Ammonia-induced dispersion and proliferation of Actinobacillus pleuropneumoniae biofilms.

Biofilm is a common status of bacteria persistent inside the host. Its dispersion can cause reactivation of bacteria, leading to disease outbreak. This study investigated ammonia's effects on Actinobacillus pleuropneumoniae, an important porcine respiratory pathogen.

Divergent Synthesis of Polycyclic N‑Heterocycles via Controllable Cyclization of Divinylallenes Catalyzed by Copper and Gold.

The generation of metal carbenes from readily available allenes represents a remarkable advance in metal carbene chemistry. However, most of these transformations are mainly restricted to the noble-metal catalysts (Au and Pt). Here, a copper-catalyzed desymmetric cyclization reaction of divinylallenes is described, enabling the practical and atom-economical synthesis of a diverse array of valuable triazolo-fused pyridazines and tetracyclic N-heterocycles by a presumable copper carbene intermediate and a highly selective 1,2-N shift process.

Ultra-broadband and ultra-narrowband actively tunable VO metamaterial perfect absorber.

To solve the problems of single absorption function and the complex structure of terahertz absorbers, this study proposes a terahertz (THz) absorber based on vanadium dioxide (VO) driven by electric dipole resonance, which can achieve wideband and narrowband absorption conversion. Simulation results indicate that in the narrowband absorption mode, two narrowband absorption peaks were observed at 14.6 THz and 16.

Epidemic Evolution Trends and Spatiotemporal Clustering of Human Brucellosis in Xilingol League Inner Mongolia, from 2004 to 2023.

Objective: Human brucellosis is a serious public health concern in the Xilingol League, Inner Mongolia; however, the epidemic trends are unclear.

Method: In this study, Joinpoint regression analysis and spatiotemporal analysis were applied to investigate the epidemic evolution of human brucellosis.

Result: From 2004 to 2023, a total of 35,747 cases were reported, with an annual average of 1787.

Spatial Confinement in Structural Biomimetic Catalysts: Enhancing Sulfur-Chain Homolysis and Enzyme-like Activity for High-Performance Lithium-Sulfur Batteries.

Our study addresses the critical challenges of sluggish sulfur reaction kinetics and severe lithium polysulfide shuttling in high-energy-density lithium-sulfur batteries under high sulfur loading and lean electrolyte conditions. Inspired by the structure of cytochrome c oxidase, we designed an enzyme-mimetic Fe-TCPP@Cu-BTC catalyst with spatial confinement effects. Its spatially confined configuration induces the homolytic cleavage of LiS to LiS and accelerates their subsequent conversion to LiS.

[Impacts of varicocele on the structure and proteomics of rat testis tissue: An experimental study].

Objective: To study the impacts of varicocele (VC) and varicocelectomy (VCT) on the proteomics of rat testis tissue, and to analyze the differential proteins and signaling pathways, and observe the microstructural changes of the testis tissue.

Methods: We selected 60 male SD rats and divided them into a sham operation (SO), a VC model control, and a VCT group. We harvested the testis tissues from the rats at 4 weeks after modeling for determination of the differential protein expressions by mass spectrometry, analysis of the changes in the protein signaling pathways by KEGG pathway repolarization, and observation of the microstructural changes in the spermatogenic cells under the transmission electron microscope (TEM).

Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking.

Heat nociception involves thermosensors like transient receptor potential channel V1 in dorsal root ganglion (DRG) neurons, but their loss only partially impairs heat sensing, suggesting other mechanisms. Autism frequently involves abnormal pain perception, but its mechanisms remain unclear. Here we show that dedicator of cytokinesis 4 (Dock4), an autism susceptibility gene, is decreased in DRG neurons across multiple pain models via histone H4K8 lactylation.

Shared diagnostic genes and potential mechanisms between intervertebral disc degeneration and diabetes mellitus revealed by integrated transcriptomic analysis and machine learning.

Introduction: Intervertebral disc degeneration (IDD) and diabetes mellitus (DM) are clinically associated beyond traditional risk factors, yet the shared molecular mechanisms remain unclear.

Methods: We integrated transcriptomic data from IDD and DM cohorts, performed differential expression and protein-protein interaction (PPI) network analyses, and applied machine learning to identify shared diagnostic genes. Pathway enrichment, immune infiltration analyses, and experimental qPCR validation were conducted to explore mechanisms and confirm findings.

Correction: Baicalin-modifed polyethylenimine for miR-34a efficient and safe delivery.

[This corrects the article DOI: 10.3389/fbioe.2023.

Initial quantitative analysis of gemstone spectral imaging CT: Analysis and discussion of the application value for the differentiation of small liver metastases (<3 cm).

BackgroundHepatic metastases are the most common malignant tumors in the liver. Conventional contrast-enhanced CT examinations face challenges in distinguishing between benign and malignant atypical metastatic liver lesions with a diameter <3 cm, and evaluating their therapeutic efficacy remains particularly difficult.ObjectiveTo assess the clinical value of quantitative iodine analysis and spectral curves for diagnosing and differentiating liver metastases using gemstone spectral CT.

Engineered Halomonas sp. Y3 enables highly efficient upcycling of poly(ethylene terephthalate) to polyhydroxyalkanoates.

The global plastic crisis demands innovative solutions for recycling polyethylene terephthalate (PET), a chemically stable polymer constituting 23 % of annual plastic waste. This study presents a significant advance in PET upcycling using engineered Halomonas sp. Y3, a halophilic bacterium uniquely suited for industrial bioprocessing.

Cancer-associated fibroblasts-secreted lactate promotes RNA polymerase III subunit G-mediated epithelial-mesenchymal transition in non-small cell lung cancer by increasing m6A modification of zinc finger protein 384.

Most advanced non-small cell lung cancer (NSCLC) patients have metastasis, which poses great risks to their survival. As the most abundant components in the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) can induce epithelial-mesenchymal transition (EMT) to promote tumor. This study aimed to explore the potential molecular mechanisms of CAFs-mediated EMT in NSCLC.

Clinical Efficacy of the Indigo Thrombectomy Catheter in Acute Superior Mesenteric Artery Embolism: A Single-center Retrospective Analysis.

Introduction: This study aims to evaluate the clinical efficacy and safety of the Indigo thrombectomy catheter in the treatment of acute superior mesenteric artery embolism (SMAE).

Methods: We conducted a single-center retrospective analysis of 15 patients who underwent endovascular thrombectomy using the Indigo Catheter between May 2023 and October 2024. The procedure was performed within 4 h of presentation.

Endoscopic treatment with lumen-apposing metal stent in a patient with esophageal stricture and esophagobronchial fistula: a case report.

Endoscopic interventions for postoperative esophageal strictures and fistulas are inherently challenging. The use of conventional self-expandable metallic stents has been restricted due to high migration rates. There has been no report about malignant esophageal stricture and postoperative fistula managed with a lumen-apposing metal stent (LAMS).

Tandem reaction-adsorption separation of perfluorinated cyclopropane/propane mixtures.

Separating perfluorinated cyclopropane/propane mixtures is critical yet challenging for sustainably producing high-purity perfluropropane in the advanced electronics industry. Conventional one-step adsorption separation methods lack proper selectivity due to similar molecular sizes and properties. We introduce a tandem reaction-adsorption approach with ultrahigh selectivity and low-pressure uptake.

YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2.

Background: Parkinson's disease (PD) is a common neurodegenerative movement disorder, mainly characterized by the degeneration and loss of dopaminergic neurons in the substantia nigra. Oxidative stress is considered to be a key contributor to dopaminergic neuronal degeneration, triggering a series of downstream events such as mitochondrial dysfunction, neuroinflammation and misfolded protein aggregation, which ultimately exacerbate the development of PD. Deubiquitinating enzymes (DUBs) regulate oxidative stress, but their roles in PD remain unclear.

Identification of QTLs for adult-plant stripe rust resistance in Chinese wheat landrace Yizhanghongkemai and assessment of their utility for decreasing yield loss.

Unlabelled: Stripe rust is prevalent in the wheat-growing region of southwestern China. Frequent changes in stripe rust pathogen virulence in this region lead to a rapid loss of disease resistance among wheat varieties. However, Chinese wheat landrace Yizhanghongkemai (YZHK) has exhibited adult-plant stripe rust resistance for more than one decade in a disease nursery in southwestern China.

Helical-like scan and upright CBCT imaging algorithms based on robotic-arm system.

Background: Upright position CT scans enable body imaging under realistic conditions and have been widely adopted in rehabilitation medicine. However, they face challenges such as limited acquisition angles, floor stability issues, and a restricted field of view (FoV) along the Z-axis.

Purpose: The objective of this study is to propose an algorithm that enables high-quality image reconstruction in lightweight robotic-arm cone-beam CT (CBCT) systems, addressing challenges related to mechanical vibrations, a limited Z-axis scanning range, and inhomogeneous sampling.

The relationship between inflammation, osteoporosis, and sleep disturbances: a cross-sectional analysis.

Background: Inflammation is a crucial factor in the development of both osteoporosis and sleep disturbances; however, the mechanisms that connect these two conditions are not yet fully understood. This study aims to investigate the relationship among inflammation, osteoporosis, and sleep disturbances, and to assess whether osteoporosis acts as a mediating factor between inflammation and sleep disturbances.

Methods: This study conducted a cross-sectional analysis utilizing data from participants aged 50 and older, sourced from the NHANES database for the years 2005-2010 and 2017-2018.

Spatial-Temporal Graph Mamba for Music-Guided Dance Video Synthesis.

We propose a novel spatial-temporal graph Mamba (STG-Mamba) for the music-guided dance video synthesis task, i.e., to translate the input music to a dance video.

Efficacy and Safety of Toludesvenlafaxine Hydrochloride Sustained-Release Tablets on Somatic Symptoms of Major Depressive Disorder: A Prospective, Single-Arm, Multicenter Clinical Study.

Importance: Depression is a significant global public health issue, with somatic symptoms being a common and challenging aspect of its management.

Objective: This study aimed to evaluate the efficacy and safety of toludesvenlafaxine hydrochloride sustained-release tablets (Roxylin) for somatic symptoms of major depressive disorder (MDD).

Design Setting And Participants: Prospective, single-arm, multicenter clinical study conducted between June 1, 2023 and May 1, 2024, enrolling patients diagnosed with MDD with somatic symptoms at four hospitals across China.

A Novel Lumbar Disc Herniation Classification Based on Endplate Destruction.

Objective: The purpose of this study was to propose a new classification system based on endplate destruction for lumbar disc herniation to guide the selection of clinical treatment strategies.

Methods: Included in this study were 300 lumbar disc herniation patients who received treatment in our center between January 2016 and March 2023. Basic demographic information, treatment plans, and the Oswestry Disability Index scores and visual analog scale scores were collected.

Oxidation behavior of TiC and TiCN and their potential photocatalytic activity in a semi-oxidized state.

The oxidation behavior of titanium carbide (TiC) and titanium carbonitride (TiCN) warrants significant attention. This study investigates the oxidation behavior of internally doped TiC and TiCN in ambient air by varying the oxidation temperature and explores their photocatalytic degradation activity. Macroscopic observations, combined with XRD and SEM analyses, reveal a pronounced color change during oxidation, with TiC exhibiting superior oxidation resistance compared to TiCN.

Chiral Perturbation Strategies for Circularly Polarized Thermally Activated Delayed-Fluorescence Small Molecules: Progress in the Application of Organic Light-Emitting Diodes.

The application of organic light-emitting diodes (OLEDs) has become widespread, with polarizers commonly employed to mitigate the influence of external light sources on OLED displays. However, when the light signal generated by the OLED emissive layer passes through the polarizer, approximately 50% of the light energy is inevitably lost. Circularly polarized luminescent (CPL) molecules, capable of emitting specific left- or right-handed circularly polarized light, theoretically enable 100% light energy utilization in corresponding OLED devices (CP-OLEDs).

Pretreatment and on-treatment ctDNA and tissue biomarkers predict recurrence in patients with stage IIIB-D/IV melanoma treated with adjuvant immunotherapy: CheckMate 915.

Purpose: CheckMate 915 (NCT03068455) compared adjuvant nivolumab monotherapy versus combination nivolumab+ipilimumab in patients with resected stage III/IV melanoma. This exploratory analysis was performed to identify biomarkers that correlate with benefit from adjuvant immunotherapy.

Patients And Methods: 1,844 patients received nivolumab 480 mg every 4 weeks or nivolumab 240 mg every 2 weeks with ipilimumab 1 mg/kg every 6 weeks.