Altered Sensorimotor Cortical Activities During Forearm Movement in Humans With Spinal Cord Injury.

Aims: Decoding the motor intention by electroencephalography to control external devices is an effective method of helping spinal cord injury (SCI) patients to regain motor function. Still, SCI patients have much lower accuracy in the decoding of motor intentions compared to healthy individuals, which severely hampers the clinical application. However, the underlying neural mechanisms are still unknown.

Ni-Catalyzed and Pentafluorobenzoate-Leaving-Group-Enabled Stereoselective -Aryl Glycosylation.

Inspired by the excellent stereoinduction of palladium catalytic glycosylation with glycals via an inner-sphere pathway, a nickel-catalyzed, stereoselective -aryl glycosylation has been developed for glucals bearing a pentafluorobenzoate (PFB) group at the C3 position. The extremely electron-deficient nature of PFB not only endows stronger activity compared to the traditional leaving groups but also functions as an orientation group, presumably through the strong π-π interactions with the bipyridine ligand coordinated to the nickel center, thereby enabling the β-selective formation of a -aryl glycosidic bond with aryl iodides as glycosyl acceptors under mild conditions. This method features a broad substrate scope, high efficiency, and scalability, providing a general solution to the synthesis of challenging β--glycosides.

Photoionization induced chemical ionization time-of-flight mass spectrometry for rapid and sensitive detection of trace gaseous chemical warfare agents.

On-site accurate and real-time monitoring of trace chemical warfare agents is a critical component of national security surveillance. In this study, a photoionization-induced chemical ionization time-of-flight mass spectrometry is developed for the detection of trace gaseous chemical warfare agents under ambient conditions. Firstly, a benzene-toluene-xylene mixture standard gas is utilized to optimize the instrument parameters, followed by screening of dopants for chemical warfare agents detection, with methanol ultimately identified as the optimal dopant.

A rapidly synthesized magnetic microporous organic network for ultrasensitive detection of non-steroidal anti-inflammatory drugs in fish.

Non-steroidal anti-inflammatory drugs (NSAIDs) residues pose a potential threat to aquatic ecosystems and food safety. In this work, novel imine bond/pyridine nitrogen-rich magnetic microporous organic networks (MMONs-Br and MMONs-I) were synthesized via a facile one-pot strategy using brominated and iodinated precursors for the detection of NSAIDs in fish. Brunauer-Emmett-Teller analysis revealed a striking 11-fold difference in specific surface areas between the two materials (MMONs-Br: 293.

Molecular characterization of endosomal self RNA Rmrp-engaged TLR3 dimerization to prime innate activation.

The pre-dimerization of endosome-localized RNA sensor Toll-like receptor 3 (TLR3) is required for its innate recognition, yet how TLR3 pre-dimers are formed and precisely primed for innate activation remains unclear. Here, we demonstrate that endosome-localized self RNA Rmrp directly binds to TLR3 and induces TLR3 dimerization in the early endosome but does not interact with endosome-localized TLR7, TLR8, TLR9 or cytoplasmic RNA sensor RIG-I under homeostatic conditions. Cryo-EM structure of Rmrp-TLR3 complex reveals a novel lapped conformation of TLR3 dimer engaged by Rmrp, which is distinct from the activation mechanism by dsRNA and the specific structural feature at the 3'-end of Rmrp is critical for its functional interaction with TLR3.