Survival Analysis of Postoperative Adjuvant Chemotherapy for Stage IB Non-Small Cell Lung Cancer Based on Racial Stratification.

Background: The survival benefits of adjuvant chemotherapy for stage IB non-small cell lung cancer (NSCLC) remain controversial. The existing evidence is mostly based on the Caucasian population, especially the differences in efficacy among different races are not yet clear.

Method: Based on the data of patients with stage T2N0M0 NSCLC in the SEER database from 2010 to 2018 (n = 7458), they were divided into white people (6076 cases) and non-white people (1382 cases).

Direct Probing the Electrical Double Layer at Graphite/Nafion Interface via Depth Profiling APXPS.

Understanding the electrical double layer (EDL) is fundamental for enhancing the efficiency, capacity, and stability of electrochemical systems. The EDL at the electrode/polyelectrolyte interface exhibits significantly different properties with a more complex structure compared to liquid electrolyte systems. Characterizing this intricate interface experimentally remains a major challenge.

Sarcopenia index based on serum creatinine and cystatin C is associated with the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study.

Objective: The sarcopenia index (SI), calculated as the serum creatinine divided by the serum cystatin C, multiplied by 100, is recommended for predicting sarcopenia. However, limited evidence exists regarding its association with incident stroke. The aim of this study was to assess the relationship between SI and the risk of stroke in middle-aged and older adults.

Generation of More Potent Components at Higher Temperatures Offsets Toxicity Reduction despite Reduced Mass Emissions during Biomass Burning.

Biomass burning organic aerosols (BBOAs) represent a major global health hazard. Their toxicity varies significantly due to the diversity of combustion conditions, which shape mixtures of components with differing toxic potency. We quantified component-specific contributions to intracellular reactive oxygen species generation in human bronchial epithelial cells exposed to BBOAs produced under controlled combustion conditions.

Real time tire stiffness estimation using enhanced GDM and RLS for autonomous vehicles.

Yaw stability is essential for vehicle lateral control and is strongly influenced by the nonlinear dynamics of tire-road interaction. Tire Lateral Stiffness (TLS), a key parameter in this process, varies with tire properties and road conditions. Accurate TLS estimation is crucial for autonomous driving safety, especially during aggressive maneuvers or on low-friction surfaces.

Genome-wide selection signal analysis reveals copy number variation associated with litter size in Guizhou Black goat.

Introduction: Copy number variation (CNV) is a common form of genomic structural variation arising from genome sequence rearrangements, which primarily involves variations in the copy number of large genomic segments. This study focuses on performing selection signal analysis of CNVs to identify candidate loci and genes associated with litter size in Guizhou Black goat.

Methods: Sample selection: 30 Guizhou Black goats were divided into high-lambing and low-lambing groups based on their continuous lambing records.

Sex differences in the association between atherogenic index of plasma and progression from normoglycemia to prediabetes: evidence from a 5-year large-scale retrospective cohort study.

Objective: Currently, there is limited research on the relationship between the atherogenic index of plasma (AIP) and the risk of prediabetes (pre-DM). This study aims to explore the potential link between AIP and the risk of progression from normoglycemia to pre-DM.

Methods: In this retrospective cohort analysis, a total of 8,295 individuals receiving routine medical examinations at Kuichong People's Hospital in Shenzhen between January 2018 and December 2023 were enrolled.

Association between atherogenic index of plasma and risk of type 2 diabetes mellitus and the mediating effect of BMI: a comparative analysis in Chinese and Japanese populations.

Objective: The atherogenic index of plasma (AIP) has emerged as a promising predictor for type 2 diabetes mellitus (T2DM), but population-specific patterns and underlying mechanisms remain poorly understood. This study investigated the association between AIP and T2DM risk in Chinese and Japanese populations, focusing on non-linear relationships, population-specific thresholds, and the mediating role of body mass index (BMI).

Methods: We conducted a retrospective cohort study using data from the China Rich Healthcare Group (n = 112,483) and the Japanese NAGALA database (n = 15,453).

One-step engineered multifunctional gauze: On-demand antibiosis, accelerated hemostasis and angiogenesis for tissue regeneration.

Traditional cotton gauze remains a primary wound dressing for initial wound protection and exudate control. However, it lacks antibacterial property and fails to support angiogenesis and epithelial regeneration. To address these limitations, a one-step solvent-based strategy was developed to uniformly integrate ZIF-8 nanoparticles onto gauze with good interfacial stability.

Plumbene: A Comprehensive Review of Theoretical and Experimental Advances.

Plumbene, a two-dimensional (2D) material consisting of a single layer of lead (Pb) atoms in a honeycomb lattice, stands as a pioneering addition to the elemental 2D material family. This comprehensive review encapsulates the theoretical predictions and experimental advancements that underscore its potential. With properties shaped by significant spin-orbit coupling and structural buckling, plumbene offers a playground for phenomena like quantum spin Hall effect, superconductivity, and topological phase transition.

Treatment Trends of Diabetic Macular Edema in Korea (TRACK) study: A Prospective Multicenter Study.

Purpose: To evaluate real-world functional and anatomical outcomes, treatment patterns, and ocular examination trends in diabetic macular edema (DME) in Korea.

Methods: A prospective, multicenter, observational study was conducted at 17 hospitals (2017-2022) involving adults with DME. Patients were categorized into center-involving (CI DME) and non-center-involving (non-CI DME) groups based on optical coherence tomography findings.

A review of C/EBP α: a potential novel target for solid tumor intervention.

C/EBPα (CCAAT enhancer binding protein) is a pivotal transcription factor with widespread expression in multiple tissues, including hematopoietic tissues, liver, lungs, mammary glands, skin, and adipose tissue. It plays a significant role in the developmental regulation of these tissues. Previous research has primarily concentrated on C/EBPα's involvement in the hematological system, particularly its role in maintaining human hematopoietic stem cell homeostasis and regulating myeloid differentiation.

Correction: The efficacy and safety of intrathecal pemetrexed for leptomeningeal metastasis from non-small cell lung cancer: a single-arm meta-analysis of Chinese patients.

[This corrects the article DOI: 10.3389/fonc.2025.

Intrinsic Layer-Dependent Surface Energy and Exfoliation Energy of van der Waals Materials.

Stacking and twisting 2D van der Waals (vdW) layers have become versatile platforms to tune the electron correlation. These platforms rely on exfoliating vdW materials down to a single vdW layer and a few vdW layers. We calculate the intrinsic layer-dependent surface and exfoliation energies of typical vdW materials such as graphite, h-BN, black P, MX (M = Mo or W; X = S, Se, or Te), MX (M = Ga or In; X = S, Se, or Te), BiTe, and MnBiTe using density functional theory.

A small-molecule compound cocktail for tumor reprogramming therapy for breast cancer.

The emergence of lineage reprogramming technology has enabled us to reprogram terminally differentiated somatic cells into other lineages. Tumor cells can reduce malignancy and even restore the function of benign cells through reprogramming technology. Establishing a tumor reprogramming system to induce tumor cell fate transformation and reduce malignancy provides a new strategy for tumor treatment.

Early dynamic changes in platelet counts and 28-day mortality in sepsis patients: a retrospective cohort study using dynamic latent class model and generalized additive mixture model analysis.

Objective: This study investigates the relationship between early dynamic changes in platelet (PLT) counts and 28-day mortality in Chinese patients with sepsis, addressing the limitations of previous studies that focused on single baseline measurements.

Methods: In this retrospective cohort study, 266 sepsis patients admitted to Shenzhen Second People's Hospital from January 2023 to December 2024 were included. A dynamic latent class model analyzed the patterns of PLT count changes during the first week of hospitalization.

Diffusion-mediated passing of molecular species in linear nanopores constrained by orientational alignment.

For diffusion-mediated catalytic conversion reactions in materials with narrow linear nanopores, e.g., mesoporous silica MCM-41, a key parameter is the propensity for product species to be able to pass reactant species and thus to efficiently exit the pore.

A core-shell structured VEGF-SiO@ZnO nanorod array for enhancing osteogenesis performance of Zn-based implants.

Excessive Zn ions are released from Zn-based implants during their degradation, inducing cytotoxicity and thereby affecting early osteogenesis. To address this issue, a core-shell structured nanorod array with ZnO as the core and VEGF-loaded mesoporous SiO as the shell was constructed on a Zn-1Ca substrate using a hybrid process comprising hydrothermal treatment (HT), a sol-gel method and impregnation. ZnO formed HT could effectively protect the substrate from serious corrosion; mesoporous SiO further increased the anti-corrosion properties of the substrate and served as a carrier for vascular endothelial growth factor (VEGF).

Nonlinear association between gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio and risk of progression from normoglycemia to prediabetes: a 5-year cohort study.

Objective: Current research on the association between the Gamma-glutamyl transferase to high-density lipoprotein ratio (GHR) and the risk of prediabetes (pre-DM) remains scarce. This study aims to explore the potential link between GHR and the risk of progression from normoglycemia to pre-DM.

Methods: This retrospective cohort study included 8,168 individuals who voluntarily underwent health examinations at Shenzhen Dapeng New District Kuichong People's Hospital between January 2018 and December 2023.

"Sandwich" structured nanorods for timely antibiosis, immunoregulation and neuroangiogenesis to accelerate osteogenesis of Zn-based implants in diabetics.

Pathological microenvironment of diabetes predisposes to induce bacterial infection, sustained inflammatory response, and impaired neuroangiogenesis, impeding fracture repair. Zn-based implants have great potential to replace conventional Ti implants as temporary fixations, but their osseointegration ability needs improvement. In this work, "sandwich" structured nanorods were constructed on Zn substrate with ZnO nanorods as core, riboflavin-encapsulated ZIF-8 as intermediate layer and HA as outer shell.

Nanozyme Coating-Mediated Mitochondrial Metabolic Reprogramming of Macrophages for Immunomodulatory Osseointegration in Rheumatoid Arthritis Case.

Conventional titanium (Ti)-based implants often fail to achieve osseointegration in bone defects accompanied by rheumatoid arthritis (RA), primarily due to the RA pathological microenvironment, characterized by elevated reactive oxygen species (ROS) levels and hypoxia. This microenvironment induces mitochondria dysfunction and intracellular Ca overload, facilitating macrophage polarization toward the M1 phenotype and thus impairing osteoimmunomodulatory osseointegration. To address this challenge, a nanozyme-inspired coating, featuring the deposition of MnFeO nanoparticles onto a polydopamine (PDA)-decorated surface of microporous TiO, is constructed on Ti (known as MFO coating).

Limited benefit of adjuvant chemotherapy for Asian patients with stage IB lung adenocarcinoma: implications for clinical practice.

Backgroud: The benefit of adjuvant chemotherapy for patients with stage IB lung adenocarcinoma remains unclear. We compared adjuvant chemotherapy outcomes in Asian and non-Asian stage IB lung adenocarcinoma patients using multi-source clinical data.

Methods: Patients with stage IB lung adenocarcinoma from the 2004–2015 Surveillance, Epidemiology, and End Results (SEER) database and the 2020–2021 thoracic surgery department of three Chinese medical centers were included.

Integrated transcriptomic analysis unveils molecular mechanisms regulating meat quality in newly improved black goat breeds.

This study aimed to integrate transcriptomes to reveal the regulatory molecular mechanisms of meat quality in different black goat breeds. A comparison of Guizhou Black Goats (GBG♂, n = 7), Black Nubian Goats (NBG♂, n = 7), and their F1 hybrids (FBG♂, GB♀ × NB♂, n = 7) revealed that the FBG demonstrated notable improvements in meat quality parameters, muscle fiber traits, fatty acid and amino acid compositions, mineral content, intramuscular fat (IMF), and inosine monophosphate (IMP) levels. Moreover, transcriptome analysis identified 119, 77, and 82 differentially expressed genes (DEGs) in the GBG vs NBG, FBG vs GBG, and FBG vs NBG comparisons, respectively.

The efficacy and safety of intrathecal pemetrexed for leptomeningeal metastasis from non-small cell lung cancer: a single-arm meta-analysis of Chinese patients.

Objectives: The purpose of this meta-analysis is to evaluate the safety and effectiveness of intrathecal pemetrexed (IP) in patients with non-small cell lung cancer with leptomeningeal metastasis (NSCLC-LM).

Methods: A systematic search of PubMed, the Cochrane library, Embase, and ClinicalTrials.gov databases was executed until December 11, 2024.