Multi-scale design of the structure and mechanical performance of the deep-sea hydrothermal mussel (Bathymodiolus aduloides) shell.

Deep-sea hydrothermal vents are renowned for being among the most extreme environments on Earth. However, the mussel shells found in these vent sites demonstrate remarkable productivity, despite being subjected to high pressure as well as unusual levels of heavy metals, pH, temperature, CO, and sulphides. To comprehend how these mussels endure such extreme conditions, a systematic comparative study was conducted, focusing on the unique chemical composition, structural designs, and mechanical properties of hydrothermal vent mussels (Bathymodiolus aduloides) in comparison to shallow-water mussels (Mytilus edulis).

Retinal Structures in Autism Spectrum Disorder: Results from a Case-Control Study.

Objective: To assess retinal structures in patients with autism spectrum disorder (ASD) and its correlation with cognitive impairments and brain volumes.

Design: A retrospective case-control study.

Subjects: Adults with ASD and matched neurotypical controls were identified from the UK Biobank (UKBB).

Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions in a Child With Inherited Co-deletion of 16p11.2 and 16p12.2: A Case Report and Literature Review.

16p11.2 deletion syndrome is a group disorder associated with intellectual impairment, developmental delay, and autism spectrum disorder (ASD). Paroxysmal kinesigenic dyskinesia with infantile convulsions (PKD/IC) is an extremely rare condition.

Application and research progress of tranexamic acid in the perioperative period of posterior lumbar interbody fusion.

Posterior lumbar interbody fusion requires stripping the multifidus muscle, destroying a large amount of cancellous bone and damaging the posterior spinal venous plexus. Typically, surgical trauma is extensive, the surgical duration is long, and the degree of bleeding is substantial. Excessive blood loss can compromise a patient's hemodynamic stability, elevate surgical risks, and cause damage to vital organs, potentially becoming life-threatening in severe cases.

Study on the Adsorption Characteristics of Kaolin Blended with Different Proportions of NaCl under High-Temperature Conditions.

Zhundong coal is characterized by its high alkali metal content, which can easily lead to slagging and scaling on the heating surfaces of the boiler during combustion. In practical applications, the blending of kaolin is commonly adopted to mitigate these slagging and fouling issues during the combustion of Zhundong coal. This study uses a three-stage, high-temperature drop tube furnace.

Multifunctional Nanoplatform Combining Photothermal Therapy and Chemoimmunotherapy for the Treatment of -Colonized Colorectal Cancer.

The presence of bacteria in colorectal cancer not only induces drug inactivation but also inhibits the antitumor immune responses. Here, a multifunctional nanoplatform (IR/CP@BNP@HA) is designed to enhance antitumor photothermal therapy and chemoimmunotherapy for the treatment of bacterium-infected tumors. IR/CP@BNP@HA consists of the hyaluronic acid (HA) shell and reactive oxygen species (ROS)-responsive chitosan biguanide-functionalized biopolymer core (IR/CP@BNP), which encapsulates chemotherapy drug camptothecin (CPT) and photothermal agent IR1048.

Drought exacerbates levofloxacin phytotoxicity: Insights from Phragmites australis.

Drought and antibiotic pollution are critical environmental stressors and their co-occurrence was increasing, yet their combined effects on wetland plant physiology and molecular mechanisms remain poorly understood. This study examines the synergistic phytotoxicity of drought stress and the commonly used fluoroquinolone antibiotic levofloxacin (LEV) on Phragmites australis, a dominant wetland species. By establishing a 2 × 2 factorial experiment, we found that drought significantly increased LEV uptake in P.

Adaptive cationic peptide bundles hydrogel for the repair of infected mandibular defects.

Due to bacterial resistance and the limited self-healing capacity, the treatment of infected mandibular defects remains great challenges. Cationic peptide bundles can kill bacteria more efficiently than the linear ones. However, they are hard to release from hydrogels because of the nonflexible structures, thus limiting its application.

Complement factor D of Paralichthys olivaceus in serum enhances C3 deposition to activate complement against bacterial infection.

The complement system has an important role in the response to bacterial infection. Complement factor D (CFD) is a serine protease involved in the alternative pathway activation by promoting complement factor B cleavage. In teleosts, the biological functions of CFD are poorly understood.

Graphene-Enhanced FePO Composites with Superior Electrochemical Performance for Lithium-Ion Batteries.

In this study, we successfully synthesized olivine-type FePO via an in situ oxidation method and further developed two composite cathode materials (o-FePO-1/GR-1 and o-FePO-1/GR-2) by incorporating graphene. The composites were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray Photoelectron Spectroscopy (XPS), revealing a three-dimensional porous layered structure with an enhanced surface area and strong interaction between FePO nanoparticles and graphene layers. Electrochemical tests demonstrated that the composite electrodes exhibited significantly improved performance compared to pristine FePO, with discharge capacities of 147 mAh g at 1C and 163 mAh g at 0.

Comparison of the SureX HPV genotyping test with the Digene Hybrid Capture 2 test in cervical cancer screening.

Introduction: Cervical cancer, predominantly caused by high-risk human papillomavirus (HR-HPV) infections, is a critical public health issue. Effective screening is essential. This study compares the SureX HPV genotyping test, which detects 25 HPV types, with the widely used Digene Hybrid Capture 2 (HC2) test, which targets 13 HR-HPV types, to determine their effectiveness in cervical cancer screening among Chinese women.

Analysis of Cardiotoxicity and Risk Factors of Breast Cancer Chemotherapy Drugs: A Five-Year Single-Centre Retrospective Study in Early Breast Cancer.

Objective: To investigate the cardiotoxicity of breast cancer (BC) chemotherapy drugs and analyse their risk factors.

Methods: Through the electronic medical record system, the data of 415 patients with early BC (EBC) who had undergone a complete chemotherapy cycle were retrospectively collected within 5 years from the beginning of chemotherapy. Baseline clinical, biochemical and echocardiographic data were retrospectively extracted for comparative analysis.

Identification of Key Lactylation-Related Genes and Their Relevance to the Connection Between Parkinson's Disease and the Immune System Through Integrated Bioinformatics Analysis.

Parkinson's disease (PD) is a complex neurodegenerative disorder with a growing body of evidence suggesting the involvement of immune responses. To better understand the interplay between lactylation-related genes and immune reactions in PD, we conducted an integrated bioinformatics analysis. Utilizing publicly available PD gene expression datasets, we performed a detailed analysis employing Single-sample Gene Set Enrichment Analysis and Weighted Gene Co-expression Network Analysis.

Clinical profiles and health-related quality of life changes after treatment in advanced colorectal cancer patients: a nationwide study in China.

Background: Colorectal cancer (CRC) is prevalent in China, but many features of CRC patients remain to be better characterized. We aimed to describe the characteristics of clinical epidemiology in CRC patients in China and to evaluate the changes in health-related quality of life (HRQOL) before and after treatment.

Methods: A hospital-based survey was conducted among CRC patients from 2020 to 2021, covering 14 cities in China.

Does microcredit for the poverty-alleviated population have an income-increasing effect? Also on the "Raising the Low" effect.

Promoting the continuous income increase of the poverty-alleviated population has become one of the key tasks to consolidate the achievements of poverty alleviation, promote rural revitalization and achieve common prosperity. Based on the survey data of 738 farmers in six poverty-alleviated counties (cities) in an underdeveloped region in northwest China, this paper uses the endogenous transformation regression model to empirically explore the income-increasing effect of microcredit for the poverty-alleviated population, and uses the quantile regression model and OLS regression model to explore raising the low effect of microcredit for the poverty-alleviated population. The results show that: (1) Based on the counterfactual hypothesis, if the farmers who obtain microcredit for poverty-alleviated population are not loaned, their production and operating income will decrease by 3.

A Novel ZjbZIP33-ZjPRX1 Module Positively Regulates Lignin Formation in the Jujube Fruit Stone.

Fruit stones play an important role in fruit development and are closely related to fruit quality. Lignification of the fruit stone (endocarp) is a typical feature of stone fruits. Stoneless jujube is a valuable jujube germplasm resource, and the degree of lignification of its fruit stone is low.

Does Caregiver Stress Get Under the Skin? Associations with Care Recipient Inflammation.

Background And Objectives: A wealth of research has focused on the caregiving stress process, while less is devoted to understanding how caregiver stress may impact health outcomes in the care recipient. We examine whether higher levels of caregiver role overload will be associated with care recipients' C-reactive protein (CRP) concentrations, an inflammatory biohormone. Additionally, this study observed whether caregivers' positive and negative appraisals of caregiving moderated this association.

Corneal higher-order aberrations following small incision lenticule extraction for high myopic astigmatism correction.

Aim: To compare the visual outcomes and corneal higher-order aberrations (HOAs) of patients with high or low myopic astigmatism after small incision lenticule extraction (SMILE).

Methods: A total of 157 eyes of 157 patients who underwent SMILE were included in this retrospective, nonrandomized, comparative study. All the eyes which were with the rule astigmatism were divided into high astigmatism group (HAG; astigmatism ≤-2.

Magnetic labelling and extraction of micrometer-sized microplastics from sandy soil.

Ubiquitous microplastics (MP) have emerged as a global environmental concern. However, limited attention has been given to the migration and distribution of small-sized MP (< 10 μm) due to the challenges associated with separating MP. Here, we show that magnetic labelling of MP greatly increases the efficiency of MP extraction from soil using a magnetic field.

Lucid episodes among people with Alzheimer's disease and related dementias and their impact on family caregiver stress and grief (LEAD): protocol for a longitudinal observational study.

Introduction: Alzheimer's disease and related dementias (ADRD) are conditions with progressive cognitive decline. Still, people living with late-stage ADRD (PLWD) have been reported to exhibit transient recovery of communication or behavioural abilities that had seemingly been lost. These lucid episodes (LEs) are underinvestigated and poorly understood.

Nomogram for predicting the severity of high-risk plaques in acute coronary syndrome.

Background: The CLIMA study [Relationship between Optical Coherence Tomography (OCT) Coronary Plaque Morphology and Clinical Outcome; NCT02883088] introduced the concept of high-risk plaque (HRP) and demonstrated that HRP was associated with a high risk of major coronary events. HRP is defined by four simultaneous characteristics: minimum lumen area (MLA) <3.5 mm, fibrous cap thickness (FCT) <75 μm, lipid arc circumferential extension >180°, and macrophage infiltration.

Design of a Universal Backbone Improving the Endonuclease Dependence Molecular Beacon Assay.

The endonuclease dependence molecular beacon assay (DEMBA) is an isothermal detection method celebrated for its high sensitivity, operational ease, and time-saving capabilities. However, the intricate design of the probes limits the extensive application of DEMBA. The main challenge is the requirement for the probe sequence to include restriction endonuclease sites, two target sequence binding sites, and self-binding sites, which frequently overlap.

ROS-Responsive Nanosystem Targeted Co-Delivery YC-1 and Regorafenib to Alleviate Hypoxia Enhancing Hepatocellular Carcinoma Therapy.

Purpose: The current treatment of hepatocellular carcinoma (HCC) is confronted with anoxic drug resistance and significant side effects. To address these issues, a Reactive Oxygen Species (ROS)-responsive and targeted nano drug delivery system named REG/YC-1@PTP-RGD NPs (RYP-RGD NPs) was designed for the co-delivery of Regorafenib (REG) and the hypoxia inhibitor 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1).

Methods: RYP-RGD NPs were fabricated through the self-assembly method.