Study on service performance and design method of vertical cutoff wall under multi-time-varying point source conditions.

Vertical cutoff wall is widely used as one of the in-situ remediation technologies for contaminated sites. In this paper, considering the unsaturated characteristics of porous media, a three-dimensional pollutant transport model of inner aquifer-vertical cutoff wall-outer aquifer is established. The main conclusions are as follows.

[Septin9 promotes viral replication by interacting with Ebola virus VP35 to regulate inclusion body formation].

The Ebola virus (EBOV), a member of the Filoviridae family, is a highly pathogenic agent responsible for severe hemorrhagic fever in humans. Understanding the molecular mechanisms governing its replication is critical for developing effective antiviral strategies. VP35-TurboID immunosuppression coupled with quantitative mass spectrometry identified Septin9, the host GTP-binding protein which played a role in cytoskeletal regulation, as a novel interactor of VP35.

An Efficient Two-Dimensional Functional Mixed-Effect Model Framework for Repeatedly Measured Functional Data.

Advancements in wearable device technology have enabled accelerometers to continuously record minute-by-minute physical activity over consecutive days, yielding curves serially correlated in dense and regular longitudinal design. Motivated by a large-scale cohort of physical activity data throughout a week, the collected repeatedly measured functional data exhibits longitudinal (interday) and functional (intraday) interactions on fine grids. To accommodate this complex data structure and investigate the relationship between health assessment results and weekly physical activity patterns, we propose an innovative and efficient two-dimensional functional mixed-effect model (2dFMM), characterizing the longitudinal and functional cross-variability while incorporating two-dimensional fixed effects and four-dimensional correlation structure in marginal representation.

Aurora B maintains spherical shape of mitotic cells via simultaneously stabilizing myosin II and vimentin.

Cells round up when they enter mitosis and maintain this rounded morphology until they pass the spindle assembly checkpoint during anaphase. However, the mechanisms that regulate and maintain this transient spherical state remain unclear. In this study, we demonstrate that both astral microtubules and Aurora B kinase are required to maintain cortex stability during prometaphase.

Expression regulation network in papillae of sea cucumbers: Whole-transcriptome and DNA methylation datasets.

To elucidate the expression regulation network of papilla size of sea cucumbers (Apostichopus japonicus), the whole-transcriptome and DNA methylome datasets of different sizes of papillae in sea cucumbers were generated. Average clean bases of whole-transcriptome (16.35 G) and DNA methylome (28.

Differential response patterns of bacterial communities in seawater and sediments to the Chaetomorpha valida bloom in sea cucumber Apostichopus japonicus aquaculture ponds.

The microbiota play a critical role in the health of the aquaculture pond ecosystem. Green tide have been found to affect the microbial community in the marine environments, but effects of Chaetomorpha valida bloom on the microbial composition in the aquaculture ponds related to the marine economic species have been rarely investigated. To address this shortcoming, we provided baseline information on the bacterial composition and diversity in C.

A pH-responsive nanoplatform enhancing tumor therapy calcium overload-induced oxidative stress to potentiate phototherapy and chemotherapy.

The specific tumor microenvironment (TME) and the ability of tumor cells to evade drug therapy pose challenges to the efficacy of single monotherapies. Herein, a multifunctional calcium carbonate-based nanoprobe (FeO/CaCO-CSL/ICG) was synthesized using a simple one-step method. This nanoprobe is designed to respond specifically to the acidic TME, where the calcium carbonate shell dissolves, releasing therapeutic agents.

High throughput screening for the design of protein binding polymers.

Using polymers for protein encapsulation can enhance stability in processing environments and prolong activity and half-life . However, finding the best polymer structure for a target protein can be difficult, labour- and cost-intensive. In this study we introduce a high throughput screening approach to identify strong polymer-protein interactions by use of Förster Resonance Energy Transfer (FRET), enabling a rapid read out.

A self-gelling hemostatic powder driven by hydrogen bonding and electrostatic interactions with antibacterial and antioxidant properties.

Self-gelling powders present distinctive advantages for managing incompressible wounds with elusive bleeding points. In this study, a self-gelling powder composed of polyacrylic acid/arginine-modified polylysine/tannic acid (PAA/PLG/TA) is developed. The system's formation is primarily driven by hydrogen bonding and electrostatic interactions.

Identification and characterization of novel CRESS-DNA viruses in the human respiratory tract.

CRESS-DNA viruses are small, circular, single-stranded DNA viruses that have been identified in diverse environments and hosts, including vertebrates, invertebrates, and environmental samples. However, their diversity and role in the human respiratory tract remain poorly understood. In this study, we employed viral metagenomics to analyze 140 nasopharyngeal swab samples from asymptomatic individuals.

A TPP-OH-based near-infrared fluorescent nanoprobe for cellular and in vivo HS detection and imaging.

The physiological and pathological processes of many diseases are influenced by hydrogen sulfide (HS), a physiologically active gaseous signaling molecule. Near-infrared fluorescent (NIR) probes are valued for their high specificity, sensitivity, simplicity, and safety. A near-infrared fluorescent probe (TPNPs), sensitive to HS, was designed and synthesized from 4-(10,15,20-triphenylporphyrin-5-yl)phenol (TPP-OH).

A Review of -GaO Films: Fabrications and Photoelectric Properties.

Gallium oxide (GaO), as an ultra-wide bandgap semiconducting material, has attracted extensive research interest in recent years. Owing to its outstanding electrical and optical properties, as well as its high reliability, GaO shows great potential in power electronics, optoelectronics, memory devices, and so on. Among all the different polymorphs, -GaO is the second most thermally stable phase.

Polygonal Wrinkles in a Soft Solidified Droplet.

The widespread occurrence of liquid freezing has profound implications for materials science, advanced manufacturing, and the global climate. Emerging from the intricate interplay of fluid dynamics, heat transfer, and phase change, recently, a captivating array of artistic and elegant patterns has been revealed. However, the solidified liquid component generally displays a pronounced resistance to deformation, thereby hindering the critical mechanical coupling inherently associated with thin films and soft materials.

Chromosomal instability by low-coverage whole-genome sequencing assay predicts prognosis in bladder cancer patients underwent radical cystectomy.

Purpose: To investigate chromosomal instability (CIN) in tumor tissue from radical bladder resection and to evaluate whether it can be used as a biomarker for the molecular typing of (BC).

Methods: DNA was extracted from formalin-fixed paraffin-embedded samples of 50 BC patients who were followed up to March 23 2023 using the Qiagen nucleic acid kits. We analyzed CIN in tumor of bladder by low-coverage whole genome sequencing (LC-WGS).

Injectable Hydrogel for Cardiac Repair via Dual Inhibition of Ferroptosis and Oxidative Stress.

Ferroptosis plays a significant role in ischemic heart disease by exacerbating myocardial injury through oxidative stress, iron metabolism disorder, and inflammation. Herein, we develop an injectable hydrogel (HSD/DFO@GMs) with antiferroptosis and antioxidant properties for cardiac repair. The hydrogel is composed of dopamine-grafted oxidized hyaluronic acid, adipic acid dihydrazide grafted hyaluronic acid, and deferoxamine loaded gelatin microsphere, connected via a dynamic Schiff base bond.

Development and Validation of a Cell-Free DNA Fragmentomics-Based Model for Early Detection of Pancreatic Cancer.

Purpose: Pancreatic ductal adenocarcinoma (PDAC), known for its high fatality rate, is often diagnosed in its advanced stages where surgical options are not viable. This highlights the critical need for innovative and effective early detection techniques. This study focuses on the potential of cell-free DNA (cfDNA) fragmentomics integrating advanced machine learning to identify early-stage PDAC with high accuracy.

The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.

Background: Psychological stress is the most common psychological comorbidity and a significant triggering factor of vitiligo. Moderate to severe psychological stress can markedly affect the efficacy of vitiligo treatment. However, the specific mechanisms underlying its involvement remain insufficiently studied.

Study on the service performance of heterogeneous cutoff walls and three-dimensional transport of pollutants considering compression effect.

Vertical cutoff walls are widely used as an effective in-situ remediation technology for non-point source contaminated sites. In this study, considering the arch effect and lateral extrusion effect of the wall, a method for calculating the heterogeneous parameters of the cutoff wall is proposed based on the horizontal spring model. A three-dimensional model of unsteady pollutant transport in the unsaturated zone (internal aquifer-cutoff wall-external aquifer) is developed, incorporating the coupled convection-diffusion-adsorption-degradation processes.

Lycii Fructus and Chrysanthemum Flos, a Chinese medicine herbal pair, ameliorates retinal degeneration of mice induced by sodium iodate and protects Müller cells from oxidative stress.

Ethnopharmacological Relevance: The combination of Lycii Fructus (LF) and Chrysanthemum Flos (CF) is a well-known herbal pair utilized in Chinese medicine for the treatment of retinal degeneration diseases commonly found in the elderly, such as age-related macular degeneration (AMD). However, the precise mechanisms of action mechanism and active constituents responsible for the therapeutic effects of the LF-CF herbal pair in improving AMD remain unknown.

Aim Of The Study: This study aims to evaluate the effect of the LF-CF herbal pair on alleviating retinal damage and apoptosis in Müller cells of a dry AMD mouse model, especially its role in enhancing oxidative stress in the retina.

Nonfouling Core-Shell Microneedle for Sequential and Sustained Drug Release: Enhancing Synergistic Photothermal Chemotherapy in Melanoma Treatment.

Melanoma is a highly aggressive and metastatic malignancy, where current treatment methods often result in damage to healthy tissues, suboptimal therapeutic outcomes, and immune-related side effects. Microneedles, as a drug delivery system, offer advantages such as localized administration, minimal invasiveness, and high delivery efficiency. In this study, we first synthesized tetradecyl-thiol-grafted PAMAM dendrimers, which significantly enhanced cellular uptake and enabled sustained release of doxorubicin (DOX), improving cumulative drug release efficiency.

A retrospective analysis of the efficacy and safety of oral tofacitinib in active vitiligo treatment.

Oral Janus Kinase (JAK) inhibitors represent a significant advancement in the treatment of vitiligo; however, large-scale clinical data on their optimal treatment duration and efficacy remain limited. This study aimed to evaluate the efficacy and safety of the oral JAK inhibitor tofacitinib in patients with active vitiligo over a 3-month period. A retrospective analysis was conducted on patients diagnosed with active vitiligo between June 2023 and January 2024 who received oral tofacitinib for at least 3 months.

A Nanoplatform of Reversing Tumor Immunosuppressive Microenvironment Based on the NIR-II Gold Hollow Nanorod for the Treatment of Hepatocellular Carcinoma.

Advanced hepatocellular carcinoma (HCC) presents a strongly immunosuppressive tumor microenvironment, which enables tumor cells to evade immune cell attacks and hinder effective drug killing, thereby hindering the achievement of the desired therapeutic effect. In response, a novel nanoplatform- AuHNR@γ-FeO@Lenvatinib@β-Glucan (AFLG) with surface modified β-1,3-glucan is developed, which exhibits potent immunostimulatory effect and the capability of repolarizing macrophages, to counteract the immunosuppressive conditions present in the tumor microenvironment. Leveraging the hollow structure of gold nanorods, Lenvatinib is efficiently loaded, a first-line targeted drug for HCC, which effectively inhibits tumor angiogenesis.

Analysis and contrast of psoriasis disease burden trends in China and globally from 1990 to 2021.

Objective: This study aimed to delineate the temporal tendency in the age and gender burden of psoriasis in China, spanning from 1990 to 2021, encompassing metrics such as incidence, prevalence, and disability-adjusted life years (DALYs). Furthermore, it sought to contrast these findings with the global disease burden. It also purposed to assess the impacts of age, time, and birth cohort, as well as to forecast the psoriasis burden in China for the upcoming 15 years.