Laser-Induced 3D Graphene Enabled Polymer Composites with Improved Mechanical and Electrical Properties Toward Multifunctional Performance.

Conductive graphene-based composites are attracting substantial interest due to their excellent mechanical and electrical properties for potential applications in electronics. Typically, such composites are fabricated by infiltrating the 3D graphene framework with the polymer matrix. However, the production of 3D graphene foams is limited by the challenges in preparing graphene dispersions, while 3D printing presents a significant breakthrough in the fabrication of desired 3D graphene-based structures.

Light-Driven, Super-Fast Self-Healing Transparent MXene/WO/Polyurethane Films with Superior Toughness for Thermal Management.

Light-driven materials have attracted great interest for their promising applications in next-generation smart devices. The incorporation of various photothermal materials into polymers has been developed for endowing composites with the capability of light harvesting and photothermal conversion, and management. However, their opaque appearance, vulnerability, and challenging processability limit their practical applications.

Large-Area Preparation of a Slippery Liquid-Infused Flexible Film via Roll-to-Roll Thermal Embossing for Anti-icing.

Slippery liquid-infused porous surfaces (SLIPS) have attracted widespread attention for their excellent anti-icing properties. However, their poor durability and limited scalability have severely hindered practical industrial applications. In this study, a simple method combining laser ablation and roll-to-roll thermal embossing is proposed to fabricate a large-area armor-protected flexible SLIPS (AF-SLIPS) with outstanding mechanical durability and anti-icing performance.

Identify drug-drug interactions via deep learning: A real world study.

Identifying drug-drug interactions (DDIs) is essential to prevent adverse effects from polypharmacy. Although deep learning has advanced DDI identification, the gap between powerful models and their lack of clinical application and evaluation has hindered clinical benefits. Here, we developed a Multi-Dimensional Feature Fusion model named MDFF, which integrates one-dimensional simplified molecular input line entry system sequence features, two-dimensional molecular graph features, and three-dimensional geometric features to enhance drug representations for predicting DDIs.

The Impacts of Farming Activities on the Coevolutionary Structure of Plant Rhizosphere Soil Microbial Communities.

Human agricultural activities can impact the soil microbial ecosystem, but the future implications of such changes remain largely unknown. This study aimed to explore how soil microbes survive and reproduce under the pressure of human agricultural cultivation and whether they resist or adapt. A 10-year continuous experiment was conducted, planting a maize and soybean rotation (control group), alfalfa (legume), and wheat (poaceae) to study the impact of different crop planting on soil microbial communities.

Association between air pollution and allergic upper respiratory diseases: a meta-analysis.

The prevalence of allergic upper respiratory diseases is rising, and while air pollution may worsen them, study results vary, and comprehensive analyses are lacking. This study aimed to systematically evaluate the link between air pollution and these diseases (allergic rhinitis, asthma and chronic sinusitis (with/without nasal polyps)) to provide evidence for reducing their prevalence. A systematic search of PubMed, Embase, Web of Science and Scopus was conducted to find studies published up to 1 September 2024, regarding association between air pollution and allergic upper respiratory diseases.

Trends in serum uric acid among US adolescents.

Serum UA concentration and prevalence of hyperuricemia have overall remained stable among US adolescents in the last 20 years.

Topical Ropivacaine Combined With Dexamethasone Spray Relieves Post-Tonsillectomy Pain in Adults.

Objective: To evaluate the efficacy of ropivacaine with dexamethasone spray for postoperative pain relief in adults undergoing tonsillectomy.

Methods: A total of 172 adult patients were randomly assigned to four groups: RD group (n = 43) received topical 1% ropivacaine with dexamethasone spray, RP group (n = 43) received topical 1% ropivacaine spray, Saline group (n = 43) received topical saline spray, and Control group (n = 43): not receive any interventions. The groups were compared on resting pain scores at 1, 2, 3, 5, 7, and 10 days, changes in pain scores over 10 days, adverse reactions (including dizziness, nausea, difficulty opening the mouth, and pharyngeal foreign body sensation), the time to first solid food intake, the time to first oral pain medication, and total pain medication dosage within 10 days postoperatively.

Baicalin Alleviates Piglet Immunosuppression Induced by via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy.

() causes vascular inflammation in piglets, resulting in vascular damage. However, the mechanism causing vascular inflammation remains unclear. Baicalin possesses an anti-inflammatory function.

Baicalin Relieves -Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets.

() infection is responsible for Glässer's disease in pigs. could trigger piglet immunosuppression, but the mechanism of inducing immunosuppression by remains unknown. Macrophage migration inhibitory factor (MIF)/CD74 axis has been shown to participate in inflammation response and immunosuppression, but the function of MIF/CD74 during immunosuppression elicited by has not been fully explored.

Efficacy of Ixekizumab in Chinese Patients with Radiographic Axial Spondyloarthritis by Baseline C-Reactive Protein Level.

Introduction: Ixekizumab, an interleukin 17A inhibitor, improved the Assessment of SpondyloArthritis international Society 40 (ASAS40) response rates irrespective of baseline inflammation in international populations with radiographic axial spondyloarthritis (r-axSpA). We investigated the association of baseline inflammation (measured by serum C-reactive protein [CRP] levels) with ixekizumab efficacy in Chinese patients with r-axSpA.

Methods: This was a subgroup analysis of a Chinese phase 3 study.

Construction of Robust Electrothermal Superhydrophobic Surface via Femtosecond Laser for Anti-Icing and Deicing.

Electrothermal superhydrophobic surfaces are regarded as possessing significant potential in anti-icing applications. However, their limited mechanical durability has constrained practical implementation. Herein, this work fabricated a robust electrothermal superhydrophobic surface by femtosecond laser texturing combined with the filling of functional coatings of TiC MXene and hydrophobic SiO nanoparticles (modified with dimethyldichlorosilane), which shows great superhydrophobic anti-icing and electrothermal deicing properties, as well as outstanding mechanical durability.

Superlow-Noise Quasi-2D Vertical Tunneling Tactile Sensor for Fine Liquid Dynamic Recognition.

To achieve high-precision intelligent tactile recognition and hyperfine operation tasks, tactile sensors need to possess the ability to discriminate minute pressures within the range of human perception. However, due to the lack of methodologies for noise suppression, existing tactile sensing mechanisms are inferior in pressure resolution. In this work, we emulate the structure of biological fingertip Merkel cells to develop a quasi-2D vertical tunneling tactile sensor based on conformal graphene nanowalls-hexagonal boron nitride-graphene (CGNWs-hBN-Gr) van der Waals (vdWs) heterojunctions.

Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Challenge.

() causes Glässer's disease and systemic inflammatory responses in the host. The currently available therapies have limited efficacy and fail to achieve a balance between anti-inflammatory and antibacterial effects. In this study, we investigated the effects of baicalin, amoxicillin, and probenecid on blood biochemical parameters, routine blood indicators, survival rate, bacterial burden, and pathological tissue damage in -challenged mice.

Establishment of a visualization platform for ADR query and analysis: an example of severe skin adverse reactions caused by sulfonylureas.

Purpose: This study aimed to develop a visualization platform for querying and analysing data from the FDA Adverse Event Reporting System (FAERS) to support the efficient collection, review, and analysis of adverse drug reactions (ADRs) for pharmacovigilance.

Methods: Data acquisition, cleaning, and integration processes were conducted to prepare FAERS data for analysis. The platform was designed with key functionalities, including multi-condition query, drug and ADR query, primary ID query, and interactive visualizations.

Construction and Effect Analysis of a Mixed Flora for Straw Returning to Albic Soil in Northeast China.

This research targets straw return in Farm 852's albic soil, China. The soil is nutrient-poor with few microbes and slow straw decomposition. Through fixed-point sampling and bacterial screening, an actinomycete consortium consisting of four strains was assembled, and two of them were identified as new actinomycetes.

Development and validation of a digital self-harm measurement: a population-based study of adolescents in China.

Background: The purpose of this study was to develop a digital self-harm scale suitable for Chinese adolescents, and to test its reliability and validity.

Methods: Through semi-structured interview, literature analysis and expert evaluation, the initial questionnaire was developed, and 1651 students from three middle schools in Jilin Province were selected for questionnaire survey. Item analysis and exploratory factor analysis were carried out, and 843 students were selected for confirmatory factor analysis, convergent validity, discrimination validity, criterion validity, content consistency reliability and retest reliability.

Smart Pharmaceutical Monitoring System With Personalized Medication Schedules and Self-Management Programs for Patients With Diabetes: Development and Evaluation Study.

Background: With the climbing incidence of type 2 diabetes, the health care system is under pressure to manage patients with this condition properly. Particularly, pharmacological therapy constitutes the most fundamental means of controlling blood glucose levels and preventing the progression of complications. However, its effectiveness is often hindered by factors such as treatment complexity, polypharmacy, and poor patient adherence.

Clinical features of inflammatory arthritis in daily practice-China's perspective.

Objective: This study aimed to analyze and compare the proportion of patients with different types of inflammatory arthritis and investigate the clinical characteristics, including symptoms and signs, medication choices, and disease activity, in the daily clinical practice of China.

Methods: Patients with inflammatory arthritis were recruited from 16 Grade-A tertiary hospitals between August 2021 and April 2022. The medical profiles, encompassing sociodemographic characteristics, clinical and laboratory date, were collected.

DUO1 Activated Zinc Finger (AtDAZ) protein role in the generative cell body morphogenesis.

Arabidopsis MYB transcription factor, AtDUO1 regulates generative cell body (GC) morphogenesis from round to semi and fully elongated forms before pollen mitosis-II (PM II). It was hypothesised that DUO1 might regulate morphogenesis through any of its direct target genes or components of the DUO1-DAZ1 network. The developmental analysis of plants harbouring T-DNA insertions in some DUO1 target genes using light and fluorescence microscopy revealed abnormal GC morphogenesis only in daz1 and daz2, but gcs1, trm16, mapkkk10, mapkkk20, tet11, and tip1 all undergo normal elongation indicating that these target genes have no important roles in morphogenesis or may be redundant.

Association between sleep duration and lung function among U.S. adults.

Background: Sleep's impact on the human immune system and inflammatory responses makes it a potential risk factor for lung function impairment. However, the relationship between sleep duration and lung function impairment in middle-aged and young adults has been rarely investigated.

Methods: A total of 9,284 aged 20-64 years were categorized into four groups according to sleep duration (≤ 6 h, 7 h, 8 h, and ≥ 9 h), with 7 h as the reference, by using the U.

Data - Knowledge driven machine learning model for cancer pain medication decisions.

Background: Cancer pain is one of the most common symptoms in cancer patients, and drug decision-making in cancer pain management remains challenges. This study aims to develop machine learning models using real-world clinical data and prior knowledge to support drug decision-making in cancer pain management.

Methods: Clinical records from the Xiangya Hospital information system and a specialized cancer pain platform were used to develop two machine learning models: one for patients newly experiencing pain and one for patients with inadequate pain control.