Deciphering potential-dependent oxygen reduction kinetics in spinel manganese ferrite.

Accurate evaluation of oxygen reduction reaction (ORR) catalysts, especially transition metal oxides, requires careful control of testing parameters. Here, we report a potential-window-dependent ORR activity for spinel manganese ferrite (MnFeO). The ORR activity exhibits a volcano-shaped dependence on the lower potential limit during cathodic scans.

Sex- and age-related differences in inflammatory markers and their association with coronary artery disease.

This study explored the differences in circulating cytokines between sexes and age and their association with the pathogenesis of coronary artery disease ( CAD ) in order to identify populations suitable for anti-inflammatory treatment. Methods：This retrospective study included hospitalized patients who underwent coronary angiography between October 2022 and November 2024. The selected participants were grouped by age and sex to compare differences in circulating inflammatory cytokine levels and CAD occurrence.

Network Pharmacology and Experimental Validation Identify Paeoniflorin as a Novel SRC-Targeted Therapy for Castration-Resistant Prostate Cancer.

Despite advances in prostate cancer treatment, castration-resistant prostate cancer (CRPC) remains clinically challenging due to inherent therapy resistance and a lack of durable alternatives. Although traditional Chinese medicine offers untapped potential, the therapeutic role of paeoniflorin (Pae), a bioactive compound derived from Paeonia lactiflora, in prostate cancer has yet to be investigated. Using an integrative approach (network pharmacology, molecular docking, and experimental validation), we identified Pae key targets, constructed protein-protein interaction networks, and performed GO/KEGG pathway analyses.

Inflammation-Targeted Molecular Imaging for Myocarditis: Recent Advances in Target Mechanisms, Probe Development, and Translational Applications.

Inflammation is the key feature of myocarditis, which remains challenging to diagnose due to its complex etiology and nonspecific clinical presentation. In recent years, inflammation-targeted molecular imaging has become a research priority, and noninvasive monitoring of cardiac inflammation is expected to improve the accuracy of clinical diagnosis. This review focuses on the molecular imaging probes and targets for myocarditis in radionuclide imaging, ultrasound imaging, and magnetic resonance imaging (MRI), discussing the characteristics and applications of each probe-target combination and their potential limitations.

In situ structure determination of conformationally flexible targets using nextPYP.

Single-particle cryoelectron tomography (SP-CET) is an imaging technique capable of determining the structure of proteins in their cellular environment at high-resolution. nextPYP is a web-based application designed to streamline the SP-CET structure determination process and facilitate the analysis of conformational variability. Here we explain how to use nextPYP-based methods to determine the structure and study the conformational heterogeneity of proteins using SP-CET.

Endothelial HMGB1-AIM2 axis worsens myocardial ischemia-reperfusion injury by regulating endothelial pyroptosis.

This study investigates mechanisms related to endothelial cells in myocardial ischaemia-reperfusion (I/R) injury, focusing on the role of high-mobility group box 1 (HMGB1) protein in these cells. Using a murine model, we observed elevated levels of HMGB1 in both the heart and circulation following I/R, with a portion originating from cardiac vascular endothelial cells and cardiomyocytes. Endothelial cell-specific HMGB1 knockout preserved cardiac function after I/R by reducing infarct size, mitigating myocardial damage, maintaining endothelial cell barrier function, and attenuating inflammatory and oxidative stress responses.

-Poly[[[aqua-copper(II)]-μ-hydroxido-κ :-μ-[3-(4-1,2,4-triazol-4-yl)benzoato]-κ : ] monohydrate].

In the title compound, {[Cu(CHNO)(OH)(HO)]·HO]} , the Cu cation is situated on a twofold rotation axis and is coordinated by two triazole N atoms from two different 3-(4-1,2,4-triazol-4-yl)benzoate (3-tba) ligands, by two hydroxyl O atoms and by a water O atom, forming a coordination environment inter-mediate between a square pyramid and a trigonal bipyramid. The Cu ions are connected by 3-tba ligand and a hy-droxy group into polymeric chains parallel to [001]. O-H⋯O hydrogen bonds and C-H⋯O inter-actions consolidate the crystal structure.

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.

We report the results of structural, functional and genetic studies on the CD33 sialic acid- binding receptor that reveal how non-coding variants in CD33 alter risk for Alzheimer's disease (AD). The full-length CD33 isoform, whose expression is upregulated by non-coding AD-risk alleles, preferentially forms dimers at the cell surface, where they interact with AD-related proteins (clusterin and Aβ). This interaction induces CD33 inhibitory signalling and downregulates protective microglial functions including phagocytic removal of amyloid plaques.

A 2D-3D Perovskite Memristor-Based Light-Induced Sensitized Neuron for Visual Information Processing.

Implementing Leaky Integrate-and-Fire (LIF) neurons in hardware is poised to enable the creation of efficient, low-power spiking neural networks (SNNs). This is attributed to the ability of LIF neurons to mimic the rapid response and sensitivity of biological neurons, thereby reducing unnecessary computational resources. The fixed firing frequency of conventional LIF neurons limits their adaptability to complex, dynamic environments.

CGRP-Loaded ROS-Responsive Hydrogel Restores Neuro-Angiogenic Signaling to Promote Bone Regeneration in Diabetes-Associated Periodontitis.

Diabetes exacerbates the development and progression of periodontitis through the aggravation of persistent inflammation and tissue destruction. While the impact of diabetes on peripheral sensory nerves is well-documented, little is known about the role of diabetic neuropathy in bone destruction in diabetes-associated periodontitis. Herein, a significant loss of periodontal nerves is observed in the diabetic state of db/db mice, with trigeminal ganglion neurons showing decreased autophagy.

[Retracted] Twist induces epithelial‑mesenchymal transition in cervical carcinogenesis by regulating the TGF‑β/Smad3 signaling pathway.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, for the Transwell migration and invasion assay experiments shown in Fig. 3C and D on p. 1791, two pairs of the data panels appeared to be overlapping, suggesting that the same data may have been used in this figure to represent data that were intended to show the results from differently performed experiments.

The restriction impacts of the Type III restriction-modification system on the transmission dynamics of antimicrobial resistance genes in .

Introduction: The spread of antibiotic resistance genes among () is a serious problem, and the effects of the restriction-modification (R-M) system on the transmission dynamics of these genes in remain poorly understood.

Materials And Methods: Complete genome sequences of strains were extracted from the BV-BRC database until March 25, 2024. The phylogenetic and the resistance analysis were used to analyze the distribution of resistance genes in .

Voluntary exercise alleviates ischemic brain injury in mice by modulating mitochondrial dysfunction.

Objectives: The relationship between exercise and mitochondrial function is unclear. This study investigated the relationship between voluntary exercise and mitochondrial dynamics in ischemic stroke model mice.

Materials And Methods: This experiment used 54 male C57BL/6 J mice to assess the therapeutic effect of voluntary exercise on ischemic stroke in a middle cerebral artery occlusion (MCAO) model.

Immune Landscape and Prognostic Significance of Gene Expression Profiles in Bladder Cancer: Insights from Immune Cell Infiltration and Risk Modeling.

To explore the immunological underpinnings and prognostic potential of gene expression profiles in bladder cancer through comprehensive analyses of The Cancer Genome Atlas (TCGA) data. We used the TCGA data to identify differentially expressed genes (DEGs) and performed enrichment analysis to reveal the related biological pathways. Meanwhile, the least absolute shrinkage and selection operator (LASSO) algorithm was adopted to develop a prognostic model.

Target-Mediated EV-SNA Clustering as an Amplifier for miRNA Imaging in Living Cells.

To overcome the low efficiency of probe delivery and the comprised detection limit due to dispersion of fluorescent molecules, we develop a miRNA detection-amplification system, called the miRDAS, which can be rapidly internalized by cells and amplify miRNA signals within living cells. The miRDAS consists of two types of extracellular vesicle spherical nucleic acid (EV-SNA), named EVsnater and EVsnafier, which are generated by hydrophobic coassembly of natural EVs with cholesterol-modified oligonucleotides and exhibit rapid cellular uptake dynamics. Upon specifically binding to its target miRNA, the EVsnater activates the fluorescence and then self-assembles with EVsnafier to form giant fluorescent clusters, resulting in a brighter and significantly amplified fluorescence signal.

Multiparametric performance comparison of dental composites for clear aligner attachments.

Background: As clear aligner technology (CAT) gains prominence, the performance of composite attachments - critical devices for optimizing aligner retention and tooth movement control - require systematic evaluation. This study assesses three light-cured composites (Filtek™ Z250 XT, Z350 XT, and P60; 3 M ESPE) regarding color stability, shear bond strength (SBS), and durability to establish evidence-based selection criteria.

Methods: Attachments were bonded to mandibular premolars, simulating the clinical process, and materials were tested for color changes (after immersion in coffee, cola, or iced tea), SBS, and durability (wear volume, surface roughness, morphology, post-aging SBS).

Comparative non-targeted metabolomics reveals distinct metabolic profiles and functional traits in six mung bean (Vigna radiata) varieties.

This study aimed to investigate the metabolic differences among six mung bean (Vigna radiata) varieties cultivated in Heilongjiang Province, China, using non-targeted metabolomics based on high-resolution mass spectrometry. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were employed to explore and distinguish the metabolomic profiles across different varieties. A total of 547 metabolites were identified, including fatty acids (9.

Developing a molecular diagnostic model for heatstroke-induced coagulopathy: a proteomics and metabolomics approach.

Background: Heatstroke (HS) is becoming more concerning, with coagulopathy contributing to higher mortality. The aim of this study was to analyze the metabolomic and proteomic profiles associated with heatstroke-induced coagulopathy (HSIC) and to develop a molecular diagnostic model based on proteomic and metabolomic patterns.

Methods: This study included 41 HS patients from the Department of Critical Care Medicine at a comprehensive teaching hospital.

Correction: Unveiling the switching mechanism of robust tetrazine-based memristive nociceptors a spectroelectrochemical approach.

[This corrects the article DOI: 10.1039/D5SC02710A.].

Fear of Progression and Its Associated Factors Among Patients With Positive Lung Cancer Screening Results: A Latent Profile Analysis.

Fear of progression is a common problem. This cross-sectional study aimed to identify distinct fear of progression profiles among patients with progressive pulmonary nodules in the preoperative period and to explore the factors associated with these patterns. A total of 259 preoperative patients with pulmonary nodules completed self-reported measures assessing fear of progression and relevant correlates (e.

FAM3A: a novel mitochondrial protein for the treatment of ischemic diseases.

FAM3 metabolism-regulating signaling molecule A (FAM3A) is a mitochondrial protein belonging to the gene family with the potential for the treatment of ischemic diseases. FAM3A promotes adenosine triphosphate (ATP) production and improves mitochondrial function by increasing ATP synthase activity and activating the protein kinase B-cyclic AMP-responsive element binding protein-forkhead box D3-ATP synthase regulatory loop, thereby reducing reactive oxygen species production and inhibiting oxidative stress-induced cell death. Additionally, FAM3A activates the nuclear factor erythroid 2-related factor 2 signaling pathway and upregulates the expression of antioxidant proteins, further enhancing the cellular oxidative defense capacity.

A case of gigantic ovarian thecoma with normal estrogen during puberty.

Thecoma is a rare type of ovarian sex cord-stromal tumor, accounting for about 0.5% to 1.0% of ovarian tumors.

Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice.

Cytoplasmic stress granules (SG) assemble in response to stress-induced translational arrest and are key signaling hubs orchestrating cell fate and regulating various physiological and pathological processes. However, the role of SG formation in the progression of allergic diseases is incompletely understood. Here, by analyzing the nasal tissues of allergic rhinitis (AR) mouse models and AR patients, we find that SGs assemble specifically in the macrophages within the nasal mucosa and promote AR progression by restraining the efferocytotic ability of macrophages, ultimately resulting in reduced Mres generation and IL-10 production.

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application.

The human perception system features many dynamic functional mechanisms that efficiently process the large amount of sensory information available in the surrounding environment. In this system, sensory adaptation operates as a core mechanism that seamlessly filters familiar and inconsequential external stimuli at sensory endpoints. Such adaptive filtering minimizes redundant data movement between sensory terminals and cortical processing units and contributes to a lower communication bandwidth requirement and lower energy consumption at the system level.

Combined association of gait speed and processing speed on cardiometabolic disease mortality risk in the US older adults: a prospective cohort study from NHANES.

Background: Gait speed and processing speed, as measured by the Digit Symbol Substitution Test (DSST), are important indicators of health in older adults, with their potential impact on mortality risk. However, their combined effects on cardiometabolic disease (CMD) mortality remain unclear.

Objective: This study investigates how gait speed and cognitive function, individually and combined, influence CMD-specific and all-cause mortality in older adults.