Systematic profiling and bioactivity evaluation of Jiuzao from light flavor baijiu: A by-product rich in bioactive compounds.

Despite being rich in bioactive compounds, Jiuzao of light flavor Baijiu (LFB) remains an underutilized by-product due to limited systematic characterization of its components and lack of efficient valorization strategies. In this study, widely targeted metabolomics was used to comprehensively analyze the water-soluble metabolites in the enzymatic hydrolysate (JEH) and water extract (JWE) of Jiuzao from LFB, and 1869 metabolites (with 887 novel compounds) were identified, including 128 bioactive compounds from traditional Chinese medicine and 95 functional peptides. JEH exhibited superior anti-glycation and antioxidant activities, with inhibition rates of 66.

Notch3 mediated TGF‑β1 activation enhances epithelial‑mesenchymal transition and cancer stemness in non‑small lung cancer.

Notch3 is a key regulator in various cancers, playing a crucial role in maintaining stemness and promoting epithelial‑mesenchymal transition (EMT). However, its differential expression and regulatory mechanisms in non‑small cell lung cancer (NSCLC) and cancer stem cells remain poorly understood. To investigate this, the present study examined Notch3 expression in NSCLC through Oncomine, The Cancer Genome Atlas and Gene Expression Omnibus databases and validated the results with immunohistochemistry, reverse transcription‑quantitative PCR and western blotting.

Preliminary study on the ability of F-fluorodeoxyglucose positron emission tomography/computed tomography radiomics to predict vessels that encapsulate tumor clusters and prognosis in hepatocellular carcinoma.

Background: Recently, a novel vascular pattern characterized by vessels encapsulating tumor clusters (VETC) was reported to be related to poor clinical outcomes in patients with hepatocellular carcinoma (HCC). The objective of this study was to preliminarily assess the ability of metabolic parameters and radiomics features derived from F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) to preoperatively predict VETC and prognosis in HCC patients.

Methods: A total of 149 patients diagnosed with HCC from two institutions (The Third Affiliated Hospital of Sun Yat-sen University and Sun Yat-sen Memorial Hospital) were retrospectively enrolled and subsequently divided into a training cohort (n=103) and a test cohort (n=46) as external validation.

Clinical characteristics of bronchopulmonary dysplasia and the risk of sepsis onset prediction via machine learning models.

Bronchopulmonary dysplasia (BPD), also known as chronic lung disease, is the most common cause of respiratory morbidity in preterm infants. Sepsis plays a significant role in the pathogenesis of BPD, and the systemic inflammatory response caused by sepsis is associated with lung development, leading to simplified alveoli and abnormal vascular development, which are the histological hallmarks of BPD. In this study, we conducted a retrospective analysis of the clinical characteristics of 306 preterm infants with BPD treated at our hospital from December 2019 to December 2022.

A smart ultra-small near infrared persistent luminescence nanoprobe for non-invasive detection of early rheumatoid arthritis.

Early detection of rheumatoid arthritis (E-RA) is crucial for long-term patient health, but current methods lack precision. Overproduced reactive oxygen species (ROS) in hypoxic and inflammatory synovium are early markers of RA, appearing years before significant radiological findings, making them attractive biomarkers for early detection. Here, an ultrasensitive ROS-responsive nanoprobe are developed based on glutathione (GSH) modified Cr doped ZnGaO ultra-small near-infrared (NIR) persistent luminescence nanoparticles (denoted as ZnGaO:Cr-GSH).

Comparison of Mortality and Morbidity of Robotic Versus Laparoscopic Radical Nephrectomy for the Treatment of Renal Cell Carcinoma-An Analysis of the National Surgery Quality Improvement Program (NSQIP) Targeted Nephrectomy Database.

Objectives: To compare the perioperative complications between robot-assisted (RARN) and laparoscopic (LRN) radical nephrectomy for the treatment of renal cell carcinoma (RCC).

Methods: We conducted a retrospective study using the National Surgical Quality Improvement Program (NSQIP) Nephrectomy-Targeted database from 2019 to 2021. After using propensity score matching, we assessed the association between LRN vs.

Complete mitochondrial genome of Houttuynia cordata sheds light on the evolution of complex structural features in early angiosperms.

Background: Houttuynia cordata is a well-known medicinal and edible plant with important economic value. It belongs to the magnoliid clade, a basal lineage of angiosperms. Currently, the limited number of reported mitochondrial genomes from magnoliids severely restricts our understanding of early mitochondrial genome evolution.

Knowledge of monkeypox and willingness to vaccinate against monkeypox among Chinese college students: A cross-sectional study.

Objective: To investigate the current knowledge level of Chinese college students about monkeypox and their willingness to receive vaccination against monkeypox and to analyze its influencing factors to provide reference for formulating targeted measures to accelerate vaccination.

Methods: This cross-sectional study was conducted as an online survey via a self-filling electronic questionnaire, and data were collected from July 1 to 16, 2023. The subjects were Chinese college students.

Medication use in the neonatal intensive care unit in a tertiary hospital in China from 2020 to 2023.

Background: The use of medication in the neonatal intensive care unit (NICU) is a complex field that requires special attention, as neonatal patients may have different sensitivities and responses to drugs than adults and older children. The administration of medication in the NICU must consider various factors, including the dosage of the medication, the route of administration, monitoring, and potential drug interactions.

Methods: In this study, we conducted a retrospective analysis of medication use in the neonatal intensive care unit of 122 preterm infants treated in our hospital from 2020 to 2023.

Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis.

Background: Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive.

Comparative chloroplast genomics provides insights into the phylogenetic relationships and evolutionary history for Actinidia species.

Actinidia species are fruit trees with various functions, such as providing edible fruit, serving as ornamental plants, and having medicinal benefits. However, the taxonomy of Actinidia species is controversial due to widespread hybridization, the history of divergence and polyploid speciation among Actinidia species also remains unclear. In this study, we conducted comparative analyses of the chloroplast genomes and ploidy among multiple Actinidia species.

Adsorption Characteristics of Organic Pollutants on Montmorillonites Modified by Quaternary Ammonium Surfactants with Organic Counterions.

Na-montmorillonite (Na-Mt) modified by quaternary ammonium surfactants containing different organic counterions [OMt-QAS·Y, Y = CHCO , CH (CH)COO, CHCH(OH)COO, and HCOO] was prepared for enhancing the adsorption capacity of 2, 4-dichlorophenol/cibacron brilliant yellow 3G-P. Compared with Na-Mt, whose adsorption efficiency for 2,4-dichlorophenol/cibacron brilliant yellow 3G-P was only 58/1.85 mg/g, the adsorption efficiency of OMt-QAS·Y was greatly improved, with OMt-QAS·CHCO having the highest adsorption capacity of 152.

CFI-Former: Efficient lane detection by multi-granularity perceptual query attention transformer.

Benefiting from the booming development of Transformer methods, the performance of lane detection tasks has been rapidly improved. However, due to the influence of inaccurate lane line shape constraints, the query sequences of existing transformer-based lane line detection methods contain a large number of repetitive and invalid information regions, which leads to redundant information in the detection region and makes the processing of information on localized feature details of the lanes biased. In this paper, a multi-granularity perceptual query attention transformer lane detection method, CFI-Former, is proposed to achieve more accurate lane detection.

Cardiovascular Outcome of the SGLT2 Inhibitor in Acute Myocardial Infarction: A Meta-Analysis.

Background: Unexpected cardiovascular events are likely to occur within a short period following an acute myocardial infarction (AMI). The sodium-glucose co-transporter 2 inhibitor (SGLT2-I) is a recently recommended drug for the treatment of AMI. However, its role in the risk of the outcomes following an AMI, including all-cause death and heart failure readmission, remains controversial.

EBNA1 Targeted Ultra-Small Near-Infrared Persistent Luminescent Nano-Inhibitor for Theranostics of EBV-Associated Cancer.

Epstein-Barr virus (EBV) is a well-recognized oncogenic virus that promotes several lymphoid and epithelial cancers. The Epstein-Barr nuclear antigen 1 (EBNA1), which is known to be expressed in all EBV-positive cancers, plays a vital role in viral genome replication and maintenance and is therefore emerged as an attractive target for clinical intervention. Several EBNA1 inhibitors have shown potency in the growth inhibition of EBV-positive cancers, yet low bioavailability and in vivo unmonitored nature hamper their further implementation.

Dynamic distribution and accumulation of polycyclic aromatic hydrocarbons in Pueraria lobata during growth based on field experiment.

The regulation investigation of the uptake, distribution, and accumulation of polycyclic aromatic hydrocarbons (PAHs) in the crop growing is essential for human health risk assessments. As an important crop with Chinese medicine homologous food function, Pueraria lobata (P. lobata) was selected as the model crop with rhizome as the products to explore the absorption, and distribution of PAHs under the natural field environment for the first time.

Differentiation of Citri Reticulatae Pericarpium varieties via HPLC fingerprinting of polysaccharides combined with machine learning.

To accurately and reliably distinguish different varieties of Citri Reticulatae Pericarpium (CRP), we propose a novel classification strategy combining polysaccharide fingerprinting and machine learning (ML). First, extraction conditions are optimized using the one-variable-at-a-time method and response surface methodology, and the extraction yield of total polysaccharides reaches 25.15%, with different varieties exhibiting different anti-oxidant abilities.

Estimates and trends in death and disability from atrial fibrillation/atrial flutter due to high sodium intake, China, 1990 to 2019.

Objective: The effect of sodium intake on atrial fibrillation (AF)/atrial flutter (AFL), with respect to sex and age, has yet to be elucidated. This study aims to compare long-term trends in AF/AFL death and disability due to high sodium intake in China from 1990 to 2019.

Methods: We utilized data from the Global Burden of Disease study to assess the mortality and disability burden of AF/AFL attributable to high sodium intake (> 5 g/d) in China from 1990 to 2019.

An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target.

Genetic screens were performed across PPARG to study how disruptive mutations across the full coding sequence affect function. An alternative translational start site in PPARG generates a truncated isoform, peroxisome proliferator-activated receptor γ (PPARγ) M135, which lacks the N-terminal activation function 1 (AF-1) domain and shows increased agonist-induced transactivation of target genes. In human carriers of rare PPARG variants, AF-1 domain-disrupting genetic variants increase agonist-induced PPARγ activity and decrease metabolic syndrome severity.

Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies.

Background: Numerous studies have shown that insulin resistance (IR) is closely related to the pathogenesis of cardiovascular disease (CVD). This study aims to summarize the correlation between the triglyceride-glucose-body mass index (TyG-BMI index), a novel surrogate indicator of insulin resistance, and the incidence of CVD in patients without CVD at baseline through meta-analysis.

Method: Cohort studies assessing multivariate-corrected hazard ratios (HRs) for associations between the TyG-BMI index and cardiovascular disease (CVD) were obtained by searching PubMed, Cochrane Library, EMBASE, and Web of Science.

F-FAPI-42 PET/CT for preoperatively identifying intrahepatic cholangiocarcinoma and hepatocellular carcinoma.

Background: Accurately differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC) is essential for therapeutic decision-making. This study aimed to explore the value of Fluor 18 (F)-conjugated fibroblast-activation protein inhibitor (FAPI-42) positron emission tomography-computed tomography (PET/CT) in distinguishing HCC from ICC preoperatively.

Methods: Patients with suspected intrahepatic lesions who underwent F-FAPI-42 PET/CT were retrospectively assessed and placed into an HCC group and an ICC group based on postoperative pathology.

Intelligent Hierarchical Targeting Near-Infrared Persistent Luminescence Nanosystem for Improved Nuclear Delivery and Simultaneous Visualization/Therapy of EBV-Associated Cancer.

Epstein-Barr nuclear antigen 1 (EBNA1), a sequence-specific DNA binding protein of Epstein-Barr virus (EBV), is essential for viral genome replication and maintenance and is therefore an attractive target for the therapeutic intervention of EBV-associated cancers. Several EBNA1-specific inhibitors have demonstrated the ability to block EBNA1 function in vitro, but practical delivery strategies for these inhibitors in vivo are still lacking. Here, we report an intelligent hierarchical targeting theranostic nanosystem (denoted as mZGOCS@MnO-P5) that integrates an azide (N3) terminal dual-targeting peptide (N3-P5), a tumor microenvironment-responsive degradable MnO nanosheet, and a mesoporous ZnGaO:Cr, Sn near-infrared persistent luminescence (NIR-PL) nanosphere (mZGOCS).

Association between the triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus in non-alcoholic fatty liver disease.

This study evaluated the ability of the triglyceride (TG) to high-density lipoprotein cholesterol (TG/HDL-C) ratio to identify individuals at risk of type 2 diabetes mellitus (T2DM) in the non-alcoholic fatty liver disease (NAFLD) population. We retrospectively studied 4,769 patients with NAFLD from the Affiliated Hospital of Hangzhou Normal University (2020-2023). Binary logistic regression models were used to evaluate the association between the TG/HDL-C ratio and lipid parameters with T2DM.

Histone Deacetylase 9 Deletion Inhibits Hepatic Steatosis and Adipose Tissue Inflammation in Male Diet-Induced Obese Mice.

Aim: The goal of this study was to determine the role of histone deacetylase 9 (HDAC9) in the development of diet-induced metabolic dysfunction-associated steatohepatitis (MASH) and white adipose tissue (WAT) dysfunctions.

Methods: We fed male and female mice with global Hdac9 knockout (KO) and their wild-type (WT) littermates an obesogenic high-fat/high-sucrose/high-cholesterol (35%/34%/2%, w/w) diet for 20 weeks.

Results: Hdac9 deletion markedly inhibited body weight gain and liver steatosis with lower liver weight and triglyceride content than WT in male mice but not females.

Polystyrene microplastics induce depression-like behavior in zebrafish via neuroinflammation and circadian rhythm disruption.

Polystyrene microplastics (PS-MPs) are widespread pollutants in aquatic environments that accumulate in various organs, including the brain, raising concerns about their neurotoxic effects. This study exposed zebrafish to environmentally relevant concentrations (25 and 250 μg/L) of PS-MPs for 40 days to investigate their impact on neurobehavior and underlying mechanisms. Results revealed that PS-MPs induced depression-like behaviors in zebrafish, characterized by reduced exploration, decreased locomotor activity, and altered social interaction.