Retinal proteomic analysis reveals ON/OFF visual stimulation-specific changes in a Guinea pig myopia model.

This study aimed to explore the effect of artificial dynamic ON/OFF stimulation on the development of myopia and associated retinal proteomic changes in guinea pigs, and elucidate the underlying mechanisms. Myopia was induced in one eye of guinea pigs using -4 diopters lenses, with the other eye used as the untreated control. 53 guinea pigs were randomly given balanced ON/OFF (natural control, NC), ON, or OFF stimulation for 7 days.

Isolation and identification of endophytic fungi from that exhibit antioxidant and antibacterial activities.

Background: As a medicinal plant, is known to contain a wealth of bioactive constituents, including flavonoids, terpenes, and triterpenoid saponins, which contribute to its anti-inflammatory and anticancer properties. Endophytic fungi, which symbiotically inhabit plant tissues, are recognized for their ability to synthesize bioactive metabolites analogous to those of their hosts. However, the potential of -associated endophytes remains underexplored.

Buckwheat resistant starch alleviates hyperlipidaemia in mice by inhibiting lipid accumulation and regulating gut microbiota.

Hyperlipidemia, a prevalent metabolic disorder disease, has become a significant global health challenge. In this research, we looked into the effects of buckwheat resistant starch (BRS) supplementation on lipid metabolism and gut microbiota in hyperlipidemic mice. Results showed that HBRS intervention significantly inhibited weight gain in high-fat diet mice, reducing body weight by 2.

Functional analysis of a novel FOXL2 mutation in blepharophimosis, ptosis, and epicanthus inversus syndrome type II and elucidation of the genotype-phenotype correlation.

Background: Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is a rare autosomal dominant disorder caused by genetic mutations. However, the genotype-phenotype correlation remains unclear. This study aimed to identify mutations in a Chinese family with BPES and elucidate the genotype-phenotype relationship.

Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity.

Histone H3 lysine 9 dimethylation and trimethylation (H3K9me2/3) are prevalent in human genomes, especially in heterochromatin and specific euchromatic genes. Methylation of H3K9 is modulated by enzymes such as SUV39H1, SUV39H2, SETDB1, SETDB2, and EHMT1/2, which influence cancer progression. This study reveals differential expression of these six H3K9 methyltransferases in tumors, with SUV39H1, SUV39H2, and SETDB1 showing significant links to cancer phenotypes.

SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma.

Glioblastoma (GBM) is the most lethal brain cancer, with GBM stem cells (GSCs) driving therapeutic resistance and recurrence. Targeting GSCs offers a promising strategy for preventing tumor relapse and improving outcomes. We identify SUV39H1, a histone-3, lysine-9 methyltransferase, as critical for GSC maintenance and GBM progression.

Conformal high-efficiency ultra-thin flexible rectifying metasurface with a simple structure.

This paper proposes a conformal high-efficiency ultra-thin flexible rectifying metasurface (RMS) with a simple structure applied for wireless power transferring (WPT), featuring polarization insensitivity and wide-angle incidence capabilities. The RMS unit adopts a rotationally symmetric structure consisting of double rings and cross-shaped elements, with two diodes placed in the gap of the cross-shaped to achieve polarization insensitivity. Simultaneously, by adjusting the dimensions of the "double ring and cross" structure, its output impedance is varied to achieve conjugate matching with the diode input impedance, thereby eliminating the impedance matching network.

Stromal vascular fraction: Mechanisms and application in reproductive disorders.

Stromal vascular fraction (SVF) is a complex mixture derived from adipose tissue, consisting of a variety of cells. Due to its potential for tissue repair, immunomodulation, and support of angiogenesis, SVF represents a promising frontier in regenerative medicine and offers potential therapy for a range of disease conditions. In this article, we delve into the mechanisms through which SVF exerts its effects and explore its potential applications in treating both male and female reproductive disorders, including erectile dysfunction, testicular injury, stress urinary incontinence and intrauterine adhesion.

Mifepristone achieves tumor suppression and ferroptosis through PR/p53/HO1/GPX4 axis in meningioma cells.

Purpose: This study explores the effects of mifepristone on the proliferation, motility, and invasion of malignant and benign meningioma cells, aiming to identify mifepristone-sensitive types and investigate the underlying molecular mechanisms.

Methods: IOMM-Lee and HBL-52 meningioma cells were treated with 0, vehicle control (VC), 5, 10, 20, 40, and 80 μM of mifepristone for 12, 24, 48, 72, and 96 h. Proliferation was assessed via CCK8 assay, while motility and invasion were measured using wound scratch and transwell assays.

Chemical constituents and biological activities of endophytic fungi from .

Background: is an important wild food and feed germplasm resource. It has high nutritional and medicinal value and is rich in natural products, including flavonoids, phenolic acids, coumarins, and alkaloids. Endophytic fungi in have emerged as valuable sources of natural products.

Resveratrol liposomes reverse sorafenib resistance in renal cell carcinoma models by modulating PI3K-AKT-mTOR and VHL-HIF signaling pathways.

RCC is a malignant tumor arising from the urothelium of renal parenchyma that remains challenging to be treated. In this study, we assessed the anti-tumor effects of Resveratrol liposomes (RES-lips) combined with sorafenib on renal cell carcinoma (RCC) and explored the potential mechanisms underlying the improvement of sorafenib resistance models. Tumor growth and survival following treatment with sorafenib alone or in combination with RES-lips was evaluated in a RCC xenograft mouse model.

SUV39H1 Preserves Cancer Stem Cell Chromatin State and Properties in Glioblastoma.

Unlabelled: Of the more than 100 types of brain cancer, glioblastoma (GBM) is the deadliest. As GBM stem cells (GSCs) are considered to be responsible for therapeutic resistance and tumor recurrence, effective targeting and elimination of GSCs could hold promise for preventing GBM recurrence and achieving potential cures. We show here that , which encodes a histone-3, lysine-9 methyltransferase, plays a critical role in GSC maintenance and GBM progression.

Associations of urinary heavy metals with age at menarche, age at menopause, and reproductive lifespan: A cross-sectional study in U.S. women.

Female reproductive timing and lifespan, with a close relation to long-term health outcomes, have been altered in U.S. women over the past decades.

Association between tobacco exposure and bladder cancer recurrence: A systematic review and meta-analysis.

Background: However, the connection between smoking and the prognosis of patients with bladder cancer remains unclear.

Aim: To determine whether smoking is linked to the recurrence and progression of bladder cancer.

Methods: As of July 20, 2022, relevant English-language research was identified by searching PubMed, the Web of Science, and the Cochrane Library.

Exploring GZMK as a prognostic marker and predictor of immunotherapy response in breast cancer: unveiling novel insights into treatment outcomes.

Background: Granzyme K (GZMK) is a crucial mediator released by immune cells to eliminate tumor cells, playing significant roles in inflammation and tumorigenesis. Despite its importance, the specific role of GZMK in breast cancer and its mechanisms are not well understood.

Methods: We utilized data from the TCGA and GEO databases and employed a range of analytical methods including GO, KEGG, GSEA, ssGSEA, and PPI to investigate the impact of GZMK on breast cancer.

Whole Exome Sequencing as an Effective Molecular Diagnosis Tool for Craniofacial Fibrous Dysplasia with Ocular Complications.

Purpose: To summarize the clinical manifestations of craniofacial fibrous dysplasia (CFD) patients with ocular complications, and find effective methods to diagnose early.

Methods: Nine CFD patients with ocular complications, and their parents were recruited in this study. All patients underwent ocular and systemic examinations.

Synthesis, Structure and Properties of Polyester Polyureas via a Non-Isocyanate Route with Good Combined Properties.

Polyureas have been widely applied in many fields, such as coatings, fibers, foams and dielectric materials. Traditionally, polyureas are prepared from isocyanates, which are highly toxic and harmful to humans and the environment. Synthesis of polyureas via non-isocyanate routes is green, environmentally friendly and sustainable.

Causal associations between infection and pregnancy and neonatal outcomes: a two-sample Mendelian randomization study.

Background: Observational studies have reported that () infection is associated with a series of pregnancy and neonatal outcomes. However, the results have been inconsistent, and the causal effect is unknown.

Methods: A two-sample Mendelian randomization (MR) study was performed using summary-level statistics for anti- IgG levels from the Avon Longitudinal Study of Parents and Children Cohort.

Association between proliferative-to-secretory endometrial compaction and pregnancy outcomes after embryo transfer: a systematic review and meta-analysis.

Study Question: Does the change in endometrial thickness (EMT) from the end of the follicular/estrogen phase to the day of embryo transfer (ET) determine subsequent pregnancy outcomes?

Summary Answer: Endometrial compaction from the late-proliferative to secretory phase is not associated with live birth rate (LBR) and other pregnancy outcomes.

What Is Known Already: Endometrial compaction has been suggested to be indicative of endometrial responsiveness to progesterone, and its association with ET outcome has been investigated but is controversial.

Study Design, Size, Duration: A systematic review with meta-analysis was carried out.

The correlation between systemic inflammatory markers and efficiency for advanced gastric cancer patients treated with ICIs combined with chemotherapy.

Currently lacking research to explore the correlation between inflammatory markers and the efficacy of immune checkpoint inhibitors (ICIs) combined with chemotherapy in the treatment of advanced gastric cancer. This study is a retrospective study and included patients with advanced gastric cancer who receiving ICIs combined with chemotherapy from January 2020 to December 2022. We analysed the relationship between systemic inflammatory markers and the efficacy of ICIs combined chemotherapy and constructed a clinical prediction model.

Pregnancy outcomes after frozen-thawed embryo transfer in women with COVID-19 history: A prospective cohort study.

The clinical effect of Coronavirus disease 2019 (COVID-19) on endometrial receptivity and embryo implantation remains unclear. Herein, we aim to investigate whether a COVID-19 history adversely affect female pregnancy outcomes after frozen-thawed embryo transfer (FET). This prospective cohort study enrolled 230 women who underwent FET cycles from December 2022 to April 2023 in an academic fertility center.