Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma.

There are no proven therapies for metastatic or unresectable Chromophobe Renal Cell Carcinoma (ChRCC). ChRCC is characterized by high glutathione levels and hypersensitivity to ferroptosis, an iron-dependent form of cell death characterized by peroxidation of polyunsaturated fatty acids. The underlying mechanisms leading to ferroptosis hypersensitivity are unknown.

BCL-xL dependency in chromophobe renal cell carcinoma.

Chromophobe renal cell carcinoma (ChRCC) is the third most common subtype of kidney cancer, with limited therapeutic options. Using BH3 profiling to screen ChRCC-derived cell lines, we discovered that BH3 peptides targeting BCL-xL promote apoptosis in ChRCC. Downregulation of BCL2L1 is sufficient to induce apoptosis in ChRCC-derived cells, consistent with our screening results.

Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma.

Purpose: While immune checkpoint inhibition (ICI) has transformed the management of many advanced renal cell carcinomas (RCCs), the determinants of effective antitumor immunity for chromophobe RCC (ChRCC) and renal oncocytic tumors remain an unmet clinical and scientific need.

Methods: Single-cell transcriptomic and T-cell receptor profiling was performed on tumor and adjacent normal tissue of patients with ChRCC and renal oncocytic neoplasms. Using machine learning, the cellular origin of renal oncocytic neoplasms was evaluated, with analysis of associated oncogenic pathways.

Right extended hemicolectomy with ileo-descending anastomosis is associated with prolonged postoperative ileus and longer hospital stay compared to right or left hemicolectomy.

Purpose: Prolonged postoperative ileus (PPOI) is associated with a lengthy hospital stay, risk of additional complications and substantial costs. Data regarding the incidence of PPOI following right extended colectomy (REC) with ileo-descending anastomosis is limited. This study aimed to compare the incidence of PPOI and evaluate risk factors for this condition among patients undergoing REC, left hemicolectomy (LC), and right hemicolectomy (RC) for colon carcinoma.

Validation of safety for self-retracting intraperitoneal device for small bowel in minimally invasive surgery.

Background: Modernly, abdominal surgery has shifted to minimally invasive techniques with an inclination towards fewer incisions. This has made intra-abdominal retraction more challenging. Despite development in retracting instrumentation for solid organs, the mobilization of the bowel remains challenging due to its friable nature.

Should We Operate Nonagenarians with Symptomatic Giant Paraesophageal Hernias?

Hiatal hernia (HH) is a common disorder of the upper gastrointestinal (UGI) tract that general surgeons encounter. Giant paraesophageal is a subtype of HH in which more than 30% of the stomach is located in the chest. It can cause symptoms such as dysphagia, UGI bleeding, gastroesophageal reflux disease, and vomiting.

Robotic Heller's myotomy using the new Hugo™ RAS system: first worldwide report.

Background: Achalasia is a rare disorder of the esophagus characterized by motor dysfunction in the esophagus and relaxation failure of the lower esophageal sphincter (LES). Currently, surgical myotomy procedures are considered the standard of care. Robotic Heller's myotomy (RHM) with fundoplication has been gaining popularity due to documented advantages in the precision of myotomy as well as avoiding the potential reflux following per-oral endoscopic myotomy (POEM).

The Angle of His as a Measurable Element of the Anti-reflux Mechanism.

Background: Gastroesophageal reflux disease (GERD) is a common condition, resulting from the loss of the anti-reflux barrier. Laparoscopic fundoplication is the surgical procedure of choice for treatment of GERD; however, there remains a debate on the exact mechanism through which it prevents reflux.

Objectives: Our aim was to understand the relationship between reflux, fundoplication, and the angle of His on an experimental model.

Health Literacy Levels and Predictors Among Lebanese Adults Visiting Outpatient Clinics in Beirut.

Background: To date, there has been a dearth of research on health literacy in the Eastern Mediterranean Region and in particular Lebanon.

Objectives: This cross-sectional study assessed the levels and correlates of health literacy in Lebanese adults.

Methods: A total of 587 participants (54.

Psoas Attenuation and Mortality of Elderly Patients Undergoing Nontraumatic Emergency Laparotomy.

Background: Emergency laparotomy (EL) is an increasingly common procedure in the elderly. Factors associated with mortality in the subpopulation of frail patients have not been thoroughly investigated. Sarcopenia has been investigated as a surrogate for frailty and poor prognosis.