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strain CRE21025 was isolated from a gallbladder abscess of a patient admitted to the hospital in Shimane Prefecture in 2021. Here, we present the complete genome sequence of this isolate, bearing a novel variant of the imipenemase-type gene, , by whole-genome sequencing using Oxford Nanopore and Illumina methods.
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http://dx.doi.org/10.1128/mra.00196-25 | DOI Listing |
Oncogene
September 2025
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
There are no proven therapies for metastatic or unresectable Chromophobe Renal Cell Carcinoma (ChRCC). ChRCC is characterized by high glutathione levels and hypersensitivity to ferroptosis, an iron-dependent form of cell death characterized by peroxidation of polyunsaturated fatty acids. The underlying mechanisms leading to ferroptosis hypersensitivity are unknown.
View Article and Find Full Text PDFMar Genomics
September 2025
MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China. Electronic address:
Dimethylsulfoniopropionate (DMSP) is a ubiquitous organosulfur compound produced by various marine organisms and plays a central role in global sulfur and carbon cycling through microbial catabolism. In this study, we present the complete genome sequence and functional annotation of Paracoccus homiensis HT-F, a marine bacterium isolated from intertidal algae of the Yellow Sea, China. The genome comprises a 2,714,952 bp circular chromosome with a GC content of 63.
View Article and Find Full Text PDFVet Microbiol
September 2025
University of Kentucky Veterinary Diagnostic Laboratory, Lexington, KY 40511, United States of America. Electronic address:
Neorickettsia risticii (N. risticii) is an obligatory intracellular bacterium that causes Potomac horse fever (PHF), a disease clinically characterized by diarrhea, pyrexia, and laminitis in horses. Although sporadic reports of N.
View Article and Find Full Text PDFCell Rep
September 2025
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA; Center for Neurogenetics, Weill Cornell Medicine, New York, NY, USA. Electronic address:
Progranulin-deficient frontotemporal dementia (GRN-FTD) is a major cause of familial FTD with TAR DNA-binding protein 43 (TDP-43) pathology, which is linked to exon dysregulation. However, little is known about this dysregulation in glial and neuronal cells. Here, using splice-junction-covering enrichment probes, we introduce single-nuclei long-read RNA sequencing 2 (SnISOr-Seq2), targeting 3,630 high-interest genes without loss of precision, and complete the first single-cell, long-read-resolved case-control study for neurodegeneration.
View Article and Find Full Text PDFSTAR Protoc
September 2025
Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands. Electronic address:
Research on multimorbidity patterns promotes our understanding of the common pathological mechanisms that underlie co-occurring diseases. Here, we present a protocol to infer multimorbidity clusters in the form of disease topics from large-scale diagnosis data using treeLFA, a topic model based on the Bayesian binary non-negative matrix factorization. We describe steps for installing software, preparing input data, and training the model.
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