CSF2RA promotes gastric cancer progression through activation of the JAK2/STAT3 signaling pathway.

Pseudoautosomal regions (PARs), located at the ends of sex chromosomes, harbor genes that may play a role in tumor pathology by regulating cell proliferation and the immune microenvironment. Gastric cancer (GC) is a prevalent and molecularly heterogeneous malignancy of the digestive system. However, studies on the role of PARs-related genes in GC are limited.

Effects of esketamine on electrophysiology and metabolic reprogramming in brain organoids: insights into antidepressant mechanisms.

Esketamine, commonly used to treat treatment-resistant depression, has pharmacological mechanisms that remain incompletely understood. Brain organoids offer a human-relevant platform for investigating the cellular and molecular effects of drugs. In this study, we investigated the effects of esketamine on the electrophysiology and metabolism of brain organoids derived from iPSCs of healthy control subjects and depressed patients.

Association between anxiety disorder, anxiolytic drugs, and risk of incident Parkinson's disease.

In this prospective cohort study, we analysed data from 502,364 participants (ages 40-69) in the UK Biobank, with follow-up until 2024. Logistic and Cox regression analysis identified generalized anxiety disorder (GAD) and obsessive-compulsive disorder (OCD) as independent risk factors for Parkinson's disease (PD), with post-traumatic stress disorder (PTSD) patients under 71 also at increased risk. Panic disorder (PAD) showed no association with PD.

A Photoelectrochemical Biosensor with On-Off-On Type Signal Conversion for Pb Detection.

Herein, a photoelectrochemical (PEC) biosensor with on-off-on type signal conversion was designed by the signal quenching of Cobalt tetraphenyl porphyrin (CoPP) to gold nanoparticles@graphitic carbon nitride (Au@g-CN) and the signal recovering triggered from a DNAzyme-mediated amplification strategy for sensitive detection of lead ion (Pb) related to environmental monitoring. Impressively, compared to pure g-CN, the Au@g-CN prepared by an in situ reduction method presented a significantly enhanced photocurrent response, which was named as the initial "on" PEC signal. Furthermore, with the incubation of S1, S2, and CoPP, the PEC signal generated from Au@g-CN could be tremendously quenched (signal-off state) owing to the electron withdrawing characteristic of CoPP and the steric hindrance effect of the CoPP-S1-S2 complex.

Global, regional, and national burden of musculoskeletal disorders, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2035.

Objectives: This study aimed to assess the global, regional, and national burdens of musculoskeletal disorders (MSDs) since 1990. It also projected trends up to 2035 and explored potential improvements through frontier analysis.

Methods: Using data from the Global Burden of Disease 2021 study, MSDs in 204 countries and territories were analyzed.

Synthesis and evaluation of lansiumamide B analogues to ameliorate acute lung injury by reducing oxidative stress and inflammation via Keap1/Nrf2/NF-κB pathway.

Acute lung injury (ALI), occurring with oxidative stress and inflammation, is a life-threatening disease, characterized by significant morbidity and mortality rates. There is a deep need to develop novel drugs. In this work we synthesized 46 novel lansiumamide B analogues with newly developed transition-metal-free strategy.

ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection.

The ERK-mediated phosphorylation of the core m6A methyltransferase METTL3 has been linked to the regulation of embryonic stem cell differentiation and tumorigenesis. However, its role in the antiviral innate immune response remains unclear. In this study, we found that during infection with the prototypical alpha-herpesvirus Pseudorabies virus (PRV), ERK2 protein expression increased significantly, while METTL3 expression decreased both in vitro and in vivo.

Comparison of the SureX HPV genotyping test with the Digene Hybrid Capture 2 test in cervical cancer screening.

Introduction: Cervical cancer, predominantly caused by high-risk human papillomavirus (HR-HPV) infections, is a critical public health issue. Effective screening is essential. This study compares the SureX HPV genotyping test, which detects 25 HPV types, with the widely used Digene Hybrid Capture 2 (HC2) test, which targets 13 HR-HPV types, to determine their effectiveness in cervical cancer screening among Chinese women.

Impact of knowledge-attitude-practice model nursing based on reproductive health education on patients with reproductive tract infections.

Objective: To evaluate the effectiveness of nursing interventions based on the Knowledge-Attitude-Practice (KAP) model in managing patients with reproductive tract infections (RTI).

Methods: Adopting a prospective randomized controlled design, patients diagnosed with reproductive tract infections between January 2023 and September 2024 were randomly assigned to either the study group (KBA model nursing intervention) or the control group (conventional nursing care). Both groups were subjected to systemic treatment with metronidazole/tinidazole, with concurrent treatment provided to the partners of patients with trichomoniasis.

A CD4+ T lymphocyte-specific TCR/GSDMD/IL-2 axis facilitates antitumor immunity.

Gasdermin (GSDM) family proteins mediate tumor pyroptosis and impact cancer progression, but other than that, their involvement in the tumor immune microenvironment remains largely unknown. Here, we show that activation of GSDMD in human tumor specimens mainly occurs in tumor-infiltrating leukocytes. Significantly, GSDMD deficiency or its inactivation in CD4+ T cells disabled CD8+ T cell-mediated antitumor immunity and caused tumor outgrowth in mice.

Characteristic alterations of gut microbiota and metabolites in patients with perianal abscess: a multi-omics analysis.

Background/objectives: Various studies have highlighted the important associations between perianal abscess (PA) and gut microbiota and related metabolites. Nevertheless, the establishment of causal relationships between these associations remains to be determined. This study aimed to provide direct evidence and a comprehensive understanding of gut microbiota disturbance in children with PA through combined 16S rRNA sequencing and untargeted metabolomic analysis.

Association between dietary inflammatory index and Parkinson's disease: a prospective study of 165,531 UK biobank participants.

Parkinson's disease (PD) is a common neurodegenerative disorder that increasingly affects the aging population. Inflammation is implicated in both the onset and progression of PD, with diet influencing inflammatory pathways. The Dietary Inflammation Index (DII) measures diet-related inflammatory potential.

Disorders of glucose metabolism and impaired energy metabolism in pfkma and pfkmb knockout zebrafish.

Background: In our previous study, Phosphofructokinase, muscle (PFKM), a key enzyme in glucose metabolism, was found to be decreased in the urinary exosomes of diabetic patients. The role of PFKM in glucose and energy metabolism is not fully understood. The study explores PFKM's implications in these metabolic pathways through the lens of a zebrafish model.

Correction: Effects of mental fatigue on biomechanical characteristics and risk associated with non-contact anterior cruciate ligament injuries during landing.

[This corrects the article DOI: 10.3389/fbioe.2025.

Bronchial granular cell tumor incidentally detected during preoperative evaluation of thyroid carcinoma: A case report.

The present case report describes a rare granular cell tumor (GCT) found in the right lower lobe bronchus of a 36-year-old male patient. The tumor was incidentally discovered during preparation for thyroid cancer surgery. The patient had noticed a neck mass 3 months prior to admission, which led to an ultrasound-guided bilateral thyroid mass perforated biopsy and pathological examination.

Efficient photoproduction of a high-value sesquiterpene pentalenene from the green microalga Chlamydomonas reinhardtii.

Microalgae can convert CO into energy-rich bioproducts through photosynthesis, emerging as promising platforms for sustainable and light-driven terpenoid production. Pentalenene, a tricyclic sesquiterpene originally identified as an antibiotic metabolite in Streptomyces species, has recently emerged as a promising candidate for advanced aviation fuels. However, pentalenene biosynthesis does not naturally occur in photosynthetic microorganisms, limiting its cost-effective production.

Impact of mental fatigue on lower limb biomechanics and non-contact anterior cruciate ligament injury risk in basketball players during the stop-jump task: a self-controlled trial.

Background: Non-contact anterior cruciate ligament (ACL) injuries are prevalent among basketball players, particularly during abrupt stop-jump actions. Most existing studies have focused primarily on the impact of physical fatigue on athletic performance, often overlooking the critical role of mental fatigue (MF). The MF experienced in high-intensity game scenarios may further increase the risk of non-contact ACL injuries by altering lower limb biomechanical characteristics; however, the underlying mechanisms remain unclear.

Nursing management of tube feeding among geriatric patients in long-term care facilities: Summary of best evidence-practiced strategies.

Aims: To summarize the best evidence-based strategies for the management and care of geriatric patients with tube feeding in long-term care facilities, providing practical guidance for clinical nursing practice.

Methods: A comprehensive search of UpToDate, BMJ Best Practice, PubMed, Web of Science, JBI database, Embase, CINAHL, Cochrane Library, CNKI, and other sources was conducted from inception to April 25, 2024. The study followed PRISMA guidelines for systematic reviews.

A study of the profiles of transition shock and their influencing factors among nursing interns: A latent profile analysis.

Background: Nursing interns often experience transition shock during clinical adaptation, which reduces their work efficiency, damages health, and hinders the transition to professional nurse role. However, most studies have overlooked the individual characteristics of nursing interns, the differences in the level of transition shock and factors causing these differences.

Purpose: To identify the latent profiles of nursing interns' transition shock and to analyze their influencing factors.

Development, validation, and updating of prognostic models for m7G-associated genes from TAMs in lower-grade gliomas.

As the crucial component of the glioma microenvironment, tumor-associated macrophages (TAMs) significantly contribute to the immunosuppressive microenvironment and strongly influence glioma progression via various signaling molecules, simultaneously providing new insight into therapeutic strategies. Studies are aiming at developing prognostic models using N7-methylguanosine (m7G)-related genes in gliomas, however, models with good predictive performance for lower-grade gliomas have yet to be developed. Based on genes with m7G variants and clinical information, two prediction models have been derived to predict the probability of survival for patients with lower-grade gliomas in TCGA.

Highly Conductive and Mechanically Robust Cellulose Hydrogels Enabled by Attapulgite-Derived Titanium Silicate.

The development of cellulose-based hydrogels with integrated mechanical robustness, ionic conductivity, and environmental tolerance is critical for advancing wearable electronics. Herein, we report a dual-cross-linked cellulose hydrogel reinforced with attapulgite-derived titanium silicate (ATS). An acid-hydrothermal approach was used to transform attapulgite into ATS.

Maintaining long-term frequent tea consumption could reduce the risk of cognitive decline: results from a 10-year longitudinal study.

Background: Previous studies have suggested that tea may have neuroprotective effect. This study aimed to investigate the association between tea consumption frequency and cognitive decline, taking into account changes in consumption habits and selection bias.

Methods: This study used data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in 2008, 2011, 2014, and 2018 years.

Model Construction for Predicting Preoperative Microvascular Invasion of Hepatocellular Carcinoma by Gadoxetic Acid Disodium-Enhanced Magnetic Resonance Imaging Combined with Serology.

BACKGROUND We aimed to establish a preoperative prediction model of microvascular invasion in hepatocellular carcinoma based on gadoxetic acid disodium-enhanced magnetic resonance imaging in conjunction with serology. MATERIAL AND METHODS In this study, the clinicopathological and imaging data of 120 patients with hepatocellular carcinoma from the Affiliated Huai'an Hospital of Xuzhou Medical University were retrospectively collected, and patients were divided into a training group and a validation group in a ratio of 7: 3. The independent risk factors were determined through logistic regression analysis, and a prediction model was established based on the derived independent risk factors, with imaging as the main factor.

Structural Characterization and Protective Effects of Fruit Shell Polysaccharides against DSS-Induced Ulcerative Colitis in Mice.

Plant polysaccharides have been reported to possess multiple pharmacological effects that can inhibit the progression of inflammatory diseases. The shell of fruits is a byproduct of the industry that is insufficiently utilized. Herein, a novel polysaccharide (CFP-A) was purified from fruit shells, and its structure elucidation and anti-inflammatory activity against dextran sulfate sodium (DSS)-induced ulcerative colitis were investigated.

Case Report: Do not diagnose lung cancer as pneumonia: continue to monitor a case of invasive mucinous adenocarcinoma as it progresses from small to large.

Background: Invasive mucinous adenocarcinoma (IMA) is a rare malignant tumor of the lung, characterized as a distinct subtype of lung adenocarcinoma, with unique histological features and clinical behavior. Because the diagnosis is often delayed due to its imaging characteristics resembling pneumonia, this neoplasm is associated with a poor prognosis.

Case Presentation: This case report describes a 69 years-old man who underwent an asymptomatic health examination, during which small ground-glass opacities were found in the periphery of both lungs.