Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation.

Anaplastic thyroid carcinoma (ATC) is one of the most lethal human malignancies, often evolving from differentiated thyroid carcinoma (DTC) through a poorly understood dedifferentiation process. To elucidate this transition, spatial transcriptomic sequencing (spRNAseq) is performed on seven samples containing coexisting regions of ATC, poorly differentiated thyroid carcinoma, and DTC. SpRNAseq revealed that ATC regions were characterized by upregulated genes involved in immune suppression, angiogenesis, and extracellular matrix remodeling.

Pressure effects on lithium anode/nickel-manganese-cobalt oxide cathode pouch cells through fixture design.

Applying external pressure to a pouch cell results in improved performance, implicating systems-level design of batteries. Here, different formats and amounts of external pressure to Li-LiNiMnCoO (Li-NMC811) pouch cells were studied under lean electrolyte conditions. Due to the more uniform lithium plating/stripping, a constant gap fixture that retains the distance of the frame during cycling performed greater than a constant pressure fixture that retains applied pressure to the cell.

Interactive dynamic scalp acupuncture enhances brain functional connectivity in bilateral basal ganglia ischemic stroke patients: a randomized controlled trial.

Aim: This randomized controlled trial investigated the effects of interactive dynamic scalp acupuncture (IDSA) on brain functional connectivity density (FCD) in patients with bilateral basal ganglia ischemic stroke (BBGIS), focusing on its potential to enhance motor recovery.

Methods: Seventy BBGIS patients (aged 45-75 years, 1-3 months post-stroke, Brunnstrom stage II-V) and 40 age-and sex-matched healthy controls (HCs) were enrolled. Resting-state functional MRI (rs-fMRI) assessed baseline FCD differences between groups, with regions showing significant alterations correlated to Fugl-Meyer Assessment (FMA) scores selected as seed points.

Factors influencing rehabilitation costs for stroke inpatients in Shenzhen: a multicenter retrospective study.

Background: Stroke is a leading cause of death and disability among Chinese residents, imposing a significant economic burden. This study aimed to analyze the current status and influencing factors of inpatient rehabilitation costs for stroke in Shenzhen, providing evidence to help reduce costs for patients with stroke in rehabilitation centers.

Methods: This multicenter retrospective study used data primarily collected from patient's medical records.

Spatial and electronic features driving SGLT1/2 selectivity: a combined molecular dynamics and quantum mechanics study.

The rising global prevalence of diabetes underscores the need for highly selective sodium-glucose cotransporter (SGLT) inhibitors, which are essential for glucose regulation. While human Na-D-glucose cotransporter (hSGLT) inhibitors offer therapeutic potential, the high sequence similarity between SGLT1 and SGLT2 complicates selective inhibitor design. To elucidate the selective inhibition mechanisms of SGLT1/2, molecular dynamics (MD) simulations and quantum calculations were combined to explore SGLT1/2 inhibition mechanisms.

Halide Perovskites for Self-Driven X-Ray Detection.

Recently, halide perovskite X-ray detectors have demonstrated sensitivity orders of magnitude higher than that of state-of-the-art α-Se X-ray detectors, holding great potential to reshape the X-ray detector industry. However, the high dark current and severe baseline drift, caused by carrier injection and ion migration under external electric fields, hinder their practical use. In this context, perovskites are engineered as either semiconductor junctions or ferroelectrics to enable self-driven X-ray detection with ultralow dark current and negligible baseline drift, marking a cutting-edge development in the field.

Regional variations in plantar fascia elasticity and their association with pain in plantar fasciitis: a cross-sectional study.

The aim of this study was to evaluate the relationship between plantar fascia (PF) elasticity, pain, visual analog scale (VAS) score, and plantar fascia thickness (PFT) in adults with plantar fasciitis (PFis). PF elasticity and PFT were measured in 40 subjects by ultrasonic shear wave elastography (USWE), and their VAS score and localized pressure pain threshold (PPT) were determined. Then, the correlations between PF elasticity and PFT, VAS score, and PPT were analyzed.

Association between life satisfaction and fall severity among hospitalized stroke patients.

Falls are common during stroke rehabilitation, leading to physical injuries and psychosocial consequences. While prior studies have explored the association between falls and life satisfaction, the effect of fall-related injury severity remains unclear. This multicenter cross-sectional study included 6,068 stroke inpatients undergoing rehabilitation.

Deformation mechanism of surrounding rock in weakly cemented thick coal seam roadways and research on graded anchor composite support technology.

In western mining areas, roadways excavated in weakly cemented thick coal seams often experience significant deformation and support failure due to poor roof conditions, low cementation strength, and stress redistribution. Taking the 11,703 transportation roadway of the Dananhu No. 7 Coal Mine in Xinjiang as a case study, this paper investigates the deformation mechanisms of the surrounding rock and proposes an optimized support technology.

Inverse relationship between serum haptoglobin and acute kidney injury in critically Ill patients with sepsis: A retrospective cohort study of the MIMIC-IV 3.0 database.

Background: Previous studies have indicated that perioperative serum haptoglobin levels are associated with the risk of Acute Kidney Injury (AKI). However, the relationship between haptoglobin and AKI in sepsis patients remains unclear. This study aimed to investigate the association between serum haptoglobin levels and AKI in critically ill sepsis patients.

Development and Application of Indirect ELISA for IBDV VP2 Antibodies Detection in Poultry.

Infectious bursal disease virus (IBDV) is one of the most important immunosuppressive viruses in poultry, causing the global spread of infectious bursal disease (IBD). It poses a significant threat to the healthy development of the poultry industry. Vaccination is an effective approach for controlling IBDV infection.

Precisely tuning band gaps of graphene/h-BN lateral heterostructures toward enhanced photocatalytic hydrogen evolution.

Constructing heterojunctions is a proven strategy for developing efficient photocatalytic hydrogen evolution catalysts. In this work, we design graphene/hexagonal boron nitride (h-BN) lateral heterostructures that combine graphene's exceptional charge transport with h-BN's stability. Using state-of-the-art many-body green's function theory (MBGFT) simulations, we establish a band engineering framework through dimensional control, demonstrating that precise modulation of graphene and h-BN domain sizes enables continuous visible-spectrum band gap tuning for efficient hydrogen generation.

Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident cardiovascular disease in middle-aged and older Chinese adults: a nationwide cohort study.

Objective: This study aimed to explore the relationships between cumulative C-reactive protein-triglyceride-glucose index (cuCTI) and CTI changes and the risk of new-onset cardiovascular disease (CVD) in middle-aged and older Chinese individuals.

Methods: This longitudinal study employed data from the China Health and Retirement Longitudinal Study. To evaluate the association between the cuCTI index and CVD risk, we conducted Cox regression analyses alongside restricted cubic spline (RCS) regression models.

Comparison of the clinicians' and experts' assessments of rehabilitation service needs for patients in the middle of China.

Clinicians' assessments of patients' rehabilitation needs are crucial, as they directly influence the continuity of care. However, the ability of clinicians to accurately assess these needs remains unclear. The purpose of the study is to compare the assessments of rehabilitation service needs for patients made by clinicians and experts, and to examine any differences across various levels of healthcare institutions.

Factors Influencing Physicians' Referral Decision-Making for Rehabilitation Outpatient Services in the Health Care Landscape of China: Cross-Sectional Study.

Background: Stratified health care systems are used globally to optimize medical resource allocation and enhance patient care experiences. Although successfully implemented in countries like the United Kingdom, Australia, and Canada, China's introduction of stratified health care in 2015 has achieved progress in disease management but still faces challenges due to the lack of a comprehensive referral evaluation system and patients' preference for higher-tier medical institutions.

Objective: This study aims to investigate the factors influencing Chinese rehabilitation physicians' referral decisions for outpatient rehabilitation patients.

Investigation and insights into the technical strategies for reducing agrochemical inputs in rice farming to enhance agroecosystem resilience and food safety, A case study in China.

The growing demand for cereal production has led to increasing agrochemical inputs; therefore, evaluation and adjustment of current practices are required to maintain and improve sustainable cropping systems. A Four-years study of multiple practices with reduced agrochemical application for rice farming was conducted and investigated in southern China to assess impacts on food safety and ecological resilience. A 30 % reduction in total pesticide use resulted in a 20 % decrease in ecological risk to earthworms, primarily due to reduced application of key pesticides: pymetrozine, pretilachlor, difenoconazole, propiconazole, thifluzamide, tricyclazole, and hexaconazole.

A graph transformer-based foundation model for brain functional connectivity network.

Although foundation models have advanced many medical imaging fields, their absence in neuroimage analysis limits progress in neuroscience and clinical practice. Brain functional connectivity (FC) analysis is central to understanding brain function and widely used in neuroscience. We propose a foundation model tailored for brain functional connectivity networks (FCN).

Prognostic Factors and Survival Outcomes in Thyroid Cancer Patients With Bone Metastasis: Insights From a Population-Based Cohort Study.

Objectives: Thyroid cancer (TC) is the most common endocrine malignancy, and bone metastasis (BM) is the second most common type of metastasis after lung. BM is associated with a poor prognosis; however, relevant research remains limited. This study aims to evaluate the prognostic factors and survival outcomes in patients with thyroid cancer with bone metastasis (TCBM).

Efficacy and Safety of Bupivacaine Liposomal in Intercostal Nerve Block for Postoperative Pain Management Following Uniportal Thoracoscopy: A Randomized Trial.

Postoperative pain in thoracic surgery often requires opioids, yet can be poorly managed with short-acting anesthetics. Liposomal bupivacaine (LB) offers prolonged analgesia, potentially improving pain control and reducing opioid use. This study evaluates LB's effectiveness and safety in thoracic postoperative pain management, aiming to provide an alternative to current practices.

Revolutionizing the Female Reproductive System Research with Additive Manufacturing.

The female reproductive system is highly complex, making it essential for applied research and translational medicine to accurately model its intricate physiological functions or develop strategies for restoring them. However, significant structural and functional differences between human and animal models, along with the limitations of static 2D cell culture technologies, underscore the need for more dynamic and sophisticated platforms, as well as therapies. These advancements are critical for deepening our understanding of reproductive biology and supporting clinical applications.

[Analysis of Efficacy and Safety of Neoadjuvant Immunochemotherapy in Patients with Stage IB-IIIB Non-small Cell Lung Cancer].

Background: Neoadjuvant immunochemotherapy has emerged as an indispensable therapeutic modality for non-small cell lung cancer (NSCLC). However, its clinical application experience remains limited, and the associations between various clinical factors and treatment benefits remain undefined. This study aims to evaluate the efficacy and safety of neoadjuvant immunochemotherapy in patients with stage IB-IIIB NSCLC in a real-world setting, analyze survival outcomes among subgroups with diverse clinical characteristics, and identify potential clinical predictive factors for pathological response.

Real-world comparative effectiveness of angiotensin-neprilysin inhibition versus angiotensin receptor blockers in acute myocardial infarction.

Background: Angiotensin-neprilysin inhibition (ARNI) reduces mortality and morbidity in chronic heart failure, but its efficacy in acute myocardial infarction (MI) remains uncertain. This study compares ARNI versus angiotensin receptor blockers (ARB) in acute MI patients.

Methods And Results: This cohort study used a target trial emulation approach to include acute MI patients between 2019 and 2022 from the Tianjin Health and Medical Data Platform, China.

Mutualistic Multi-Network Noisy Label Learning (MMNNLL) Method and Its Application to Transdiagnostic Classification of Bipolar Disorder and Schizophrenia.

The subjective nature of diagnosing mental disorders complicates achieving accurate diagnoses. The complex relationship among disorders further exacerbates this issue, particularly in clinical practice where conditions like bipolar disorder (BP) and schizophrenia (SZ) can present similar clinical symptoms and cognitive impairments. To address these challenges, this paper proposes a mutualistic multi-network noisy label learning (MMNNLL) method, which aims to enhance diagnostic accuracy by leveraging neuroimaging data under the presence of potential clinical diagnosis bias or errors.

Comparative Analysis of the Feasibility Between Single-Channel Frontal Pole Flexible Electrode Sleep Patches and Polysomnography in Stroke Survivors.

Polysomnography (PSG), the gold standard for sleep monitoring, remains limited by its high cost and technical complexities in operation and data analysis. The flexible electrode sleep patch (FESP) is a novel wearable frontal single-channel EEG device for rapid sleep monitoring via FP1 and FP2 sites. Although preliminary studies support its reliability in healthy individuals, its feasibility for stroke patients remains unexplored.

Non-linear relationship between the hepatic steatosis index and glycemic progression: evidence from a large-scale retrospective cohort study in a Chinese population.

Background: The hepatic steatosis index (HSI) is a validated tool for assessing hepatic steatosis. While previous investigations have explored the link between HSI and prediabetes and diabetes, the connection between HSI and glycemic progression is still being explored. This research seeks to clarify the association between HSI and glycemic progression risk among a Chinese demographic.