SegTom: A 3D Volumetric Medical Image Segmentation Framework for Thoracoabdominal Multi-Organ Anatomical Structures.

Accurate segmentation of thoracoabdominal anatomical structures in three-dimensional medical imaging modalities is fundamental for informed clinical decision-making across a wide array of medical disciplines. Current approaches often struggle to efficiently and comprehensively process this region's intricate and heterogeneous anatomical information, leading to suboptimal outcomes in diagnosis, treatment planning, and disease management. To address this challenge, we introduce SegTom, a novel volumetric segmentation framework equipped with a cutting-edge SegTom Block specifically engineered to effectively capture the complex anatomical representations inherent to the thoracoabdominal region.

A systematic analysis of the network of lncRNAs and mRNAs regulated by TP53 and TP53 mutants with hotspot mutations.

The transcription factor TP53 exhibits the preeminent frequency of genetic mutations across various cancer types. Long non-coding RNAs (lncRNAs) stand as pivotal molecules in the initiation and progression of carcinogenesis. Nonetheless, the specific roles of TP53-regulated lncRNAs in colon cancer remain largely unexplored.

Effect of Incorporating L-Shaped Folded Metal Aggregates on the Performance of Asphalt Mixtures.

With the increase in heavy-load traffic and the growing frequency of extreme weather events, traditional rock aggregates, due to poor morphological stability, are unable to meet the performance requirements of high-grade asphalt pavements in complex environments. Most existing research on metal reinforcement focuses on fiber forms. This study innovatively introduces L-shaped multi-faceted metal aggregates (LFMAs).

Photocatalytic Nanoscale Metal-Organic Frameworks for Proximity Labeling in Living Cells.

The mechanism of nanoparticle-based therapeutics and biomaterials can be understood through the elucidation of their precise localization and biomolecular interactions within living cells. To this end, although proximity labeling catalyzed by enzymes and small molecules are broadly applied for mapping interaction networks, technologies that can map the intracellular microenvironments of nanoparticles with biomolecular precision have long been sought. Here, an approach that uses photocatalytic nanoparticles for proximity labeling (PNPL) that exploits photocatalytic generation of singlet oxygen to selectively label histidine side chains of proteins with a biotin tag to identify nanoparticle-protein co-localization in living cells is described.

Pulsed electric field ablation process-a study of the effect of different shapes (materials) of metal stents on the ablation effect.

Background: Arrhythmias are a common group of cardiovascular diseases, and in recent years, pulsed electric field ablation technology has made great progress in the treatment of arrhythmias. However, the effect of different materials and shapes of cardiac stents on the ablation effect at the target site during epicardial ablation has not been effectively studied.

Methods: The ablation targeting position was modeled and simplified, the ablation catheter and cardiac stent were restored in real size, and the ablation region was modeled in three dimensions using a computer.

Effects of electric field and heat distribution due to trends in metal stent diameter in epicardial pulsed field ablation.

The autonomic nervous system of the heart plays a crucial role in the onset and progression of atrial fibrillation (AF). Selective ablation of the epicardial autonomic nervous system has been proposed as a potential treatment for AF. Metallic stents implanted in the epicardial fat layer of coronary arteries may undergo diameter changes due to plaque accumulation and vascular alterations.

Layered Double Hydroxide Nanoparticles Loaded with Resveratrol Inhibit Glycolysis and Show Efficacy in the Treatment of Breast Cancer.

Background: Breast cancer is one of the most common cancers among women. Tumor cell proliferation is highly dependent on aerobic glycolysis, so regulating aerobic glycolysis in breast cancer cells is a promising therapeutic strategy. Resveratrol (Res), as a potential new anti-breast cancer drug, has been shown to regulate the glycolysis of cancer cells and inhibit the metastasis and recurrence of breast cancer.

Efficient Breast Lesion Segmentation From Ultrasound Videos Across Multiple Source-Limited Platforms.

Medical video segmentation is fundamentally important in clinical diagnosis and treatment procedures, offering dynamic tracking of breast lesions across frames in ultrasound videos for improved segmentation performance. However, existing approaches face challenges in striking a balance between segmentation performance and inference speed, hindering real-time application in resource-constrained medical environments. In order to address these limitations, we present BaS, a blazing-fast on-device breast lesion segmentation model.

Online Self-distillation and Self-modeling for 3D Brain Tumor Segmentation.

In the specialized domain of brain tumor segmentation, supervised segmentation approaches are hindered by the limited availability of high-quality labeled data, a condition arising from data privacy concerns, significant costs, and ethical issues. In response to this challenge, this paper presents a training framework that adeptly integrates a plug-and-play component, MOD, into current supervised learning models, boosting their efficacy in scenarios with limited data. The MOD consists of an Online Tokenizer and a Dense Predictor, which employs self-distillation and self-modeling on masked patches, promoting swift convergence and efficient representation learning.

Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments.

Aims: The study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.

Methods: Potatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.

No closure of the linea alba cervicalis reduces complications in endoscopic thyroidectomy.

The benefits of not suturing the linea alba cervicalis and using negative pressure wound therapy after endoscopic thyroidectomy have attracted increasing attention. Therefore, this study aims to determine whether the non-closure of the linea alba cervicalis after endoscopic thyroidectomy can significantly reduce postoperative complications and evaluate the application of NPWT to prevent cavity-related complications. A retrospective analysis was performed.

Conformal high-efficiency ultra-thin flexible rectifying metasurface with a simple structure.

This paper proposes a conformal high-efficiency ultra-thin flexible rectifying metasurface (RMS) with a simple structure applied for wireless power transferring (WPT), featuring polarization insensitivity and wide-angle incidence capabilities. The RMS unit adopts a rotationally symmetric structure consisting of double rings and cross-shaped elements, with two diodes placed in the gap of the cross-shaped to achieve polarization insensitivity. Simultaneously, by adjusting the dimensions of the "double ring and cross" structure, its output impedance is varied to achieve conjugate matching with the diode input impedance, thereby eliminating the impedance matching network.

Rational design and characterization of enhanced alcohol-inducible synthetic promoters in .

The C1 and C2 alcohols hold great promise as substrates for biomanufacturing due to their low cost and rich resources. is considered a preferred host for methanol and ethanol bioconversion due to its natural utilization of methanol and ethanol. However, the scarcity of strong and tightly regulated alcohol-inducible promoters limits its extended use.

Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis.

Aggregation of TAR-DNA binding protein-43 (TDP-43) is a pathological feature present in nearly 97 % cases of amyotrophic lateral sclerosis (ALS), making it an attractive target for pathogenic studies and drug screening. Here, we have performed a high-throughput screening of 1500 compounds from a natural product library and identified that lycorine, a naturally occurring alkaloid, significantly decreases the level of TDP-43 in a cellular model. We further demonstrate that lycorine reduces the level of TDP-43 both through inhibiting its synthesis and by promoting its degradation by the ubiquitin-proteasome system (UPS).

Inorganic Salt Solution-Based Aerosols for Fabricating Honeycomb-Patterned Porous Membranes.

Porous membranes with uniform pore sizes have shown potential applications. Although the breath figure method is renowned for its simplicity, it requires high humidity conditions, presenting challenges in energy consumption and safety, especially in arid climates. This study introduces an approach that uses inorganic salt-based aerosols to successfully fabricate honeycomb-patterned porous membranes at low humidity levels, where pure water vapor cannot produce such structures.

Xenotropic and polytropic retrovirus receptor 1 (XPR1) promotes progression of papillary thyroid carcinoma via the BRAF-ERK1/2-P53 signaling pathway.

Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Xenotropic and polytropic retrovirus receptor 1 (XPR1), identified as a cellular receptor, plays roles in many pathophysiological processes. However, the underlying function and molecular mechanisms of XPR1 in PTC remain unclear.

Fixation behavior of oceanic manganese nodule-sodium alginate composite microspheres for heavy metal release during manganese nodule mining.

Research on the environmental impact of deep-sea mining is crucial, particularly for fragile deep-sea ecosystems. This research focuses on the issue of heavy metal release during mining activities. Through simulation experiments, we investigated the release of Cu, Co, and Ni from sediments under disturbance conditions and the fixation behavior during the deployment of ocean manganese nodule-sodium alginate composite microspheres (OMN@SA).

Distribution characteristics of Purkinje fibres in the canine left ventricle.

Purkinje-related ventricular arrhythmias have been increasingly reported, and with the development of catheter ablation techniques, intervention for Purkinje-related arrhythmias has been shown to be effective. The characteristics of Purkinje fibres orientation in the 12 canine left ventricles were observed at a gross level by staining the endocardium with Lugol's solution. Purkinje fibres were observed microscopically by HE, Masson's, PAS glycogen, and Cx40 immunohistochemical staining.

Temporal Trend of Incidence and Prevalence of Eosinophilic Esophagitis in Asia: A Systematic Review and Meta-Analysis.

Introduction: There are limited epidemiological studies on eosinophilic esophagitis (EoE) in Asia. We studied the temporal trend of EoE in Asia, the presenting symptoms, and association with atopic diseases.

Methods: Literature search on PubMed, Embase, MEDLINE, Scopus, and Web of Science was performed to retrieve studies published between 1980 and 2023 that reported the prevalence or incidence of EoE in Asia.

Epicardial pulsed-field ablation-impact of electric field and heat distribution induced by coronary metallic stents.

Background: Pulsed-field ablation (PFA) technique is a nonthermal ablation technique. No study has yet evaluated the effect of the positional relationship between the ablation electrode (AE) and the coronary metal stent (CMS) on the electric field distribution and temperature distribution in epicardial ablation. Our study aimed to evaluate the effect of the CMS on the electric field as well as the temperature distribution in different models.

Magnamosis improves the healing of gastrojejunal anastomosis and down-regulates TGF-β1 and HIF-1α in rats.

This study elucidated the unique pathological features of tissue healing by magnamosis and revealed the changes in landmark molecule expression levels related to collagen synthesis and tissue hypoxia. Forty-eight male Sprague-Dawley rats were divided into the magnamosis and suture anastomosis groups, and gastrojejunal anastomosis surgery was performed. Rats were dissected at 6, 24, and 48 h and 5, 6, 8, 10, and 12 days postoperatively.

Clinical Significance of Sarcopenia in Elderly Patients Undergoing Endoscopic Submucosal Dissection: A Systematic Review and Meta-analysis.

Background And Aims: As global life expectancy rises and gastrointestinal tumor incidence increases, more elderly patients are undergoing endoscopic submucosal dissection (ESD) for tumor treatment. The current situation highlights the importance of sarcopenia assessment before ESD. This systematic review and meta-analysis aim to assess sarcopenia's role in predicting post-ESD adverse outcomes in the elderly.