Nonlinear Dose-Response of Cadmium on Drosophila Larval Locomotion: Machine Learning Decodes Behavioral Complexity.

The prevalent environmental contaminant cadmium threatens ecosystems, yet the lack of high-resolution behavioral kinematics hinders assessment of cadmium neurotoxicity in ecologically critical insect larvae. This study integrated machine learning-based trajectory tracking methodologies, to meticulously quantify dose-dependent effects of cadmium on the locomotion velocity, angular velocity, directional preference, and trajectory alterations, using Drosophila larvae as a model organism. Results demonstrated that cadmium exposure not only increased the larval movement speed and the proportion of active duration but also substantially diminished the angular velocity and the duration of high angular velocity.

One-step engineered multifunctional gauze: On-demand antibiosis, accelerated hemostasis and angiogenesis for tissue regeneration.

Traditional cotton gauze remains a primary wound dressing for initial wound protection and exudate control. However, it lacks antibacterial property and fails to support angiogenesis and epithelial regeneration. To address these limitations, a one-step solvent-based strategy was developed to uniformly integrate ZIF-8 nanoparticles onto gauze with good interfacial stability.

Association between hemoglobin glycation index and carotid plaques in non-dialysis CKD stage 3-5 patients: a retrospective cross-sectional study.

Purpose: Carotid atherosclerosis is a major cardiovascular complication in patients with chronic kidney disease (CKD). The hemoglobin glycation index (HGI) has been linked to glycation stress and vascular inflammation, which may contribute to atherosclerosis. However, its relationship with carotid plaque in patients with CKD remains unclear.

Enhanced global extreme droughts driven by the Indian Ocean and Pacific Ocean on decadal timescales.

In the 21st century, two record-breaking years of extreme drought coverage swept across the globe. These resulted in billions of agriculture losses and led to hunger and poverty in those developing countries. Recent decadal increasing extreme droughts are closely associated with the decadal modulated oscillation (DMO) signal, majorly in charge by the Indian Ocean Dipole (IOD) and Pacific Decadal Oscillation (PDO).

Single LED visible light positioning scheme based on intelligent reflecting surfaces.

Visible light positioning (VLP) systems have gained attention for their ability to operate without additional infrastructure. However, most positioning schemes rely on multiple LEDs, which presents a considerable challenge in scenarios where only a single-light-source is available. To address this issue, this work proposes using intelligent reflective surfaces (IRS) as virtual light sources for VLP.

Efficacy and Safety of Afatinib Plus Bevacizumab as First-Line Treatment for Advanced NSCLC Patients With Epidermal Growth Factor Receptor (EGFR) Mutations: A Multicenter, Phase II Trial.

Background: Studies indicated that afatinib combined with angiogenesis inhibitor may achieve promising efficacy in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations.

Methods: This is a multicenter, Phase II trial to explore the efficacy and safety of afatinib plus bevacizumab at first-line setting for EGFR-mutant NSCLC patients. The primary end point was progression-free survival (PFS).

CRISPR/Cas-Based Electrochemical Biosensor for Human Immunodeficiency Virus-1 Nucleic Acid Amplification-Free Detection to the Attomolar Level.

Aiming at realizing field detection during HIV-1 patient screening in developing countries and point of care testing (POCT) of virus levels in HIV-1 patients receiving medication, an urgent demand for portable nucleic acid detection technology with low cost and sensitivity is raised. To solve this, a CRISPR/Cas13a-based electrochemical detection platform by a multiple combined crRNAs strategy is developed. This sensing platform is based on the Ion Current Rectification regulation through a Porous Anodic Alumina membrane decorated with ssRNA chains, which are trans-cleavage substrates for activated Cas13a and become shorter when the target gene exists, resulting in an altered motion of transmembrane ions.

Common bias-digital subcarrier multiplexing scheme for integrated sensing and communication in short-reach optical transmission systems.

The integration of sensing and communication (ISAC) based on optical fibers has been a key enabling technique to achieve high-speed communication while ubiquitous sensing. In this paper, to ensure the coexistence of communication signal and sensing signal in low-cost optical access networks i.e.

Ultrasound-based radiomics combined with B3GALT4 level to predict sentinel lymph node metastasis in primary breast cancer.

Objective: To evaluate the value of the clinical model for predicting axillary lymph node metastasis (ALNM) of breast cancer before operation by integrating ultrasound (US) and β-1,3-galactosyltransferase-4 (B3GALT4) expression level of the primary tumor.

Methods: A total of 135 breast cancer patients who underwent US examination and axillary lymph nodes dissection (ALND) were enrolled. They were randomly divided into a training group (95 cases) and a verification group (40 cases).

Tetrandrine slows disease progression on high-resolution computed tomography and lung function decline in artificial stone-associated silicosis: a retrospective cohort study.

Background: Silicosis, a progressive fibrotic lung disease caused by silica dust inhalation, is a significant occupational health concern, particularly among artificial quartz stone workers. Tetrandrine, a bisbenzylisoquinoline alkaloid, is the only plant-derived drug approved for the treatment of silicosis in China. The present study aimed to evaluate the efficacy of tetrandrine in slowing the progression of artificial stone-associated silicosis.

Reuse oriented information analysis methodology study on information analysis componentization.

Nowadays, the trend of computerization in information analysis is becoming increasingly evident. However, with the development of computer technology, the engineering and reusability of information analysis work has not improved. To solve this problem, we propose the concept of componentization to guide information analysis.

scAGCI: an anchor graph-based method for cell clustering from integrated scRNA-seq and scATAC-seq data.

Single-cell multi-omics clustering confronts noise and heterogeneity barriers. Current multi-view anchor graph approaches, though successful in noise reduction, inadequately model higher order feature interactions. To address this issue, we propose scAGCI, a cell clustering method based on anchor graphs that integrates both scRNA-seq and scATAC-seq data.

Adaptively programmable metasurface for intelligent wireless communications in complex environments.

The programmable metasurface or reconfigurable intelligent surface is one of the emerging technologies for next-generation wireless communications, but the existing programmable metasurfaces still rely on human control to reshape the electromagnetic (EM) environment as desired. Here, we propose an adaptively programmable metasurface (APM), which integrates the capabilities of acquiring wireless environment information and manipulating the EM waves in programmable manners. APM can sense the complex EM field distributions around and dynamically manipulate the EM waves and signals in real time under the guidance of the sensed information, eliminating the need for prior knowledge or external input on the wireless environment.

Dual band bandpass filters with full band reflectionless response and enhanced upper stopband suppression.

This paper presents a novel dual-band bandpass filter (BPF) with two-port all-frequency reflectionless characteristics and enhanced upper-band suppression. The design integrates a square ring resonator (SRR) and advanced coupled lines (CLs), incorporating complementary absorptive branches to achieve broadband reflectionless performance. To mitigate upper-band harmonics, radial-stub-loaded resonators (RSLSs) with high-impedance transmission lines (HITLs) are introduced, extending suppression up to 10f without significantly increasing the circuit footprint.

β-hydroxybutyrate, a ketone body, suppresses tumor growth, stemness, and invasive phenotypes in non-small cell lung cancer.

Lung cancer is the most common cancer worldwide. The stemness and metastasis of tumor cells present major challenges to effective lung cancer treatment. Beta-hydroxybutyrate (BHB), a ketone body, plays a key role in various cancers.

sp. nov., a bacterium isolated from the gill homogenate of the mussel in a cold seep.

A novel Gram-negative, oxidase- and catalase-positive, rod-shaped bacterium, designated strain KX21116, was isolated from the mussel collected from a cold seep field in the South China Sea. Strain KX21116 grew optimally at 28 °C, pH 6.0 with 3% (w/v) NaCl, under aerobic and microaerobic conditions.

Non-linear associations between serum manganese with chronic kidney disease: results from two nationwide studies in the United States and China.

Introduction: This study aimed to better evaluate the association between serum manganese (Mn) and chronic kidney disease (CKD) by using data from the United States National Health and Nutrition Examination Survey (NHANES) and the Chinese Longitudinal Healthy Longevity Study (CLHLS).

Materials And Methods: A total of 15411 and 451 participants were selected from NHANES and CLHLS, respectively. The primary diagnosis of CKD was defined as eGFR <60 mL/min/1.

Tongue swab-based molecular diagnostics for pulmonary tuberculosis and drug resistance in adults: A prospective multicenter diagnostic accuracy study.

Background: Tongue swabs have emerged as a promising non-invasive alternative for TB diagnosis. This study aimed to evaluate the diagnostic performance of tongue swab-based assays for detecting Mycobacterium tuberculosis (MTB) and anti-TB drug resistance.

Methods: We conducted a multicenter study in five TB-designated hospitals in China from May to August 2024.

Coenzyme Q10 supplementation in adult-onset focal segmental glomerulosclerosis caused by the Chinese common pathogenic variant c.737G > A (p.Ser246Asn) in the gene.

COQ8B nephropathy, a mitochondrial disorder caused by mutations in the gene, is a major pediatric genetic focal segmental glomerulosclerosis (GFSGS) etiology and stands out as one of the few treatable forms with good response to coenzyme Q10 (CoQ) supplementation. As the diagnosis and clinical experience of COQ8B nephropathy were predominantly in the pediatric population, the long-term efficacy of CoQ supplementation and its application in the adult-onset patients remains largely unknown. Here, we report three cases of adult-onset FSGS from unrelated families, all carrying the Chinese common  mutation (c.

Design of a miniaturized terahertz traveling wave tube with embedded single-walled carbon nanotubes cold cathode.

In this paper, a miniaturized terahertz traveling wave tube (TWT) based on the embedded single-walled carbon nanotubes (SWCNTs) cold cathode electron source is studied. The cold cathode suitable for the terahertz TWT requires stable high emission current density and enhanced electron beam focusing performance due to the small size of the electron beam tunnel and the long beam-wave interaction length of the terahertz TWT. Firstly, a stable SWCNTs cold cathode is fabricated by an improved screen-printing method, which achieves a low turn-on field of 0.

Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway.

Background: Ischemia-reperfusion injury (IRI) is the primary cause of acute kidney injury (AKI), which can result in chronic kidney disease (CKD) with renal fibrosis. Magnesium lithospermate B (Mlb), a bioactive compound produced from Salvia miltiorrhiza Bunge, exerts nephroprotective effects against AKI. However, the significance of Mlb in the evolution of IRI-induced AKI in patients with CKD remains unclear.