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Aims: The study aims to investigate the impact of key parameters of pulsed field ablation (PFA) on lesion depth, including voltage (V), pulse width (PW), number of pulses (P), and ablation number (N), using potato models.
Methods: Potatoes are utilized as a display of the irreversible electroporation lesion. The key ablation parameters were varied systematically to explore its influences on lesion depths.
Results And Conclusion: The key ablation parameters have varying degrees of influence on lesion depths, following the order of PW>V; V>P; PW>P; N>P. Lesion depths increased with higher values of V and P. However, when the total number of pulses reached 9,600, there was no significant increase in injury depth.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832666 | PMC |
http://dx.doi.org/10.3389/fcvm.2025.1525762 | DOI Listing |
Echocardiography
September 2025
Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Objectives: To explore the relationships between cardiac parameters and body composition indices, identifying predictors of subclinical cardiac systolic dysfunction.
Methods: Using anthropometric and serological parameters, echocardiography, and body composition analysis, this study evaluated metabolic profiles, cardiac remodeling patterns, and body composition characteristics in young adult obese patients, while quantifying the correlations between cardiac parameters and body composition indices. Subclinical left ventricular systolic dysfunction was defined as global longitudinal strain (GLS) < 18%.
Cell Mol Biol (Noisy-le-grand)
September 2025
Associate Professor, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh-Punjab 147301, India.
Alcoholic fatty liver disease (AFLD) is a leading cause of chronic liver disease worldwide, contributing to significant morbidity and mortality. Despite its growing prevalence, no FDA-approved pharmacological treatments exist, leaving lifestyle modifications as the primary intervention. AFLD pathogenesis involves a complex interplay of lipid accumulation, oxidative stress, insulin resistance, and inflammation, highlighting the need for innovative therapeutic approaches.
View Article and Find Full Text PDFChaos
September 2025
Department of Mathematics, Visva-Bharati, Santiniketan 731235, India.
Biological models are important in describing species interaction, disease spread, and environmental processes. One key aspect in improving the predictive capability of these models is deciding which parametrization is used to formulate the mathematical model. Considering two distinct functions with similar shapes and the same qualitative properties in a model can lead to markedly different model predictions.
View Article and Find Full Text PDFChaos
September 2025
School of Engineering, University of Applied Sciences of Western Switzerland HES-SO, CH-1950 Sion, Switzerland.
We investigate species-rich mathematical models of ecosystems. While much of the existing literature focuses on the properties of equilibrium fixed-points, persistent dynamics (e.g.
View Article and Find Full Text PDFNanoscale
September 2025
College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.
With the progress of study, MoS has been proven to show excellent properties in electronics and optoelectronics, which promotes the fabrication of future novel integrated circuits and photodetectors. However, highly uniform wafer-scale growth is still in its early stage, especially regarding how to control the precursor and its distribution. Herein, we propose a new method, spraying the Mo precursor, which is proven to fabricate highly uniform 2-inch monolayer MoS wafers.
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