Association between diabetes mellitus and adhesive capsulitis of shoulder: A 2-sample Mendelian randomization study.

The objective of this study was to investigate whether there is a causal relationship between diabetes mellitus and adhesive capsulitis of shoulder (ACS). A 2-sample Mendelian randomization analysis was performed using publicly available genome-wide association study statistics. To determine whether diabetes was causally associated with ACS, 2 datasets on diabetes among Europeans from the genome-wide association studies catalogue and ACS among Europeans from FinnGen were extracted and the data were analyzed using inverse variance-weighted, Mendelian randomization 123456123451231 Egger regression, weighted medians, weighted modes and simple modes.

Risk factors for severe COVID-19 and development of a predictive model.

A clinical case‒control study was conducted to identify risk factors for severe COVID-19 and to develop a predictive risk model to provide a reference for the dynamic assessment of the severity of disease in COVID-19 patients. A total of 410 patients with COVID-19 were included in the study, of whom 132 had severe or critical cases. The clinical data of the patients were collected, and the variables were subsequently screened via LASSO regression analysis and 10-fold cross-validation.

Corrigendum to: real-time and noninvasive tracking of injectable hydrogel degradation using functionalized AIE nanoparticles.

[This corrects the article DOI: 10.1515/nanoph-2020-0087.].

Localized Surface Plasmon Resonance Effect for Superior Fenton-Like Catalysis.

Nanomaterial-mediated Fenton-like reactions, central tools to address the increasing prevalence of micropollutants, predominantly use chemically stable hydrogen peroxide (HO) as the oxidant despite its high activation energy that leads to rather low catalytic activity. Here, we report that the efficiency of Fenton-like reaction can be substantially increased through the localized surface plasmon resonance (LSPR) effect, initiated by a plasmonic catalyst comprising a ruthenium nanocluster anchored on titanium dioxide nanobelt (TNB-Ru). Experimental results and simulation studies unravel the formation of LSPR on the catalyst surface upon visible light irradiation, which promises the conversion of photon energy into localized heat, contributing to remarkable catalytic performance and high utilization rate of HO (40%) in Fenton-like reaction.

Targeting the NAT10/XIST/YAP1 Axis-Mediated Vascular Abnormalization Enhances Immune Checkpoint Blockade in Gastric Cancer.

Tumor vascular normalization has emerged as a promising strategy to potentiate immune checkpoint blockade in solid tumors. Here, we unveil a previously unrecognized NAT10/XIST/YAP1/VEGFA signaling axis driving vascular abnormalization in gastric cancer (GC) and demonstrate its therapeutic potential in remodeling the tumor immune microenvironment. Through integrative analysis of acetylated RNA immunoprecipitation sequencing (acRIP-seq) and functional validation, we identified NAT10-mediated N4-acetylcytidine (ac4C) modification as a critical stabilizer of lncRNA XIST.

The application of artificial intelligence models in predicting the risk of diabetic foot: a multicenter study.

This study explores diabetic foot (DF), a severe complication in diabetes, by combining deep learning (DL) and machine learning (ML) to develop a multi-model prediction tool. Early identification of high-risk DF patients can reduce disability and mortality. The research also aims to create an integrated application to assist clinicians in precise, efficient risk assessment for early intervention.

Assessing the impact of liver fat fraction on portal hemodynamics in nonalcoholic fatty liver disease using MRI proton density fat fraction and MRI 4D Flow.

Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition with significant implications for liver and cardiovascular health. Alterations in portal hemodynamics due to hepatic steatosis remain poorly understood.

Aim: This study aims to explore the correlation between liver fat fraction (FF) and portal hemodynamics in NAFLD patients.

Genetic effects on chromatin accessibility reveal the molecular mechanisms of complex traits in maize.

Cis-regulatory elements (CREs) are critical for modulating gene expression and phenotypic diversity in maize. While genome-wide association study (GWAS) hits and expression quantitative trait loci (eQTLs) are often enriched in CREs, their molecular mechanisms remain poorly understood. Characterizing CREs within accessible chromatin regions (ACRs) offers a powerful approach to link noncoding variants to chromatin structure alterations and phenotypic variation.

Research progress of nano-based drug delivery systems based on stimuli-responsive materials for the treatment of lung diseases.

Since the lungs are directly connected to the external environment and have a rich blood supply, they are susceptible to damage and tumor growth. However, the pharmacokinetics of traditional drugs in the lungs are limited when administered orally or intravenously, posing challenges for clinical treatment. Compared to traditional drug delivery methods, nano-based drug delivery systems (NDDSs) have the advantages of high drug loading capacity, strong targeting, low cellular toxicity, and extended circulation time in the blood.

Patient journey and Quality of Life for Patients with Idiopathic Pulmonary Fibrosis (IPFLife) in China: a sequential exploratory mixed methods research protocol.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a rare, chronic and progressive lung disease with a significant impact on patients' quality of life. While much research has focused on disease mechanisms and treatment efficacy, limited attention has been paid to the landscape, unmet needs, patient experiences and quality of life. Understanding these aspects through the patient journey is essential for developing patient-centred therapeutic strategies.

Genetic insights into SGLT2 inhibition and atrial fibrillation: exploring the mediating role of inflammatory proteins.

Background: This study aimed to employ Mendelian randomization (MR) analysis to investigate the causal relationship between sodium-glucose cotransporter 2 (SGLT2) inhibition and atrial fibrillation (AF), as well as assess the potential mediating role of inflammatory proteins in this association.

Methods: A two-sample MR analysis was conducted using summary-level data from the genome-wide association study (GWAS) were used to evaluate the genetic prediction of SGLT2 inhibition and AF. Additionally, a two-step MR approach was applied to explore the causal mediation effects of inflammatory proteins in the SGLT2-AF pathway.

Disrupted static and dynamic small-world brain network topologies in patients with schizophrenia.

Background: Schizophrenia is a common and severe mental disorder, but its pathogenesis remains unclear. This study aimed to explore the underlying neuropathological mechanisms of schizophrenia by simultaneously examining changes in the static and dynamic small-world brain network properties.

Methods: In this study, 82 patients with schizophrenia and 76 age- and sex-matched healthy controls were recruited.

FGA-Corn: an integrated system for precision pesticide application in center leaf areas using deep learning vision.

Introduction: In corn pest and disease prevention, traditional blanket pesticide spraying has led to significant pesticide waste and environmental pollution. To address this challenge, research into precision agricultural equipment based on computer vision has become a hotspot.

Methods: In this study, an integrated system named the FGA-Corn system is investigated for precision pesticide application, which consists of three important parts.

Association of an antioxidant-rich diet with all-cause and cardiovascular mortality in hypertensive patients: A prospective study.

This study investigates the relationship between the composite dietary antioxidant index (CDAI) and the risk of all-cause and cardiovascular mortality in individuals with hypertension, aiming to provide dietary recommendations to reduce mortality. Data were sourced from the National Health and Nutrition Examination Survey (NHANES) database. The best cut-off for CDAI in relation to survival outcomes was determined using the maximally selected rank statistics method.

High-throughput end-to-end aphid honeydew excretion behavior recognition method based on rapid adaptive motion-feature fusion.

Introduction: Aphids are significant agricultural pests and vectors of plant viruses. Their Honeydew Excretion(HE) behavior holds critical importance for investigating feeding activities and evaluating plant resistance levels. Addressing the challenges of suboptimal efficiency, inadequate real-time capability, and cumbersome operational procedures inherent in conventional manual and chemical detection methodologies, this research introduces an end-to-end multi-target behavior detection framework.

Bacteria into bloodstream caused by oral probiotics based on whole genome sequencing: A case report.

Rationale: Bacillus licheniformis and Lactiplantibacillus plantarum are facultative anaerobes and gram-positive bacteria. They are commonly included in probiotic preparations and are administered orally in clinical practice to promote a balanced gut microbiota.

Patient Concerns: An 85-year-old man with irritable bowel syndrome and reflux esophagitis underwent distal pancreatectomy and was administered oral probiotics.

Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial.

Tetanus remains an important global public health concern. Currently, the only recommended passive immunization therapy for tetanus prophylaxis is plasma-derived human tetanus immunoglobulin (HTIG), which faces a global supply shortage and can transmit infectious pathogens. Despite not being endorsed by WHO due to safety concerns, equine tetanus antitoxin remains widely used in some countries.

Life's Crucial 9 Score as a Novel Role for Chronic Obstructive Pulmonary Disease Screening.

Purpose: This study aims to investigate the association between the Life's Crucial 9 (LC9) score and chronic obstructive pulmonary disease (COPD) in middle-aged and older adults.

Patients And Methods: We screened the NHANES database for data from 2007-2018. Logistic regression analysis and subgroup analysis were used to explore the association between LC9 score and COPD in middle-aged and older adults.

Lattice matching FeP-CuP heterointerfaces for efficient hydrogen evolution reaction in alkaline and seawater media.

The production of hydrogen via water/seawater electrolysis is economically promising but faces challenges due to the insufficient activity and durability of catalysts. Herein, theoretical calculations indicate that FeP-CuP facilitates charge density redistribution at the heterointerfaces, thereby enhancing adsorption behaviors and speeding up the dynamics of hydrogen evolution reaction (HER). Subsequently, the FeP-CuP heterointerface on Ni Foam is effectively established through lattice-matching approach.

Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis.

Ischemic stroke (IS), a leading global cause of mortality and long-term disability, necessitates immediate intervention for eligible patients. Current guidelines mandate intravenous thrombolysis within 4.5 h of symptom onset for individuals without contraindications, achieving vessel recanalization rates up to 85% in treated cohorts.

Enhanced machine learning models for predicting three-year mortality in Non-STEMI patients aged 75 and above.

Background: Non-ST segment elevation myocardial infarction (Non-STEMI) is a severe cardiovascular condition mainly affecting individuals aged 75 and above, who are at higher risk of mortality due to age-related vulnerabilities and other health issues. Current prognostic models are often inadequate in addressing the complexity of this population. This study aims to develop and validate a machine learning (ML) model to predict three-year mortality in Non-STEMI patients aged 75 and above, to assist clinicians in decision-making.

Immune Dysregulation and Hub Gene Identification in Non-Pulmonary Sepsis-Induced Acute Lung Injury: Insights from Transcriptomic and Experimental Analyses.

Objective: Sepsis-induced acute lung injury (ALI) poses a critical challenge in critical care, yet its immunoregulatory mechanisms remain poorly defined. This study aimed to delineate immune dysregulation networks and identify therapeutic targets through multiomics data integration.

Methods: Transcriptomic datasets (GSE40180 and GSE165226) were analyzed through a multiphase bioinformatics workflow, including gene set enrichment analysis (GSEA), immune cell deconvolution (CIBERSORT), differential gene expression profiling (|log2FC|> 1.

Correction: Biomineralized composite liquid crystal fiber scaffold promotes bone regeneration by enhancement of osteogenesis and angiogenesis.

[This corrects the article DOI: 10.3389/fphar.2021.

Establishing a Novel Heterologous Secretion Expression System Mediated by mScarlet3 for the Expression of a Novel Lipolytic Enzyme.

Our previous study demonstrated that an heterologous secretion expression system, mediated by superfolder green fluorescent protein (sfGFP) mutants, significantly enhances recombinant lipase yield and reduces large-scale production costs. In this study, we identified mScarlet3, a fast-folding fluorescent protein, as another effective mediator of secretion expression in . A novel lipolytic enzyme, named LipHu6, was identified through sequence alignment.

Relationship Between Salt Intake and Cardiovascular Disease.

Cardiovascular disease (CVD) is a predominant global health issue, with dietary salt intake recognized as a crucial modifiable risk factor. This review elucidates the multifaceted relationship between salt consumption and CVD, exploring both its direct and indirect effects. While early research emphasized salt's influence on blood pressure, contemporary studies highlight the combined effects of dietary habits and genetic factors on CVD risk.