Analysis of risk factors for tubular atrophy/interstitial fibrosis in primary membranous nephropathy.

Tubular atrophy/interstitial fibrosis (TA/IF) is a pathology that can occur in nearly all chronic kidney diseases. However, few studies have investigated the risk factors for the development of TA/IF in patients with primary membranous nephropathy (PMN) during the normal renal function stage have been carried out. This study investigates the risk factors for the development of TA/IF in PMN with normal glomerular filtration rate.

Tissue-Specific Co-Expression Patterns of BAF Complexes Provide Regulatory Insights Across Human Tissues with Implications for Endocrine and Non-Endocrine Functions.

BRG1/BRM-associated factor (BAF) chromatin remodeling complexes are essential for normal endocrine function and are implicated in various metabolic and developmental disorders. However, the full range of chromatin-based regulatory modules in endocrine development remains unclear. We developed a computational pipeline to analyze bulk RNA-seq data from 54 human tissues and constructed tissue-specific co-expression networks for 30 core BAF complex genes.

AI aversion or appreciation? A capability-personalization framework and a meta-analytic review.

Artificial intelligence (AI) is transforming human life. While some studies find that people prefer humans over AI (AI aversion), others find the opposite (AI appreciation). To reconcile these conflicting findings, we introduce the Capability-Personalization Framework.

Tying the Knot for Parents: How Adult Children's Marital Choices Impact Parental Depression in China.

Background And Objectives: This study aims to examine the causal effect of adult children's marital status on parental depressive symptoms in the Chinese context, and whether parents' demographic characteristics play a role in the association.

Research Design And Methods: We utilized the 5 waves of China Health and Retirement Longitudinal Study spanning over 9 years. The participants were categorized into 3 distinct groups: (1) the individuals with at least 1 divorced adult child; (2) those with at least 1 unmarried child aged 30 or older; and(3) a reference group consisting of those not meeting criteria for the first 2 categories.

Tongue swab-based molecular diagnostics for pulmonary tuberculosis and drug resistance in adults: A prospective multicenter diagnostic accuracy study.

Background: Tongue swabs have emerged as a promising non-invasive alternative for TB diagnosis. This study aimed to evaluate the diagnostic performance of tongue swab-based assays for detecting Mycobacterium tuberculosis (MTB) and anti-TB drug resistance.

Methods: We conducted a multicenter study in five TB-designated hospitals in China from May to August 2024.

An entire-process MaxEnt framework for habitat suitability modeling on Google Earth Engine: A case study of the oriental white stork in eastern mainland China.

The MaxEnt model is a probabilistic statistical model based on the principle of maximum entropy. It can predict species' suitable habitats with limited species distribution data while maintaining high accuracy, making it widely used for extracting potentially suitable habitats for species. Although the model has been integrated into the Google Earth Engine (GEE) platform, few studies have explored its entire process simulation of species' suitable habitats at large spatial scales.

Investigation of hydrolysis of olmesartan medoxomil in different pH buffers by simultaneously measuring olmesartan medoxomil and olmesartan.

Olmesartan medoxomil (OLM) is an ester prodrug of olmesartan (OL) developed to overcome the poor permeability of OL. OLM is an angiotensin receptor blocker and is commonly used to treat hypertension. However, OLM has low water solubility and low bioavailability of 26%.

An enhanced model for accumulated CO2 concentration in closed Escherichia coli fermenters.

Microbial growth kinetics models like Logistic and Gompertz quantitatively depict growth and are used in linear detection methods, but they have limitations in analyzing continuously accumulated growth products. This study combines the Logistic growth kinetics model with the Luedeking-Piret product synthesis model to accurately track the accumulated CO2 concentration in a closed Escherichia coli (E. coli) fermentation system.

5-hydroxymethylcytosine sequencing of plasma cell-free DNA identifies epigenomic features in prostate cancer patients receiving androgen deprivation therapies.

Background: We evaluated whether 5hmC signatures in cell-free DNA (cfDNA) are associated with treatment failure to androgen-deprivation therapies (ADT) among men with hormone-naive prostate cancer.

Methods: We collected a total of 139 serial plasma samples from 55 prostate cancer patients receiving ADT at 3 time points including baseline (before initiating ADT, n = 55); 3 months (after initiating ADT, n = 55); and disease progression (n = 15) within 24 months or 24 months if no progression was detected (n = 14). We used selective chemical labeling sequencing to quantify 5hmC abundance across the genome and Kaplan-Meier analysis to assess survival association.

Are there differences in overall survival among older breast cancer patients by race and ethnicity?

Background: Non-Hispanic Black women have lower breast cancer incidence but twice the mortality of non-Hispanic White women. Recent data suggest that the overall survival difference may not be observed in older women. This study aims to determine overall survival in women aged ≥70 years with operable breast cancer by race and ethnicity and factors contributing to overall survival.

Nursing bibliometric analysis of wound infections.

Background: This paper aims to perform a bibliometric analysis of research pertaining to the nursing care of infected wounds. It also aims to examine the current focal points and trends in research development. The paper offers research references that may be useful for practitioners interested in related areas.

EZH2-H3K27me3-Mediated Epigenetic Silencing of DKK1 Induces Nucleus Pulposus Cell Pyroptosis in Intervertebral Disc Degeneration by Activating NLRP3 and NAIP/NLRC4.

Nucleus pulposus (NP) cell pyroptosis is crucial for intervertebral disc degeneration (IDD). However, the precise mechanisms underlying pyroptosis in IDD remain elusive. Therefore, this study aimed to investigate how dickkopf-1 (DKK1) influences NP cell pyroptosis and delineate the regulatory mechanisms of IDD.

Exploring novel type of lipid-bases drug delivery systems that contain one lipid and one water-soluble surfactant only.

None of transitional lipid-based drug delivery systems (LBDDS) includes compositions containing one lipid and one water-soluble surfactant that form stable microemulsions. The conversion of liquid LBDDS to solid LBDDS has been limited by low drug loading. Previously, we have developed drug solid microemulsions containing one lipid and TPGS (a water-soluble surfactant) that achieved high drug loading and remarkably increased oral bioavailability.

Maximum tolerated dose and toxicity evaluation of orally administered docetaxel granule in mice.

Oral delivery of chemotherapy drugs is the most favorable and preferred route of drug administration. However, because of poor solubility and/or permeability, most chemotherapy drugs are given by intravenous administration. Docetaxel (DTX) is a potent chemotherapy drug that inhibits microtubular depolymerization and is widely used to treat numerous cancers.

Refining quinoa storage stability through microwave-induced structural alterations and activity suppression of key enzymes.

This study investigated the effects of microwave on preserving the quality of quinoa during storage. Quinoa treated with 9W/60s exhibited a significant decrease in fatty acid values compared to hot air treatment. Microwave effectively delayed lipid oxidation during quinoa storage by suppressing the increase in peroxide values.

Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway.

Background: Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in the treatment of osteosarcoma (OS) and to investigate the underlying mechanisms, particularly focusing on mitophagy.

Methods: The effects of SI on the proliferation, apoptosis, migration, and invasion of U2OS cells were analyzed.

The Development of Lipid-Based Sorafenib Granules to Enhance the Oral Absorption of Sorafenib.

Sorafenib (SFN) is an anticancer multi-kinase inhibitor with great therapeutic potential. However, SFN has low aqueous solubility, which limits its oral absorption. Lipids and surfactants have the potential to improve the solubility of water-insoluble drugs.

Roles of rRNA N-methyladenosine modification in the function of ribosomes.

The N-methyladenosine (m6A) modification of ribosomal RNA (rRNA) plays critical roles in regulating the function of ribosomes, the essential molecular machines that translate genetic information from mRNA into proteins. Specifically, m6A modification affects ribosome biogenesis, stability, and function by regulating the processing and maturation of rRNA, the assembly and composition of ribosomes, and the accuracy and efficiency of translation. Furthermore, m6A modification allows for dynamic regulation of translation in response to environmental and cellular signals.

Prevalence and clinico-genomic characteristics of patients with TRK fusion cancer in China.

Neurotrophic tyrosine kinase (NTRK) fusions involving NTRK1, NTRK2, and NTRK3 were found in a broad range of solid tumors as driver gene variants. However, the prevalence of NTRK fusions in Chinese solid tumor patients is rarely reported. Based on the next-generation sequencing data from 10,194 Chinese solid tumor patients, we identified approximately 0.

High-speed counter-current chromatography assisted preparative isolation of phenolic compounds from the flowers of Chrysanthemum morifolium cv. Fubaiju.

Chrysanthemum morifolium cv. Fubaiju is rich in phenolic compounds with various benefits such as anti-inflammatory, antioxidant, and cardiovascular protection. In this study, 12 phenolic compounds, including five flavonoid glycosides and seven quinic acid derivatives, were successfully separated from the flowers of Chrysanthemum morifolium cv.