Lessons from the coronavirus disease 2019 pandemic: Investigating the bidirectional relationship between coronavirus disease 2019 and migraine based on the MECH-HK cohort study.

Background: Although the coronavirus disease 2019 (COVID-19) pandemic has ended, its impact on patients with migraine has revealed critical gaps in understanding how migraine interacts with respiratory infections. Exploring this bidirectional relationship is essential for improving migraine management and protecting vulnerable populations during future outbreaks.

Objectives: To examine (1) the impact of migraine on COVID-19 manifestations and the risk of post-acute sequelae of COVID-19 (PASC), and (2) the effect of COVID-19 infection on migraine features.

Integrated multi-omics analysis identifies SELENOP and PKMYT1 as immune-metabolic hub genes in breast cancer.

Background: Metabolic reprogramming and immune evasion synergistically drive breast carcinogenesis, but their combined impact remains unclear.

Methods: Transcriptomic data from the TCGA and GEO cohorts were integrated. Differentially expressed genes were identified, followed by WGCNA to detect immune-correlated co-expression modules.

Vanillin restrains proliferation of triple negative breast cancer cells by inducing ferroptosis via mediating the KLF2/GPX4 axis.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. Treatment options of TNBC are limited, which is prone to recurrence and metastasis, posing a serious threat to patients' health. Recent studies revealed the important role of ferroptosis in TNBC.

MRI Versus CT in Planning Primary Debulking Surgery for Epithelial Ovarian Cancer.

Objective: To assess the performance of whole-abdomen diffusion-weighted imaging (DWI) combined with conventional MRI compared with CT in preoperative planning of the primary debulking surgery (PDS) in epithelial ovarian cancer (EOC) patients.

Methods: Fifty-seven patients with EOC who underwent preoperative whole-abdomen MRI and CT were recruited for this study. During a multidisciplinary treatment (MDT) discussion, anatomical sites were allocated to specialized surgeons and the surgical plan, including assistant and backup surgeons, was finalized.

Predictors of migraine prevalence among different age groups in Hong Kong Chinese women: Machine learning analyses on the MECH-HK cohort.

Purpose: To identify age-specific predictors of migraine prevalence among Chinese women.

Methods: In this cross-sectional analysis, 54 predictors were collected from the MECH-HK cohort. Migraine was assessed by the ICHD 3rd edition.

Layered double hydroxide-delivered si-NEAT1 inhibits breast cancer immune evasion and malignant progression by modulating the miR-141-3p/PD-L1 axis.

Breast cancer has the highest incidence of female cancers globally and is a significant cause of death among female cancers. The field of breast cancer immunotherapy is rapidly evolving, offering new treatment options and hope to patients. Immune checkpoint inhibitors (ICBs) fight cancer by reprogramming the host immune system, leading a new paradigm in the treatment and application of specific types of breast cancer.

Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer.

Breast cancer (BC) is the most prevalent and highly heterogeneous malignancy affecting females worldwide, and its development is closely linked to metabolic reprogramming. In this study, label-free quantification (LFQ) was used to analyze the protein expression in exosomes secreted by BC drug-resistant cells, identifying RAS-associated binding protein (RAB) 10 as the most significantly upregulated protein. RAB10, a member of the small GTPase family with complex biological functions, is highly expressed in BC and is associated with poor prognosis.

Effectiveness of Digital Health Interventions on Sedentary Behavior Among Patients With Chronic Diseases: Systematic Review and Meta-Analysis.

Background: Individuals with chronic diseases commonly engage in a sedentary lifestyle, which may exacerbate poor disease progression and increase the burden of care. Digital health interventions have been broadly used in promoting healthy lifestyles in recent decades, while their effectiveness on sedentary behavior (SB) remains inconsistent and inconclusive.

Objective: This review aimed to evaluate the effectiveness of digital health interventions in reducing SB among patients with chronic diseases.

A multi-stage metabolic pattern of adrenocortical adenomas offers diagnostic potential of uric acid, isocitric acid, and proline.

Background: The development of adrenocortical adenoma (ACA) affects the endocrine homeostasis of the patient and causes various pathophysiological abnormalities. At this stage, the diagnosis of the disease and the distinguishing of adenoma subtypes in patients with ACA remains an unresolved clinical issue. Our study aimed to identify biomarkers for adenoma subtypes and their altered metabolic profiles.

Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.

Background: Accumulative prior studies have demonstrated that immune inflammation profoundly influences reproductive disorders of mesodermal origin. However, little is known about the causal relationship between immune factors and diseases of the reproductive system.

Methods: Thorough two-sample Mendelian randomization (MR) analyses were conducted to determine the causal effects of 731 immune traits on reproductive ill-health, including abnormal spermatozoa (AS), polycystic ovary syndrome (PCOS), and spontaneous abortion (SA).

Lacticaseibacillus paracasei NCU-21 improves ethanol-induced gastric mucosal injury by regulating the Nrf2/HO-1 signalling pathway and gastrointestinal microbiota in mice.

Alcohol-induced gastric ulcer (GU) is a gastrointestinal disorder resulting from excessive alcohol consumption. The precise therapeutic effects and underlying mechanisms of Lacticaseibacillus paracasei NCU-21 in ameliorating alcohol-induced GUs remain ambiguous. In this study, we identified and isolated a strain of L.

Ameliorative effect of "intestinal-vaginal" probiotics on 5-fluorouracil-induced microbial dysbiosis in colorectal cancer.

The interaction between the gut microbiome and cancer chemotherapy has been extensively studied. However, the exact role of the vaginal microbiome in chemotherapy remains unknown. To address this issue, we established a colorectal cancer chemotherapy mouse model.

The interrelated roles of RAB family proteins in the advancement of neoplastic growth.

Rab Proteins, A Subfamily Of The Ras Superfamily Of Small Gtpases, Are Critical Regulators Of Intracellular Vesicular Trafficking, Which Is Intricately Linked To Various Cellular Processes. These Proteins Play Essential Roles Not Only In Maintaining Cellular Homeostasis But Also In Mediating The Complex Interplay Between Cancer Cells and Their Microenvironment. Rab Proteins Can Act As Either Oncogenic Factors Or Tumor Suppressors, With Their Functions Highly Dependent On The Cellular Context.

Layered Double Hydroxide Nanoparticles Loaded with Resveratrol Inhibit Glycolysis and Show Efficacy in the Treatment of Breast Cancer.

Background: Breast cancer is one of the most common cancers among women. Tumor cell proliferation is highly dependent on aerobic glycolysis, so regulating aerobic glycolysis in breast cancer cells is a promising therapeutic strategy. Resveratrol (Res), as a potential new anti-breast cancer drug, has been shown to regulate the glycolysis of cancer cells and inhibit the metastasis and recurrence of breast cancer.

Nicotinamide riboside supplementation protects against maternal diabetes-associated decline in oocyte quality.

In Brief: NAD+ levels were reduced in streptozotocin (STZ)-induced diabetic mice, but nicotinamide riboside (NR) supplementation improved these levels in diabetic ovaries and oocytes, enhancing oocyte quality and early embryo development by improving mitochondrial function and lowering reactive oxygen species (ROS) levels.

Abstract: Diabetes mellitus is strongly correlated with a decline in oocyte quality; however, noninvasive and effective methods to improve this issue have yet to be fully development. Here, we demonstrate that in vivo supplementation with NR 400 mg/kg/day for 14 days effectively enhances the quality of oocytes from diabetic mice induced by streptozocin 190 mg/kg by restoring nicotinamide adenine dinucleotide (NAD+) levels.

Layered Double Hydroxide LDH-Loaded miR-141-3p Targets RAB10 Suppressing Cellular Autophagy to Reverse Paclitaxel Resistance in Breast Cancer.

Autophagy is a cellular protective mechanism. As tumor cells are stimulated by drugs, autophagy is activated to increase their resistance to drugs. In gene regulation, microRNA (miRNA) plays a vital role.

Nicotinamide Riboside Supplementation Alleviates Testicular Aging Induced by Disruption of Qprt-Dependent NAD De Novo Synthesis in Mice.

Recent studies have shown that disruptions in the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway accelerate ovarian aging, yet its role in spermatogenesis remains largely unknown. In this study, we investigated the impact of the NAD de novo synthesis pathway on spermatogenesis by generating Qprt-deficient mice using CRISPR-Cas9 to target quinolinate phosphoribosyl transferase (Qprt), a key enzyme predominantly expressed in spermatocytes. Our results revealed that the deletion of Qprt did not affect NAD levels or spermatogenesis in the testes of 3-month-old mice.

Nicotinamide riboside supplementation ameliorates ovarian dysfunction in a PCOS mouse model.

Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility among women of reproductive age, yet the range of effective treatment options remains limited. Our previous study revealed that reduced levels of nicotinamide adenine dinucleotide (NAD) in ovarian granulosa cells (GCs) of women with PCOS resulted in the accumulation of reactive oxygen species (ROS) and mitochondrial dysfunction. However, it is still uncertain whether increasing NAD levels in the ovaries could improve ovarian function in PCOS.

Conversational agents in physical and psychological symptom management: A systematic review of randomized controlled trials.

Background: Effective management of physical and psychological symptoms is a critical component of comprehensive care for both chronic disease patients and apparently healthy individuals experiencing episodic symptoms. Conversational agents, which are dialog systems capable of understanding and generating human language, have emerged as a potential tool to enhance symptom management through interactive support.

Objective: To examine the characteristics and effectiveness of conversational agent-delivered interventions reported in randomized controlled trials (RCTs) in the management of both physical and psychological symptoms.

Naked eye three-dimensional teaching assistant system applied to undergraduate medical imaging education: A pilot study.

The traditional approach of using PowerPoint (PPT) presentations in medical imaging theory classes hinders the spatial thinking ability of most students. Consequently, the learning outcomes are often unsatisfactory. This article proposes a naked eye three-dimensional (3D) medical imaging teaching assistant app based on augmented reality (AR) technology to enhance learning interest, teaching interaction, and effectiveness.

Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males.

Silicon dioxide nanoparticles (SiO NPs) are widely utilized in biomedicine due to their controllable size and biocompatibility. While previous studies have demonstrated that prenatal exposure to SiO NPs can traverse the placental barrier and induce neurotoxicity in offspring. However, their reproductive toxicity remains unclear.

In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent.

A non-platinum-metal decanuclear complex [NiL(CHCOO) (CHOH)]·8(CHOH) (Ni complex) has been developed with a tri-dentate 2,3-dihydroxybenzaldehyde-2-aminophenol Schiff base ligand (HL). Single crystal X-ray analysis reveals that the Ni complex displays a sandwich loaf-shaped decanuclear structure and its anticancer activity was evaluated. The cell cytotoxicity results indicating that the Ni complex is most effective to human breast cancer cells MDA-MB-231 and its mechanism were further investigated.

Combined lifestyle factors and metabolic syndrome risk: a systematic review and meta-analysis.

Background/objectives: The metabolic syndrome is a complex condition influenced by many factors including lifestyle. Recently, more and more studies explored the relationships between combined lifestyle factors (often measured as lifestyle scores/indices) and metabolic syndrome due to the co-occurrence of these factors. These scores/indices considered potential interactions among lifestyle factors, offering a more comprehensive understanding of their relationship with metabolic syndrome.

Wearable device-measured bouted and sporadic physical activity patterns and incident COPD: A prospective cohort study from UK Biobank.

Objectives: Moderate-to-vigorous physical activity (MVPA) is associated with a reduced risk of chronic obstructive pulmonary disease (COPD), but the optimal accumulation patterns are unclear. We aimed to investigate the associations between accelerometer-measured bouted and sporadic MVPA and incident COPD in the UK Biobank.

Study Design: Prospective cohort study.