Multifunctional Nanoplatform Combining Photothermal Therapy and Chemoimmunotherapy for the Treatment of -Colonized Colorectal Cancer.

The presence of bacteria in colorectal cancer not only induces drug inactivation but also inhibits the antitumor immune responses. Here, a multifunctional nanoplatform (IR/CP@BNP@HA) is designed to enhance antitumor photothermal therapy and chemoimmunotherapy for the treatment of bacterium-infected tumors. IR/CP@BNP@HA consists of the hyaluronic acid (HA) shell and reactive oxygen species (ROS)-responsive chitosan biguanide-functionalized biopolymer core (IR/CP@BNP), which encapsulates chemotherapy drug camptothecin (CPT) and photothermal agent IR1048.

Analysis of the detection rate and related factors of thyroid nodules in the healthy population.

In a cross-sectional analysis of 14,973 adults from North China, thyroid nodules (TNs) were detected via high-resolution ultrasonography in 8,104 participants (54.1%), with a higher prevalence among women. The mean age of those with TNs was significantly higher (51.

Effects of polyethylene and polypropylene microplastics on the DEP degradation mechanisms initiated by •OH and SO• in aquatic environments.

Microplastics (MPs), as emerging contaminants, are widely distributed in aquatic environments and influence the transformation and ultimate outcome of organic pollutants through adsorption and interfacial effects. This study systematically explored the degradation mechanisms of diethyl phthalate (DEP) initiated by hydroxyl radicals (•OH) and sulfate radicals (SO•⁻), with a focus on how polyethylene (PE) and polypropylene (PP) microplastics affect these processes. Density functional theory (DFT) computations were employed to identify the transformation pathways of DEP in the presence of both radicals, and transition state theory (TST) combined with diffusion-controlled rate corrections was further applied to calculate reaction rate constants.

The riddle of α-resorcinol revisited-New perspectives on "pocket-like" structure.

The riddle of α-resorcinol was initially studied extensively as an abnormal growth phenomenon, which significantly contributed to our understanding of asymmetric growth mechanisms in organic polar crystals, yet the crystalline surface structure and solvent behavior have not received adequate attention. To address this and meet the demand for advanced organic nonlinear optical (NLO) materials, 2,7-dihydroxynaphthalene (2,7-DHN) was studied as a model substance to revisit the riddle of α-resorcinol. Surprisingly, 2,7-DHN crystals expose naphthalene-rich and hydroxyl-rich surfaces along polar c-axis, similar to the packing of α-resorcinol.

Colorimetric detection of tetracycline by enhancing peroxidase-like activity of polymerized MnO@ZIF-67 nanocomposites.

Concerns regarding the hazard of the antibiotic tetracycline (TC) have driven the attempt to exploit efficient, straightforward, and economic assays for warning early food safety and environmental security. Here, we report the development of MnO@ZIF-67@MAA colorimetric sensor, which was constructed by polymerization reaction using manganese dioxide (MnO) nanomaterials modified by metal-organic framework (ZIF-67) as support carriers and catalysts for the rapid detection and determination of TC. The MnO@ZIF-67@MAA has peroxidase-like activity and catalyzed the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of HO to produce blue oxTMB.

Synergistic Nitric Oxide Therapy and Phototherapy Using a Novel Bacteria Scavenger for Treatment of Acute Rhinosinusitis.

Acute rhinosinusitis is one of the most prevalent diseases seriously affecting the well-being and quality of life. To address this condition, a novel intelligent liposome nanoparticle (BHL@IR780@LNP) was constructed by coloading the photosensitizer IR780 and a nitric oxide donor (l-arginine-loaded biguanide chitosan-hyaluronic acid composite nanoparticles, BHL) onto liposome nanoparticles composed of cholesterol and soybean phospholipids. Under irradiation with an 808 nm near-infrared laser, BHL@IR780@LNP was able to generate heat and reactive oxygen species, resulting in the precise release of nitric oxide, which effectively killed 97.

Digestion kinetics of protein feed ingredients and their impact on nitrogen utilization in growing pigs.

The velocity of nitrogen release impacts nitrogen utilization efficiency and animal growth. Yet the crucial junctures linking nitrogen release and utilization from diverse feed ingredients to digestion kinetic parameters remain obscure. This study aimed to evaluate and subdivide in vitro protein digestion characteristics (such as release rate of free amino acids [FAA]) of three commonly used protein feed ingredients and to correlate the characteristics with nitrogen utilization in vivo.

The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis.

Background: Asthma is a common chronic respiratory disease, and its potential association with the central nervous system has garnered increasing attention in recent years. While observational studies suggest that asthma may affect hippocampal structure and function through mechanisms such as chronic inflammation and hypoxia, its causal relationship remains unclear.

Methods: In this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing large-scale genome-wide association study (GWAS) data to systematically investigate the potential causal relationship between asthma and hippocampal volume.

Glucose release kinetics of different feed ingredients and their impact on short-term growth of pigs by influencing carbon-nitrogen supply synchronization.

Background: Pigs fed diets with different ingredients but identical nutritional levels show significant differences in growth performance, indicating that growth may also be influenced by the synchronicity of dietary carbon and nitrogen supply. Therefore, this study aimed to determine glucose release kinetics of various feed ingredients, to investigate a glucose release pattern that is conducive to synchronized carbon-nitrogen supply, and to elucidate the underlying mechanisms by which this synchronization optimizes growth of pigs.

Results: We analyzed the glucose release kinetics of 23 feed ingredients in vitro and found that their glucose release rates and amounts varied greatly.

An Enclosed Encapsulation Strategy toward Stable Perovskite Quantum Dots: Structure, Lead Immobilization, and Backlight Display Applications.

Lead halide perovskite quantum dots have drawn great attention in the wide-color gamut display area. However, their poor stability restricts their practical application as well as the leakage of a toxic lead element. In this study, an enclosed encapsulation strategy is adopted to form CsPbBr quantum dots embedded in the channels of molecular sieve SBA-15 with SiO outer layer as enclosing protection (denoted as CsPbBr@SBA-15@SiO), which is achieved through a facile solid-state sintering method with post-treatment.

Construction of MGO@ZIF-8@MIPs as peroxidase-like nanozyme for the targeted colorimetric detection of perfluorooctanoic acid in water and milk.

Perfluorooctanoic acid (PFOA) poses a threat to the environment and human health due to its persistence, bioaccumulation, and reproductive toxicity. Developing and fabricating straightforward and selective sensors for the immediate identification of PFOA is substantial and demanding. In this paper, the advancement in the creation of molecularly imprinted sensors (MGO@ZIF-8@MIPs) utilizing magnetic graphene oxide (MGO) modified with metal-organic frameworks as substrates and catalytic agents is described.

Muribaculum intestinale restricts Salmonella Typhimurium colonization by converting succinate to propionate.

Insufficient dietary fiber intake is associated with dysbiosis and compromised colonization resistance (CR) to enteric infections. However, a detailed understanding of the relationship between dietary fiber insufficiency and CR remains elusive. Our study aimed to delineate the impact of fiber deprivation on gut microbiome and CR in a murine model with Salmonella Typhimurium infection.

Construction of hydrophilic magnetic imprinted covalent organic framework composite for targeted separation and enrichment of tetracycline.

Tetracycline (TC) contamination poses a serious environmental and public health threat, therefore this work presents a sensitive and selective TC separation and detection method. Hydrophilic molecularly imprinted polymers (IL-MMIPs) were designed for the first time, using magnetic graphene oxide modified covalent organic framework (MGO-COF) as the support, double ionic liquids N-trimethyl-(4-vinylbenzyl) ammonium chloride and 1-vinyl-3-ethylimidazole bromide as functional monomer and cross-linker, respectively. The IL-MMIPs exhibited high adsorption capacity and fast adsorption kinetics for TC through the recognition of surface molecular imprinting and the strong electrostatic interaction and hydrogen bonding between ionic liquids.

Self-Template Evolution Toward Hierarchically Hollow Spherulites of Energetic Materials for Safety Control and Combustion Enhancement.

The hierarchical hollow structure can endow functional materials with concerning performances, whereas its rational design remains challenging, especially for organic molecules. Herein, a novel strategy of self-template evolution is presented to construct hollow spherulites (HSs) for energetic organic materials with controllable safety and enhanced combustion, utilizing the mechanism of pseudomorphic replacement coupled with Ostwald ripening. Specifically, the spherulites of thermodynamically metastable β-2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (β-CL-20) as the self-template spontaneously evolves into the HSs of CL-20-based inclusion compounds in solution, during which the dissolution of β-CL-20 and the crystallization of CL-20-based inclusion compounds are spatiotemporally correlated, enabling pseudomorphic replacement preserving the spherulitic structure, and cavities are formed inside via Ostwald ripening.

CFD-DEM coupling analysis of the negative pressure inlet structural parameters on the performance of integrated positive-negative pressure seed-metering device.

To assess the influence of the structural parameters of the negative pressure inlet pipe on the seeding performance of the integrated positive-negative pressure seed-metering device, angles and , along with taper , were selected as test variables for conducting coupling simulation tests and physical bench tests. The results indicate that the average differential pressure across the holes in the seed-filling zone (Δ ), the airflow rate at the interaction interface between the negative pressure inlet pipe and the negative pressure chamber (), the average drag force on seeds in the seed-filling zone ( ), and the average drag force on seeds in the seed-cleaning zone ( ) are all significantly affected by the test factors. The structural parameters of the negative pressure inlet pipe can be accurately predicted using the prediction model developed through regression analysis of the central composite test results.

Dietary Qiwenghuangbo powder-enriched Limosilactobacillus reuteri protects the intestinal epithelium and alleviates inflammation via a strain-specific mechanism.

Background: Qiwenghuangbo powder (QP), composed of Astragalus, Phellodendron chinensis, and Radix pulsatilla, is a traditional Chinese herbal formula, but its effects on weaned piglets remained unclear.

Methods: Weaned piglets fed with 0.5 kg/t QP (QP1), 1 kg/t QP (QP2), low-zinc oxide (ZnO; negative control), and high-ZnO (positive control) diets in two phases, respectively, and the growth performance, intestinal morphology, cytokines, and microbial communities were profiled.

Dual Cascade-Responsive Multifunctional Nanoparticles to Overcome Bacterium-Induced Drug Inactivation and Enhanced Photodynamic and Chemo-Immunotherapy of Pancreatic Cancer.

The harsh biological barriers and bacteria within tumor microenvironment not only hinder drug penetration and induce drug inactivation, but also inhibit antitumor immune responses. Here a tumor microenvironment dual cascade-responsive multifunctional nanoparticle, Gem/Emo@NP@GHA is reported, which is engineered from a hyaluronidase (HAase)-responsive guanidine group functionalized hyaluronic acid (GHA) shell and a glutathione (GSH)-responsive biopolymer core (Gem/Emo@NP), that encapsulates anticancer drug gemcitabine (Gem) and two-photon-excited photosensitizer emodin (Emo). The constructed Gem/Emo@NP@GHA can specifically target the tumor and subsequently be degraded by HAase-abundant in the extracellular matrix.

Single-Molecule Detection via Pore Nanoconfinement of Covalent Organic Frameworks for Surface-Enhanced Raman Scattering.

Surface-enhanced Raman scattering (SERS) offers significant advantages for single-molecule detection. However, stochastic molecular motion makes it challenging to consistently capture signals from single-molecule binding events, particularly in complex environments. Herein, we propose a novel SERS system via the pore nanoconfinement effect of covalent organic frameworks (COFs) to achieve reliable single-molecule detection.

Maternal dietary inulin intake during late gestation and lactation ameliorates intestinal oxidative stress in piglets with the involvements of gut microbiota and bile acids metabolism.

Maternal inulin intake has been shown to alleviate oxidative stress in piglets, but the role of bile acids (BAs) in this process remains unknown. This study aimed to investigate the roles of gut microbiota and BAs metabolism in the amelioration of intestinal oxidative stress in piglets through a maternal inulin diet. A total of 40 sows were allocated into two dietary treatments from day 85 of gestation until the end of lactation: CON (control diet) and INU (diet with 2% wheat bran replaced by inulin).

Ferulic acid mediates microbial fermentation of arabinoxylan to enhance host immunity by suppressing TLR4/NF-κB signaling.

The study was conducted to explore the relationship between arabinoxylan (AX) structure and microbial fermentation characteristics, and reveal molecular mechanism of AX on regulating immune function of the host. Results indicated that the group of wheat bran AX showed greater activity of feruloyl esterase, production of short chain fatty acids and ferulic acid compared with the blank group (P < 0.05).

Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study.

Background & Aims: Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods: Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets.

Characterization and rational engineering of a novel laccase from Geobacillus thermocatenulatus M17 for improved lignin degradation activity.

Lignin, with its complex, high-molecular-weight aromatic polymer structure and stable ether or ester bonds, greatly impedes the efficient degradation of lignocellulosic waste. Bacterial laccases have gained attention for their potential in lignocellulosic waste degradation due to their resilience in extreme conditions and ability to be produced in large quantities. In this study, a novel laccase from Geobacillus thermocatenulatus M17 was identified and expressed in E.

[Current status and influential factors of self-management ability in patients with systemic lupus erythematosus].

Objective: To investigate the current status of self-management ability in patients with systemic lupus erythematosus (SLE), and to analyze the related factors affecting the self-management ability of SLE patients.

Methods: A total of 180 SLE patients who were selected from the outpatient department and ward of the Department of Rheumatology and Immunology of a Tertiary Hospital in Beijing from January 2024 to March 2024. General information questionnaire, SLE self-management ability assessment scale, general self-efficacy scale (GSES) and family concern index questionnaire (APGAR) were used for questionnaire investigation, so as to investigate the current status and related influencing factors of self-management ability in patients with SLE.

Advanced imidazole-functionalized metal-organic framework-based dual-mode sensor for rapid detection of FLU pesticide residues in food.

In this study, an advanced imidazole-functionalized 2D metal-organic framework (HBU-169), {[Cd(L)HO](HO)}·(4HO)·(DMF) was presented, which possesses both fluorescent properties and oxidase-like activity. HBU-169 demonstrates the ability to detect fluazinam (FLU) via fluorescent and colorimetric modes. In the fluorescent mode, a pronounced fluorescence quenching is observed, with the limit of detection (LOD) of 1.