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Article Abstract
The physiological and pathological processes of many diseases are influenced by hydrogen sulfide (HS), a physiologically active gaseous signaling molecule. Near-infrared fluorescent (NIR) probes are valued for their high specificity, sensitivity, simplicity, and safety. A near-infrared fluorescent probe (TPNPs), sensitive to HS, was designed and synthesized from 4-(10,15,20-triphenylporphyrin-5-yl)phenol (TPP-OH). Due to the creation of hydroxyl groups from ether thiolation, it was discovered that NaS treatment of TPNPs with NaS as the HS donor produced a large "turn-on" near-infrared fluorescence response. Additionally, the fluorescence intensity of TPNPs at 650 nm was significantly enhanced with the increase of NaS content. The fluorescence intensity of TPNPs at 650 nm showed a strong linear relationship with NaS concentration within the concentration range of 0-50 μM, with a detection limit of 0.88 μM. Furthermore, TPNPs were effectively used to investigate exogenous and endogenous HS in mice and live cells.
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| http://dx.doi.org/10.1016/j.colsurfb.2025.114848 | DOI Listing |
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