Intrinsically Temperature-Insensitive and Highly Sensitive Flexible Wireless Strain Sensor.

Accurate strain monitoring in environments with coexisting mechanical deformation and temperature fluctuations─such as solid rocket propellants, battery enclosures, and human ligaments─remains a longstanding challenge for flexible electronics. Conventional strain sensors suffer from significant thermal drift due to the intrinsic temperature dependence of their sensing materials, limiting their reliability in wireless and implantable applications. Here, we report an intrinsically temperature-insensitive, highly sensitive, wireless flexible strain sensor based on near-field communication technology.

The morphology, genetic structure, and haplotype distribution of the invasive freshwater snails Biomphalaria straminea and Physa acuta in Guangdong, China.

Background: Biomphalaria and Physa (order Gastropoda) serve as vectors and reservoirs for infectious agents that affect both humans and animals. This study provides updated insights into the epidemiology, morphology, phylogeny, and haplotype diversity of Biomphalaria and Physa snails in Guangdong Province, southern China.

Methods: Field surveys were conducted across Guangdong Province from 2016 to 2023.

Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection.

Background: Schistosomiasis, a parasitic disease affecting more than 240 million people worldwide, is characterized by chronic inflammation and tissue fibrosis primarily induced by parasite egg deposition. Bromodomain-containing protein 4 (BRD4), an epigenetic and transcriptional regulator, has emerged as a potential therapeutic target due to its dual role in modulating Schistosoma japonicum (S. japonicum) reproductive development and organ fibrosis.

Identification of key genes regulating brown adipose tissue thermogenesis in goat kids () by using weighted gene co-expression network analysis.

Brown adipose tissue (BAT) is crucial for the maintenance of body temperature in newborn animals through non-shivering thermogenesis (NST). However, which kind key genes involved in the regulation of BAT thermogenesis and the internal regulation mechanism of heat production in goat BAT were still unclear. In this study, we analyzed the perirenal adipose tissue transcriptome of Dazu black goats from 0, 7, 14, 21 and 28 days after birth using weighted gene co-expression network analysis (WGCNA) to identify key genes involved in the thermogenesis of BAT.

Metabolomics, E-tongue and HS-SPME-GC-MS reveal the smoking process of Prunus mume: Changes in flavor and chemical compositions.

Smoked Prunus mume (SPM), known as Wumei, experiences remarkable alterations in flavor and chemical composition. However, no research has reported on the smoking process. In this study, the changes of flavor and chemical compositions were analyzed via E-tongue, metabolomics, and HS-SPME-GC-MS during the smoking process.

Periplakin Attenuates Liver Fibrosis via Reprogramming CD44 Cells into CD44 Liver Progenitor Cells.

Background & Aims: Liver progenitor cells (LPCs) contribute significantly to the restoration of injured liver parenchyma and promote liver regeneration, thereby ameliorating liver fibrosis. However, the mechanism of the derivation of LPCs remains poorly understood.

Methods: We first examined the expression of periplakin (PPL) in patients and mouse models with liver fibrosis.

Evaluation of Enrichment Approaches for the Study of the Viromes in Mollusk Species.

Invasive alien species such as freshwater snails have significantly affected the food, environment, and the health of humans and animals, which have unfortunately received insufficient attention. To facilitate the study of viromes in snail species, we compared the enrichment effect of cesium chloride (CsCl) and sucrose density gradient ultracentrifugations in the recovery of diverse viruses in Pomacea canaliculata and Achatina fulica. First, we showed that CsCl-based ultracentrifugation enriched more virus contigs and reduced the nucleic acid background of the Pomacea canaliculata and was thus beneficial for virus recovery.

Ultrasonic-Assisted Extraction of Phenolic Compounds from Flowers at Three Harvest Periods: Comparison of Composition, Characterization, and Antioxidant Activity.

Hemsl. () is a promising industrial crop with flowers rich in phenolic compounds. In this study, an ultrasound-assisted extraction (UAE) was designed to extract phenolic compounds from flowers (LSFs).

Extraction Optimization of Phenolic Compounds from Leaves: Identification, Characterization and Antioxidant Activity.

() has attracted much attention because of the high oil content in its seeds, but there are few systematic studies on the phenolic compounds of leaves (TSP). In this study, the extraction process of TSP was optimized by response surface methodology. The phenolic components of these extracts were analyzed by high-performance liquid chromatography (HPLC).

Randomized Controlled Trial of Awake Transnasal Laser-Assisted Surgery for Benign Laryngeal Lesions.

Objective: To compare functional and cost-effectiveness of awake transnasal laser assisted-surgery versus microlaryngeal surgery for benign laryngeal lesions.

Methods: This was a prospective non-inferiority randomized controlled trial conducted from May 2021 to December 2022 at two tertiary referral hospitals in Hong Kong. Patients were block-randomized to receive either awake transnasal laser-assisted surgery or microlaryngeal surgery, with post-operative follow-up in a multidisciplinary voice clinic for 1-year.

The transplant rejection response involves neutrophil and macrophage adhesion-mediated trogocytosis and is regulated by NFATc3.

The anti-foreign tissue (transplant rejection) response, mediated by the immune system, has been the biggest obstacle to successful organ transplantation. There are still many enigmas regarding this process and some aspects of the underlying mechanisms driving the immune response against foreign tissues remain poorly understood. Here, we found that a large number of neutrophils and macrophages were attached to the graft during skin transplantation.

Nitric oxide-induced endoplasmic reticulum stress of Schistosoma japonicum inhibits the worm development in rats.

Schistosomiasis, caused by Schistosoma spp., is a zoonotic parasitic disease affecting human health. Rattus norvegicus (rats) are a non-permissive host of Schistosoma, in which the worms cannot mature and cause typical egg granuloma.

Applying Computer-Based Language Test to Young Children.

Introduction: This study aimed at exploring the feasibility of applying a computer-based language test to young children aged 2-4 years.

Methods: Thirty-two Cantonese-speaking children, aged 2-4 years, were recruited from local kindergartens. All participants underwent an assessment using both the computer-based and paper-pencil versions of the Macau Cantonese Language Screening Scale for Preschool Children, following a crossover study design.

Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis.

Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in host preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus fortis, exhibits natural anti-schistosome characteristics. The mechanisms of host susceptibility remain poorly understood.

Feasibility and self-perceived effectiveness of an online training program on dysphagia in residential aged care homes in mainland China.

Background: With a rapidly aging population in mainland China, dysphagia has become one of the common geriatric disorders which creates a huge demand on speech and language therapists (SLTs). The major challenge is the shortage of SLTs in China. In addition, frontline practitioners in mainland China may not be well equipped with the knowledge and practical skills in dysphagia management due to lack of systematic training and the work nature.

CRISPR/Cas9-mediated gene knockout of Sj16 in Schistosoma japonicum eggs upregulates the host-to-egg immune response.

Schistosomiasis is an important, neglected tropical disease. Schistosoma japonicum can evade host attacks by regulating the host's immunity, causing continuous infection. However, interactions between the host's immune system and S.

Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis.

Trogocytosis occurs when one cell contacts and quickly nibbles another cell and is characterized by contact between living cells and rapid transfer of membrane fragments with functional integrity. Many immune cells are involved in this process, such as T cells, B cells, NK cells, APCs. The transferred membrane molecules including MHC molecules, costimulatory molecules, receptors, antigens, etc.

Recombinant protein -derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis.

Background: Inflammatory bowel disease (IBD) affects millions of people worldwide and has emerged as a growing problem in industrialized nations. The lack of therapeutic targets has limited the treatment of IBD. Studies found that parasitic nematode infections can ameliorate clinical and experimental colitis.

Effect of organic loading rate on dark fermentative hydrogen production in the continuous stirred tank reactor and continuous mixed immobilized sludge reactor from waste pastry hydrolysate.

Waste pastry (6%, w/v) was hydrolyzed by the produced glucoamylase and protease to obtain the glucose (19.8g/L) and free amino nitrogen (179mg/L) solution. Then, the effect of organic loading rate (OLR) (8-40kgCOD/(md)) on dark fermentative hydrogen production in the continuous stirred tank reactor (CSTR) and continuous mixed immobilized sludge reactor (CMISR) from waste pastry hydrolysate was investigated and compared.

Biohydrogen production in the suspended and attached microbial growth systems from waste pastry hydrolysate.

Waste pastry was hydrolyzed by glucoamylase and protease which were obtained from solid state fermentation of Aspergillus awamori and Aspergillus oryzae to produce waste pastry hydrolysate. Then, the effects of hydraulic retention times (HRTs) (4-12h) on hydrogen production rate (HPR) in the suspended microbial growth system (continuous stirred tank reactor, CSTR) and attached microbial growth system (continuous mixed immobilized sludge reactor, CMISR) from waste pastry hydrolysate were investigated. The maximum HPRs of CSTR (201.