[The value of DCE-MRI combined with spectral CT in the short-term efficacy of concurrent chemoradiotherapy for nasopharyngeal carcinoma].

To explore the value of spectral CT parameters combined with dynamic contrast enhanced magnetic resonance imaging（DCE-MRI） parameters in the short-term efficacy of concurrent chemoradiotherapy for nasopharyngeal carcinoma. A total of 110 cases with nasopharyngeal carcinoma Ⅲ-Ⅳ staging who received synchronous radiotherapy and chemotherapy at our Hospital from October 2022 to October 2024 were regarded as the study subjects. Complying with the evaluation results after radiotherapy and chemotherapy, they were divided into a complete remission（CR） group of 53 cases and a non CR group of 57 cases.

Gadolinium and Europium Doped Chiral Perovskite Films with Magnetic Circular Dichroism and Circularly Polarized Luminescence for Information Encryption Applications.

All inorganic lead halide perovskite (CsPbX) has become a hot topic in chiral optics for its high quantum yield and tunable luminescence. The environmental degradation tendency and lack of magneto-optical coupling mechanism of lead-based perovskite severely restrict its chirality integrated application. Rare-earth ions (such as Gd, Eu), with their unique 4f electronic configuration, not only passivate the lattice defects to improve stability but also expand the spectral response range through electronic localization effects.

Root specialized metabolites shape plant-beneficial bacterial communities to mitigate hydrocarbon stress.

Plant roots secrete various compounds to attract beneficial microbes from soil, enhancing resilience to environmental stresses. The mechanisms by which perennial grasses accumulate specific plant-beneficial bacteria under organic pollution remain unclear. We conducted a pot experiment using ryegrass grown in diesel-contaminated soils (0-15 g/kg) to analyze rhizosphere bacterial community and root exudate, using 16S rRNA gene amplicon sequencing and untargeted metabolomics.

Comparative neurotoxic effects and mechanism of cadmium chloride and cadmium sulfate in neuronal cells.

Cadmium (Cd), a known food pollutant, has been demonstrated in numerous studies to induce neurological damage. The pathogenic mechanisms of cadmium chloride (CdCl) and cadmium sulfate (CdSO) are generally attributed to the induction of oxidative stress and apoptosis. Nevertheless, the extent to which these two cadmium compounds exhibit differential concentration-dependent neurotoxic effects, as well as the specific underlying mechanisms involved, remain to be elucidated.

A Functional Regulatory Variant of Gene Affected the Body Weight in Hu Sheep.

Body weight (BW) is a critical economic trait closely linked to livestock meat production performance and producer profitability. In the present study, we measured individual BW of 1070 male Hu sheep at six growth stages (80, 100, 120, 140, 160, and 180 days of age) and conducted descriptive statistical analyses. Results showed that the coefficient of variation (CV) for BW at each stage was higher than 13%.

Efficacy of maxillary occlusal splints on mobile posterior teeth in patients with stage III or IV periodontitis during steps 1 and 2 of periodontal therapy: a randomized parallel-controlled clinical trial.

Aim: The present study aims to assess the efficacy of elastic occlusal splints on mobile posterior teeth in patients with stage III or IV periodontitis during Steps 1 and 2 of periodontal therapy.

Materials And Methods: Thirty-eight periodontitis patients, each with at least one mobile maxillary posterior tooth (mobility degree II or III), were randomly assigned to either the Splint group (n = 19), which received maxillary elastic occlusal splints, or the Control group (n = 19), without splints treatment. All patients received Steps 1 and 2 of periodontal therapy.

Associations Between Occupational Noise Exposure, Aging, and Gender and Hearing Loss: A Cross-Sectional Study in China.

Hearing loss is increasingly prevalent and poses a significant public health concern. While both aging and occupational noise exposure are recognized contributors, their interactive effects and gender-specific patterns remain underexplored. This cross-sectional study analyzed data from 135,251 employees in Jiangsu Province, China.

FBLN7 KO attenuates age-related cardiac fibrosis by promoting TGFBR3/ALK1/Smad1 signaling and inhibiting the profibrotic phenotypes of cardiac fibroblasts.

Aging induces structural and functional changes in the heart, including left ventricular (LV) hypertrophy, a decline in diastolic function, and even heart failure. Fibulin 7 (FBLN7) is a key mediator of extracellular matrix (ECM) remodeling under pathological conditions. In our study, we aim to explore whether FBLN7 is also involved in the development of age-related cardiac fibrosis and its underlying mechanisms.

Structural and functional insights into γ-glutamyl carboxylase-factor IX interaction: implications for vitamin K-dependent bleeding disorders.

Not available.

Laccase-mimicking chiral Cu-nanozymes for enantioselective catalysis of phenolic substrates.

Laccase-mimicking nanozymes showed huge prospects for the catalytic oxidation of numerous phenolic substrates. Some phenolic substrates exhibited distinct chirality, and it was still a great challenge to design laccase-mimicking chiral nanozymes with high enantioselectivity. Taking inspiration from the catalytic active sites of natural laccase, chiral Cu-based nanozymes with laccase-like activity were prepared by using different chiral ligands.

Identifying Parameters Associated with Delayed Diagnosis in Thrombotic Antiphospholipid Syndrome: Data from China Prospective APS Cohort.

Introduction: The aim of this study was to  evaluate the rate of delayed diagnosis in patients with thrombotic antiphospholipid syndrome (tAPS) and explore potential risk factors and prognosis of delayed diagnosis.

Methods: This single-center, prospective study included consecutive patients with tAPS fulfilling the 2006 Sydney Revised Classification Criteria referred to Peking Union Medical College Hospital from June 2012 to September 2022. Patients diagnosed after more than two aPL-related clinical events had occurred were defined as having delayed diagnosis.

The distinct subtypes and prognosis of acute myocardial infarction in antiphospholipid syndrome patients.

Introduction: Acute myocardial infarction (AMI) can be divided into myocardial infarction with coronary artery disease (MICAD) or with nonobstructive coronary arteries (MINOCA) according to the severity of artery stenosis. Antiphospholipid syndrome (APS) can present with AMI, but the subtype and prognosis are not fully understood.

Methods: The study was conducted based on the APS cohort in Peking Union Medical College Hospital.

Immunophenotypic characteristics and prognostic value of peripheral blood circulating plasma cells in patients with newly diagnosed multiple myeloma.

Background: To investigate the immunophenotypic characteristics and prognostic value of peripheral blood circulating plasma cells (CPCs) in patients with newly diagnosed multiple myeloma (NDMM).

Methods: This retrospective study was conducted on NDMM patients treated at Beijing Chaoyang Hospital, Capital Medical University, between January 2020 and June 2023. A total of 57 patients were included, with a median age of 64 years, comprising 27 males.

Improving the accuracy of vortex beam rotational velocity measurement based on phase recovery and polarization reference.

In remote rotational velocity measurements, atmospheric turbulence-induced phase distortion of the vortex beam increases velocity measurement error (VME). Previous studies overlooked the reference to new dimensional information for measurement error analysis and accuracy enhancement. Our work proposes the Optimal Joint Reference VME (OJR-σ) method as a, to our knowledge, novel error optimization method; it references the measurement error information from the left- and right-handed polarized components (LP and RP) of the polarized vortex beam and optimizes the velocity measurements values weights of LP and RP in the result to minimize the VME.

High-repetition-rate ultrafast fiber lasers enabled by BtzBiI: a novel bismuth-based perovskite nonlinear optical material.

Recent advances in perovskite crystals have highlighted their exceptional optical properties, making them promising candidates for a wide range of photonic applications. However, the exploration of high-repetition-rate laser systems based on these materials remains underdeveloped, hindering their potential in ultrafast laser technologies and related fields such as optical communications and precision metrology. In this study, we present, for the first time, the saturable absorption characteristics of a novel organic-inorganic hybrid perovskite incorporating the heavy metal bismuth (Bi), specifically N-methylbenzothiazoleBiI (BtzBiI).

Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons.

Age-related cognitive decline is linked to impaired autophagy and hippocampal dysfunction. This study investigates the role of Sirtuin 2 (SIRT2) in age-related cognitive decline, focusing on its impact on autophagy and hippocampal function. Quantitative proteomic analysis revealed 67 significantly dysregulated proteins in the hippocampus of naturally aged male mice, including upregulated SIRT2 and impaired autophagy.

Exploring of bladder cancer immune-related genes and potential therapeutic targets based on transcriptomic data and Mendelian randomization analysis.

Background: Despite advancements in clinical treatment modalities, immune-related molecular mechanisms underlying bladder cancer remain unclear. Therefore, this study aimed to identify immune-related biomarkers and potential therapeutic targets for bladder cancer, thereby contributing to the development of novel therapeutic interventions.

Methods: By integrating data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and genome-wide association study (GWAS) databases, combined with differential expression analysis, weighted gene co-expression network analysis (WGCNA), and Mendelian randomization analysis, key immune-related genes in bladder cancer were identified.

Automated 3D Computed Tomography Bronchography and Angiography as a Useful Tool for the Clinical Medicine Education of Lung Segmentectomy.

ObjectiveAs pulmonary segmentectomy becomes increasingly common in the treatment of early-stage lung cancer, providing relevant clinical training for residents is essential. However, understanding pulmonary segment anatomy can be challenging due to its complex and variable structures. This study aimed to evaluate the value of automated three-dimensional CT bronchography and angiography (3D-CTBA) technology in training surgical residents for segmentectomy.

Pyridoxal phosphate inhibits alpha-synuclein-induced ferroptosis by activating GOT1 to enhance the methionine salvage pathway in Parkinson's disease.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the overpression of α-synuclein (α-syn) and the degeneration of dopaminergic neurons. Ferroptosis, a form of cell death driven by aberrant iron metabolism and lipid peroxidation, has been reported to play a crucial role in the pathogenesis of dopaminergic neurons death while the precise mechanisms remain elusive. In this study, we identified a cytosolic enzyme glutamic-oxalacetic transaminase (GOT)-1 as a negative regulator of ferroptosis through analyses of public databases.

Au-BiSe hybrid nanosheets with enhanced SERS activity for detecting polystyrene plastics.

Polystyrene (PS) plastics were potentially present in consumer products through the use of plastics packaging. The migration and enduring presence for bioaccumulation posed significant threats to human health and the environment. It was significant to develop a simple and reliable approach for sensitive PS plastics detection.

Sleep disorders and aging: Mendelian randomization analysis of epigenetic and frailty markers.

Background: Sleep disorders-including daytime sleepiness (DS), insomnia, and sleep apnea (SA)-have been linked to aging-related phenotypes, but their causal roles remain unclear. This study aimed to examine the potential causal effects of these sleep traits on biological aging using a Mendelian randomization (MR) approach.

Methods: We conducted two-sample MR analyses using genetic instruments from large-scale genome-wide association studies (GWAS) for DS, insomnia, and SA.

Automatic PID Control Strategy via Energy Dissipation for Tapping Mode Atomic Force Microscopy.

This study presents an automatic PID control strategy for Tapping-Mode Atomic Force Microscopy (TM-AFM) that addresses the impacts of energy dissipation on tip-sample interactions. Our methodology integrates energy analysis to quantify the critical relationship between energy loss and phase lag dynamics in tapping mode. Additionally, systematic decomposition of interaction force is performed to enable the reconstruction of system transfer functions.

Integrative Analysis of Transcriptomics and Metabolomics Provides Insights into Meat Quality Differences in Hu Sheep with Different Carcass Performance.

Meat quality is a critical determinant of consumer preference and economic value in the livestock industry. However, the relationship between carcass performance and meat quality remains poorly understood. In our study, we conducted an integrative analysis of transcriptomics and metabolomics to investigate the molecular mechanisms underlying meat quality differences in Hu sheep with high (HHS, = 10) and low (LHS, = 10) carcass performance.

Gallic Acid Alleviates Acetaminophen-Induced Acute Liver Injury by Regulating Inflammatory and Oxidative Stress Signaling Proteins.

Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury (DILI) globally, which necessitates effective therapies. Gallic acid (GA), a naturally abundant polyphenol, possesses potent antioxidant and anti-inflammatory properties that may overcome the limitations of N-acetylcysteine (NAC), such as its narrow therapeutic window. This study systematically investigated the hepatoprotective effects and underlying molecular mechanisms of GA against APAP-induced acute liver injury (ALI).