Technical research on surrounding rock control of roadways crossing collapse columns in strong mine pressure working faces.

When roadways in strong mine pressure working faces traverse collapse columns, the complex stress redistribution frequently induces surrounding rock instability and support structure failure. This study investigates the 2702 intake airway crossing the X26 collapse column (75.8 m wide) at Zhangcun Coal Mine through an integrated approach combining theoretical analysis, numerical modeling, and field validation.

Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007-2018.

Melanoma incidence is increasing worldwide, prompting exploration into novel risk factors beyond traditional exposures like ultraviolet radiation. Recent studies suggest that metabolic and circadian disruptions may also contribute to melanoma development, yet their influence is poorly understood. This study examines the relationships between metabolic syndrome (MetS), circadian syndrome (CircS) and melanoma risk, emphasizing differences between different genders.

Recent advances in the application of subcritical water to plant and fungi polysaccharides preparation: A review.

Subcritical water can enhance the extraction yield of polysaccharides due to its unique extraction mechanism and is widely applied to the preparation of polysaccharides from plant and fungi. Subcritical water demonstrated distinct conditional regularities in the extraction of polysaccharides from diverse materials, particularly plant- and fungus-derived polysaccharides. A summary of these regularities was essential to provide theoretical guidance for the future application of subcritical water.

Selective leaching behavior and kinetics of wasteful Titanium-bearing blast furnace slag via low concentration hydrochloric acid.

Titanium-bearing blast furnace slag (TBFS) is rich in metallic resources but poses considerable environmental risks during long-term storage. Conventional selective extraction methods are limited by high acid consumption, prolonged processing time, and excessive energy requirements. This study developed a thermodynamically controlled selective leaching approach using low-concentration hydrochloric acid (HCl) to enhance elemental recovery and reduce environmental impact.

Target-Mediated EV-SNA Clustering as an Amplifier for miRNA Imaging in Living Cells.

To overcome the low efficiency of probe delivery and the comprised detection limit due to dispersion of fluorescent molecules, we develop a miRNA detection-amplification system, called the miRDAS, which can be rapidly internalized by cells and amplify miRNA signals within living cells. The miRDAS consists of two types of extracellular vesicle spherical nucleic acid (EV-SNA), named EVsnater and EVsnafier, which are generated by hydrophobic coassembly of natural EVs with cholesterol-modified oligonucleotides and exhibit rapid cellular uptake dynamics. Upon specifically binding to its target miRNA, the EVsnater activates the fluorescence and then self-assembles with EVsnafier to form giant fluorescent clusters, resulting in a brighter and significantly amplified fluorescence signal.

Microplastic pollution in the Indian Ocean: Fiber-dominated contamination and comparative bioaccumulation in Auxis thazard and Symplectoteuthis oualaniensis.

Microplastics are minute particles that originate from the breakdown of large plastic materials or are put on as microbeads, creating critical hazards to ecosystems. Currently, there is a lack of research on microplastics (MPs) in the surface waters of the Indian Ocean and local marine organisms. This study investigates the abundance, composition, and potential ecological impacts of MPs in the surface waters of the Indian Ocean, and MPs in the bodies of two typical marine organisms in the local area were detected.

Marginal zone lymphoma masquerading as phymatous acne rosacea: a case study.

Marginal zone lymphoma (MZL) is an indolent B-cell lymphoma characterized by considerable heterogeneity in clinical presentation. Cutaneous MZL typically manifests as papules, plaques or nodules, often affecting the trunk and arms. Rare cases of MZL presenting as acne rosacea have been reported; however, these have been primarily reported as granulomatous rosacea.

Global, regional, and national burden of orofacial clefts, 1990-2021: an analysis of data from the global burden of disease study 2021.

Background: Orofacial clefts (OFCs) are congenital craniofacial malformation caused by embryonic developmental abnormalities, characterized by incomplete fusion of the upper lip and/or palate, leading to feeding difficulties, speech impairments, and other functional challenges. OFCs represent the most prevalent congenital malformations of oral and maxillofacial region. We aim to characterize disease burden of OFCs across regions and countries, analyze temporal trends from 1990 to 2021, examine relationship with Socio-demographic Index (SDI), explore gender disparities and predict future epidemiological patterns.

The ESCRT component FYVE4 modulates salt-stress response by strengthening the SOS1-SOS2 interaction in Arabidopsis.

The plant-specific FYVE-domain-containing protein FYVE4, a component of the endosomal sorting complex required for transport III (ESCRT-III), participates in membrane protein sorting. However, the mechanism by which FYVE4 coordinates plant growth responses to environmental stress remains unclear. In this study, we reveal a novel function of FYVE4 in positively regulating plant salt resistance by modulating the Salt Overly Sensitive (SOS) signaling pathway.

Gentle Gradient-Reduction of Graphene Oxide Membranes by Interfacial Redox Reaction toward Breaking Selectivity-Permeability Trade-off.

Graphene oxide membranes hold promising application potential in molecular nanofiltration, but the traditional selectivity-permeability trade-off is still a challenge. Here, an interfacial redox reaction strategy based on poly(m-phenylenediamine)-graphene oxide (PmPD-GO) interaction was successfully designed to achieve the fabrication of an ultrathin graphene oxide membrane (∼28 nm) with a reasonable reduction state (C/O ratio of 11.2) and adequate interlayer spacing stabilized at 8 ± 0.

Functional and transcriptomic characterization of the receptor-like protein kinase gene GmHSL1b involved in salt stress tolerance in soybean roots.

The survival and adaptation of plants to adverse environmental conditions is crucial and is facilitated by receptor-like kinases, which act as cell surface receptors for a variety of signals. In this study, we identified a gene, GmHSL1b, encoding a receptor-like protein kinase that is responsive to abscisic acid (ABA) hormonal signals and is involved in the plant's response to drought and salt stresses. Subcellular localization assays have demonstrated that the GmHSL1b protein is located in the plasma membrane.

Selective separation and utilization of valuable metals from vanadium slag for the preparation of VOSO electrolyte.

The traditional processing methods of vanadium slag have been narrowly focused on the extraction of vanadium, resulting in a significant squandering of resources and environmental pollution of V(V) and Cr(VI). Addressing this, this study investigates the separation and comprehensive utilization of Fe(II), Mn(II), Cr(III), Ti(IV), and V(IV) in vanadium slag. Low temperature sulfate roasting was applied to prepare low valence multiple metals solution from vanadium slag, it avoids the formation of toxic V(V) and Cr(VI) compounds.

Polymyxin B induces pigmentation by upregulating ATG2A-ERK/CREB-MITF-PMEL17 signaling axis.

Polymyxin B serves as the last line of defense in treating multidrug-resistant Gram-negative bacterial infections. However, its distinctive side effect of hyperpigmentation significantly impacts patients' psychological well-being and treatment adherence. Currently, the underlying mechanism of polymyxin B-induced pigmentation remains to be incompletely investigated.

Effect of priority cranioplasty on post-traumatic hydrocephalus with severe collapse of brain tissue: A case report.

Trephine syndrome and post-traumatic hydrocephalus are frequent complications following decompressive craniectomy in patients with traumatic brain injury. The recommended treatments for trephine syndrome and post-traumatic hydrocephalus include cranioplasty and ventriculoperitoneal shunt placement. However, There is no consensus on the priority of these two procedures.

Exosome Source Matters: A Comprehensive Review from the Perspective of Diverse Cellular Origins.

Exosomes have emerged as promising therapeutic agents in regenerative medicine. This review introduces a novel cell type-oriented perspective to systematically analyze exosomal properties in regenerative therapies. To our knowledge, this review is the first to comprehensively compare exosomes based on cellular source type, offering unprecedented insights into selecting optimal exosome producers for targeted regenerative applications.

Differential Regulation of miRNA and Protein Profiles in Human Plasma-Derived Extracellular Vesicles via Continuous Aerobic and High-Intensity Interval Training.

Both continuous aerobic training (CAT) and high-intensity interval training (HIIT) are recommended to promote health and prevent diseases. Exercise-induced circulating extracellular vesicles (EX-EVs) have been suggested to play essential roles in mediating organ crosstalk, but corresponding molecular mechanisms remain unclear. To assess and compare the systemic effects of CAT and HIIT, five healthy male volunteers were assigned to HIIT and CAT, with a 7-day interval between sessions.

Effects of electromagnetic radiation from offshore wind power on the physiology and behavior of two marine fishes.

With the widespread promotion of wind power, its potential ecological impacts on marine ecosystems have raised concerns, among which electromagnetic radiation is one of the significant impacts. It is well known that the effects of electromagnetic fields on different marine organisms vary greatly, but little is known about their effects on commercially important fish species. We studied the toxicity differences between the large yellow croaker (Larimichthys crocea) and the black sea bream (Acanthopagrus schlegelii) when exposed to magnetic field strengths of 0mT, 0.

Stealth in non-tuberculous mycobacteria: clever challengers to the immune system.

Non-tuberculous Mycobacteria (NTM) are found extensively in various environments, yet most are non-pathogenic. Only a limited number of these organisms can cause various infections, including those affecting the lungs, skin, and central nervous system, particularly when the host's autoimmune function is compromised. Among these, Non-tuberculous Mycobacteria Pulmonary Diseases (NTM-PD) are the most prevalent.

Targeted metals extraction from spent LiNiCoMnO batteries via thermochemical-induced sulfation roasting: Thermodynamics & kinetics.

To alleviate the energy crisis and control environmental pollution raised by spent lithium-ion batteries (LIBs), the development of efficient and economic methods for their recycling is crucial for sustainable development of new energy industry. Herein, a combined pyro - hydrometallurgical process was adopted for recovery of valuable metal elements for spent LiNiCoMnO (NCM523). Different from conventional pyrometallurgical methods with high temperature and energy consumption, the NHHSO roasting strategy works at 400 °C and achieves remarkable leaching efficiencies of Li, Co, Mn, and Ni achieved 97.

An integrated microfluidic device for sorting of tumor organoids using image recognition.

Tumor organoids present a challenge in drug screening due to their considerable heterogeneity in morphology and size. To address this issue, we proposed a portable microfluidic device that employs image processing algorithms for specific target organoid recognition and microvalve-controlled deflection for sorting and collection. This morphology-activated organoid sorting system offers numerous advantages, such as automated classification, portability, low cost, label-free sample preparation, and gentle handling of organoids.

Icariside II Preparation from Icariin Separated from Herbal Extract Powder by a Special Icariin Glycosidase.

In this study, icariside II was prepared from icariin by a special enzyme. The yield of the substrate icariin from a powdered extract of the popular herb was 16.9%.

A Comprehensive Review of the Mechanism and Modification Strategies of VO Cathodes for Aqueous Zinc-Ion Batteries.

Aqueous zinc-ion batteries (AZIBs) have attracted wide attention due to their affordability, inherent safety, and environmental friendliness, recognized as one of the most ideal next generation energy storage systems. Vanadium-based cathodes have garnered significant interest in the field of AZIBs, presenting vast application prospects in stationary energy storage. Among them, layered vanadium pentoxide (VO) stands out a promising material due to its high theoretical capacity, drawing extensive research efforts.

Fluctuation theorem in the quantum Otto engine with long-range interaction.

The fluctuation of the quantum Otto engine has recently received a lot of attention, while applying the many body with a long-range interaction to a quantum heat engine may enhance our ability of controlling it. Using the two-point measurement and its generalization, we explore the fluctuation theorem of work and heat in a single stroke as well as in a cycle. We discover that the fluctuations of work in a cycle as well as fluctuations of heat in a single stroke or cycle can be connected to the fluctuation of work in a single stroke.