Wettability Regulated Two-Phase Flow of Supercritical CO and Water in Confined Nanochannels.

Supercritical carbon dioxide (scCO) has emerged as a promising agent in enhanced oil recovery (EOR) due to its ability to reduce interfacial tension and enhance oil mobility in reservoirs. Water is ubiquitous in oil reservoirs, yet the underlying mechanisms governing scCO transport in the presence of water within nanoscale channels remain inadequately understood. Using molecular dynamics simulations combined with analytical models, this study explores the two-phase flow behavior of scCO and water in confined nanochannels, emphasizing the effects of water saturation () and channel wettability.

(CNH)HCNS: Trithiocyanurate Exhibiting Giant Optical Anisotropy via Weak Interaction-Mediated Functional Module Alignment.

There is an immediate demand for identifying birefringent materials that possess substantial optical anisotropy to meet the requirements of photonic applications. Optimizing the orientation of functional modules to achieve enormous anisotropy is essential for enhancing the linear optical properties of birefringent materials. In this research, the arrangement of anionic groups was regulated by the hydrogen bonds formed between group (CNH) and (HCNS) groups, and coupled with the synergistic effect of the repulsive force between the same groups, this resulted in the design and synthesis of the first metal-free trithiocyanurate ultraviolet (UV) birefringent crystal (CNH)HCNS.

PCSK9 inhibitors reduces arterial stiffness in patients with acute coronary syndrome.

Background: This study focuses on uncovering the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in attenuating arterial stiffness in patients with acute coronary syndrome (ACS) and atherosclerosis.

Methods: A total of 71 ACS patients were enrolled in this study from April 1, 2022, to June 31, 2022. Patients were randomly assigned to two groups: one group received statin therapy combined with PCSK9 inhibitors (Evolocumab 140 mg or Alirocumab 75 mg every two weeks) (n = 36), and the other group received statins alone (n = 35).

Concentrations, Compositions and Human Exposure Risks to Organophosphate Esters in Indoor Air from Various Microenvironments in Guangzhou, China.

Limited research has characterized the occurrence of organophosphate esters (OPEs) in indoor microenvironment air. To address this gap, ten OPE congeners were measured in air samples collected from 46 homes, 12 offices, 6 student dormitories, and 60 private cars in Guangzhou, China. Among the four microenvironments, private vehicles exhibited the highest total OPE concentrations (ΣOPEs), with an average of 264.

A high throughput and micrometre spatial resolution design for a versatile resonant inelastic X-ray scattering spectrometer.

A versatile scheme has been meticulously engineered for a resonant inelastic X-ray scattering spectrometer, enabling free switching between high throughput configurations with narrow spatial-resolution and low throughput setups boasting broad spatial-resolution capabilities. The high throughput mode enhances signal intensity threefold compared with setups with only the dispersive subassembly, while achieving 2.7 µm resolution within a 16 µm range.

Mechanisms of Sepsis from a Metabolic Immunology Perspective: A Bidirectional Mendelian Randomization and Single-Cell Sequencing Study of CD39+ Cells.

Background: Interactions between immune phenotypes and metabolites in sepsis pathogenesis remain poorly defined. We integrated Mendelian randomization (MR) and single-cell transcriptomics to investigate metabolic mediation in immune-sepsis associations.

Methods: Bidirectional two-sample MR analyzed sepsis GWAS (11,643 cases), 1,400 metabolites, and 731 immune phenotypes.

Deciphering the mucin defense mechanisms against SARS-CoV-2 using molecular simulations.

SARS-CoV-2 primarily infects hosts via the respiratory tract, with the mouth and nose as key entry sites. Mucins, essential components of the airway mucosal barrier, function as binding sites for viral adhesion and intercept viral particles as physical barriers. Mucin 1 (MUC1) has been reported to restrict SARS-CoV-2 entry into host cells, but its protective mechanism and structural basis remain unclear.

Broad-spectrum insight into precise removal of immobilized hard acids for fluoride: DFT simulations, experiments, and QICAR analysis.

Fluoride, a typical hard-base ligand in chemical processes, presents a significant ecological threat due to its enrichment in aquatic environment. In this work, the specific affinities of hard-acid metal cations toward F were evaluated from a broad-spectrum perspective with the assistance of density functional theory (DFT), and six metal cations were screened and immobilized on D412 carrier. Batch experiments and mechanism analysis validated the DFT predictions, demonstrating that the ionic size, electrostatic interaction, and electronic hardness of hard-acid cations are related to F removal efficiency.

Growth of Monolayer WS Lateral Homojunctions via Domain Engineering.

Two-dimensional (2D) lateral homojunctions possess unique geometries and properties distinct from those of other heterostructures, including perfect lattice matching and clean carrier diffusion channels, showing great potential in beyond-silicon nanoelectronics. However, the direct growth of 2D lateral homojunctions within the same crystal phase and layer remains challenging due to the limited choice of elements. Here, we report the epitaxy growth of semiconducting monolayer WS lateral homojunctions by domain engineering during chemical vapor deposition (CVD).

Immune response induced by the recombinant novel coronavirus vaccine (Adenovirus type 5 vector) (Ad5-nCoV) in persons living with HIV (PLWH).

Background: Despite higher risk of poorer outcomes and potential sub-optimal vaccine effectiveness, people living with HIV (PLWH) are underrepresented in SARS-CoV-2 vaccine trials. We evaluated the safety and immunogenicity of the Ad5-nCoV vaccine (CanSino Biologics Inc./The Beijing Institute of Biotechnology) in PLWH.

Genotype and Outcomes of Cochlear Implantation in Children With Incomplete Partition Type III.

Objectives: To investigate the molecular findings and long-term outcomes of cochlear implantation (CI) in a relatively large cohort of patients with incomplete partition type-III malformation (IP-III), and to analyze the correlation between genotype and CI outcomes.

Study Design: Cross-sectional (genomic) and retrospective cohort (auditory and speech outcomes with CI) study.

Setting: Tertiary referral center.

Link between fertility behavior and edentulous jaw in middle-aged Chinese women: a cross-sectional study from the CHARLS.

Background: Women's health is a critical topic in global public health. Female fertility, an important stage in a woman's life, is closely tied to overall health. Currently, there is a lack of research exploring the relationship between oral health and female fertility.

Identifying Influential Nodes Based on Evidence Theory in Complex Network.

Influential node identification is an important and hot topic in the field of complex network science. Classical algorithms for identifying influential nodes are typically based on a single attribute of nodes or the simple fusion of a few attributes. However, these methods perform poorly in real networks with high complexity and diversity.

Early Gap Detection Threshold Predicts Late Speech Perception in Cochlear Implant Users.

ObjectiveTo study whether the ability to detect frequency changes or temporal gaps at the early phase postactivation can predict speech perception performance at the late phase postactivation in postlingually deafened cochlear implant (CI) users.MethodPsychophysical tests and event-related potential (ERP) tests were conducted at the third-month postactivation (early phase postactivation, T1) and after 1-year postactivation (late phase postactivation, T2) in 27 postlingually deafened CI users. CI hearing thresholds and speech perception performance were measured at T1 and T2.

[A clinical study of electrocochleography monitoring for residual hearing retention during minimally invasive cochlear implant].

To investigate the application value of intraoperative electrocochleography（ECochG） monitoring technique and insertion techniques in cochlear implant（CI） and analyze its relationship with postoperative residual hearing（RH） preservation. Thirty-one patients（35 ears） who received CI in our hospital from June 2022 to July 2024 were enrolled. The Advanced Bionics Active Insertion Monitoring（AIM） system was used for real-time ECochG monitoring during surgery.

Grain Boundary Guided Folding of Graphene for Twisted Bilayer Graphene.

Bilayer graphene exhibits intriguing physical and mechanical properties that are suitable for advanced electronic device applications. By introducing a new degree of freedom through interlayer twisting, exotic phenomena such as superconductivity can arise. However, in practical experiments, manual manipulation is often required to fabricate such a configuration and therefore, scaled production of magic angle bilayer graphene is challenging.

Effects of Huoxue Chubi decoction on protein kinase B-mammalian target of rapamycin autophagy pathway in scleroderma Balb/c model mice.

Objective: To explore the mechanisms by which Huoxue Chubi decoction (, HXCB) affects the protein kinase B (Akt)-mammalian target of rapamycin (mTOR) autophagy pathway in scleroderma Balb/c model mice.

Methods: A scleroderma model was established in male Balb/c mice, followed by daily administration of HXCB (4.6, 2.

Can Reimplantation Be Performed After Peri-Implant Recurrent Pyogenic Granuloma Leads to Implant Failure? A Case Report.

Background: Peri-implant pyogenic granuloma (PG) is a benign vascular lesion associated with dental implants, typically resulting from local irritation. While peri-implant PG can ultimately lead to implant failure, there is no established consensus regarding the feasibility of reimplantation after implant removal.

Case Report: A 66-year-old female patient presented to the clinic with painful erythematous and swollen gingiva in the left posterior maxillary region, accompanied by a bleeding tendency.

Enhancing Heterointerface Coupling for Durable Industrial-Level Proton Exchange Membrane Water Electrolysis.

The industrial-level application of proton exchange membrane water electrolysis (PEMWE) lies in the capacity of operating at high current density in order for higher power density and lower operational cost. However, it poses a significant challenge to the overall performance of catalysts. Heterointerface engineering has emerged as an ideal strategy for addressing the anodic intrinsic activity limitations.

Trends in Coenzyme Q10 Supplement Use and Associations With All-Cause and Cardiovascular Mortality: A Population-Based Cohort Study.

Coenzyme Q10 (CoQ10) is a fat-soluble nutrient, which has antioxidant and anti-inflammatory properties. However, there is insufficient evidence on its daily use and the association with mortality. We aimed to evaluate the trends of CoQ10 supplement use among US noninstitutionalized adults and explore its associations with all-cause and CVD mortality.

Exploring the pathogenesis of sepsis-induced cardiomyopathy: Multilayered mechanisms and clinical responses.

Sepsis-induced cardiomyopathy (SIC), as a common complication in the intensive care unit, not only increases the complexity of patient care but also greatly enhances the risk of death. Currently, clinical management of SIC remains challenging, mainly due to the complexity of its pathogenesis and the lack of targeted therapies. Although the specific etiology of SIC is not yet fully understood, existing studies have revealed several vital pathological processes that are intertwined and contribute to the progression of the disease.

OTUD7B is a new deubiquitinase targeting p53.

The tumor suppressor p53 safeguards against cellular transformation, with its expression regulated by diverse post-translational modifications (PTMs). While polyubiquitination by Mdm2 principally drives its proteasomal degradation, the identity of p53 deubiquitinases (DUBs) remains less well defined. This study investigates the role of the deubiquitinase enzyme OTUD7B in hepatocellular carcinoma (HCC), where it is notably downregulated and proposed to function as a tumor suppressor.

Ultrastable supported oxygen evolution electrocatalyst formed by ripening-induced embedding.

The future deployment of terawatt-scale proton exchange membrane water electrolyzer (PEMWE) technology necessitates development of an efficient oxygen evolution catalyst with low cost and long lifetime. Currently, the stability of the most active iridium (Ir) catalysts is impaired by dissolution, redeposition, detachment, and agglomeration of Ir species. Here we present a ripening-induced embedding strategy that securely embeds the Ir catalyst in a cerium oxide support.

Light-driven dancing of nematic colloids in fractional skyrmions and bimerons.

Materials with full and fractional skyrmions are important for fundamental studies and can be applied as information carriers for applications in spintronics or skyrmionics. However, creation, direct optical observation and manipulation of different skyrmion textures remain challenging. Besides, how the transformation of skyrmion textures directs the dynamics of colloids is not well understood.

Long-Term Auditory and Speech Outcomes of Cochlear Implantation in Children with IP-I Malformation.

Objectives: This study aimed to investigate the long-term auditory and speech outcomes in children with Incomplete Partition Type I (IP-I) who underwent cochlear implantation (CI) and compared their progress to implanted children with normal cochlea.

Methods: This study tracked 17 children with IP-Ι for an average of 3.5 years post-implantation.