Aryl hydrocarbon receptor (AhR) alleviates the LPS-induced inflammatory responses in IPEC-J2 cells by activating PINK1/Parkin-mediated mitophagy.

Objective: This study investigates the role of the aryl hydrocarbon receptor (AhR) in lipopolysaccharide (LPS)-induced inflammatory responses in IPEC-J2 cells.

Methods: Inflammatory responses were triggered in IPEC-J2 cells using 5 μg/ml LPS. AhR was activated with tryptophan or FICZ and knocked down via RNA interference.

Broad-spectrum insight into precise removal of immobilized hard acids for fluoride: DFT simulations, experiments, and QICAR analysis.

Fluoride, a typical hard-base ligand in chemical processes, presents a significant ecological threat due to its enrichment in aquatic environment. In this work, the specific affinities of hard-acid metal cations toward F were evaluated from a broad-spectrum perspective with the assistance of density functional theory (DFT), and six metal cations were screened and immobilized on D412 carrier. Batch experiments and mechanism analysis validated the DFT predictions, demonstrating that the ionic size, electrostatic interaction, and electronic hardness of hard-acid cations are related to F removal efficiency.

[Correlation between autophagy-associated miRNAs and prostate cancer: An update].

Prostate cancer (PCa) is one of the common tumors in the genitourinary system, with an increasing morbidity and mortality in China. Recent studies show that autophagy plays an important pathophysiological role in many diseases, including cancers. Besides, some miRNAs are also key regulatory factors for autophagy in PCa cells, and play an important role in the development, progression, diagnosis and treatment of PCa.

Implementation and optimization of SpMV algorithm based on SW26010P many-core processor and stored in BCSR format.

The irregular distribution of non-zero elements of large-scale sparse matrix leads to low data access efficiency caused by the unique architecture of the Sunway many-core processor, which brings great challenges to the efficient implementation of sparse matrix-vector multiplication (SpMV) computing by SW26010P many-core processor. To address this problem, a study of SpMV optimization strategies is carried out based on the SW26010P many-core processor. Firstly, we design a memorized data storage transformation strategy to transform the matrix in CSR storage format into BCSR (Block Compressed Sparse Row) storage.

[Research on the mechanism of Miao ethnicity medicine formula of Oxalis corniculata against chronic non-bacterial prostatitis].

Objective： To explore the mechanism of Miao ethnicity medicine formula of Oxalis corniculata against chronic non-bacterial prostatitis. Methods: The rat model of chronic abacterial prostatitis was induced by stimulation with 2% sterile carrageenan solution. After modeling, the rats were randomly divided into two groups, Model control group (Model group) and oxalis group.

[Clinical study of artificial intelligence-guided image fusion assisted transperineal prostate biopsy].

Objective: To compare the diagnostic efficacy of AI-guided mpMRI-TRUS fusion assisted transperineal systematic biopsy, targeted biopsy and combined biopsy in the diagnosis of PCa, and to evaluate the clinical application value of combined biopsy.

Methods: From April 2022, the general personal information and clinical data of patients with suspicious prostate lesions (PI-RADS≥3) detected by 3.0T mpMRI were collected, then underwent AI-guided mpMRI-TRUS fusion-assisted transperineal prostate biopsy.

Effect of antibiotic exposure on the characteristics of activated sludge in a landfill leachate biological treatment system.

Changes in the activated sludge performance in an anaerobic/aerobic biological treatment system for leachate was discussed under the condition of tetracycline (TC) exposure. The results show that a low concentration of TC did not have an obvious effect on the removal of chemical oxygen demand (COD) while a high concentration of TC had a certain promoting effect. Under the stimulation of TC, the particle size distribution of anaerobic/aerobic sludge tended to be more uniform, the particle size of anaerobic sludge decreased while the settleability increased; however, the particle size of aerobic sludge increased due to bulking.