Synchronous percutaneous microwave ablation combined with percutaneous biopsy for highly suspected malignant pulmonary nodules: a retrospective study.

Background: There is still a lack of studies on the optimal sequence of treatment for microwave ablation (MWA) combined with percutaneous biopsy (PB) in the treatment of highly suspected malignant pulmonary nodules (PNs). This study aimed to investigate the feasibility, safety, and efficacy of computed tomography (CT)-guided simultaneous MWA combined with PB in the treatment of highly suspected malignant PNs and discuss the influence of the sequential order of MWA and PB on the treatment outcome.

Methods: From January 2021 to December 2024, 91 patients with single highly suspected malignant PNs underwent synchronous MWA combined with PB.

Potential function exploration of lncRNAs in idiopathic pulmonary fibrosis: insights from whole transcriptome sequencing data analysis.

Background: Research has shown that long noncoding RNAs (lncRNAs) play a role in Idiopathic Pulmonary Fibrosis (IPF), but their specific functions and patterns of expression are still unclear.

Method: A diagnostic study was conducted by utilizing analysis techniques. RNA sequencing (RNA-seq) data from 12 IPF patients and 5 controls was used to study lncRNA functions in IPF.

Low-intensity pulsed ultrasound ameliorates pancreatic injury and glucose metabolism in type 2 diabetic mice: regulatory role of the oxidative phosphorylation pathway.

Type 2 diabetes mellitus (T2DM) poses a significant global health challenge. While pharmacological interventions exist, increasing attention has been directed toward novel non-invasive therapeutic strategies. The pancreas plays a crucial role in T2DM pathogenesis, and its dysfunction is closely linked to mitochondrial abnormalities and oxidative stress.

Superior Performance of Synchronized Percutaneous Microwave Ablation and Immediate Percutaneous Biopsy for Highly Suspected Malignant Pulmonary Ground-Glass Nodules.

Objective: In recent years, experience has been accumulated in microwave ablation (MWA) of ground-glass nodules (GGNs). The goal of this retrospective study was to explore the feasibility, safety, and efficacy of synchronized computed tomography (CT)-guided MWA combined with intraoperative percutaneous biopsy (PB) for the treatment of highly suspected malignant GGNs.

Methods: From January 2021 to February 2025, 93 patients with highly suspected malignant GGNs underwent MWA and PB.

Wearable ultrasound regulation of blood glucose levels in type 2 diabetic db/db mice.

Type 2 diabetes mellitus (T2DM), a chronic metabolic disorder, imposes a notable burden on human health. Current treatments that require long-term medication and dietary control often face challenges with patient compliance. Although low-intensity pulsed ultrasound (LIPUS) shows promise in regulating blood glucose, the clinical application of traditional ultrasound devices remains challenging due to their large size and high cost.

The potential of low-intensity pulsed ultrasound to apply the long-term ovary protection from injury induced by 4-vinylcyclohexene diepoxide through inhibiting granulosa cell apoptosis.

The potential of low-intensity pulsed ultrasound (LIPUS) in regulating ovarian function has been demonstrated; however, there is a lack of scientific evidence regarding the long-term efficacy of LIPUS in treating ovarian injury and understanding its regulatory mechanisms. In this study, 4-vinylcyclohexene diepoxide (VCD) was used to induce ovarian injury in rats, and LIPUS was applied to target the damaged ovarian tissues. The research aimed to investigate the long-term protective effect of LIPUS against ovum toxicity induced by VCD and elucidate the associated molecular mechanisms.

Explore the Effect of Low-Intensity Focused Ultrasound on Pain Relief in Patients With Diabetic Peripheral Neuropathy: A Pilot Randomized Trial.

Objectives: To evaluate the efficacy of low-intensity focused ultrasound (LIFU) in alleviating pain in patients with painful diabetic peripheral neuropathy (PDPN).

Methods: Between November 2022 and January 2024, a total of 50 participants diagnosed with PDPN were randomly assigned to either LIFU therapy or placebo therapy. Pain levels were assessed using the numeric pain rating scale (NRS), while neuropathic symptoms and signs were evaluated using the neuropathy symptom score (NSS) and neuropathy deficit score (NDS), respectively.

Vanillic acid ameliorates collagen-induced arthritis by suppressing the inflammation response via inhibition of the MAPK and NF-κB signaling pathways.

Objective: To explore the potential therapeutic effects and underlying mechanism of vanillic acid (VA) in the treatment of rheumatoid arthritis (RA).

Methods: A collagen-induced arthritis (CIA) model was established in DBA/1 J mice. Methotrexate (MTX, 1 mg/kg/d) and VA (5 mg/kg/d, 10 mg/kg/d, 20 mg/kg/d) were then administered to investigate their therapeutic efficacy on RA in vivo.

Robust Radiomics Models for Predicting HIFU Prognosis in Uterine Fibroids Using SHAP Explanations: A Multicenter Cohort Study.

This study sought to develop and validate different machine learning (ML) models that leverage non-contrast MRI radiomics to predict the degree of nonperfusion volume ratio (NVPR) of high-intensity focused ultrasound (HIFU) treatment for uterine fibroids, equipping clinicians with an early prediction tool for decision-making. This study conducted a retrospective analysis on 221 patients with uterine fibroids who received HIFU treatment and were divided into a training set (N = 117), internal validation (N = 49), and an external test set (N = 55). The 851 radiomics features were extracted from T2-weighted imaging (T2WI), and the max-relevance and min-redundancy (mRMR) and the least absolute shrinkage and selection operator (LASSO) regression were applied for feature selection.

Soft elasticity enabled adhesion enhancement of liquid crystal elastomers on rough surfaces.

The fabrication of pressure-sensitive adhesives (PSA) using liquid crystal elastomers (LCE) that are tolerant to substrate roughness is explored in this work. Traditional soft adhesives are designed by maintaining a balance between their cohesive strength and compliance. However, rough surfaces can significantly affect the adhesion strength of PSAs.

The incremental value of trace nucleic acid detection in CT-guided percutaneous biopsy needle rinse solutions for the diagnosis of tuberculosis.

Introduction: Tuberculosis (TB) diagnosis still faces challenges with high proportion of bacteriologic test negative incidences worldwide. We assessed the diagnostic value of digital PCR (dPCR) analysis of ultramicro () nucleic acid in CT-guided percutaneous biopsy needle rinse solution (BNRS) for TB.

Methods: BNRS specimens were consecutively collected and total DNA was purified.

Prediction of non-perfusion volume ratio for uterine fibroids treated with ultrasound-guided high-intensity focused ultrasound based on MRI radiomics combined with clinical parameters.

Background: Prediction of non-perfusion volume ratio (NPVR) is critical in selecting patients with uterine fibroids who will potentially benefit from ultrasound-guided high-intensity focused ultrasound (HIFU) treatment, as it reduces the risk of treatment failure. The purpose of this study is to construct an optimal model for predicting NPVR based on T2-weighted magnetic resonance imaging (T2MRI) radiomics features combined with clinical parameters by machine learning.

Materials And Methods: This retrospective study was conducted among 223 patients diagnosed with uterine fibroids from two centers.

Electrowetting of a Soft Elastic Gel.

A liquid drop may change its wettability on a surface with an applied voltage, known as electrowetting. Herein, we report an electrowetting phenomenon of a soft elastic gel, where gel elasticity plays an important role. We have designed experiments to measure the voltage-dependent adhesion energy between the gel and a metal electrode and proposed an electromechanical model for the electrowetting behavior of the gel.

Banking of perinatal mesenchymal stem/stromal cells for stem cell-based personalized medicine over lifetime: Matters arising.

Mesenchymal stromal/stem cells (MSCs) are currently applied in regenerative medicine and tissue engineering. Numerous clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for patients. MSCs derived from either human adult or perinatal tissues have their own unique advantages in their medical practices.

Radiomics analysis of lung CT for multidrug resistance prediction in active tuberculosis: a multicentre study.

Objectives: Multidrug-resistant TB (MDR-TB) is a severe burden and public health threat worldwide. This study aimed to develop a radiomics model based on the tree-in-bud (TIB) sign and nodules and validate its predictive performance for MDR-TB.

Methods: We retrospectively recruited 454 patients with proven active TB from two hospitals and classified them into three training and testing cohorts: TIB (n = 295, 102), nodules (n = 302, 97), and their combination (n = 261, 81).

A wearable cardiac ultrasound imager.

Continuous imaging of cardiac functions is highly desirable for the assessment of long-term cardiovascular health, detection of acute cardiac dysfunction and clinical management of critically ill or surgical patients. However, conventional non-invasive approaches to image the cardiac function cannot provide continuous measurements owing to device bulkiness, and existing wearable cardiac devices can only capture signals on the skin. Here we report a wearable ultrasonic device for continuous, real-time and direct cardiac function assessment.

Research on efficient feature extraction: Improving YOLOv5 backbone for facial expression detection in live streaming scenes.

Facial expressions, whether simple or complex, convey pheromones that can affect others. Plentiful sensory input delivered by marketing anchors' facial expressions to audiences can stimulate consumers' identification and influence decision-making, especially in live streaming media marketing. This paper proposes an efficient feature extraction network based on the YOLOv5 model for detecting anchors' facial expressions.