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Article Abstract
() infection is responsible for Glässer's disease in pigs. could trigger piglet immunosuppression, but the mechanism of inducing immunosuppression by remains unknown. Macrophage migration inhibitory factor (MIF)/CD74 axis has been shown to participate in inflammation response and immunosuppression, but the function of MIF/CD74 during immunosuppression elicited by has not been fully explored. This experiment explored the efficacy of baicalin on immunosuppression elicited by alleviation through regulating polarization via the MIF/CD74 signaling pathway. Our data indicated that baicalin reduced IL-1β, IL-6, IL-8, IL-18, TNF-α, and COX-2 expression, and regulated MIF/CD74 axis expression in the spleen. Immunohistochemistry analysis showed that baicalin enhanced CD74 protein levels in the spleen of piglets induced by . Baicalin regulated the PI3K/Akt/mTOR signaling pathway and RAF/MEK/ERK signaling activation, modified the expression of the autophagy-related proteins Beclin-1, P62, and LC3B, promoted M2 polarization to M1 polarization, and enhanced CD3, CD4, CD8, and TIM3 levels in the spleen of piglets elicited by . Our study reveals the important functions of the MIF/CD74 axis in -induced immunosuppression and may offer a new therapeutic method to control infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108920 | PMC |
| http://dx.doi.org/10.3390/biom15050640 | DOI Listing |
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