Stable and highly sensitive self-powered X-ray detection high-density CsPbBr-type Dion-Jacobson trilayer hybrid perovskites.

Dion-Jacobson (DJ)-type organic-inorganic hybrid perovskites have emerged as promising candidates for X-ray detection owing to their exceptional stability and remarkable X-ray absorption ability. Nevertheless, achieving enhanced detection sensitivity continues to pose a significant challenge in this research domain. Herein, we have successfully synthesized and grown a DJ-type (4-AMP)CsPbBr (1, 4-AMP = 4-ammoniomethylpiperidinium) hybrid perovskite single crystal with a high density of 3.

Crosslinking polymer based on amino chitosan for the adsorption of phenoxycarboxylic acids: Kinetics, isotherm, and thermodynamics.

In this work, new crosslinking polymer adsorbents were synthesized based on amino chitosan. Crosslinked amino chitosan (CNCS) was characterized by porous structure, high specific surface area (23.49 m/g), and multiple amino groups.

Mesaconic acid as a key metabolite with anti-inflammatory and anti-aging properties produced by Lactobacillus plantarum 124 from centenarian gut microbiota.

The gut microbiota of centenarians plays a vital role in promoting healthy longevity. We performed a cross-sectional study of 224 people from Jiaoling, China, which is globally recognised for the longevity of its residents. Compared with younger people, centenarians showed significantly increased alpha-diversity, enrichment of the beneficial bacteria Lactobacillus, Akkermansia, and Christensenella, and increased redox capacity in the gut microbiota.

Pulp Residues Polysaccharide Alleviates High-Fat Diet-Induced Obesity by Modulating Intestinal Mucus Secretion and Glycosylation.

Although pulp residues polysaccharides (HPPP) have shown potential in improving metabolic disorders and intestinal barrier function, the mechanism by which they exert their effects through regulating O-glycosylation modifications in the mucus layer remains unclear. Therefore, this study established a HFD-induced obese colitis mouse model ( = 5 per group) and combined nano-capillary liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) technology to quantitatively analyze the dynamic changes in O-glycosylation. Additionally, through quantitative O-glycosylation proteomics and whole-proteome analysis, we identified 155 specifically altered O-glycosylation sites in colon tissue, with the glycosylation modification level of the MUC2 core protein increased by approximately 2.

Gut microbiome and serum metabolic alterations in recurrent gestational diabetes mellitus.

Aim: This study aimed to identify gut microbiome and serum metabolic alterations in women with recurrent gestational diabetes mellitus (GDM), which affects a significant proportion of those with a prior history.

Methods: Seventy pregnant women with prior GDM from Beijing, China, participated in this prospective cohort study. Fecal and serum samples were collected in the first (8-12 weeks) and second trimesters (24-28 weeks).

Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes.

Background: Despite optimized blood pressure control and glycemic management reducing the incidence of diabetic nephropathy (DN), significant residual risk remains, suggesting the contribution of pathogenic factors independent of glucose metabolism and hemodynamic disturbances.

Methods: Renal tissues from db/db mice underwent integrative multi-omics analysis, encompassing transcriptomics, metabolomics, and lipidomics. Orthogonal projection to latent structures-discriminant analysis (OPLS-DA) was applied to identify significant metabolic perturbations, while bidirectional O2PLS integration elucidated metabolic-transcriptomic correlations.

High-Performance Electrochemiluminescence Imaging Immunosensor for Adeno-Associated Virus Serotype 8 Detection Based on Nanobody-Functionalized Covalent Organic Frameworks and Au@Rh Catalytic Amplification.

Adeno-associated virus serotype 8 (AAV8) is a widely used gene therapy vector with the characteristics of high transduction efficiency and tissue specificity. Reliable detection of AAV8 is crucial for assessing therapeutic efficacy and tracking its in vivo distribution. Herein, we develop a nanobody-based electrochemiluminescence (ECL) imaging immunosensor based on integrating advanced functional materials with spatially resolved signal output for sensitive and visual detection of AAV8.

SIRT4-Mediated Deacetylation of PRDX3 Attenuates Liver Ischemia Reperfusion Injury by Suppressing Ferroptosis.

Liver ischemia-reperfusion injury (LIRI) is an important cause of the clinical prognosis of liver transplantation. Despite Sirtuin 4 (SIRT4) is involved in various post-translational modifications, its role in LIRI is unclear. This research aimed to investigate the influence of SIRT4 on the pathogenesis of LIRI.

A Real-Time Vision-Based Adaptive Follow Treadmill for Animal Gait Analysis.

Treadmills are a convenient tool to study animal gait and behavior. Traditional animal treadmill designs often entail preset speeds and therefore have reduced adaptability to animals' dynamic behavior, thus restricting the experimental scope. Fortunately, advancements in computer vision and automation allow circumvention of these limitations.

Fouling Mitigation of Silicon Carbide Membranes by Pre-Deposited Dynamic Membranes for the Separation of Oil-in-Water Emulsions.

Membrane fouling poses a significant challenge in the widespread adoption and cost-effective operation of membrane technology. Among different strategies to mitigate fouling, dynamic membrane (DM) technology has emerged as a promising one for effective control and mitigation of membrane fouling. Silicon carbide (SiC) membranes have attracted considerable attention as membrane materials due to their remarkable advantages, yet membrane fouling is still inevitable in challenging separation tasks, such as oil-in-water (O/W) emulsion separation, and thus effective mitigation of membrane fouling is essential to maximize their economic viability.

Modified Target Delineation and Moderately Hypofractionated Radiotherapy for High-Grade Glioma: A Randomized Clinical Trial.

Importance: Optimizing irradiation volumes and evaluating the effect of dose escalation on total and fractionated doses are critical for improving outcomes in high-grade glioma (HGG).

Objective: To assess the efficacy of modified target delineation guided by multimodal magnetic resonance imaging and white matter tracts combined with moderately hypofractionated simultaneous boost intensity-modulated radiotherapy (HSIB-IMRT) in patients with newly diagnosed HGG.

Design, Setting, And Participants: This single-center, 2-arm, open-label randomized clinical trial enrolled 154 patients aged 18 to 70 years with histologically confirmed, newly diagnosed HGG at a Chinese medical center from January 1, 2018, to August 31, 2022.

PNMA1 mediates melphalam chemoresistance in retinoblastoma via promoting DNA repair.

Retinoblastoma (RB) is the most common malignant eye tumor in children. Cytotoxic drugs like melphalam often cause significant side effects and acquired resistance in RB treatment. Here, the impact of Paraneoplastic Ma1 (PNMA1) on RB progression and chemotherapy resistance was investigated.

Ensemble learning for microbiome-based caries diagnosis: multi-group modeling and biological interpretation from salivary and plaque metagenomic data.

Background: Oral microbiota is a major etiological factor in the development of dental caries. Next-generation sequencing techniques have been widely used, generating vast amounts of data which is underexplored. The advancement of artificial intelligence (AI) technologies has made it possible to mine information from these large datasets.

Assessment of first-trimester insulin resistance indices for gestational diabetes mellitus: a prospective cohort study.

Background: Insulin resistance (IR) is a significant factor in gestational diabetes mellitus (GDM) development. The triglyceride-glucose (TyG) index, triglyceride-glucose body mass index (TyG-BMI), atherogenic index of plasma (AIP), and metabolic score for insulin resistance (METS-IR) are simple and reliable surrogates for assessing IR, but their predictive potential for GDM remains unexplored.

Methods: Data from 46,992 singleton pregnancies delivered at Beijing Obstetrics and Gynecology Hospital between 2018 and 2022 were prospectively collected.

Highly Stretchable Transparent Electrodes for Wearable Near-Infrared Organic Photodetectors Enabling Vital Monitoring, Imaging, and Communication.

Stretchable near-infrared organic photodetectors (NIR OPDs) are crucial for the development of wearable and implantable electronics. However, these devices commonly underperform compared to their rigid counterparts, primarily due to the lack of high-quality stretchable transparent electrodes. Here, we develop silver nanowires (AgNWs)/thermoplastic polyurethane (TPU) composite electrodes by introducing 3-[-tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic acid sodium salt (HOS).

Association Between Triglyceride-glucose Index, Its Trajectories and the Risk of Large for Gestational Age - Beijing Municipality, China, 2018-2022.

What Is Already Known About This Topic?: Large for gestational age (LGA) presents significant risks for both mothers and children. Studies have shown a positive association between the first trimester triglyceride-glucose (TyG) index and LGA risk.

What Is Added By This Report?: The TyG index in all three trimesters is positively associated with the risk of LGA.

Preclinical and phase I randomized study of a potent inhalable nanobody targeting TSLP for the treatment of airway inflammation.

Background: TSLP, a cytokine derived from epithelial cells at barrier surfaces, has been extensively studied as a pivotal regulator of type 2 and non-type-2 immune responses, implicated in inflammatory airway diseases. Although mAb therapy targeting TSLP has shown significant therapeutic effects, there is still no approved TSLP-targeting inhaled formulation.

Objectives: Leveraging the distinct advantages of nanobodies (Nbs) in maintaining efficacy during storage and administration, our objective is to develop a novel inhalable TSLP Nb for effectively treating airway inflammation.

Antibodies elicited by hepatitis E vaccination in humans confer cross-genus protection against rat hepatitis E virus.

Background & Aims: Paslahepevirus balayani (bHEV), also known as hepatitis E virus (HEV), encompasses eight genotypes, five of which infect humans. Rats are natural reservoirs of Rocahepevirus ratti genotype 1 (HEV-r-1; rat HEV; rHEV), which has recently been implicated in viral hepatitis. Despite the antigenic divergence between bHEV and rHEV, studies on shared protective antibodies remain rare.

Flexible and High-Performance Solution-Processable Single-Detector Organic Spectrometer.

Spectrometers are indispensable tools for civil and military-related optoelectronic applications. To meet the requirements of the revolutionary data/AI-driven era, next-generation spectrometers must not only be flexible with minimal sizes but exhibit high accuracy and resolution. In this study, a compact, high-performance, and flexible organic spectrometer is reported, fabricated using solution processing, which employs an optical cascade architecture by integrating organic electrochromic devices and photodetectors.

β-Hydroxybutyrate Facilitates Homeostasis of Hypoxic Endothelial Cells After Myocardial Infarction via Histone Lysine β-Hydroxybutyrylation of CPT1A.

Myocardial infarction (MI) initiates a robust angiogenic response crucial for tissue repair. β-hydroxybutyrate (BHB) is an essential circulating metabolite, and its role in angiogenesis under pathological conditions remains unclear. We evaluated the coronary collateral circulation in 114 patients with MI and investigated its correlation with serum BHB levels.

Prefrontal Blood Flow Activity During Drawing Intervention in School-Age Children with Autism: An fNIRS Hyperscanning Study.

Art-based interventions have been shown to enhance communication skills in children with autism spectrum disorder (ASD), yet their impact on prefrontal hemodynamics remains unclear. This study employed functional near-infrared spectroscopy (fNIRS) to examine hemoglobin oxygenation (HbO) changes in the prefrontal cortex of school-age children with ASD, providing empirical support for its therapeutic efficacy. Sixty age-matched children participated in a 9-week art therapy program, including twenty ASD children and forty typically developing peers.

Accurate prediction of virulence factors using pre-train protein language model and ensemble learning.

Background: As bacterial pathogens develop increasing resistance to antibiotics, strategies targeting virulence factors (VFs) have emerged as a promising and effective approach for treating bacterial infections. Existing methods mainly relied on sequence similarity, and remote homology relationships cannot be discovered by sequence analysis alone.

Results: To address this limitation, we developed a protein language model and ensemble learning approach for VF identification (PLMVF).

Evaluating safe infrared neural stimulation parameters: Calcium dynamics and excitotoxicity thresholds in dorsal root ganglia neurons.

Background: As a promising neural stimulation technique, infrared neural stimulation (INS) has recently gained significant attention due to its ability to stimulate neuronal activities without needing exogenous agents. NIR light is absorbed by water of the tissue producing local thermal effects. Therefore, INS is a suitable candidate for localized and targeted neural stimulation.

Multiple perinatal characteristics affect the association between maternal diabetes status and early neonatal gut microbiota.

Unlabelled: Increasing evidence has suggested that maternal gestational diabetes mellitus (GDM) can influence the neonatal gut microbiota. However, the initial microbial colonization of neonates is still unclear. The discrepancy in results between studies may be due to many other prenatal characteristics.

Silicon Monoxide Anodes Co-Modified with ZnS and Nitrogen-Doped Carbon via Facile Synthesis: Toward High-Energy Lithium-Ion Battery Applications.

Silicon monoxide (SiO) has emerged as a promising silicon-based anode material owing to its high theoretical specific capacity and extended cycle life. Nevertheless, its practical application is hindered by significant volume expansion and insufficient cycling stability. In this study, a composite material of SiO coated with zinc sulfide and nitrogen-doped carbon (ZnS&NC/SiO) was successfully prepared via a developed method of in situ conversing MOFs into nitrogen-doped carbon and ZnS.