Factors influencing rehabilitation costs for stroke inpatients in Shenzhen: a multicenter retrospective study.

Background: Stroke is a leading cause of death and disability among Chinese residents, imposing a significant economic burden. This study aimed to analyze the current status and influencing factors of inpatient rehabilitation costs for stroke in Shenzhen, providing evidence to help reduce costs for patients with stroke in rehabilitation centers.

Methods: This multicenter retrospective study used data primarily collected from patient's medical records.

Comparative Analysis of the Feasibility Between Single-Channel Frontal Pole Flexible Electrode Sleep Patches and Polysomnography in Stroke Survivors.

Polysomnography (PSG), the gold standard for sleep monitoring, remains limited by its high cost and technical complexities in operation and data analysis. The flexible electrode sleep patch (FESP) is a novel wearable frontal single-channel EEG device for rapid sleep monitoring via FP1 and FP2 sites. Although preliminary studies support its reliability in healthy individuals, its feasibility for stroke patients remains unexplored.

Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis.

Background: Immune checkpoint inhibitors (ICI) have revolutionized the therapeutic direction for lung cancer, yet their response rates remain unsatisfactory. Recently, the combination of ICI and low dose radiotherapy (LDR), a novel approach that effectively mobilizes innate and adaptive immunity, has gained interest among scientists. However, the underlying molecular mechanisms are not clearly elucidated.

The positive role of Chinese herbal medicine as an adjunctive therapy for refractory gastroesophageal reflux disease: A systematic review and network meta-analysis.

Background: Proton pump inhibitors are currently the primary treatment option for refractory gastroesophageal reflux disease (rGERD), yet they have limitations, including poor efficacy and potential adverse events. Chinese herbal medicine (CHM) may offer an effective and safe adjunctive therapy.

Methods: This network meta-analysis investigate the adjunctive therapeutic effect and safety of CHM on rGERD.

Clinical efficacy observation of repetitive magnetic stimulation for treating upper limb spasticity after stroke.

To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) for managing upper limb muscular spasticity after stroke, and to examine its therapeutic effects on spasticity and motor function in the upper limb. A total of 110 post-stroke patients with upper limb spasticity were randomly assigned to the experimental or the control group. The experimental group received rTMS in conjunction with conventional rehabilitation therapy.

Mixed adverse ergonomic factors exposure in relation to work-related musculoskeletal disorders: a multicenter cross-sectional study of Chinese medical personnel.

Exposure to adverse ergonomic factors is associated with elevated risk of work-related musculoskeletal disorders (WMSDs) in medical personnel. We aimed to reveal how different adverse ergonomic factors act individually and in combination to influence the risk of WMSDs in medical personnel. From June 2018 to December 2020, we applied multistage cluster random sampling to select a total of 6,099 medical personnel from 54 hospitals in 12 cities in China.

Identification of Marker Peptides in Gelatins from Sika Deer () Using Ultra-High-Performance Liquid Chromatography-Quadrupole-Exactive-Orbitrap Mass Spectrometry.

Gelatin from deer has garnered attention as a high-value health-promoting resource given its history of usage as a traditional Chinese medicine and recent studies demonstrating its biological activities. Mass spectrometry-based methods have increasingly been employed for species identification in collagen-based materials, effectively addressing challenges in quality control and authenticity verification. This study aims to identify characteristic marker peptides in gelatins from sika deer () to support their effective use as a health-promoting resource.

Cardiorespiratory fitness in stroke patients with different activities of daily living levels: a cross-sectional study.

Understanding the relationship between cardiorespiratory function (CRF) and activities of daily living (ADL) in stroke patients is essential for improving rehabilitation outcomes. A total of 153 participants were enrolled in this study. Cardiopulmonary exercise was tested at admission.

Multilayer Separator-Driven interface stabilization and dendrite suppression for Long-Cycling lithium metal batteries.

Lithium metal batteries (LMBs) offer a high theoretical capacity and low electrochemical potential. However, the uncontrolled growth of lithium dendrites and ongoing side reactions during cycling can lead to premature battery failure and increase the risk of thermal runway severely limiting their practical applications. In this work, we designed a multilayer separator composed of methanol-intercalated Li-Al hydrotalcite-like nanosheets with expanded layer spacing, sandwiched between electrochemically stable PVDF-HFP nanofiber membranes.

3D Silsesquioxane Cage-Based Covalent Organic Frameworks Enabling Efficient Ion Transport in Quasi-Solid-State Lithium Metal Batteries.

The resurgence of lithium metal batteries (LMBs) necessitates advancements in electrolyte engineering to regulate ion transport and manipulate interfacial characteristics. Noteworthy strategies encompass the development of high-efficiency lithium-ion conductors for quasi-solid-state composite electrolytes. In this context, two crystalline 3D COFs are presented that are thoughtfully designed by selecting decasilsesquioxane (T) cage building blocks and linear linkers to open up efficient ion-conducting pathways.

One-step strand displacement-mediated nucleic acids signal-amplified analytical strategy based on superparamagnetism-functionalized DNA arrays.

DNA nanostructure, as polymeric material with remarkable molecular recognition property, has been widely used in bioassay. However, it still faces some challenges to overcome complexity of signal-amplified strategies and to realize efficient separation of reaction products. Herein, we present an innovative signal-amplified approach by integrating the toehold-mediated strand displacement reaction with DNA tile self-assembly technology to construct superparamagnetism-functionalized DNA polymeric materials, establishing a new signal-amplified analytical strategy for nucleic acids.

Construction and in vitro activity evaluation of protein transduction domain-transactivator of transcription and lipase B fusion proteins.

Protein transduction domain (PTD)- transactivator of transcription (Tat) and the alkaline cold-active lipase Candida antarctica lipase B (calB) were used to construct a calB-Tat recombinant protein and examine its membrane-penetrating ability. The calB gene was fused with a PTD-Tat-encoding fragment to create the in-frame calB-Tat. After digestion with Nco I and Xho I, the calB-Tat fragment was subcloned and inserted into the expression vector pET28a.

Peripheral Electrical Stimulation on Motor Function and Activities of Daily Living After Stroke: A Systematic Review and Network Meta-analysis.

Objective: To compare the effects of different peripheral electrical stimulation protocols and current frequencies for poststroke motor function and activities of daily living.

Data Sources: Seven databases (PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, VIP Database, Wan-Fang Database, and Chinese Biomedical Database) were searched from inception to August 2024.

Study Selection: Two reviewers independently performed the literature selection.

Prevalence and Risk Factors of Lower Extremity Musculoskeletal Disorders Among Occupational Groups in Key Industries - China, 2018-2023.

What Is Already Known About This Topic?: Lower extremity musculoskeletal diseases (LE-MSDs) have emerged as a significant contributor to the global disease economic burden and worker absenteeism, becoming a global public health concern. However, the epidemic characteristics of LE-MSDs among occupational populations in China are unknown.

What Is Added By This Report?: This report finds that the LE-MSDs prevalence rate among key occupational groups in China is 17.

Cutaneous squamous cell carcinoma-derived exosomal MicroRNA-31 acts as an oncogene by targeting the tumor suppressor RhoBTB1.

Tumor-derived exosomes that transport MicroRNAs significantly influence cutaneous squamous cell carcinoma(CSCC) progression. However, the molecular mechanisms of exosomal MicroRNA-31 regulation of CSCC are mostly undefined. To determine whether a targeting relationship exists between MicroRNA-31 (miR-31) in CSCC-derived exosomes and the tumor suppressor RhoBTB1, and the regulatory effect of the relationship on tumor cells.

Microneedles: multifunctional devices for drug delivery, body fluid extraction, and bio-sensing.

Microneedles represent a miniaturized mechanical structure with versatile applications, including transdermal drug delivery, vaccination, body-fluid extraction, and bio-sensing. Over the past two decades, microneedle-based devices have garnered considerable attention in the biomedicine field, exhibiting the potential for mitigating patient discomfort, enhancing treatment adherence, avoiding first-pass effects, and facilitating precise therapeutic interventions. As an application-oriented technology, the innovation of microneedles is generally carried out in response to a specific demand.

Neural effects of acupuncture on stroke patients with motor dysfunction: an activation likelihood estimation meta-analysis.

Background: Functional magnetic resonance imaging has been used in many studies to explore the neural mechanism of acupuncture in patients with post-stroke motor dysfunction. Inconsistent results have been found in these studies, however. This activation likelihood estimation (ALE) meta-analysis was designed to quantitatively integrate changes in brain activity and the neurological effects of acupuncture on patients with motor dysfunction after stroke.

Impact of diverse aerobic exercise plans on glycemic control, lipid levels, and functional activity in stroke patients with type 2 diabetes mellitus.

Aims: This study aimed to assess the effects of Low-to-Moderate Intensity Continuous Training (LMICT), Moderate-Intensity Interval Training (MIIT), and Reduced-Exertion High-Intensity Training (REHIT) on blood glucose regulation, functional recovery, and lipid levels in individuals who have experienced a stroke and are diagnosed with Type 2 Diabetes Mellitus (T2DM).

Methods: Forty-two T2DM stroke patients were randomly allocated to four groups: LMICT, MIIT, REHIT, and a control group (CON). Participants continuously monitored their blood glucose levels throughout the intervention using continuous glucose monitoring (CGM) devices.

Exploring the association between activities of daily living ability and injurious falls in older stroke patients with different activity ranges.

Injurious falls pose a significant threat to the safety of stroke patients, particularly among older adults. While the influence of activities of daily living (ADL) on falls is acknowledged, the precise connection between ADL ability and fall-related injuries in older stroke patients undergoing rehabilitation, particularly those with varying mobility levels, remains unclear. This multicenter cross-sectional study in China recruited 741 stroke patients aged 65 years and above, categorized into bedridden, domestic, and community groups based on their mobility levels using the Longshi Scale.

The Evolution of Microfluidic-Based Drug-Loading Techniques for Cells and Their Derivatives.

Conventional drug delivery techniques face challenges related to targeting and adverse reactions. Recent years have witnessed significant advancements in nanoparticle-based drug carriers. Nevertheless, concerns persist regarding their safety and insufficient metabolism.

Laser Fabrication of Humidity Sensors on Ethanol-Soaked Polyimide for Fully Contactless Respiratory Monitoring.

Humidity-sensor-based fully contactless respiratory monitoring can eliminate the discomfort and infection risks associated with any wearable device. However, challenges in the facile fabrication of highly sensitive humidity sensors continue to hinder their widespread application for fully contactless respiratory monitoring. In this study, we introduce a simple method to fabricate highly sensitive humidity sensors.