mesenchymal stem cells (BMSCs) are pluripotent and self-renewing, exerting a crucial role in the domain of regenerative medicine. Nevertheless, BMSCs encounter challenges such as low cell viability and inadequate homing during transplantation, thereby restricting their therapeutic efficacy. Hence, current research is concentrated on identifying optimal retention approaches following BMSCs transplantation to enhance its effectiveness.

The potential of low-intensity pulsed ultrasound to apply the long-term ovary protection from injury induced by 4-vinylcyclohexene diepoxide through inhibiting granulosa cell apoptosis.

The potential of low-intensity pulsed ultrasound (LIPUS) in regulating ovarian function has been demonstrated; however, there is a lack of scientific evidence regarding the long-term efficacy of LIPUS in treating ovarian injury and understanding its regulatory mechanisms. In this study, 4-vinylcyclohexene diepoxide (VCD) was used to induce ovarian injury in rats, and LIPUS was applied to target the damaged ovarian tissues. The research aimed to investigate the long-term protective effect of LIPUS against ovum toxicity induced by VCD and elucidate the associated molecular mechanisms.

Metabolomic network reveals novel biomarkers for type 2 diabetes mellitus in the UK Biobank study.

Aims: To identify hub metabolic biomarkers that constructively shape the type 2 diabetes mellitus (T2DM) risk network.

Materials And Methods: We analysed data from 98 831 UK Biobank participants, confirming T2DM diagnoses via medical records and International Classification of Diseases codes. Totally 168 circulating metabolites were quantified by nuclear magnetic resonance at baseline.

Recent advances in CDC7 kinase inhibitors: Novel strategies for the treatment of cancers and neurodegenerative diseases.

Cell division cycle 7 (CDC7) plays an indispensable regulatory role in various cellular processes, encompassing the initiation of DNA replication and the maintenance of replication checkpoints. However, dysregulation of CDC7 protein levels is closely associated with the development and progression of several human diseases, particularly cancers and neurodegenerative diseases. Therefore, targeting the CDC7 kinase is deemed a potential avenue for disease management.

Construction of two strains of recombinant lactobacilli expressing the HA2 protein of avian influenza virus subtype H9N2 in different ways and study on the effect of immunisation.

In recent years, the H9N2 subtype of LPAI has become one of the most widespread diseases in poultry in the world, and infected poultry usually show no obvious symptoms, mainly in the form of reduced performance. However, when secondary infection with other pathogenic bacteria occurs, it can significantly increase the morbidity and mortality of poultry, causing huge losses to the poultry industry. At present, vaccination is still the most common way to prevent and control avian influenza, but the traditional vaccine has deficiencies such as short duration of maintaining immunity, poor mucosal immunity and re-enforcement of virulence.

Nonreciprocal chirality conversion in spatiotemporal evolutions of nematic colloidal entanglement.

In soft matter systems, there is a wealth of topological phenomena, such as singular disclination lines and nonsingular defects of skyrmions and hopfions. In a liquid crystal (LC), the topological nature of disclination lines and colloids induces chiral colloidal entanglements. How the chirality of the entanglements is deterministically created and how the chirality conversion is actuated in the disclinations with Möbius strip topology have never been explored.

Light-driven dancing of nematic colloids in fractional skyrmions and bimerons.

Materials with full and fractional skyrmions are important for fundamental studies and can be applied as information carriers for applications in spintronics or skyrmionics. However, creation, direct optical observation and manipulation of different skyrmion textures remain challenging. Besides, how the transformation of skyrmion textures directs the dynamics of colloids is not well understood.

Exploring the clinical value of procalcitonin, c-reactive protein, white blood cell count, and neutrophil-to-lymphocyte ratio in the early diagnosis of bloodstream infections in children.

Backgroud: In the diagnosis of bloodstream infections (BSI) in children, compared to the gold standard of blood culture, markers in the blood offer advantages such as rapid results and cost-effectiveness. Therefore, we investigated the clinical value of procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC), and neutrophil-to-lymphocyte ratio (NLR) in the early diagnosis of BSI in children.

Methods: This study included a retrospective analysis of 309 suspected BSI cases and patients were categorized into 2 groups based on blood culture results: blood culture-positive group, and blood culture-negative group.