Helical-like scan and upright CBCT imaging algorithms based on robotic-arm system.

Background: Upright position CT scans enable body imaging under realistic conditions and have been widely adopted in rehabilitation medicine. However, they face challenges such as limited acquisition angles, floor stability issues, and a restricted field of view (FoV) along the Z-axis.

Purpose: The objective of this study is to propose an algorithm that enables high-quality image reconstruction in lightweight robotic-arm cone-beam CT (CBCT) systems, addressing challenges related to mechanical vibrations, a limited Z-axis scanning range, and inhomogeneous sampling.

3D Ordered Macroporous Mn, Zr-Doped CaCO Nanomaterials for Stable Thermochemical Energy Storage.

Developing high-performance Ca-based materials that can work for long-term heat transfer and storage in concentrated solar power plants is crucial to achieve the large-scale conversion of solar photon fluxes to dispatchable electricity. This work demonstrates that a series of Mn, Zr co-doped CaCO nanomaterials with the 3D ordered macroporous (3DOM) skeletons are successfully prepared by a novel strategy of templated metal salt co-precipitation. The characterization results indicate that a majority of Zr and Mn are atomically dispersed into the highly-crystallized CaCO framework, whereas a minor amount of Mn is present in the form of CaMnO nanoparticles (NPs).

Surface Oxygen Defect Engineering of ABO Pyrochlore Semiconductors Boosts the Electrocatalytic Reduction of CO-to-HCOOH.

The electrocatalytic conversion of inert CO to value-added chemical fuels powered by renewable energy is one of the benchmark approaches to address excessive carbon emissions and achieve carbon-neutral energy restructuring. However, the adsorption/activation of supersymmetric CO is facing insurmountable challenges that constrain its industrial-scale applications. Here, this theory-guided study confronts these challenges by leveraging the synergies of bimetallic sites and defect engineering, where pyrochlore-type semiconductor ABO is employed as research platform and the conversion of CO-to-HCOOH as the model reaction.

The neural implausibility of the diffusion decision model doesn't matter for cognitive psychometrics, but the Ornstein-Uhlenbeck model is better.

In cognitive psychometrics, the parameters of cognitive models are used as measurements of the processes underlying observed behavior. In decision making, the diffusion decision model (DDM) is by far the most commonly used cognitive psychometric tool. One concern when using this model is that more recent theoretical accounts of decision-making place more emphasis on neural plausibility, and thus incorporate many assumptions not found in the DDM.

A new projection correction based voting strategy for breast calcification artifact reduction.

Digital Breast Tomosynthesis (DBT) is an imaging technique that combines traditional tomography with image processing and reconstruction techniques. In screening for breast cancer, high attenuation lesion will cause calcification hardening artifacts, which reduces the reconstructed image quality and limits diagnostic accuracy. We focus on the reconstruction artifacts that are caused by high-attenuation features in DBT, and aim to propose an efficient and accurate method to remove calcification artifacts and retain calcification information.

JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.

Jumonji domain containing protein 2C (JMJD2C) could epigenetically regulate cancer cells. We specifically explored the downstream mechanism of JMJD2C in non-small cell lung cancer (NSCLC) from the long non-coding RNA metastasis associated with lung adenocarcinoma transcript 1/microRNA-503-5p/septin 2 (MALAT1/miR-503-5p/SEPT2) axis. NSCLC clinical tissues were utilized to assess JMJD2C, MALAT1, miR-503-5p and SEPT2 levels.

The Vif protein of caprine arthritis encephalitis virus inhibits interferon production.

Caprine arthritis-encephalitis (CAE) is a chronic progressive infectious disease caused by caprine arthritis-encephalitis virus (CAEV) that seriously threatens the goat industry. Chronic infection and life-long multi-tissue inflammation are the typical features of the disease. Innate antiviral immunity is essential for the host defense system that rapidly recognizes and eliminates invading viruses.

Downregulation of Rab17 promotes cell proliferation and invasion in non-small cell lung cancer through STAT3/HIF-1α/VEGF signaling.

Background: Rab GTPases play a key role in regulating intercellular vesicle trafficking in both exo- and endocytic pathways. Recent studies have reported that Rab small GTPases and the associated regulatory proteins and effectors are involved in many cancers. The purpose of this study was to investigate the biological role of Rab17 in non-small cell lung cancer (NSCLC) and the relative mechanism.

PPAR- Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2.

Purpose: Peroxisome proliferator-activated receptor- (PPAR-) is a nuclear hormone receptor with a key role in lipid metabolism. Previous studies have identified various roles of PPAR- in cell cycle progression, cellular proliferation, and tumor progression. However, no report has described a role for PPAR- in human nasopharyngeal carcinoma (NPC).

MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells.

Objective: This study aims to demonstrate the role of miR-182 in the glucose metabolism of NSCLC cells and the potential mechanism.

Methods: MTT Cytotoxicity Assay was used to measure the function of differentially expressed miR-182 on two NSCLC cell lines proliferation. Metabolite analysis was introduced to monitor the glucose consumption, lactate release and glycolytic intermediate metabolites.

Porcine FcεRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction.

Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FcεRI in ADE is still unclear. In this study, the expression of different Fc receptors (FcRs) on macrophages was investigated in a PRRSV 3D4/21 cell infection model in the presence or absence of PRRSV antibody. The transcription level of FcγII and FcεRI was significantly up-regulated under PRRSV-antibody complex infection.

Melatonin attenuates lung ischaemia-reperfusion injury via inhibition of oxidative stress and inflammation.

Objectives: Lung ischaemia-reperfusion injury is a complex pathophysiological process due to the production of reactive oxygen species and the generation of inflammatory reaction. We investigated the protective effects and the corresponding mechanism of melatonin (MT), a potent free-radical scavenger, on lung injury induced by ischaemia-reperfusion in a mouse model.

Methods: Adult male C57BL/6J mice (n = 30) were randomly and equally allocated into 5 groups: sham controls, IR, IR + 10 mg/kg MT, IR + 20 mg/kg MT and IR + 30 mg/kg MT.

Rapid detection of food-borne Salmonella contamination using IMBs-qPCR method based on pagC gene.

Detection of Salmonella is very important to minimize the food safety risk. In this study, the recombinant PagC protein and PagC antibody were prepared and coupled with immunomagnetic beads (IMBs) to capture Salmonella cells from pork and milk samples. And then the SYBR Green qualitative PCR was developed to detect the pathogenic Salmonella.

Staphylococcus enterotoxin profile of China isolates and the superantigenicity of some novel enterotoxins.

The genus of staphylococcus widely distributes in environments and contributes to a variety of animal and human diseases. The enterotoxins (SEs) secreted by this type of pathogen have been the leading cause of bacterial toxic shock syndrome and food poisoning, and thus present a substantial concern to public health. In this study, we analyzed the superantigen profile of 122 staphylococcus strains isolated from diverse sources.

Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression.

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease of unknown etiology that is currently untreatable. In this study we aim to characterize the potential of extracellular/circulating microRNAs (miRNAs) in serum as biomarkers for IPF.

Methods: Total serum RNAs were isolated from serum from healthy control subjects (n=12), rapid progressive (n=12) and slowly progressive IPF patients (n=12).

Participation of autophagy in lung ischemia-reperfusion injury in vivo.

Background: In response to stress, autophagy is activated and may present as a cell survival mechanism or lead to cell death. Although there has been some progress in studying the function of autophagy in the ischemia-reperfusion (I/R) injury of other organs, little is known about the role autophagy plays in lung I/R injury.

Methods: A lung I/R injury model in rats was developed to explore the level of autophagy in lung I/R injury.

Analysis of prognostic factors for surgery after neo-adjuvant therapy for stage III non-small cell lung cancer.

In order to explore the possibility to predict the risk factors for postoperative complications and survival time, the clinical data of 152 patients (including 116 males and 36 females) who had undergone neo-adjuvant therapy and surgery for stage IIIA and B non-small cell lung cancer (NSCLC) were retrospectively analyzed. Demographic data, preoperative functional parameters, staging, induction regimen (chemotherapy alone or associated with radiotherapy), associated disorders, and data about operation were collected. Chi-square test and multivariate analysis fitting the unconditional logistic regression model were performed to identify predictors of postoperative complications, while Kaplan-Meier and multivariate Cox proportional hazard model were employed to identify predictors of survival time, respectively.

[In vitro experiment of inhibiting cell proliferation on human esophageal squamous cell cancer T. Tn cell line by proliferating cell nuclear antigen antisense oligodeoxynucleotide].

Background & Objectives: The high expression of proliferation cell nuclear antigen were found in the patients with esophageal carcinoma in poor prognosis. The aim of this study was to investigate the effect in vitro of antisense oligodeoxynucleotide (ASODN) of PCNA on its gene expression and cell proliferation in human esophageal squamous cell cancer T. Tn cell line.