Extracts and pimaradienoic acid from Eleutherococcus trifoliatus L. S. Y. Hu for the treatment of Rheumatoid Arthritis by modulating NF-κB signaling pathway.

Ethnopharmacological Relevance: The use of Eleutherococcus trifoliatus L. S. Y.

Direct and indirect measurement of liquid film thickness by common optical methods.

Liquid film phenomena widely exist in nature and industrial processes. They have the advantages of low flow velocity, small temperature difference, high heat flux density, and high heat and mass transfer efficiency. For these reasons, they are widely used in various engineering processes.

Color imaging system high dynamic range colorimetric characterization modeling based on fusion kernel XGBoost.

High dynamic range imaging exhibits lower resolution in both highly bright and deeply dark colors, which results in reduced accuracy in the measurement of photometry and colorimetry using color imaging systems. Based on the nonlinear capability of the Gaussian kernel function and the global linear trend of the linear kernel function, a Gaussian-linear fusion kernel is designed. Through multi-dimensional space mapped by the designed fusion kernel, a kernel XGBoost colorimetric characterization model is proposed.

ZnS-SnS-NiCoS: a new breakthrough in quaternary sulfide composites for the oxygen evolution reaction.

A ZnS-SnS-NiCoS composite was fabricated on Ni foam by polymetallic compositing of NiS. The optimized catalyst exhibits outstanding OER performance with a low overpotential (149 mV at 10 mA cm) and Tafel slope (33.57 mV dec), offering a promising strategy for efficient water splitting and sustainable hydrogen production.

The role of genetic testing in evaluating surgical outcomes for pediatric focal cortical dysplasia associated with NPRL3 variant.

This case report describes a 5-year-and-10-month-old female patient who developed sleep-related hypermotor epilepsy, at the age of 2, exhibiting various forms of seizures since the age of 2. Initially, the seizures were controlled for one year with multiple anti-seizure medications; however, symptoms recurred when the patient was 3 years and 5 months old, leading to an increased seizure frequency and a poor response to combined drug therapy. Long-term video-EEG revealed discharges originating from the frontal lobe, while MRI and PET-CT scans indicated FCD in the left frontal region.

MAZ Coordinates With HDAC1 to Promote Hepatocarcinoma Proliferation and Metastasis Through Transcriptional Repression of CSK.

The transcription factor Myc-associated zinc finger protein (MAZ) is highly expressed in various malignant tumors, and it is known to activate the expression of a large number of proto-oncogenes through transcription. However, the specific molecular mechanism of how MAZ regulates transcriptional repression in hepatocarcinoma remains unclear. To identify the interacting proteins of MAZ, we employed immunoaffinity purification followed by silver-stain mass spectrometry.

Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection.

Background: Schistosomiasis, a parasitic disease affecting more than 240 million people worldwide, is characterized by chronic inflammation and tissue fibrosis primarily induced by parasite egg deposition. Bromodomain-containing protein 4 (BRD4), an epigenetic and transcriptional regulator, has emerged as a potential therapeutic target due to its dual role in modulating Schistosoma japonicum (S. japonicum) reproductive development and organ fibrosis.

: An Overview of Phytochemistry, Pharmacology, Clinical Prospects, and Network Analysis of Drug Targets.

Jones () has a long history of medicinal use owing to its significant therapeutic effects, particularly in the treatment of mental diseases such as depression, and on account of its cytotoxicity against various cancer cells. The chemical composition, pharmacological properties, and mechanisms of have been extensively explored in various studies published between 2017 and 2023 on major databases such as Web of Science, PubMed, and CNKI[Formula: see text] Investigations have identified 128 compounds including iridoids, sesquiterpenoids, volatile oils, lignans, and miscellaneous compounds based on their structural characteristics. Pharmacological research has documented its impact on the central nervous system, and its antitumor, gastroprotective, antioxidant, and anti-inflammatory effects.

Landscape of Histone Posttranslational Modifications in Osteoarthritis.

Osteoarthritis (OA) is a complex, progressive, and age-associated disease characterized by aberrant epigenetic expression. Epigenetic analysis has helped clarify the role of histone post-translational modifications (PTMs) in OA. PTMs affect histone structure and function and, therefore, regulate the expression of genes implicated in various biological processes.

Comprehensive genome-wide analysis of peroxidase gene family in the Herpetospermum pedunculosum identifies HpPRX involved in lignan-specific biosynthesis.

In plateau plants, high expression of peroxidase is a physiological mechanism by which the reactive oxygen species system is activated. Peroxidase was identified to catalyze novel lignan biosynthesis in Herpetospermum pedunculosum, with phenolic oxidative coupling serving as the critical biosynthetic step. The enzyme involved in hepatoprotective lignan biosynthetic pathway was functionally characterized through whole genome analysis, which detected 84 peroxidase gene family members in H.

Iterative Screening of Vitamin E-Based Functional Lipid Nanoparticles for mRNA Delivery.

Ionizable lipids are crucial for the effective delivery of mRNA by using lipid nanoparticles (LNPs). Endowing ionizable lipids with tailored biological properties could potentially augment the therapeutic efficacy of mRNA-based treatments. Herein, a functional vitamin E (VE)-based lipid library with distinct head groups was designed and synthesized.

Multifaceted roles of lactate dehydrogenase in liver cancer (Review).

Hepatocellular carcinoma (HCC) has high morbidity and mortality rates, and metabolic reprogramming of HCC cells supports the proliferation and development of tumor cells. Lactate dehydrogenase (LDH), a key metabolic enzyme, can maintain the rapid proliferative demand of tumor cells by promoting glycolysis and lactate production in HCC cells. In addition, LDH regulates redox homeostasis and influences lipid synthesis and signaling pathways, further promoting tumor invasion and metastasis.

Enhancing dichromate transport and reduction via electric fields induced by photocatalysis.

Mass transport is a fundamental yet often overlooked factor in influencing adsorption and photocatalytic reaction kinetics. This study examines the role of mass transport using the model system of monoclinic bismuth vanadate (BiVO) films and potassium dichromate (KCrO) in a representative photocatalytic reaction. We show that diffusion-driven delivery of KCrO to the BiVO surface increases adsorption capacity but decreases the adsorption rate constant.

TCH: A novel multi-view dimensionality reduction method based on triple contrastive heads.

Multi-view dimensionality reduction (MvDR) is a potent approach for addressing the high-dimensional challenges in multi-view data. Recently, contrastive learning (CL) has gained considerable attention due to its superior performance. However, most CL-based methods focus on promoting consistency between any two cross views from the perspective of subspace samples, which extract features containing redundant information and fail to capture view-specific discriminative information.

Bioactive Zn ingredients endow Ti-Zn composites with exceptional mechanical and osteogenic properties as biomedical implants.

Titanium-based (Ti-) alloys are promising materials as bioimplants with superior mechanical properties and excellent biocompatibility. However, their bioinertia and high elastic moduli are not comparable to natural bone tissue; thus, novel Ti alloys with good biomechanical adaptation and high bioactivity are desired. Zinc (Zn) is recognized for ideal biodegradability and its biological effects can be considered to endow pure Ti with rewarding bio functions.

Genome-wide identification and expression analysis of the gene family in L. under UV-B stress.

are key genes that catalyze the interconversion between alcohols and aldehydes, which play crucial roles in plant adaptation to a range of abiotic stresses. However, the characterization and evolutionary pathways of genes in the antimalarial plant are still unclear. This study identified 49 genes in and conducted a detailed analysis of their structural features, conserved motifs, and duplication types, revealing that tandem and dispersed duplications are the primary mechanisms of gene expansion.

Engineered vesicular cancer vaccines for immunosuppressive microenvironment reversion and in situ vaccine generation.

It is crucial to reverse immunosuppressive tumor microenvironment (TME) and effectively activate both cellular and humoral immunity in cancer immunotherapy. We have found that decitabine, an epigenetic regulator, can increase antigen exposure and induce double-stranded RNA (dsRNA) accumulation in tumor cells. The corresponding cell-derived nanovesicles (NV) have the ability to stimulate both cellular and humoral immunity due to the internal dsRNA.

Periplakin Attenuates Liver Fibrosis via Reprogramming CD44 Cells into CD44 Liver Progenitor Cells.

Background & Aims: Liver progenitor cells (LPCs) contribute significantly to the restoration of injured liver parenchyma and promote liver regeneration, thereby ameliorating liver fibrosis. However, the mechanism of the derivation of LPCs remains poorly understood.

Methods: We first examined the expression of periplakin (PPL) in patients and mouse models with liver fibrosis.

Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Infections.

The ubiquitous opportunistic pathogen () causes biofilm-associated drug-resistant infections that often lead to treatment failure. Targeting the bacterium's quorum sensing (QS) and iron homeostasis presents a promising strategy to combat biofilm formation. This study synthesized benzothiazole-conjugated hydroxamic acid derivatives as dual-acting biofilm inhibitors, and compound was identified as the hit compound with potent submicromolar biofilm inhibitory activity (IC = 0.

Harnessing Computational Strategies to Overcome Challenges in mRNA Vaccines.

In recent years, the introduction of mRNA vaccines for SARS-CoV2 and respiratory syncytial virus (RSV) has highlighted the success of the mRNA technology platform. Designing mRNA sequences involves multiple components and requires balancing several parameters, including enhancing transcriptional efficiency, boosting antigenicity, and minimizing immunogenicity. Moreover, changes in the composition and properties of delivery vehicles can also affect vaccine performance.

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor 2 encephalitis with olfactory hallucination: a case report and literature review.

Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis is a rare autoimmune disease divided into two subtypes, anti-AMPAR1 encephalitis and anti-AMPAR2 encephalitis, depending on the presence of autoantibodies targeting the GluR1 and GluR2 subunits of the AMPA receptor. The main manifestations are limbic encephalitis, including cognitive impairment, seizures, and psychiatric symptoms. The reported cases of anti-AMPAR encephalitis have grown; however, no research has yet described the clinical characteristics of each subtype.

Rhizosphere microbiome metagenomics in PGPR-mediated alleviation of combined stress from polypropylene microplastics and Cd in hybrid Pennisetum.

The simultaneous presence of microplastics (MPs) and heavy metals in soil may result in heightened toxicity, causing more significant adverse effects on plant growth. Plant growth-promoting rhizobacteria (PGPR) have demonstrated significant capacities in alleviating the toxic stress caused by the combined pollution of heavy metals and other contaminants. However, research on the impacts and processes of PGPR in alleviating stress induced by the combined pollution from MPs and heavy metals is still insufficient.

Study on the change rule of airflow temperature field in ultra-deep mining shaft.

In the background of increasing depth of metal mining, the issue of airflow temperature field during the construction of ultra-deep shaft is very important, in view of the fact that there is still very little research related to this content at home and abroad, so this aspect of the research is very necessary in the process of the development of deep shaft mining. This paper focuses on the study of the patterns of change in the airflow temperature field during the construction of ultra-deep shaft, based on Newton's law of cooling and the first law of thermodynamics, and from the perspective of fluid dynamics, it puts forward a new theory - the theory of equilibrium enthalpy interface, which qualitatively and quantitatively derives the critical conditions of the three changes in the wind temperature of ultra-deep shaft and uses numerical simulation to study the content of the theory. The results of the study show that when the airflow runs from bottom up in the ultra-deep shaft, the change of airflow temperature is not a simple linear relationship, but a curve relationship similar to a cubic function, showing a law of decreasing first, then increasing and then decreasing.

Study on the size and spatial configuration of liquid metal droplets in conductive hydrogels induced by surface acoustic waves.

Conductive hydrogels based on liquid metal microdroplets are widely used as wearable electronic devices. Droplet uniformity affects sensor sensitivity for weak signals, such as heart rate and pulse rate. Surface acoustic waves at micrometer wavelengths allow precise control of a single droplet, and have the potential to make uniformly discrete liquid metal droplets and distribute them in hydrogels.