Intrinsically Temperature-Insensitive and Highly Sensitive Flexible Wireless Strain Sensor.

Accurate strain monitoring in environments with coexisting mechanical deformation and temperature fluctuations─such as solid rocket propellants, battery enclosures, and human ligaments─remains a longstanding challenge for flexible electronics. Conventional strain sensors suffer from significant thermal drift due to the intrinsic temperature dependence of their sensing materials, limiting their reliability in wireless and implantable applications. Here, we report an intrinsically temperature-insensitive, highly sensitive, wireless flexible strain sensor based on near-field communication technology.

Large-sized polystyrene microplastics induce oxidative stress in AML12 cells.

Microplastics (MPs), particularly those exceeding 20 μm in diameter, are increasingly detected in environment and animal tissues, yet their cytotoxicity remains poorly understood. While existing studies focused on MPs with relatively small sizes (≤ 20 μm) or nanoplastics (NPs), the biological impacts of large-sized MPs and amino-modified MPs are underexplored. In this study, we investigated the oxidative stress (OS)-mediated responses of alpha mouse liver 12 (AML12) cells to 50 μm polystyrene MPs (PS-MPs) and polystyrene-amine modified MPs (PS-NH-MPs) at concentrations of 0, 0.

Angle Estimation for Range-Spread Targets Based on Scatterer Energy Focusing.

Wideband radar is becoming increasingly significant in modern radar systems. However, traditional monopulse angle estimation techniques are not suitable for wideband targets exhibiting range extension effects. To address this, we explore the angle estimation problem for wideband Linear Frequency-Modulated (LFM) signals and propose a new monopulse angle estimation algorithm tailored for range-spread targets.

Microplastics in the Amur tiger's habitat: Occurrence, characteristics, and risk assessment.

Microplastics (MPs) are emerging environmental pollutants that pose a significant threat to wildlife within forest ecosystems. However, the quantity and types of MPs in wildlife forest habitats remain unclear. This study is the first to assess the distribution of MPs in the Amur tiger habitat of northeast China.

A bibliometric analysis of the top 100 most cited articles on corticospinal tract regeneration from 2004 to 2024.

Objective: Here, bibliometric and visual analytical techniques were employed to assess the key features of the 100 most cited publications concerning corticospinal tract (CST) regeneration.

Methods: Research was conducted within the Web of Science Core Collection to pinpoint the 100 most cited publications on CST regeneration. From these, comprehensive data encompassing titles, authorship, key terms, publication venues, release timelines, geographic origins, and institutional affiliations were extracted, followed by an in-depth bibliometric examination.

[Characteristics of Nitrogen Cycle-related Bacterial Community and Its Response to Soil in the Main Lead-zinc Mine Reclamation Area of Lanping].

The nitrogen cycle has an important impact on the element cycle of the soil ecosystem. Moreover, it is important to clarify the key environmental factors of nitrogen cycle microorganisms for ecological restoration in mining areas. The functional flora can regulate the growth of vegetation by participating in the biogeochemical cycle of soil elements in the mining area, which is beneficial to the reclamation of the mining area.

Impact of Abiotic Stress on Rice and the Role of DNA Methylation in Stress Response Mechanisms.

With the intensification of global climate change and the increasing complexity of agricultural environments, the improvement of rice stress tolerance is an important focus of current breeding research. This review summarizes the current knowledge on the impact of various abiotic stresses on rice and the associated epigenetic responses (DNA methylation). Abiotic stress factors, including high temperature, drought, cold, heavy metal pollution, and high salinity, have a negative impact on crop productivity.

Interactions between microplastics and heavy metals in leachate: Implications for landfill stabilization process.

The emission of microplastics and heavy metals in landfills has attracted widespread attention for its stabilization process. Microplastics have become carriers of heavy metals due to their adsorption properties, affecting their environmental behavior. However, the effects of landfill stabilization on the interaction between microplastics and heavy metals in leachate are ambiguous.

Molecular characterization on the fractionation of organic phosphorus induced by iron oxide adsorption using ESI-FT-ICR MS.

The interaction between organic phosphorus (OP) and iron oxide significantly influences the phosphorus cycle in the natural environment. In shallow lakes, intense oxidation-reduction fluctuations constantly alter the existing form of iron oxides, but little is known about their impact on the adsorption and fractionation of OP molecules. In this study, electrospray ionization coupled with Fourier transform ion cyclotron resonance mass spectrometry (ESI-FT-ICR MS) was used to investigate the fractionation of OP from alkali-extracted sediment induced by crystalline goethite and amorphous ferrihydrite adsorption at a molecular scale.

Pan-cancer analysis for the prognostic and immunological role of CD47: interact with TNFRSF9 inducing CD8 + T cell exhaustion.

Purpose: The research endeavors to explore the implications of CD47 in cancer immunotherapy effectiveness. Specifically, there is a gap in comprehending the influence of CD47 on the tumor immune microenvironment, particularly in relation to CD8 + T cells. Our study aims to elucidate the prognostic and immunological relevance of CD47 to enhance insights into its prospective utilities in immunotherapeutic interventions.

Roles of rRNA N-methyladenosine modification in the function of ribosomes.

The N-methyladenosine (m6A) modification of ribosomal RNA (rRNA) plays critical roles in regulating the function of ribosomes, the essential molecular machines that translate genetic information from mRNA into proteins. Specifically, m6A modification affects ribosome biogenesis, stability, and function by regulating the processing and maturation of rRNA, the assembly and composition of ribosomes, and the accuracy and efficiency of translation. Furthermore, m6A modification allows for dynamic regulation of translation in response to environmental and cellular signals.

Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis.

Aspirin and its active metabolite salicylate have emerged as promising agents for the chemoprevention of colorectal cancer (CRC). Moreover, aspirin suppresses the progression of established CRCs. However, the underlying molecular mechanisms are not completely understood.

Investigation of phytoplankton community structure and formation mechanism: a case study of Lake Longhu in Jinjiang.

In order to explore the species composition, spatial distribution and relationship between the phytoplankton community and environmental factors in Lake Longhu, the phytoplankton community structures and environmental factors were investigated in July 2020. Clustering analysis (CA) and analysis of similarities (ANOSIM) were used to identify differences in phytoplankton community composition. Generalized additive model (GAM) and variance partitioning analysis (VPA) were further analyzed the contribution of spatial distribution and environmental factors in phytoplankton community composition.

Pretreatment radiomic biomarker for immunotherapy responder prediction in stage IB-IV NSCLC (LCDigital-IO Study): a multicenter retrospective study.

Background: The predictive efficacy of current biomarker of immune checkpoint inhibitors (ICIs) is not sufficient. This study investigated the causality between radiomic biomarkers and immunotherapy response status in patients with stage IB-IV non-small cell lung cancer (NSCLC), including its biological context for ICIs treatment response prediction.

Methods: CT images from 319 patients with pretreatment NSCLC receiving immunotherapy between January 2015 and November 2021 were retrospectively collected and composed a discovery (n=214), independent validation (n=54), and external test cohort (n=51).

CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34.

The miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription factor, and presumably mediate part of the tumor suppressive effects of p53. Here, we sought to determine their functional relevance by inactivating miR-34a and/or miR-34b/c using a CRISPR/Cas9 approach in the colorectal cancer (CRC) cell line HCT116. Concomitant deletion of miR-34a and miR-34b/c resulted in significantly reduced suppression of proliferation after p53 activation, enhanced migration, invasion and EMT, as well as reduced sensitivity to chemotherapeutics, increased stress-induced autophagic flux, decreased apoptosis and upregulation of autophagy-related genes after 5-FU treatment.

Development of Wide-Angle Depolarizing Reflector at 1064 nm.

Optical coherence tomography is a new promising chromatographic imaging technique with the advantages of noncontact and high resolution without damage, which is widely used in the field of biological tissue detection and imaging. As an important optical element in the system, the wide-angle depolarizing reflector plays a key role in the accurate acquisition of optical signals. TaO and SiO are selected as the coating materials for the technical parameter requirements of the reflector in the system.

Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis.

Curcumin, a natural phytochemical isolated from tumeric roots, represents a candidate for prevention and therapy of colorectal cancer/CRC. However, the exact mechanism of action and the downstream mediators of curcumin's tumor suppressive effects have remained largely unknown. Here we used a genetic approach to determine the role of the p53/miR-34 pathway as mediator of the effects of curcumin.

Development of a Genetically Encoded Magnetic Platform in Magnetospirillum gryphiswaldense MSR-1 for Downstream Processing of Protein Expression System.

Background: Protein downstream processing remains a challenge in protein production, especially in low yields of products, in spite of ensuring effective disruption of cell and separation of target proteins. It is complicated, expensive and time-consuming. Here, we report a novel nano-bio-purification system for producing recombinant proteins of interest with automatic purification from engineered bacteria.

Meta-analysis of miR-34 target mRNAs using an integrative online application.

Members of the microRNA-34/miR-34 family are induced by the p53 tumor suppressor and themselves possess tumor suppressive properties, as they inhibit the translation of mRNAs that encode proteins involved in processes, such as proliferation, migration, invasion, and metastasis. Here we performed a comprehensive integrative meta-analysis of multiple computational and experimental miR-34 related datasets and developed tools to identify and characterize novel miR-34 targets. A miR-34 target probability score was generated for every mRNA to estimate the likelihood of representing a miR-34 target.

Preparation of Nanofiber Bundles via Electrospinning Immiscible Polymer Blend for Oil/Water Separation and Air Filtration.

Nanofiber bundles with specific areas bring a new opportunity for selective adsorption and oil/water or air separation. In this work, nanofiber bundles were prepared by the electrospinning of immiscible polystyrene (PS)/N-trifluoroacetylated polyamide 6 (PA6-TFAA) blends via the introduction of carbon nanotubes (CNTs) or a copolymer of styrene and 3-isopropenyl-α, α'-dimethylbenzene isocyanate (TMI), which was denoted as PS-co-TMI. Herein, CNT was used to increase the conductivity of the precursor for enhancing the stretch of PS droplets under the same electric field, and PS-co-TMI was used as a reactive compatibilizer to improve the compatibility of a PS/PA6-TFAA blend system for promoting the deformation.

Transcriptional expressions of hsa-mir-183 predicted target genes as independent indicators for prognosis in bladder urothelial carcinoma.

Objective: To uncover novel prognostic and therapeutic targets for BLCA, our study is the first to investigate the role of hsa-mir-183 and its up-regulated predicted target genes in bladder urothelial carcinoma.

Methods: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, TIMER2.0, cBioPortal and Genomics of Drug Sensitivity in Cancer databases.

Long non-coding RNA H19 confers resistance to gefitinib via miR-148b-3p/DDAH1 axis in lung adenocarcinoma.

Epidermal growth factor receptor tyrosine kinase inhibitors therapy, such as gefitinib, have proven to be effective for lung adenocarcinoma with epidermal growth factor receptor-sensitive mutations. However, drug resistance remains inevitable and the underlying mechanisms are still elusive and poorly understood. In order to explore the mechanisms underlying tyrosine kinase inhibitors resistance, we used long non-coding RNA microarray analysis and found that long non-coding RNA H19 was highly expressed in gefitinib-resistant cell lines.

[Expression of MiR-148b-3p in Lung Adenocarcinoma and Its Correlation with Prognosis].

Background: MiR-148b-3p is an important microRNA that has been reported to be significantly related to various types of cancer, but its role in lung adenocarcinoma remains elusive. The purpose of this study is to detect the expression level of miR-148b-3p in lung adenocarcinoma specimens, and to analyze its correlation with the clinicopathological features as well as the prognosis of patients with lung adenocarcinoma.

Methods: A total of 123 tumor specimens from lung adenocarcinoma patients who underwent surgical resection in our department from January 2011 to December 2012 were collected.