Enhanced Improvement of Menstrual Blood Derived Endometrial Stem Cells Encapsulated in Cross-Linked Hyaluronic Acid on Intrauterine Adhesions.

Intrauterine adhesions (IUA), characterized by fibrotic adhesions within the uterine cavity, frequently result in menstrual irregularities, recurrent miscarriages, secondary infertility, and increased pregnancy risks among women of childbearing age. Unfortunately, conventional clinical interventions mainly including surgical separation and physical isolation exhibit limited efficacy in promoting the regeneration of the injured endometrium and are associated with a high recurrence rate. Consequently, it is imperative to investigate novel therapies aimed at repairing the injured endometrium in IUA patients, particularly those desiring fertility.

Knowledge of monkeypox and willingness to vaccinate against monkeypox among Chinese college students: A cross-sectional study.

Objective: To investigate the current knowledge level of Chinese college students about monkeypox and their willingness to receive vaccination against monkeypox and to analyze its influencing factors to provide reference for formulating targeted measures to accelerate vaccination.

Methods: This cross-sectional study was conducted as an online survey via a self-filling electronic questionnaire, and data were collected from July 1 to 16, 2023. The subjects were Chinese college students.

Fully-biodegradable and self-powered intelligent filter assembled by fibrous cellulose and MOF-functionalized poly(lactic acid) core-shell nanofibers for active PM capturing and passive respiratory sensing.

With the increasing demand for ecofriendly air filtration materials, poly(lactic acid) (PLA) nanofibrous membranes (NFMs) show significant potential for efficient air purification while evading plastic pollution. However, there is still an urgent need to solve the issues of intrinsically low electroactivity and poor electret performance for PLA. Here, we prepared MOF-functionalized core-shell beaded PLA (MCSB-PLA) gradient nanofibers at fibrous cellulose, featuring a PLA/MOF-5 composite shell layer by coaxial electrospinning.

Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis.

Background: Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive.

Development and validation of novel models based on clonality immunoglobulin gene rearrangement for evaluation of bone marrow involvement and prognostic prediction in patients with diffuse large B-cell Lymphoma: a multicenter retrospective study.

Introduction: Bone marrow involvement (BMI) is a poor prognostic factor in diffuse large B cell lymphoma (DLBCL), and accurate evaluation of BMI is crucial for determining stages and prognosis. This study aimed to identify the most effective examinations for evaluating BMI in DLBCL, including positron emission tomography-computed tomography (PET/CT), immunoglobulin gene rearrangement (IGR), flow cytometry (FCM), bone marrow cytology (BMC) and bone marrow biopsy pathology (BMB), and to further explore its prognostic significance in DLBCL patients.

Methods: This retrospective study included 364 newly diagnosed DLBCL patients, all of whom underwent PET/CT, IGR, FCM, BMC, and BMB at diagnosis.

Cardiovascular Outcome of the SGLT2 Inhibitor in Acute Myocardial Infarction: A Meta-Analysis.

Background: Unexpected cardiovascular events are likely to occur within a short period following an acute myocardial infarction (AMI). The sodium-glucose co-transporter 2 inhibitor (SGLT2-I) is a recently recommended drug for the treatment of AMI. However, its role in the risk of the outcomes following an AMI, including all-cause death and heart failure readmission, remains controversial.

Surround modulation is predominantly orientation-unspecific in macaque V1.

Surround modulation is a fundamental property of V1 neurons, playing critical roles in stimulus integration and segregation. It is believed to be orientation-specific, as neurons' responses at preferred orientations are suppressed more by iso-oriented surrounds than by cross-oriented surrounds. Here, we investigated an alternative hypothesis that surround modulation is primarily orientation-unspecific, in that the observed "orientation-specific" surround effects actually reflect overall gain changes that affect neurons tuned to all orientations.

MSC-EV-transmitted HSPA8 alleviates cisplatin-induced ovotoxicity by regulating the MGARP/PRDX2 axis.

Cisplatin (Cis) is among the most widely employed antitumour agents, although its clinical application is limited by self-induced multiple-organ toxicity. Previous studies have demonstrated the essential role of mitochondrial injury in the pathogenesis of Cis-induced ovotoxicity. Notably, mesenchymal stem cell-extracellular vesicles (MSC-EVs), potential cell-free therapeutic agents, exhibit pronounced advantages for the treatment of ovarian dysfunction.

Lotus leaf-inspired poly(lactic acid) nanofibrous membranes with enhanced humidity resistance for superefficient PM filtration and high-sensitivity passive monitoring.

The biomimetic design principles offer promising solutions to fabrication of multifunctional nanofibrous membranes (NFMs) with on-demand hierarchies and properties. Herein, a combined electrospinningelectrospray approach was employed to firmly anchor MOF nanocrystals onto poly(lactic acid) (PLA) nanofibers, resembling the naturally occurring dense protrusions at the lotus leaf. The formation of unique MOF-protruding superstructures gave rise to an exceptional combination of increased electroactivity, in-situ electret properties and charge regeneration mechanisms, as well as remarkable humidity resistance.

Estimates and trends in death and disability from atrial fibrillation/atrial flutter due to high sodium intake, China, 1990 to 2019.

Objective: The effect of sodium intake on atrial fibrillation (AF)/atrial flutter (AFL), with respect to sex and age, has yet to be elucidated. This study aims to compare long-term trends in AF/AFL death and disability due to high sodium intake in China from 1990 to 2019.

Methods: We utilized data from the Global Burden of Disease study to assess the mortality and disability burden of AF/AFL attributable to high sodium intake (> 5 g/d) in China from 1990 to 2019.

Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies.

Background: Numerous studies have shown that insulin resistance (IR) is closely related to the pathogenesis of cardiovascular disease (CVD). This study aims to summarize the correlation between the triglyceride-glucose-body mass index (TyG-BMI index), a novel surrogate indicator of insulin resistance, and the incidence of CVD in patients without CVD at baseline through meta-analysis.

Method: Cohort studies assessing multivariate-corrected hazard ratios (HRs) for associations between the TyG-BMI index and cardiovascular disease (CVD) were obtained by searching PubMed, Cochrane Library, EMBASE, and Web of Science.

Association between the triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes mellitus in non-alcoholic fatty liver disease.

This study evaluated the ability of the triglyceride (TG) to high-density lipoprotein cholesterol (TG/HDL-C) ratio to identify individuals at risk of type 2 diabetes mellitus (T2DM) in the non-alcoholic fatty liver disease (NAFLD) population. We retrospectively studied 4,769 patients with NAFLD from the Affiliated Hospital of Hangzhou Normal University (2020-2023). Binary logistic regression models were used to evaluate the association between the TG/HDL-C ratio and lipid parameters with T2DM.

Testing Hubel and Wiesel's "ice-cube" model of functional maps at cellular resolution in macaque V1.

Hubel and Wiesel's ice-cube model proposed that V1 orientation and ocular dominance functional maps intersect orthogonally to optimize wiring efficiency. Here, we revisited this model and additional arrangements at both cellular and pixel levels in awake macaques using two-photon calcium imaging. The recorded response fields of view were similar in size to hypercolumns, each containing up to 2,000 identified neurons and representing full periods of orientation preferences and ocular dominance.

Estimates and trends in the global burden of glaucoma influenced by metabolic risk factors from Global Burden of Disease Study between 1990 to 2019.

PurposeGlaucoma is an irreversible eye disease that causes blindness, which not only causes visual impairment and economic burden to patients, but also increases the social burden. This study aimed to estimate the global burden of glaucoma due to metabolic risk over the past 30 years.MethodsThe number and rate of deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASRs) for metabolic risk factors-induced glaucoma were extracted.

SKI-606, a Src inhibitor, ameliorates benzene-induced hematotoxicity via blocking ROS/Src kinase-mediated p38 and Akt signaling pathways.

Exposure to benzene causes acute myelosuppression and other hematologic disorders. However, the detailed mechanism by which benzene exerts its severe hematotoxicity and potential treatments still require further deciphering and exploration. Herein, we found that hydroquinone (HQ), a main benzene metabolite, significantly increased intracellular reactive oxygen species (ROS) formation and subsequently caused damage to DNA, leading to impaired colony formation capacity and induction of apoptosis in human hematopoietic stem/progenitor cells (HSPCs) in vitro.

Ultrathin near-infrared transmitting films enabled by deprotonation-induced intramolecular charge transfer of a dopant.

Near-infrared transparent films demonstrate important applications in many fields, but how to eliminate light interference from ultraviolet-visible region and how to tackle the trade-off effect between film thickness and transmittance remain as challenges. Herein, we report a near-infrared transparent film that achieves high-efficient combination of thin thickness (16 μm), suitable cut-off wavelength (890 nm), and ideal transmittance (T > 90%, T < 1%). Moreover, the film is photo-chemically stable, heating resistance and moisture insensitive.

Association of marital status with cardiovascular death risk in patients with lung cancer: A population-based study.

Background: To investigate the association of marital status on cardiovascular death risk in lung cancer patients.

Methods: Using data from the Surveillance, Epidemiology, and End Results (SEER) database in the United States from 2011 to 2015 (N = 118,293), the association between marital status and cardiovascular death (CVD) risk in patients with lung cancer was assessed by competing-risks regression models.

Results: Unmarried status was associated with increased risk of cardiovascular death in lung cancer patients [hazard ratio (HR)  =  1.

The impact of organic carbon mineralization on pollution and toxicity of toxic metal in sediments: Yellow Sea and East China Sea study.

Organic carbon mineralization is the main driving force of metal migration and transformation in sediments, greatly influencing the distribution, pollution degree, and toxicity of toxic metals. However, relevant research on this subject is still limited. In this study, the concentration of toxic metals (Cr, Cd, Cu, Pb, Zn, Co, Fe, Mn, Ni, As) in the solid and liquid phase (porewater) of sediments were measured, toxic metal pollution degree and toxicity of the Yellow Sea (YS) and the East China Sea (ECS) were assessed.

Association Between Remnant Cholesterol and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis.

Lipid disorders are related to the risk of nonalcoholic fatty liver disease (NAFLD). Remnant cholesterol (RC), a nonclassical and once-neglected risk factor for NAFLD, has recently received new attention. In this study, we assessed the relationship between the RC levels and NAFLD risk.

Ultrahigh Power Factor of Sputtered Nanocrystalline N-Type BiTe Thin Film via Vacancy Defect Modulation and Ti Additives.

Magnetron-sputtered thermoelectric thin films have the potential for reproducibility and scalability. However, lattice mismatch during sputtering can lead to increased defects in the epitaxial layer, which poses a significant challenge to improving their thermoelectric performance. In this work, nanocrystalline n-type BiTe thin films with an average grain size of ≈110 nm are prepared using high-temperature sputtering and post-annealing.

Liensinine inhibits IL-1β-stimulated inflammatory response in chondrocytes and attenuates papain-induced osteoarthritis in rats.

Osteoarthritis (OA) is a joint disease caused by inflammation of cartilage and synovial tissue. Suppressing the process of inflammatory reaction and the generation of oxidative stress is an effective strategy to alleviate the progression of OA. Liensinine is one of the main components of lotus seeds, which has anti-hypertensive and anti-arrhythmia activities.

Associations between metabolic dysfunction-associated fatty liver disease and atherosclerotic cardiovascular disease.

Non-alcoholic fatty liver disease (NAFLD) is closely related to metabolic syndrome and remains a major global health burden. The increased prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide has contributed to the rising incidence of NAFLD. It is widely believed that atherosclerotic cardiovascular disease (ASCVD) is associated with NAFLD.

Bio-inspired gradient poly(lactic acid) nanofibers for active capturing of PM and real-time respiratory monitoring.

The concept of bio-inspired gradient hierarchies, in which the well-defined MOF nanocrystals serve as active nanodielectrics to create electroactive shell at poly(lactic acid) (PLA) nanofibers, is introduced to promote the surface activity and electroactivity of PLA nanofibrous membranes (NFMs). The strategy enabled significant refinement of PLA nanofibers during coaxial electrospinning (∼40 % decline of fiber diameter), accompanied by remarkable increase of specific surface area (nearly 1.5 m/g), porosity (approximately 85 %) and dielectric constants for the bio-inspired gradient PLA (BG-PLA) NFMs.