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What Is Already Known About This Topic?: Large for gestational age (LGA) presents significant risks for both mothers and children. Studies have shown a positive association between the first trimester triglyceride-glucose (TyG) index and LGA risk.
What Is Added By This Report?: The TyG index in all three trimesters is positively associated with the risk of LGA. Managing the TyG index may help reduce this risk.
What Are The Implications For Public Health Practice?: These results suggest that monitoring the TyG index from the first trimester throughout pregnancy could help clinicians identify women at higher risk for LGA, guiding early interventions to mitigate risks. Further research is needed to explore the relationship and mechanisms between the TyG index and LGA.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227888 | PMC |
http://dx.doi.org/10.46234/ccdcw2025.115 | DOI Listing |
Anim Reprod Sci
September 2025
Department of Biomedical & Clinical Sciences (BKV), BKH/Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping SE-58185, Sweden.
Embryo transfer (ET) is a valuable reproductive technology in pigs, albeit its efficiency remains significantly lower than that of natural mating or artificial insemination (AI), owing to high embryonic death rates. Critical for embryo survival and pregnancy success is the placenta, which supports conceptus development through nutrient exchange, hormone production, and immune modulation. Alterations in placental development and function may therefore underlie the reduced efficiency of ET.
View Article and Find Full Text PDFArch Gynecol Obstet
September 2025
Department of Obstetrics and Gynaecology, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy.
Objectives: Recommendations regarding the use of third-trimester ultrasound lack universal consensus. Yet, there is evidence which supports its value in assessing fetal growth, fetal well-being, and a number of pregnancy-related complications. This literature review evaluates the available scientific evidence regarding its applications, usefulness, and the timing of the third-trimester scan in a low-risk population.
View Article and Find Full Text PDFFolia Parasitol (Praha)
September 2025
Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
Taenia crassiceps (Zeder, 1800), a zoonotic cestode with a wide geographical distribution, utilises canids as definitive hosts and small rodents as intermediate hosts. However, accidental infections in non-human primates, particularly in captive lemurs, have been increasingly documented. In this case report, we describe the first documented case of cysticercosis caused by the larval stage of T.
View Article and Find Full Text PDFNAR Mol Med
July 2025
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
Advanced maternal age increases the risk of pregnancy complications due, in part, to changes in the uterine environment. Here, we show that uterine aging in mice is associated with a progressive increase in transcriptional variation, accompanied by a notable accumulation of activating histone marks at multiple genomic loci. Importantly, the transcriptional signatures of uterine aging differ substantially from senescence markers associated with organismal aging.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Introduction: Midlife hypertension is associated with dementia risk, although uncertainties remain regarding its association with subtypes and regarding the effect of pregnancy-related hypertension on dementia risk.
Methods: In the Million Women Study, 1,363,457 women (mean age 57) were asked about current treatment for hypertension and hypertension in pregnancy and were followed for first hospital record with any mention of dementia. Cox regression yielded hazard ratios (HRs) adjusted for socioeconomic, lifestyle, and metabolic factors.