Fluorescent Self-Healing Elastomers with Triple Dynamic Bonds for 2D/3D Printed Information Encryption.

The development of novel optical self-healing materials holds significant importance for applications in anticounterfeiting and information encryption, but remains a formidable challenge. This study presents a fluorescent self-healing material designed for 2D/3D printing anticounterfeiting applications, exhibiting outstanding properties such as high transmittance, excellent mechanical strength, and remarkable self-healing efficiency. The triple dynamic bond networks provide robust mechanical and self-healing capabilities, with the polymer demonstrating a tensile strength of 26.

Intrinsic Photo-Crosslinkable Semiconductive Small-Molecule Crystals (i-PSSCs) for Patterning Electronic Devices.

Precise patterning of small-molecule semiconductive crystals without external chemical additives remains a significant challenge. Herein, intrinsic photo-crosslinkable semiconductive small-molecule crystals (i-PSSCs) are designed and synthesized by associating [1]benzothieno[3,2-b]benzothiophene core with diacetylene-ended groups. The i-PSSCs undergo self-crosslinking directly upon UV light irradiation to yield micron-scale patterned crystalline films through a combination of photo-crosslinking and solvent rinsing.

Light-triggered degradable bridged polysilsesquioxane nanoplatforms for spatiotemporally controlled drug release.

Developing stimuli-responsive nanoplatforms is a promising strategy for controlling the release of targeted molecules. In this study, nitrobenzyl ester was chosen as a photoresponsive moiety to functionalize an organic bridged linker, facilitating the synthesis of a photoresponsive silane, namely 2-nitro-1,3-phenyl bis(methylene mercaptoacetate ester) bridged trimethoxysilane (SMS). Light-triggered degradable bridged polysilsesquioxane nanoparticles (SMPS) were achieved through hydrolysis-condensation reactions using SMS as a precursor in suspension polymerization.

Intensive care unit outcomes and prognostic factors of esophageal cancer: A cross-sectional study in Chinese cancer-specialized hospitals.

Background: Esophageal cancer patients had the highest intensive care unit (ICU) admitted rate in cancer patients. But their prognosis and evaluation methods were rarely studied.

Aim: To depict the short-term mortality outcome and identify the potential prognostic factors of esophageal cancer patients admitted into ICU.

Enhancing head and neck cancer detection accuracy in digitized whole-slide histology with the HNSC-classifier: a deep learning approach.

Head and neck squamous cell carcinoma (HNSCC) represents the sixth most common cancer worldwide, with pathologists routinely analyzing histological slides to diagnose cancer by evaluating cellular heterogeneity, a process that remains time-consuming and labor-intensive. Although no previous studies have systematically applied deep learning techniques to automate HNSCC TNM staging and overall stage prediction from digital histopathology slides, we developed an inception-ResNet34 convolutional neural network model (HNSC-Classifier) trained on 791 whole slide images (WSIs) from 500 HNSCC patients sourced from The Cancer Genome Atlas (TCGA) Head and Neck Squamous Cell dataset. Our pipeline was designed to distinguish cancerous from normal tissue and to predict both tumor stage and TNM classification from histological images, with the dataset split at the patient level to ensure independence between training and testing sets and performance evaluated using comprehensive metrics including receiver operating characteristic (ROC) analysis, precision, recall, F1-score, and confusion matrices.

[Ineffective triggering and double triggering in patients with acute brain injury undergoing invasive mechanical ventilation].

Objective: To investigate the frequency and related factors of ineffective triggering (IT) and double triggering (DT) in patients with acute brain injury undergoing invasive mechanical ventilation.

Methods: A retrospective cohort study was conducted using data from a single-center observational trial. Patients with acute brain injury [traumatic brain injury, stroke, and post-craniotomy for brain tumors] undergoing mechanical ventilation in the intensive care unit (ICU) of Beijing Tiantan Hospital, Capital Medical University between June 2017 and July 2019 were retrospectively analyzed.

Kun-Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile.

Purpose: The Kun-Qi birth cohort (KQBC) was established to investigate the incidence, aetiology and risk factors of chronic kidney disease (CKD) in early childhood (0-6 years). Additionally, the study analysed developmental phenotypic trajectories and their associated paediatric diseases.

Participants: Infants registered or residing in Kunshan and Qidong, Jiangsu Province, who participated in the Chinese Child Healthcare Programme (0-6 years) were enrolled.

The m6A methyltransferase METTL14 promotes oncogenic Kras induced juvenile myelomonocytic leukemia through dysregulating autophagy.

The N6-methyladenosine (m6A) modification plays an important role in the pathogenesis of various myeloid malignancies. However, its specific role in RAS mutation-induced myeloid malignancy is incompletely understood. In this study, we found that m6A methyltransferase methyltransferase-like 14 (METTL14) was highly expressed and associated with a shorter survival in a RAS-mutation myeloid malignancy, juvenile myelomonocytic leukemia (JMML).

Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial.

Women with pre-existing sleep disturbance frequently experience postoperative sleep disturbance after surgery. This randomized, double-blind, placebo-controlled, parallel-group trial was conducted to investigate the efficacy of intraoperative adjunctive esketamine administration in the reduction of postoperative sleep disturbance following surgical abortion for women with pre-existing sleep disturbance. 204 women who had sleep disturbance and were scheduled for elective surgical abortion were randomized in a one-to-one allocation ratio to receive either a single intravenous injection of 0.

Modulating AMPA receptor-dependent synaptic plasticity: Mechanistic interventions against remifentanil-induced hyperalgesia in reoperative rats - A randomised controlled trial.

Background And Aims: Intraoperative remifentanil can induce postoperative hyperalgesia. In clinical practice, either unplanned or planned second operations may occur within a short period. However, the impact of remifentanil during this process remains unclear.

Non-solvent cinnamic acid-based gel patch for transdermal drug delivery.

Introduction: Drugs entitled polymeric network special functions in bio-applications. However, the introduction of appropriate solvent for drugs generally incurred tedious inclusion methods, intensive chemical design and aging caused by solvent loss. Herein, a novel non-solvent gel system was proposed for water-insoluble drug loading and subsequent controlled transdermal drug release.

Co-operative epigenetic remodelling by Setd2 deficiency and Kras mutation drives juvenile myelomonocytic leukaemia development and MEK inhibitor sensitivity.

Juvenile myelomonocytic leukaemia (JMML) primarily stems from the Rat Sarcoma (RAS)/Extracellular Signal-Regulated Kinase (ERK) pathway mutations, and currently, there are no effective regimens against JMML, yet various studies have highlighted the importance of deciphering secondary genetic and/or epigenetic alterations in pursuit of treatments. Setd2-mediated-H3K36me3 participates in myriad biological functions and primarily serves as a tumour suppressor gene in carcinogenesis. However, little is known about the synergism between Setd2 deficiency and Kras mutation during JMML onset and progression.

Electrochemical Oxygen Reduction Reaction-Coupled Dechlorination Promoting Acylation Reaction for Aromatic Ester Synthesis.

Aromatic ester compounds are one of the most versatile chemicals in many applications. Acylation reactions using acyl chlorides as building blocks are of great significance for their synthesis. However, novel and efficient strategies for acyl chlorides formation are limited.

NOX2/NLRP3-Inflammasome-Dependent Microglia Activation Promotes As(III)-Induced Learning and Memory Impairments in Developmental Rats.

Inorganic arsenic [As(III) and As(V)] is a pervasive environmental contaminant in groundwater systems, early-life exposure to which is associated with an impaired cognitive ability and an increased risk of neurobehavioral disorders. Although the effect of As(III) on the neurons is well studied, the involvement of the microglia remains unclear. In this study, the effects of sodium arsenite (NaAsO) on microglial activation and the underlying NLRP3 inflammasome mechanism were determined.

Chito-oligosaccharide composites enhanced the adaptability of cotton seedlings to salinized soil by modulating photosynthetic efficiency and metabolite.

Agricultural production on salinized lands is an important direction of current agricultural research. Chito-oligosaccharide has been used as an excellent soil amendment in recent years. However, the mechanism of chito-oligosaccharide composites (COS-PA) impacting cotton seedlings on salinized lands is still unclear.

Sonogenetics regulation of intelligent engineered bacteria to reverse immune escape.

Cancer immunotherapy resistance significantly challenges its clinical application. Traditional immunotherapy strategies are limited by the difficulty in delivering macromolecular immune modulators into the hypoxic core of tumors, leading to reduced efficacy and the development of resistance. Recently, bacterial-based delivery systems have been identified as a new approach in cancer therapy since bacteria have the potential of penetrating vascular barriers, infiltrating into deep tumor tissues and delivering therapeutics.

Body mass index should be considered as an indicator for laparoscopic surgery or robot-assisted surgery selection in patients with hiatal hernia.

Background: Hiatal hernia (HH), a prevalent clinical condition characterized by the protrusion of abdominal viscera into the thoracic cavity through the esophageal hiatus, remains a subject of ongoing debate regarding optimal surgical management strategies. This study aimed to analyze and compare the efficacy of robot-assisted versus laparoscopic repair of HH in patients with varying body mass index (BMI).

Methods: We retrospectively analyzed the clinical data of patients with HH treated at the Chinese People's Liberation Army (PLA) General Hospital from December 2013 to December 2023.

Implementation and maintenance of breast cancer screening among Chinese rural women: a mixed-methods evaluation based on RE-AIM framework.

Background: Significant disparities in breast cancer screening coverage existed between high-income and low-income regions. This study aims to assess the implementation, effectiveness, and sustainability of a breast cancer screening program in China to provide insights into developing an effective implementation strategy suitable for rural areas with limited health resources.

Methods: This study employed the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework to assess the implementation, effectiveness, and sustainability of a breast cancer screening program in Ordos, Inner Mongolia, China.

Triazine-Based Porous Organic Polymers with High CO Adsorption Capacity: Enhancing Flame Retardancy and Preventing Molten Dripping in Biobased Nylon 56.

Biobased Nylon 56 is inherently flammable and prone to producing significant melt droplets during combustion, presenting substantial challenges for flame-retardant applications. Herein, we propose a novel and eco-friendly flame-retardant strategy for Nylon 56 by leveraging the high CO adsorption capacity of triazine-based organic porous polymers. These triazine-based organic porous polymers (PTs), constructed within the fabric through a simple in situ polymerization process, form a robust protective barrier during combustion.

Prognostic significance of angiogenesis-associated molecules and Immunologic characteristic in elderly patients with acute myeloid leukemia.

Background:  Neovascularization mechanisms are hyperactivated in tumors, leading to vascular dysfunction and contributing to tumor metastasis and growth. This study aims to comprehensively analyze angiogenesis-associated genes in relation to the prognosis of elderly patients with acute myeloid leukemia (AML).

Methods: Leukemia gene expression data were obtained from the GSE37642 (training set) and TCGA_LAML (validation set) datasets.

Characterization and functional analysis of BRCA1 and BRCA2 variants in a cohort of 100 unselected patients undergoing germline screening.

Germline loss-of-function mutations in BRCA1 and BRCA2 (BRCA) genes are well-established as causative factors for hereditary breast and ovarian cancer (HBOC), conferring an approximately tenfold increased lifetime risk. The identification of BRCA mutations is essential for risk assessment and management in high-risk individuals and cancer patients. In this study, we utilized next-generation sequencing (NGS) to comprehensively analyze the entire coding regions of BRCA genes in a cohort of 100 unselected patients undergoing germline screening (average age ≤45 years and/or family history of related cancers).

Nanoscale Engineering of Ladder-Like Polysilsesquioxane Dielectric Surfaces Enables High-Performance Flexible Electronics.

Achieving high-performance flexible organic thin-film transistors (OTFTs) operating at low voltages is vital for next-generation electronics. Here, we report a novel ladder-like polysilsesquioxane (LPSQ) dielectric with nanoscale functionalities (long alkyl chains and epoxy groups) that simultaneously enhance organic semiconductor (OSC) self-assembly and dielectric performance. Alkyl chains promote chain-on crystallization of C10-DNTT, while epoxy groups boost dielectric polarization and enable UV photopatterning.

Transcription factors ERF74/77/108/125 enhance thermotolerance in rice by regulating common and distinct heat-responsive gene expression.

Heat stress severely impacts crop productivity, necessitating the identification of key regulatory genes for improving thermotolerance. Here, we demonstrate that the rice nuclear-localized AP2/ERF transcription factors ERF74/77/108/125 function as critical regulators of heat stress responses. Loss-of-function mutant seedlings of ERF74/77 or ERF108/125 exhibit increased heat sensitivity, whereas overexpression of each ERF74, ERF77, ERF108 or ERF125 individually enhances thermotolerance, indicating their positive role in heat adaptation.

Intensive Systolic Blood Pressure Reduction and Kidney and Cardiovascular Outcomes: A Secondary Analysis of a Randomized Clinical Trial.

Importance: Intensive blood pressure (BP) control is effective in reducing major cardiovascular events. However, whether the reduction of systolic BP may lead to kidney injury remains controversial.

Objective: To elucidate the association of intensive BP control with kidney and cardiovascular outcomes in individuals with hypertension without chronic kidney disease.

[Characteristics of Gut Microbiota Changes and Their Relationship with Infectious Complications During Induction Chemotherapy in AML Patients].

Objective: To investigate the characteristics of gut microbiota changes in patients with acute myeloid leukemia (AML) undergoing induction chemotherapy and to explore the relationship between infectious complications and gut microbiota.

Methods: Fecal samples were collected from 37 newly diagnosed AML patients at four time points: before induction chemotherapy, during chemotherapy, during the neutropenic phase, and during the recovery phase. Metagenomic sequencing was used to analyze the dynamic changes in gut microbiota.