Isokinetic eccentric vs. concentric training for functional ankle instability: a randomized controlled trial.

Objective: To investigate the effects of a 12-week isokinetic eccentric training program on postural control and ankle muscle strength in individuals with functional ankle instability (FAI).

Methods: In this randomized controlled trial, 42 participants with unilateral FAI were randomly assigned to either an experimental group (n = 21), receiving isokinetic eccentric training, or a control group (n = 21), receiving isokinetic concentric training. Both groups trained three times per week for 12 weeks.

Perioperative Repetitive Transcranial Magnetic Stimulation Reduces Postoperative Cognitive Dysfunction and Inflammation in Elderly Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial.

Background: Postoperative cognitive dysfunction (POCD) is a major complication in elderly patients undergoing total knee arthroplasty (TKA), often linked to neuroinflammation. Repetitive transcranial magnetic stimulation (rTMS) has shown potential in modulating neural activity and reducing inflammation, but its perioperative efficacy in preventing POCD remains underexplored. This study aimed to evaluate the effectiveness of perioperative rTMS in reducing POCD and inflammation in elderly patients undergoing TKA.

ECMO combined with IABP for the treatment of fulminant myocarditis caused by the targeted drug entrectinib for lung adenocarcinoma: a case report.

Background: Entrectinib, a recently approved multikinase inhibitor indicated for advanced ROS1-positive non-small cell lung cancer (NSCLC), has demonstrated significant survival benefits in metastatic disease. However, it carries risks of severe cardiotoxicity. We report the successful management of entrectinib-induced fulminant myocarditis using integrated venoarterial extracorporeal membrane oxygenation (V-A ECMO) and intra-aortic balloon pump (IABP) circulatory support.

Identification of novel Listeria monocytogenes serotype 4h with specific antisera against wall teichoic acid.

Listeria monocytogenes (Lm) strains are serotyped based on their somatic (O) and flagellar (H) antigens. The newly designated serotype (ST) 4h exhibits a greater ability to colonize organs than well-characterized hypervirulent strains. Therefore, simple and rapid identification methods for Lm ST 4h are urgently needed for effective monitoring and prevention.

Pharmacological targeting of large tumor suppressor kinases (LATS) 1 and 2 augments tissue repair and regeneration.

Background And Purpose: Large tumor suppressor kinases (LATS1 and 2) are core kinases of the Hippo signalling pathway, directly phosphorylate and inactivate the transcriptional coactivator Yes-associated protein 1 (YAP), playing a pivotal role in cell self-renewal and tissue regeneration. Hippo signalling inhibitors are urgently needed, both as tools for pharmacological studies of the Hippo pathway and as leads for developing novel, molecularly targeted drugs for the treatment of tissue injury and regeneration.

Experimental Approach: An enzyme linked immunosorbent assay (ELISA)-based in vitro high-throughput biochemical assay was used to the identification of a potent and reversible LATS1/2 inhibitor, N-(2-chloro-6-fluorobenzyl)-5-(1H-pyrrolo[2,3-b] pyridin-3-yl) furan-3-carboxamide (named as LPi-1).

AuNP/Magnetic Bead-Enhanced Electrochemical Sensor Toward Dual Saliva Alzheimer's Biomarkers Detection.

Alzheimer's disease (AD) early screening requires non-invasive, high-sensitivity detection of low-abundance biomarkers in complex biofluids like saliva. In this study, we present a miniaturized, silicon-based electrochemical sensor for sequential detection of two AD salivary biomarkers, lactoferrin (Lf) and amyloid β-protein 1-42 (Aβ), on a single reusable electrode. The sensor features a three-electrode system fabricated by sputter-coating a quartz substrate with gold (Au) sensing electrodes, which are further modified with gold nanoparticles (AuNPs) to form 3D dendritic structures that enhance surface area and electron transfer.

Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of chronic pain on chronic kidney diseases and renal function.

Objective: A growing body of research has shown a connection between chronic pain and chronic kidney disease (CKD). However, it is unclear if these correlations point to a cause-and-effect link. Our goal is to investigate the causal link between renal function or CKD and chronic pain.

A Programmable Nonvolatile Schottky Diode Based on van der Waals Ferroelectric Junction.

Programmable and nonvolatile Schottky junctions are highly desirable for next-generation electronic and neuromorphic systems. However, conventional metal-semiconductor and even van der Waals (vdW) Schottky diodes often suffer from fixed rectifying behaviors or limited tunability. Here, we report a programmable nonvolatile ferroelectric Schottky diode based on a vdW heterojunction between semimetallic 1T'-MoTe and ferroelectric α-InSe.

[Research on medical needles excavated from the tomb of , Marquis of Haihun in Nanchang].

Several metal needles were unearthed from the tomb of , the Marquis of Haihun in Nanchang, Jiangxi province. Based on the inscription on the signboard unearthed from the tomb and the handed down literature, these needles should be closely related to the "nine needles" mentioned in the handed down medical classics. These needles should be used in acupuncture and moxibustion at that time, and their diameters are close to the specifications and dimensions of the needles in the modern time, which provides the important cultural relics data of the Han Dynasty for the research of early acupuncture and moxibustion of traditional Chinese medicine.

Discovery of an ALK degrader for lorlatinib-resistant compound mutations.

Three generations of ALK tyrosine kinase inhibitor (ALK TKI) have achieved significant clinical success in the treatment of ALK rearranged non-small cell lung cancer (NSCLC). However, the emergence of acquired mutations after sequential ALK TKI therapies poses significant challenges for cancer treatment. Here we identified WZH-15-125 as a potent ALK inhibitor that can effectively override drug resistance, especially compound ALK mutations, including the highly refractory G1202R/L1196M mutation that is resistant to lorlatinib.

Efficacy and preliminary safety assessment of EXG001-307 AAV gene therapy for spinal muscular atrophy.

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder characterized by progressive muscular weakness due to the loss of lower motor neurons. The most severe and common form, SMA type 1 (Werdnig-Hoffmann disease), is a devastating childhood condition. Exegenesis Bio is developing EXG001-307, a recombinant adeno-associated virus (rAAV) gene therapy, for SMA type 1 patients lacking functional and possessing only 1-2 copies of .

Combined pathogenic characteristics to analyze susceptibility factors of postoperative pneumonia in patients undergoing cardiac surgery.

Postoperative infection prevention is crucial for cardiac surgery patients. This study enrolled 579 cardiac surgery patients from November 2021 to July 2022, reporting a 12.3% incidence of postoperative pneumonia.

A multi-channel wearable sensing patch based on gate-all-around field-effect transistors.

Field-effect transistors (FETs), known for their rapid response and signal amplification capabilities, have attracted significant research interest for the detection of biomarkers. However, the development of multi-channel sensors using FETs and their wearable applications are impeded by the rigid substrates and large areas. Here, we reported a wearable EGFET sensor array patch that integrates gate-all-around field-effect transistors (GAA FETs) and flexible printed circuit board (FPCB) patches to overcome these challenges.

To verify the biological characteristics of disulfidptosis associated gene ADORA2B in esophageal cancer.

Esophageal cancer is an aggressive malignant tumor. Statistics show that esophageal cancer has claimed the lives of approximately 300,000 people worldwide. Many patients are diagnosed as stage 3 or 4 when they visit a doctor; however, the prognosis may not be accurate because the disease's early signs are not always evident.

Short-term memory retrieval enhances brain functional connectivity.

Introduction: Short-term memory poses a significant challenge, involving complex processes of image perception, memory formation, and execution. However, the mechanisms underlying the formation, storage, and execution of short-term memory remain poorly understood.

Methods: In this study, 41 healthy college students participated in a memory challenge test designed to investigate these processes.

Pseudosymmetric Epitaxy for Scalable Growth of Uniform Two-Dimensional Ferroelectric α-InSe Monolayer.

The 2D ferroelectric semiconductor α-InSe offers compelling opportunities for next-generation ultrathin electronics, but the controllable growth of a monolayer with large-scale uniformity and single phase has proven challenging. Here, we demonstrate the pseudosymmetry epitaxial growth of a uniform centimeter-scale α-InSe monolayer by leveraging a fluorophlogopite mica (F-mica) substrate with its pseudohexagonal surface atom configuration, in a confined space chemical vapor deposition setup. Transmission electron microscopy and in-plane XRD reveal the pseudohexagonal symmetry of an F-mica surface and establish the in-plane epitaxial relation of (100) α-InSe∥(010) F-mica with a 4 × 4 α-InSe unit cell matching the F-mica surface.

Influence of surface coal mining on carbon storage in semi-arid steppe.

Clarifying the impact of surface coal mining on carbon storage in semi-arid steppe is an important means to promote low-carbon emission reduction and green high-quality development in semi-arid steppe surface coal mining area under the background of the "double carbon" goal. Based on the land use data of eight periods from 2002 to 2023, the carbon module of the InVEST model was used to estimate and analyze the spatiotemporal evolution characteristics of carbon storage in the mining area, and the impact of surface coal mining on the carbon sequestration capacity of semi-arid grassland ecosystem and the spatial differentiation of carbon storage were discussed. The results show that: (1) The total carbon storage in the study area showed a decreasing trend year by year, with a total decrease of 187.

Establishment and Characterization of Hepatocyte Line from Turbot (Scophthalmus maximus L.) and Its Application in the Study of Glucose Metabolism.

The present study was to establish a hepatocyte line and investigate its role in glucose metabolism. A continuous cell line, THL (turbot hepatocyte line), was established from the liver tissue of turbot (Scophthalmus maximus L.).

Three-dimensional KV(PO)@Carbon core-shell coaxial nanowire networks for High-rate sodium-ion batteries.

Potassium vanadium phosphate is an emerging sodium superionic conductor (NASICON) material with great potential as a cathode for sodium-ion batteries, owing to its high operating voltage, structural stability, and low cost. However, its poor electronic conductivity, along with significant volume expansion and stress effects during Na insertion and extraction, severely limits its electrochemical performance, hindering its practical application. In this study, a three-dimensional (3D) carbon-coated KV(PO) core-shell coaxial nanowire network (KVP@C) was synthesized using a simple electrospinning method combined with high-temperature annealing.

Muribaculum intestinale restricts Salmonella Typhimurium colonization by converting succinate to propionate.

Insufficient dietary fiber intake is associated with dysbiosis and compromised colonization resistance (CR) to enteric infections. However, a detailed understanding of the relationship between dietary fiber insufficiency and CR remains elusive. Our study aimed to delineate the impact of fiber deprivation on gut microbiome and CR in a murine model with Salmonella Typhimurium infection.

Comparative chloroplast genomics provides insights into the phylogenetic relationships and evolutionary history for Actinidia species.

Actinidia species are fruit trees with various functions, such as providing edible fruit, serving as ornamental plants, and having medicinal benefits. However, the taxonomy of Actinidia species is controversial due to widespread hybridization, the history of divergence and polyploid speciation among Actinidia species also remains unclear. In this study, we conducted comparative analyses of the chloroplast genomes and ploidy among multiple Actinidia species.

Small extracellular vesicle miRNAs as biomarkers for predicting antitumor efficacy in lung adenocarcinoma treated with chemotherapy and checkpoint blockade.

Checkpoint blockade combined with chemotherapy has become an important treatment option for lung cancer patients in clinical settings. However, biomarkers that effectively identify true responders remain lacking. We assessed the potential of plasma small extracellular vesicle (sEV)-derived microRNAs (miRNAs) as biomarkers for predicting and identifying responders to combined immunochemotherapy.

Identification and Validation of T Cell-Related Hub Biomarkers for Early Diagnosis of Diabetic Kidney Disease Using Single-Cell and Bulk Dataset Analysis.

Unlabelled: Diabetic kidney disease (DKD) is the most common complication of diabetes and a leading cause of chronic kidney disease that frequently leads to end-stage renal disease (ESRD). The pathogenesis of DKD is complex and is not fully understood. This study was designed to identify key targets for DKD diagnosis and explore the underlying molecular mechanisms.