Emergence of Robust 1D Atomic and Electronic Textures in Mn Ultrathin Films via Antiferromagnet-Ferromagnet Interfaces.

1D electronic structures on 2D crystalline surfaces are crucial for investigating low-dimensional quantum phenomena and enabling the development of dimensionally engineered nanodevices. However, the inherent periodic symmetry of 2D atomic lattices generally leads to delocalized electronic band extending across the surface, making the creation of periodic 1D electronic states a significant challenge. Here, robust 1D electronic ordering is demonstrated in ultrathin Mn films grown on an atomically flat, non-reconstructed body-centered cubic Fe substrate.

Impact of Enterococcus faecium 129 BIO 3B-R on Helicobacter pylori eradication therapy side effects in adult patients: a randomized, double-blind, placebo-controlled study.

Managing the side effects of diarrhea, which is associated with intestinal microbial dysbiosis, is a crucial challenge in Helicobacter pylori eradication therapy. The aim of this study is to explore whether administration of a probiotic strain Enterococcus faecium 129 BIO 3B-R, a multi-antibiotic resistant lactic acid bacterium, influences the side effects of Helicobacter pylori eradication therapy in adults. Seventy-six adults undergoing this therapy were randomized to receive either Enterococcus faecium 129 BIO 3B-R or a placebo in a double-blind manner.

Identification of Orbital Pumping from Spin Pumping and Rectification Effects.

The recently predicted mechanism of orbital pumping can enable the generation of pure orbital current from a precessing ferromagnet (FM) without the need for electrical current injection. This orbital current can be efficiently injected into an adjacent nonmagnetic material (NM) without being hampered by electrical conductivity mismatch. However, experimentally identifying this novel effect presents significant challenges due to the substantial background contributions from spin pumping and spin rectification effects (SREs).

Usefulness of gel immersion endoscopy for endoscopic resection in stomachs with residue.

Background And Aims: EMR and endoscopic submucosal dissection are widely used for treating intramucosal gastric neoplasms. However, securing a clear visual field in a stomach with residue is challenging. In this article, we present 2 cases in which tumors were endoscopically resected by securing the visual field using the gel immersion method in remnant stomachs after proximal gastrectomy with residue.

Dialysis, Antithrombotics, and Lesion Location: Who Benefits Most from Gel Immersion Endoscopy in Gastric Endoscopic Submucosal Dissection?

Introduction: Gel-immersion endoscopy (GIE) is a technique used to maintain a clear view during gastric endoscopic submucosal dissection (ESD). We aimed to identify cases most likely to benefit from GIE for ESD bleeding by reviewing our clinical experience and determining the associated factors.

Methods: We retrospectively analyzed 470 lesions in 380 patients who underwent gastric ESD between October 2020 and March 2023.

Validation of Two-Factor Authentication Technology Using Smartcard with Biometric Capabilities.

This study investigated a low-cost two-factor authentication system using smartcards with biometric fingerprint authentication. Compared to traditional two-factor methods, the proposed system simplifies implementation and reduces costs by requiring only a smartcard authentication system without the need for an additional biometric authentication server. The system also streamlines initial enrolment while maintaining security through fingerprint verification, which disables lost or stolen cards after failed attempts.

Kidney Function Trajectories with Tolvaptan in ADPKD Patients with CKD-G5.

Introduction: Improvement of estimated glomerular filtration rate (eGFR) slope has been established using tolvaptan in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). In Japan, the therapeutic dose of tolvaptan (60-120 mg/d) must be discontinued at chronic kidney disease stage G5 (CKD-G5), eGFR < 15 ml/min per 1.73 m.

Retrospective study comparing rectal endoscopic submucosal dissection with and without Foley catheter drainage tube placement.

Background And Study Aims: Endoscopic submucosal dissection (ESD) is a minimally invasive and effective treatment for rectal tumors but maintaining a clear surgical field during the procedure is challenging, especially for novice operators. This study aimed to investigate whether continuous drainage using a Foley catheter could enhance efficiency and safety of rectal ESD performed by novice endoscopists under expert supervision.

Patients And Methods: This retrospective study involved 26 patients who underwent rectal ESD between March 2023 and October 2024.

Direct Generation of Carboxyl Radicals from Carboxylic Acids Catalyzed by Photoactivated Ketones.

Carboxyl radicals are reactive intermediates, which potentially offer opportunities to develop unique transformations in radical chemistry, yet their straightforward generation from carboxylic acids has largely relied on the use of environmentally less benign methods, and their application has been mainly limited to decarboxylative functionalizations. Here, we present a photoactivated ketone-catalyzed direct generation of carboxyl radicals via hydrogen atom transfer (HAT) from the O-H bond of carboxylic acids. An integrated approach combining theoretical predictions and experimental validation guided the development of this simple, chemoselective O-H HAT catalysis, which is facilitated by hydrogen-bonding interaction between the ketone photocatalyst and the carboxylic acid and leaves weaker C-H bonds intact.

Complete genome sequence of a clinical isolate harboring a novel variant of the carbapenemase gene, .

strain CRE21025 was isolated from a gallbladder abscess of a patient admitted to the hospital in Shimane Prefecture in 2021. Here, we present the complete genome sequence of this isolate, bearing a novel variant of the imipenemase-type gene, , by whole-genome sequencing using Oxford Nanopore and Illumina methods.

Development of a peptide-based vaccine using a T cell epitope derived from SARS-CoV-2.

Follicular helper T (Tfh) cells are a subset of CD4 T cells that help B cells to produce high-affinity antibodies. Efficient Tfh cell induction by vaccines is critical for protective efficacy against diseases. A Tfh epitope, identified from the SARS-CoV-2 spike protein, has been shown to bind to the corresponding HLA and activates Tfh cells.

Site-specific aptamer immobilization via amine-to-thiol cross-linking on field-effect transistor biosensor for cortisol detection.

The detection of various biomarkers using field-effect transistor (FET) biosensors is expected to effectively contribute to the promotion of human health. Aptamers, single-stranded DNA molecules, are promising candidates as receptors for FET biosensors, capable of recognizing a wide range of targets from viruses to small-molecule hormones. By immobilizing aptamers on the FET gate surface through terminally modified functional groups, effective changes in surface potential can be induced upon binding to the target molecule.

Impact of glucocorticoid tapering speed on renal outcomes in proliferative lupus nephritis: a multicentre retrospective study.

Objectives: Recent guidelines and recommendations for LN suggest rapid glucocorticoid (GC) reduction; however, robust supporting evidence remains limited. This study aimed to evaluate the impact of rapid GC reduction on renal outcomes in patients with proliferative LN.

Methods: We conducted a multicentre retrospective chart review of patients with GC-naïve, biopsy-proven proliferative LN with available urinary protein-to-creatinine ratio (UPCR) data before and 52 weeks after GC treatment.

Higher Absolute Lymphocyte Counts and Lower Des-γ-Carboxyprothrombin Levels After Treatment Initiation Are Associated With the Clinical Efficacy of Tremelimumab Plus Durvalumab Combination Therapy for Hepatocellular Carcinoma.

Background And Aims: Tremelimumab plus durvalumab (Dur/Tre) combination therapy is now a first-line systemic therapy for advanced hepatocellular carcinoma (HCC). Because systemic therapy is not effective in some patients, it is clinically important to identify factors that could predict the response to treatment at an early stage. We investigated the factors associated with the response to Dur/Tre for advanced HCC in a clinical setting.

Repeated sequential administration of pegylated emulsion of SU5416 and liposomal paclitaxel enhances anti-tumor effect in 4T1 breast cancer-bearing mice.

To improve vascular normalization strategy for intractable triple-negative breast cancer 4T1, we examined the anti-tumor effects of repeated sequential administration of polyethylene glycol (PEG)-modified emulsion of SU5416 (PE-SU5416), a vascular endothelial growth factor (VEGF) receptor-2 kinase inhibitor, and PEG-modified liposomal paclitaxel (PL-PTX) in mice bearing 4T1 cells. Three sequential administrations (Seq×3) of PE-SU5416 and PL-PTX exhibited significantly higher anti-tumor activity than a single sequential administration (Seq×1). The tumor vasculatures were structurally normalized until after two PE-SU5416 (PE-SU5416×2) or sequential (Seq×2) administrations, while the improvement in vascular function, such as oxygen supply, blood flow, and PEG-liposomal distribution, was evident until after three administrations of PE-SU5416 (PE-SU5416×3) and Seq×3.

Clinical characteristics of monoclonal immunoglobulin-associated renal disease: a retrospective cohort study.

Introduction: Clinical epidemiological data on monoclonal gammopathy of renal significance (MGRS) are lacking. In this retrospective observational study, MGRS was compared with B-cell or plasma cell malignancies (BCM/PCM) with renal involvement to clarify differences in their clinical features.

Methods: Among the 1408 renal biopsies performed at our hospital, 25 MGRS and 18 BCM/PCM patients were identified.

Strain-Releasing Ring-Opening Diphosphinations for the Synthesis of Diphosphine Ligands with Cyclic Backbones.

Diphosphine ligands based on cyclobutane, bicyclo[3.1.1]heptane, and bicyclo[4.

γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO Radical Anion.

γ-Butyrolactone structures are commonly found in various natural products and serve as crucial building blocks in organic synthesis. Consequently, the development of methods for synthesizing γ-butyrolactones has garnered significant interest within the organic synthesis community. In this study, we present a direct and highly efficient approach for the synthesis of γ-butyrolactones from allylic alcohols.

Therapeutic Vaccines and Nucleic Acid Drugs for Cardiovascular Disease.

To combat the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), novel vaccine modalities, such as messenger RNA vaccines, were rapidly developed and have shown high efficacy. This new vaccine technology, underpinned by intensive immunological analysis, is now being applied to the production of other vaccines. For over 10 years, we have been developing therapeutic vaccines for non-infectious diseases.

Immunogenic Comparison of Nucleic Acid-Based Vaccines Administered by Pyro-Drive Jet Injector.

mRNA vaccines were successfully developed and approved for emergency use to fight coronavirus disease 2019. However, the effect of DNA vaccines against SARS-CoV-2 is considerably lower than that of mRNA vaccines. A pyro-drive jet injector (PJI) efficiently delivers plasmid DNA intradermally into animal models.