lncRNA EBLN3P Promotes Proliferation, Metastasis and Stemness of Gastric Cancer Cells via miR-141-3p/HMGCS1.

Long non-coding RNAs (lncRNAs) have become an essential factor in gastric cancer (GC) initiation and metastasis. This study is aimed to uncover the functional significance of EBLN3P in GC. In GC, EBLN3P and HMGCS1 was significantly increased.

A plasmonic meta-rotary travelling-wave oscillator with ultrahigh phase accuracy and figure of merit.

High phase accuracy and figure of merit (FOM) of quadrature signals are essential for integrated systems, including quadrature amplitude modulation (QAM) communications and multi-input multi-output (MIMO) radar. However, the traditional quadrature oscillators often struggle to meet the stringent requirements of high FOM and high quadrature phase accuracy simultaneously. To address this challenge, we propose a spoof surface plasmon polariton (SPP) metawaveguide (Meta) to design on-chip rotary traveling-wave oscillator (RTWO).

Why patients say no: Patient barriers to epilepsy surgery among patients with drug-resistant epilepsy in Singapore.

Objective: Epilepsy surgery is globally underutilized due to disease-, system-, and patient-related barriers. These barriers are suboptimally understood in Asia. Patient-related barriers are of particular interest because they are culture-specific and may present a significant obstacle regardless of resource availability.

Insulin-like growth factor-neutralizing antibodies for cancer therapy.

The insulin-like growth factor (IGF) axis is crucial for regulating cell growth, survival, and differentiation. While therapies targeting the IGF-1 receptor (IGF-1R) have shown limited clinical success as single agents, the abnormal expression of its ligands, IGF-I and IGF-II, has been shown to contribute significantly to resistance against IGF-1R-targeted treatments. This review explores recent advancements in neutralizing antibodies against IGF-I and/or IGF-II, including monoclonal antibody, bispecific antibodies and engineered antibody domains.

Root exudates mediate tobacco microbial community remodeling and resistance to bacterial wilt disease.

Background: Bacterial wilt, a devastating soil-borne disease affecting tobacco, is primarily caused by the pathogenic bacterium (Ralstonia solanacearum). R. solanacearum represents a substantial threat to the consistent enhancement of tobacco yield and quality.

Controlled-release oxidants for in situ remediation of organic contaminated soil and groundwater: Material preparation, mechanisms, and applications.

Controlled-release oxidation materials (CROMs) have emerged as a promising strategy to overcome the limitations of in situ chemical oxidation (ISCO) technologies, which was attributed to their long-term release of active substances. This review systematically summarized the preparation methods, applications, release and oxidation mechanisms of CROMs. Specifically, the correlations among preparation methods, encapsulation materials, and morphological characteristics of CROMs based on three different oxidants (permanganate, persulfate, peroxide) were discussed.

In-situ and long-lasting oxidation of SMX by Mg/Al-PDS LDH in soil: Key role of solid-phase activation and CO effect.

To develop a long-term oxidative technology, peroxydisulfate intercalated magnesium aluminum layered double hydroxide (Mg/Al-PDS LDH) was prepared for in-situ oxidation of sulfamethoxazole (SMX) in soil. In the airtight system, Mg/Al-PDS LDH exhibited 99.54 % SMX removal in solution, as most PDS was retained within the LDH interlayers.

Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection.

Background: Schistosomiasis, a parasitic disease affecting more than 240 million people worldwide, is characterized by chronic inflammation and tissue fibrosis primarily induced by parasite egg deposition. Bromodomain-containing protein 4 (BRD4), an epigenetic and transcriptional regulator, has emerged as a potential therapeutic target due to its dual role in modulating Schistosoma japonicum (S. japonicum) reproductive development and organ fibrosis.

Cerebral hypoperfusion-related hemichorea: A case report and literature review.

Rationale: Hemichorea is an extrapyramidal disorder with diverse etiologies. Vascular hemichorea is most commonly caused by cerebral infarction in the putamen or caudate nucleus, with head diffusion weighted imaging (DWI) showing restricted diffusion at the site of the responsible lesion. Negative DWI in the basal ganglia is extremely rare.

Trogocytosis: revealing new insights into parasite-host interactions.

Trogocytosis - a process whereby cells physically nibble and ingest membrane fragments and other components from neighboring cells - plays a critical role in host-parasite interactions by modulating parasite survival and host immune responses. This review explores trogocytosis in parasitic infections, revealing its dual roles: parasites use it for nutrient acquisition and immune evasion, whereas hosts use it for pathogen clearance. We analyze the molecular machinery driving this process, its impact on infection outcomes, and parallels in tumors/transplantation.

Inhibition of the Foxo3/Txnip Axis Alleviates Ventilator-Induced Diaphragmatic Dysfunction by Downregulating MuRF1.

Ventilator-induced diaphragm dysfunction (VIDD) is one of the main causes of weaning from mechanical ventilation (MV). The forkhead box O3 (Foxo3) has been identified as being involved in regulating the contractile function of skeletal muscle. This study aimed to figure out the regulatory role and mechanism of Foxo3 on VIDD.

A nuclear-encoded endonuclease governs the paternal transmission of mitochondria in Cucumis plants.

Non-Mendelian transmission of mitochondria has been well established across most eukaryotes, however the genetic mechanism that governs this uniparental inheritance remains unclear. Plants in the genus Cucumis, specifically melon and cucumber, exhibit paternal transmission of the mitochondrial (mt) DNA, making them excellent models for exploring the molecular mechanisms underlying mitochondrial transmission. Here, we develop a toolkit to screen for mutants in mitochondrial inheritance (mti), and use fine mapping to successfully identify a mitochondrially targeted endonuclease gene (MTI1) controlling mitochondrial transmission.

MMG-Based Motion Segmentation and Recognition of Upper Limb Rehabilitation Using the YOLOv5s-SE.

Mechanomyography (MMG) is a non-invasive technique for assessing muscle activity by measuring mechanical signals, offering high sensitivity and real-time monitoring capabilities, and it has many applications in rehabilitation training. Traditional MMG-based motion recognition relies on feature extraction and classifier training, which require segmenting continuous actions, leading to challenges in real-time performance and segmentation accuracy. Therefore, this paper proposes an innovative method for the real-time segmentation and classification of upper limb rehabilitation actions based on the You Only Look Once (YOLO) algorithm, integrating the Squeeze-and-Excitation (SE) attention mechanism to enhance the model's performance.

Habitat Analysis in Tumor Imaging: Advancing Precision Medicine Through Radiomic Subregion Segmentation.

Radiomics received a lot of attention because of its potential to provide personalized medicine in a non-invasive manner, usually focusing on the analysis of the entire lesion. A new method called habitat can identify subregional phenotypic changes within the lesion, thereby improving the ability to distinguish heterogeneity. The clustering method can be applied to multiple measurement parameters to separate different tumor habitats by segmentation.

Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity.

Histone H3 lysine 9 dimethylation and trimethylation (H3K9me2/3) are prevalent in human genomes, especially in heterochromatin and specific euchromatic genes. Methylation of H3K9 is modulated by enzymes such as SUV39H1, SUV39H2, SETDB1, SETDB2, and EHMT1/2, which influence cancer progression. This study reveals differential expression of these six H3K9 methyltransferases in tumors, with SUV39H1, SUV39H2, and SETDB1 showing significant links to cancer phenotypes.

Periplakin Attenuates Liver Fibrosis via Reprogramming CD44 Cells into CD44 Liver Progenitor Cells.

Background & Aims: Liver progenitor cells (LPCs) contribute significantly to the restoration of injured liver parenchyma and promote liver regeneration, thereby ameliorating liver fibrosis. However, the mechanism of the derivation of LPCs remains poorly understood.

Methods: We first examined the expression of periplakin (PPL) in patients and mouse models with liver fibrosis.

CD44 cells enhance pro-tumor stroma in the spatial landscape of colorectal cancer leading edge.

Background: The heterogeneity of tumors significantly impacts on colorectal cancer (CRC) progression. However, the influence of this heterogeneity on the spatial architecture of CRC remains largely unknown.

Methods: Spatial transcriptomic (ST) analysis of AOM/DSS-induced colorectal cancer (CRC), integrated with single-cell RNA sequencing, generated a comprehensive spatial atlas of CRC.

Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma.

Background: Cervical adenocarcinoma (ADC) is more aggressive compared to other types of cervical cancer (CC), such as squamous cell carcinoma (SCC). The tumor immune microenvironment (TIME) and tumor heterogeneity are recognized as pivotal factors in cancer progression and therapy. However, the disparities in TIME and heterogeneity between ADC and SCC are poorly understood.

SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma.

Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse and improving outcomes. We identify SUV39H1, a histone-3, lysine-9 methyltransferase, as critical for GSC maintenance and GBM progression.

Killing the killers: Natural killer cell therapy targeting glioma stem cells in high-grade glioma.

High-grade gliomas (HGGs), including glioblastoma (GBM) in adults and diffuse intrinsic pontine glioma (DIPG) in children, are among the most aggressive and deadly brain tumors. A key factor in their resilience is the presence of glioma stem cells (GSCs), which drive tumor initiation, progression, and resistance to treatment. Targeting and eradicating GSCs holds potential for curing both GBM and DIPG.

Metabolomic analysis of the intrinsic resistance mechanisms of Microtus fortis against Schistosoma japonicum infection.

Microtus fortis (M. fortis) is the only mammal known in China that is intrinsically resistant to Schistosoma japonicum (S. japonicum) infection.

CV1-secreting sCAR-T cells potentiate the abscopal effect of microwave ablation in heterogeneous tumors.

Microwave ablation (MWA) triggers a weak systemic immune response that leads to the abscopal regression of distant metastases while killing local tumors, known as the abscopal effect. Combining MWA with chimeric antigen receptor (CAR)-T cells demonstrates promise in enhancing the abscopal effect in antigen-homogeneous tumors. However, the loss of the antigen recognized by CAR or intrinsic antigenic heterogeneity in solid tumors poses a major obstacle.

Analysis of laser spot centroiding errors for laser acquisition system in gravitational wave detection missions.

In space-based gravitational wave detection, establishing ultra-long-distance and ultra-high-precision laser links between satellites is achieved through the laser acquisition and tracking system. The laser spot centroid positioning method, which offers low computational complexity and strong adaptability to beam shape, is currently the core measurement method during the laser acquisition phase. However, due to various interference factors encountered in practical tests, this algorithm often falls short of meeting the extremely high requirements.

METTL3-Mediated m6A Modification of ISG15 mRNA Regulates Doxorubicin-Induced Endothelial Cell Apoptosis.

N6-adenosine methylation (m6A) of RNA is involved in the regulation of various diseases. However, its role in chemotherapy-related vascular endothelial injury has not yet been elucidated. We found that methyltransferase-like 3 (METTL3) expression was significantly reduced during doxorubicin (DOX)-induced apoptosis of vascular endothelial cells both in vivo and in vitro, and that silencing of METTL3 further intensified this process.