Acupuncture for Rapid Pain Relief and Restoration of Motor Function in Acute Lateral Ankle Sprains: A Randomized Controlled Trial Protocol Based on Infrared Thermography.

Purpose: Acute lateral ankle sprain (ALAS) is a prevalent clinical sports injury disease, rapid relief of symptoms and return to normal functional activity are urgent needs of ALAS patients. The aim of this study is to observe the immediate therapeutic effect of acupuncture on ALAS patients in the short term and to evaluate the efficacy at different time points through a multidimensional assessment system, which is expected to provide a simple, rapid, safe and effective therapeutic option for ALAS patients.

Patients And Methods: This is a single-center, prospective, randomized clinical trial.

Breaking the Conversion Limit in an Intercalation-Type Cathode by Loosening Aqueous Cation Coordination.

Intercalation-type cathodes continue to dominate aqueous multivalent ion storage, despite higher theoretical capacities being available from conversion reactions involving multiple electron transfer. Pushing intercalation-type cathodes into conversion is certainly desirable, conventionally with great sacrificing cycling-stability, kinetics, and discharge potential. To date, limited progress has been achieved in overcoming this longstanding and formidable performance trade-off.

Adolescent executive function as a resilience factor in the family stress model among Mexican-origin families.

Mexican-origin families often face economic hardship due to systemic oppression, increasing the likelihood of adolescent marijuana use. While the family stress model provides insight into the mechanism of the association between family economic hardship and adolescent marijuana use, resilience factors are relatively unknown. The present study uses a three-wave longitudinal data set of Mexican immigrant families in the United States (Wave 1-adolescents: = 12.

Bridging the Gap Between Radiology and Microscopy Using microCT: Implications for Neoplastic and Non-neoplastic Lung Disease.

Purpose: Accurate lung cancer TNM staging depends on macroscopic and microscopic tumor evaluation of resection specimens. However, small nodules (<1 cm) are difficult to extract and correlate with in vivo imaging. We investigated whether microCT could better localize lesions or guide pathology to otherwise undetected abnormalities.

Secondary amine-activated ferrate(VI) for isoquinoline degradation: Relationship between molecular structure and reactive performance.

This study elucidates the electronic structure-activity relationship between secondary amines and ferrate(VI) (Fe(VI)) activation. Comparative experiments demonstrated that pyrrolidine (Py) significantly outperformed diethylamine (Di) in enhancing Fe(VI)'s oxidation capability across various dosage conditions, pollutants, and water matrices. Specifically, for isoquinoline (IQL) degradation, Py-Fe(VI) achieved an approximately 7-fold higher rate constant than Fe(VI) alone, versus a 2-fold improvement observed with Di-Fe(VI).

Magnocellular-biased interocular integration during onset rivalry in normal vision and binocular imbalance.

Previous studies have indicated that the magnocellular (M) pathway may resist binocular rivalry, but the roles of the M and parvocellular (P) pathways in binocular rivalry and integration have been unclear, as was whether these pathways show different deficits in visual disorders. This study used a self-designed dichoptic paradigm to investigate the roles of the M and P pathways in interocular integration and onset rivalry in normal and unbalanced vision. Results showed that interocular motion integration increased with higher temporal and lower spatial frequencies, aligning with M pathway properties.

Ultrasound combined with microbubble enhanced renoprotective effects of NLRP3 inflammasome inhibitor MCC950 in CKD model.

Objective: This study evaluated the effectiveness of the NLRP3 inflammasome inhibitor MCC950 combined with ultrasound (US) and microbubbles (MBs) on kidney function and fibrosis in a rat model of chronic kidney disease (CKD).

Methods: After establishing the model, SD rats were divided into eight groups (n = 5): Control, CKD, MCC950 (10 mg/kg), MCC950 (5 mg/kg), US + MCC950 (5 mg/kg), US + MBs + MCC950 (5 mg/kg), US and US + MBs. MCC950 was administered at high (10 mg/kg) or low (5 mg/kg) doses, and 200 μL of sulfur hexafluoride microbubbles was delivered via tail vein injection.

Blockade of interleukin-17A contributes to a novel mechanism by which casticin relieves chronic migraine.

Ethnopharmacological Relevance: Glycolysis-related microglial polarization contributes to the migraine (CM), which are closely associated with the PKM2-STAT3/NF-κB axis. Viticis Fructus has been historically prescribed in Traditional Chinese Medicine for alleviating CM, casticin as the active compound of Viticis Fructus has the therapeutic potential for CM.

Aim Of The Study: To investigate the mechanism of casticin in treating CM, highlighting the role of PKM2-STAT3/NF-κB axis in mediating microglial polarization and glycolysis.

Are parents as great as they think they are? A longitudinal study of parent-child perceived parenting discrepancies on adolescent depressive symptoms in U.S. families of Chinese origin.

A developmental perspective is needed to reveal the long-lasting influence of perceived parenting discrepancies on youth depressive symptoms from early adolescence to emerging adulthood. This is particularly important for U.S.

Attenuated and delayed neural activity in cortical microcircuitry of monocular processing and binocular interactions in human amblyopia.

Disruption of retinal input early in life can lead to amblyopia, a condition characterized by reduced visual acuity after optical correction. While functional abnormalities in the early visual areas have been observed in amblyopia, mesoscale deficits in cortical microcircuitry across cortical depth remain unexplored in humans. Using a combination of submillimeter 7T fMRI and EEG frequency-tagging methods, we investigated neural deficits in monocular processing and binocular interactions in human adults with unilateral amblyopia.

Application of artificial intelligence in echocardiography from 2009 to 2024: a bibliometric analysis.

Background: Echocardiography is a cornerstone in the clinical diagnosis of cardiovascular diseases, providing critical insights into cardiac structure and function. Over recent years, artificial intelligence (AI) has emerged as a transformative adjunct to traditional echocardiographic techniques, enhancing diagnostic accuracy through innovations such as automatic view labeling, advanced image segmentation, and predictive disease modeling. The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2024 through bibliometric analysis and to forecast future developmental trajectories.

Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice.

Acute pancreatitis (AP) is a complex and potentially severe inflammatory disorder of the pancreas and is one of the most common causes of gastrointestinal hospitalization. Although environmental risk factors such as alcohol and gallstones are well recognized, only a subset of exposed individuals develop AP, suggesting that intrinsic factors, including genetic susceptibility, influence disease onset and progression. Endoplasmic reticulum (ER) stress has emerged as a key mechanism in AP pathogenesis, because ER is essential for protein synthesis, folding, degradation and secretion (proteostasis).

Age-Related Alterations in the Expression of Mesencephalic Astrocyte-derived Neurotrophic Factor in the Brain and Their Impact on Neurobehavioral Functions.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a neurotrophic protein localized in the endoplasmic reticulum (ER) and pivotally involved in maintaining ER homeostasis. MANF plays an important role in mitigating neurodegenerative processes. Aging, the primary risk factor for neurodegenerative diseases (NDDs), is associated with significant alterations in ER function.

Recent Advances in Targeted Protein Degradation Molecular Glues as Anticancer Drugs.

Molecular glues have emerged as a novel class of targeted protein degraders with broad potential in cancer therapy. By inducing proximity between E3 ubiquitin ligases and oncogenic proteins, these agents activate the ubiquitin-proteasome system to drive selective protein degradation. This review systematically explores the application strategies of molecular glues in the targeted degradation of cancer-related proteins located in different subcellular compartments: nuclear cancer proteins (Ikaros, Helios, Aiolos, B-cell lymphoma 6 protein, cyclin K, RNA binding motif protein 39) and cytoplasmic cancer proteins (β-catenin, casein kinase 1α, G1 to S phase transition factor 1).

Facilitating microglial phagocytosis by which Jiawei Xionggui Decoction alleviates cognitive impairment via TREM2-mediated energy metabolic reprogramming.

Triggering receptor expressed on myeloid cells 2 (TREM2)-mediated microglial phagocytosis is an energy-intensive process that plays a crucial role in amyloid beta (Aβ) clearance in Alzheimer's disease (AD). Energy metabolic reprogramming (EMR) in microglia induced by TREM2 presents therapeutic targets for cognitive impairment in AD. Jiawei Xionggui Decoction (JWXG) has demonstrated effectiveness in enhancing energy supply, protecting microglia, and mitigating cognitive impairment in APP/PS1 mice.

Language Brokering Conditions the Indirect Association Between Mexican-Origin Adolescents' Academic Discrimination and Educational Expectations.

Mexican-origin adolescents, a significant portion of the US Latino population, often experience a decline in educational expectations from early to late adolescence. Contextual factors such as academic discrimination and language brokering for parents may contribute to this decline. This study investigates the indirect effect of academic discrimination experienced in middle school on educational expectations in young adulthood through high school grades and engagement, and the moderating role of language brokering experiences in these relations.

Effects of alcohol on gut microbiome in adolescent and adult MMTV-Wnt1 mice.

Introduction: Breast cancer is the most frequently diagnosed cancer in women worldwide. Alcohol consumption is a significant and modifiable risk factor, yet the mechanisms linking alcohol to breast cancer progression remain unclear. Recent evidence suggests that the gut microbiome-a complex ecosystem that modulates metabolism, immunity, and inflammation-may act as a mediator of alcohol-induced tumor promotion.

A superhydrophilic PEGDA-coated PBT membrane prepared by photoinitiated polymerization for hemodialysis therapy.

Conventional hydrophobic hemodialysis membranes risk exacerbating patient conditions through thrombosis induction during dialysis procedures, while current systemic anticoagulation strategies face a critical dilemma between insufficient heparinization and heparin overdose. This necessitates urgent development of superhydrophilic modification strategies for dialysis membranes. Here we report a poly(ethylene glycol) diacrylate (PEGDA) coating strategy that imparts extreme hydrophilicity to hydrophobic poly(butylene terephthalate) (PBT) dialysis membranes polymerization of PEGDA, leveraging its highly hydratable ether bonds.

Electron Donors in the Intertwined Interface Restore Oxy-Substituted Selenides.

Nature chose selenium as the antioxidant element center in proteins, permitting the reversible conversion of organic bioenzymes between oxidized and selenized forms. Despite the importance of such antielectronegativity reversibility, it has not yet been demonstrated in inorganic selenides. We report an unexpected example showing that oxy-substituted sites in metal selenides can be restored to selenized forms reversibly by mild electrochemical manipulation in a copper aqueous solution.

Spatial Transcriptomics Analysis Uncovers ER stress in MANF-deficient Purkinje Cells Underlying Alcohol-induced Cerebellar Vulnerability in Mice.

Cerebellar Purkinje cells (PCs) are among the most vulnerable neurons to alcohol neurotoxicity. Alcohol can induce endoplasmic reticulum (ER) stress and alter the structure and function of PCs. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress inducible protein highly expressed in PCs.

EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis.

Idiopathic scoliosis (IS) is the most common form of spinal deformity with unclear pathogenesis. In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subsequently, we mapped these loci to candidate genes using either location-based or function-based strategies.

Case report: Nephrotic syndrome induced by Lenvatinib treatment in a patient with von Hippel-Lindau syndrome.

Von Hippel-Lindau (VHL) syndrome is an autosomal dominant hereditary disease characterized with mutiple organ tumors. Tyrosine kinase inhibitor (TKI) is one of the targetd treatment for VHL syndrome. Lenvatinib (LEN), an oral small-molecule multiple TKI, and proteinuria is one of the most common adverse events associated with LEN.

Optimal techniques for obtaining superior liver specimens at endoscopic ultrasound-guided biopsy: a pilot study on pigs.

Background: Endoscopic ultrasound (EUS)-guided liver biopsy has been an effective method for acquiring liver tissue. However, currently, there is no consensus on the technical details of biopsy sampling. This study aimed to optimize the EUS-guided liver biopsy techniques to improve specimen quality.

Enhanced specific energy in fast-charging lithium-ion batteries negative electrodes via Ti-O covalency-mediated low potential.

Developing lithium-ion batteries with high specific energy and fast-charging capability requires overcoming the potential-capacity trade-off in negative electrodes. Conventional fast-charging materials (e.g.